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Conserved domains on  [gi|1275378735|gb|PIM03413|]
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putative 26S proteasome regulatory subunit 6b [Toxoplasma gondii COUG]

Protein Classification

26S proteasome regulatory subunit 6B( domain architecture ID 11488542)

26S proteasome regulatory subunit 6B is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
11-408 0e+00

26S protease regulatory subunit 6B-like protein; Provisional


:

Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 803.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  11 AEASLCPSDASGDSLHTRDLYAQLKALQKRLEFLNIQEEYIKDEQKNLKREFYRAREELKRIQSVPLVIGQFMELINANE 90
Cdd:PTZ00454    1 VATTAAAAVASSTTHTERDLYEKLKELEKELEFLDIQEEYIKEEQKNLKRELIRAKEEVKRIQSVPLVIGQFLEMIDSNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  91 GIVASTAGSSYVVRILSTLNRELLKTGCSVALHRHSHSVVDILPPEADSTIQTLQMQEKPDVTYSDIGGMDIQKQEIREA 170
Cdd:PTZ00454   81 GIVSSTSGSNYYVRILSTLNRELLKPNASVALHRHSHAVVDILPPEADSSIQLLQMSEKPDVTYSDIGGLDIQKQEIREA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 171 VELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPA 250
Cdd:PTZ00454  161 VELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 251 IVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 330
Cdd:PTZ00454  241 IIFIDEVDSIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1275378735 331 RRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPKDFEKGWKAHVRKHERDFDFYS 408
Cdd:PTZ00454  321 KRLIFQTITSKMNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRKNRYVILPKDFEKGYKTVVRKTDRDYDFYS 398
 
Name Accession Description Interval E-value
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
11-408 0e+00

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 803.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  11 AEASLCPSDASGDSLHTRDLYAQLKALQKRLEFLNIQEEYIKDEQKNLKREFYRAREELKRIQSVPLVIGQFMELINANE 90
Cdd:PTZ00454    1 VATTAAAAVASSTTHTERDLYEKLKELEKELEFLDIQEEYIKEEQKNLKRELIRAKEEVKRIQSVPLVIGQFLEMIDSNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  91 GIVASTAGSSYVVRILSTLNRELLKTGCSVALHRHSHSVVDILPPEADSTIQTLQMQEKPDVTYSDIGGMDIQKQEIREA 170
Cdd:PTZ00454   81 GIVSSTSGSNYYVRILSTLNRELLKPNASVALHRHSHAVVDILPPEADSSIQLLQMSEKPDVTYSDIGGLDIQKQEIREA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 171 VELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPA 250
Cdd:PTZ00454  161 VELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 251 IVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 330
Cdd:PTZ00454  241 IIFIDEVDSIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1275378735 331 RRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPKDFEKGWKAHVRKHERDFDFYS 408
Cdd:PTZ00454  321 KRLIFQTITSKMNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRKNRYVILPKDFEKGYKTVVRKTDRDYDFYS 398
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
37-391 6.72e-146

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 418.82  E-value: 6.72e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  37 LQKRLEFLNIQEEYIKDEQKNLKREFYRAREELKRIQSVPLVIGQFMELINANEGIVASTAGSSYVVRILSTLNRELLKT 116
Cdd:TIGR01242   4 LDVRIRKLEDEKRSLEKEKIRLERELERLRSEIERLRSPPLIVGTVLEVLDDNRVVVKSSTGPNFVVNVSAFIDRKSLKP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 117 GCSVALHRHSHSVVDILPPEADSTIQTLQMQEKPDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYG 196
Cdd:TIGR01242  84 GARVALNQQTLTIVDVLPTSKDPLVKGMEVEERPNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 197 PPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADREVQ 276
Cdd:TIGR01242 164 PPGTGKTLLAKAVAHETNATFIRVVGSELVRKYIGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRTDSGTSGDREVQ 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 277 RILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSR 356
Cdd:TIGR01242 244 RTLMQLLAELDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRIIEVPLPDFEGRLEILKIHTRKMKLAEDVDLEAIAKM 323
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1275378735 357 PEKVSAADIAAICQEAGMQAVRKNRYVILPKDFEK 391
Cdd:TIGR01242 324 TEGASGADLKAICTEAGMFAIREERDYVTMDDFIK 358
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
148-403 3.10e-132

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 382.82  E-value: 3.10e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 148 EKPDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQ 227
Cdd:COG1222    71 ESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVS 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 228 KYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGAdrEVQRILLELLNQMDGFDQTTTVKVIMATNRADTL 307
Cdd:COG1222   151 KYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSG--EVQRTVNQLLAELDGFESRGDVLIIAATNRPDLL 228
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 308 DPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPK 387
Cdd:COG1222   229 DPALLRPGRFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIREGRDTVTME 308
                         250
                  ....*....|....*.
gi 1275378735 388 DFEKGWKAHVRKHERD 403
Cdd:COG1222   309 DLEKAIEKVKKKTETA 324
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
153-323 1.16e-114

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 331.99  E-value: 1.16e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 153 TYSDIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGE 232
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 233 GPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALL 312
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFDSGTGGDREVQRTMLELLNQLDGFDPRGNIKVIMATNRPDILDPALL 160
                         170
                  ....*....|.
gi 1275378735 313 RPGRLDRKIEF 323
Cdd:cd19502   161 RPGRFDRKIEF 171
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
192-325 1.14e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 174.70  E-value: 1.14e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDaqtGA 271
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGS---GG 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1275378735 272 DREVQRILLELLNQMDGFDQTT-TVKVIMATNRADTLDPALLrpGRLDRKIEFPL 325
Cdd:pfam00004  78 DSESRRVVNQLLTELDGFTSSNsKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
188-327 7.35e-20

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 85.50  E-value: 7.35e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  188 PPTGVLLYGPPGTGKTMLAKAVANN---TTATFIRVVGSEF--------------VQKYLGEGPRMVRDVFRLARENSPA 250
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARElgpPGGGVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1275378735  251 IVFIDEVDAIATKRFdaqtgadrEVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPgRLDRKIEFPLPD 327
Cdd:smart00382  81 VLILDEITSLLDAEQ--------EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
 
Name Accession Description Interval E-value
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
11-408 0e+00

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 803.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  11 AEASLCPSDASGDSLHTRDLYAQLKALQKRLEFLNIQEEYIKDEQKNLKREFYRAREELKRIQSVPLVIGQFMELINANE 90
Cdd:PTZ00454    1 VATTAAAAVASSTTHTERDLYEKLKELEKELEFLDIQEEYIKEEQKNLKRELIRAKEEVKRIQSVPLVIGQFLEMIDSNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  91 GIVASTAGSSYVVRILSTLNRELLKTGCSVALHRHSHSVVDILPPEADSTIQTLQMQEKPDVTYSDIGGMDIQKQEIREA 170
Cdd:PTZ00454   81 GIVSSTSGSNYYVRILSTLNRELLKPNASVALHRHSHAVVDILPPEADSSIQLLQMSEKPDVTYSDIGGLDIQKQEIREA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 171 VELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPA 250
Cdd:PTZ00454  161 VELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 251 IVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 330
Cdd:PTZ00454  241 IIFIDEVDSIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1275378735 331 RRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPKDFEKGWKAHVRKHERDFDFYS 408
Cdd:PTZ00454  321 KRLIFQTITSKMNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRKNRYVILPKDFEKGYKTVVRKTDRDYDFYS 398
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
34-405 1.35e-171

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 485.11  E-value: 1.35e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  34 LKALQKRLEFLNIQEE-------YIKDEQKNLKREFYRAREELKRIQSVPLVIGQFMELINANEGIVASTAGSSYVVRIL 106
Cdd:PRK03992    3 LEALEERNSELEEQIRqlelklrDLEAENEKLERELERLKSELEKLKSPPLIVATVLEVLDDGRVVVKSSGGPQFLVNVS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 107 STLNRELLKTGCSVALHRHSHSVVDILPPEADSTIQTLQMQEKPDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQIGI 186
Cdd:PRK03992   83 PFIDREKLKPGARVALNQQSLAIVEVLPSEKDPRVQAMEVIESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 187 DPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFD 266
Cdd:PRK03992  163 EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTD 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 267 AQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSD 346
Cdd:PRK03992  243 SGTSGDREVQRTLMQLLAEMDGFDPRGNVKIIAATNRIDILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMNLAD 322
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1275378735 347 EVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPKDFEKGWKAHVRKHERDFD 405
Cdd:PRK03992  323 DVDLEELAELTEGASGADLKAICTEAGMFAIRDDRTEVTMEDFLKAIEKVMGKEEKDSM 381
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
26-392 6.48e-159

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 454.61  E-value: 6.48e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  26 HTRDLYAQLKaLQKRLEFLNIQEEYI--KDEQKNLKREFYRAREELKRIQSVPLVIGQFMELINANEGIVASTAGSSYVV 103
Cdd:PTZ00361   53 NTKCRLRLLK-LERIKDYLLLEEEFItnQEAQKPAQEKNEAELKKVDDLRGSPLSVGTLEEIIDENHAIVSSSVGPEYYV 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 104 RILSTLNRELLKTGCSVALHRHSHSVVDILPPEADSTIQTLQMQEKPDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQ 183
Cdd:PTZ00361  132 NILSFVDKEQLEPGCSVLLHNKTHSVVGILLDEVDPLVSVMKVDKAPLESYADIGGLEQQIQEIKEAVELPLTHPELYDD 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 184 IGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATK 263
Cdd:PTZ00361  212 IGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTK 291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 264 RFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMN 343
Cdd:PTZ00361  292 RYDATSGGEKEIQRTMLELLNQLDGFDSRGDVKVIMATNRIESLDPALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKMT 371
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1275378735 344 LSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPKDFEKG 392
Cdd:PTZ00361  372 LAEDVDLEEFIMAKDELSGADIKAICTEAGLLALRERRMKVTQADFRKA 420
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
37-391 6.72e-146

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 418.82  E-value: 6.72e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  37 LQKRLEFLNIQEEYIKDEQKNLKREFYRAREELKRIQSVPLVIGQFMELINANEGIVASTAGSSYVVRILSTLNRELLKT 116
Cdd:TIGR01242   4 LDVRIRKLEDEKRSLEKEKIRLERELERLRSEIERLRSPPLIVGTVLEVLDDNRVVVKSSTGPNFVVNVSAFIDRKSLKP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 117 GCSVALHRHSHSVVDILPPEADSTIQTLQMQEKPDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYG 196
Cdd:TIGR01242  84 GARVALNQQTLTIVDVLPTSKDPLVKGMEVEERPNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 197 PPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADREVQ 276
Cdd:TIGR01242 164 PPGTGKTLLAKAVAHETNATFIRVVGSELVRKYIGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRTDSGTSGDREVQ 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 277 RILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSR 356
Cdd:TIGR01242 244 RTLMQLLAELDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRIIEVPLPDFEGRLEILKIHTRKMKLAEDVDLEAIAKM 323
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1275378735 357 PEKVSAADIAAICQEAGMQAVRKNRYVILPKDFEK 391
Cdd:TIGR01242 324 TEGASGADLKAICTEAGMFAIREERDYVTMDDFIK 358
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
148-403 3.10e-132

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 382.82  E-value: 3.10e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 148 EKPDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQ 227
Cdd:COG1222    71 ESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVS 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 228 KYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGAdrEVQRILLELLNQMDGFDQTTTVKVIMATNRADTL 307
Cdd:COG1222   151 KYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSG--EVQRTVNQLLAELDGFESRGDVLIIAATNRPDLL 228
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 308 DPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPK 387
Cdd:COG1222   229 DPALLRPGRFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIREGRDTVTME 308
                         250
                  ....*....|....*.
gi 1275378735 388 DFEKGWKAHVRKHERD 403
Cdd:COG1222   309 DLEKAIEKVKKKTETA 324
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
153-323 1.16e-114

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 331.99  E-value: 1.16e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 153 TYSDIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGE 232
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 233 GPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALL 312
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFDSGTGGDREVQRTMLELLNQLDGFDPRGNIKVIMATNRPDILDPALL 160
                         170
                  ....*....|.
gi 1275378735 313 RPGRLDRKIEF 323
Cdd:cd19502   161 RPGRFDRKIEF 171
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
148-399 8.47e-81

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 262.92  E-value: 8.47e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 148 EKPDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQ 227
Cdd:TIGR01243 446 EVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILS 525
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 228 KYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRfdaqtGADRE---VQRILLELLNQMDGFDQTTTVKVIMATNRA 304
Cdd:TIGR01243 526 KWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPAR-----GARFDtsvTDRIVNQLLTEMDGIQELSNVVVIAATNRP 600
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 305 DTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVI 384
Cdd:TIGR01243 601 DILDPALLRPGRFDRLILVPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSP 680
                         250
                  ....*....|....*
gi 1275378735 385 LPKDFEKGWKAHVRK 399
Cdd:TIGR01243 681 AKEKLEVGEEEFLKD 695
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
17-391 1.64e-78

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 247.90  E-value: 1.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  17 PSDASGDSLHTRDLYAQLKALQKRLEFLNIQEEYIKDEQKNLKREFYRAREELKRIQSVPLVIGQFMELINANEGIVAST 96
Cdd:COG0464    17 LLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGE 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  97 AGSSYVVRILSTLNRELLKTGCSVALHRHSHSVVDILPPEADSTIQTLQM--QEKPDVTYSDIGGMDIQKQEIREAVELP 174
Cdd:COG0464    97 LLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEelLELREAILDDLGGLEEVKEELRELVALP 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 175 LTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIVFI 254
Cdd:COG0464   177 LKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFI 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 255 DEVDAIATKRfdaQTGADREVQRILLELLNQMDGFdqTTTVKVIMATNRADTLDPALLRpgRLDRKIEFPLPDRRQRRLI 334
Cdd:COG0464   257 DEADALAGKR---GEVGDGVGRRVVNTLLTEMEEL--RSDVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEI 329
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1275378735 335 FQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPKDFEK 391
Cdd:COG0464   330 FRIHLRKRPLDEDVDLEELAEATEGLSGADIRNVVRRAALQALRLGREPVTTEDLLE 386
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
144-391 2.12e-78

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 250.67  E-value: 2.12e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 144 LQMQEKPDVTYSDIGGMDIQKQEIREAVELpLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGS 223
Cdd:TIGR01241  44 LLNEEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGS 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 224 EFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNR 303
Cdd:TIGR01241 123 DFVEMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGNDEREQTLNQLLVEMDGFGTNTGVIVIAATNR 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 304 ADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYV 383
Cdd:TIGR01241 203 PDVLDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKKLAPDVDLKAVARRTPGFSGADLANLLNEAALLAARKNKTE 282

                  ....*...
gi 1275378735 384 ILPKDFEK 391
Cdd:TIGR01241 283 ITMNDIEE 290
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
150-379 2.94e-74

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 245.59  E-value: 2.94e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 150 PDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKY 229
Cdd:TIGR01243 173 PKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKY 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 230 LGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRfDAQTGadrEVQ-RILLELLNQMDGFDQTTTVKVIMATNRADTLD 308
Cdd:TIGR01243 253 YGESEERLREIFKEAEENAPSIIFIDEIDAIAPKR-EEVTG---EVEkRVVAQLLTLMDGLKGRGRVIVIGATNRPDALD 328
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1275378735 309 PALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRK 379
Cdd:TIGR01243 329 PALRRPGRFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALRR 399
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
152-321 3.76e-71

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 220.95  E-value: 3.76e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 152 VTYSDIGGMDIQKQEIREAVELpLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLG 231
Cdd:cd19501     1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 232 EGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPAL 311
Cdd:cd19501    80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHDEREQTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPAL 159
                         170
                  ....*....|
gi 1275378735 312 LRPGRLDRKI 321
Cdd:cd19501   160 LRPGRFDRQV 169
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
144-391 1.49e-70

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 232.23  E-value: 1.49e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 144 LQMQEKPDVTYSDIGGMDIQKQEIREAVELpLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGS 223
Cdd:COG0465   131 LYDEDKPKVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGS 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 224 EFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNR 303
Cdd:COG0465   210 DFVEMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFEGNEGVIVIAATNR 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 304 ADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLedyvsrpEKV-------SAADIAAICQEAGMQA 376
Cdd:COG0465   290 PDVLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARKKPLAPDVDL-------EVIarrtpgfSGADLANLVNEAALLA 362
                         250
                  ....*....|....*
gi 1275378735 377 VRKNRYVILPKDFEK 391
Cdd:COG0465   363 ARRNKKAVTMEDFEE 377
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
156-323 1.92e-69

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 216.39  E-value: 1.92e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 156 DIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPR 235
Cdd:cd19503     1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 236 MVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADRevqRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPG 315
Cdd:cd19503    81 NLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVER---RVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPG 157

                  ....*...
gi 1275378735 316 RLDRKIEF 323
Cdd:cd19503   158 RFDREVEI 165
ftsH CHL00176
cell division protein; Validated
143-391 3.21e-69

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 230.32  E-value: 3.21e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 143 TLQMQEKPDVTYSDIGGMDIQKQEIREAVELpLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVG 222
Cdd:CHL00176  171 RFQMEADTGITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISG 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 223 SEFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATN 302
Cdd:CHL00176  250 SEFVEMFVGVGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAGIGGGNDEREQTLNQLLTEMDGFKGNKGVIVIAATN 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 303 RADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRY 382
Cdd:CHL00176  330 RVDILDAALLRPGRFDRQITVSLPDREGRLDILKVHARNKKLSPDVSLELIARRTPGFSGADLANLLNEAAILTARRKKA 409

                  ....*....
gi 1275378735 383 VILPKDFEK 391
Cdd:CHL00176  410 TITMKEIDT 418
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
156-324 8.51e-65

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 204.59  E-value: 8.51e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 156 DIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPR 235
Cdd:cd19519     1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 236 MVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADRevqRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPG 315
Cdd:cd19519    81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVER---RIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFG 157

                  ....*....
gi 1275378735 316 RLDRKIEFP 324
Cdd:cd19519   158 RFDREIDIG 166
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
164-321 4.13e-64

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 202.51  E-value: 4.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 164 KQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRL 243
Cdd:cd19511     2 KRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQK 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1275378735 244 ARENSPAIVFIDEVDAIATKRfdAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKI 321
Cdd:cd19511    82 ARQAAPCIIFFDEIDSLAPRR--GQSDSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLI 157
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
164-321 2.21e-62

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 198.10  E-value: 2.21e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 164 KQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRL 243
Cdd:cd19529     2 KQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRK 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1275378735 244 ARENSPAIVFIDEVDAIATKRfdAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKI 321
Cdd:cd19529    82 ARQVAPCVIFFDEIDSIAPRR--GTTGDSGVTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLI 157
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
163-323 6.30e-59

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 189.03  E-value: 6.30e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 163 QKQEIREAVELPLTCPELyQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFR 242
Cdd:cd19481     1 LKASLREAVEAPRRGSRL-RRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 243 LARENSPAIVFIDEVDAIATKRFDaqTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKIE 322
Cdd:cd19481    80 RARRLAPCILFIDEIDAIGRKRDS--SGESGELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIE 157

                  .
gi 1275378735 323 F 323
Cdd:cd19481   158 F 158
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
147-392 3.01e-57

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 198.33  E-value: 3.01e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 147 QEKPDVTYSDIGGMDIQKQEIREAVELpLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFV 226
Cdd:PRK10733  144 EDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFV 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 227 QKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADT 306
Cdd:PRK10733  223 EMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDV 302
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 307 LDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILP 386
Cdd:PRK10733  303 LDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAARGNKRVVSM 382

                  ....*.
gi 1275378735 387 KDFEKG 392
Cdd:PRK10733  383 VEFEKA 388
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
164-321 2.20e-56

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 182.71  E-value: 2.20e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 164 KQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRL 243
Cdd:cd19528     2 KRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDK 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1275378735 244 ARENSPAIVFIDEVDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKI 321
Cdd:cd19528    82 ARAAAPCVLFFDELDSIAKARGGNIGDAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLI 159
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
155-404 1.68e-55

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 183.16  E-value: 1.68e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 155 SDIGGMDIQKQEIREAVElPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGP 234
Cdd:COG1223     2 DDVVGQEEAKKKLKLIIK-ELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 235 RMVRDVFRLARENsPAIVFIDEVDAIATKRFDAQtgaDR-EVQRILLELLNQMDGFDQttTVKVIMATNRADTLDPALLR 313
Cdd:COG1223    81 RNLRKLFDFARRA-PCVIFFDEFDAIAKDRGDQN---DVgEVKRVVNALLQELDGLPS--GSVVIAATNHPELLDSALWR 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 314 pgRLDRKIEFPLPDRRQRRLIFQTITAKMNLSDEVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPKDFE--- 390
Cdd:COG1223   155 --RFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLEGLSGADIEKVLKTALKKAILEDREKVTKEDLEeal 232
                         250
                  ....*....|....
gi 1275378735 391 KGWKAHVRKHERDF 404
Cdd:COG1223   233 KQRKERKKEPKKEG 246
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
192-325 1.14e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 174.70  E-value: 1.14e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDaqtGA 271
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGS---GG 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1275378735 272 DREVQRILLELLNQMDGFDQTT-TVKVIMATNRADTLDPALLrpGRLDRKIEFPL 325
Cdd:pfam00004  78 DSESRRVVNQLLTELDGFTSSNsKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
164-319 3.25e-53

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 174.60  E-value: 3.25e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 164 KQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRL 243
Cdd:cd19530     5 REELTMSILRPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQR 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1275378735 244 ARENSPAIVFIDEVDAIATKRFDAQTGAdreVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDR 319
Cdd:cd19530    85 ARASAPCVIFFDEVDALVPKRGDGGSWA---SERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDK 157
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
156-321 5.15e-51

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 169.12  E-value: 5.15e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 156 DIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPR 235
Cdd:cd19518     1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 236 MVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADRevqRILLELLNQMDGF----DQTTTVKVIMATNRADTLDPAL 311
Cdd:cd19518    81 KIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMER---RIVSQLLTCMDELnnekTAGGPVLVIGATNRPDSLDPAL 157
                         170
                  ....*....|
gi 1275378735 312 LRPGRLDRKI 321
Cdd:cd19518   158 RRAGRFDREI 167
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
157-321 1.12e-47

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 160.21  E-value: 1.12e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 157 IGGMDIQKQEIREAVELPLTCPELYQQIgIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRM 236
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPDLFPGL-RGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 237 VRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADRevqRILLELLNQMDGF--DQTTTVKVIMATNRADTLDPALLRp 314
Cdd:cd19509    80 VRALFALARELQPSIIFIDEIDSLLSERGSGEHEASR---RVKTEFLVQMDGVlnKPEDRVLVLGATNRPWELDEAFLR- 155

                  ....*..
gi 1275378735 315 gRLDRKI 321
Cdd:cd19509   156 -RFEKRI 161
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
163-322 2.08e-46

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 156.82  E-value: 2.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 163 QKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFR 242
Cdd:cd19526     1 VKKALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 243 LARENSPAIVFIDEVDAIATKRFDAQTGAdreVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDRKIE 322
Cdd:cd19526    81 RAQSAKPCILFFDEFDSIAPKRGHDSTGV---TDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
149-321 7.03e-45

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 153.09  E-value: 7.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 149 KPDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQiGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQK 228
Cdd:cd19521     1 KPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTG-NRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 229 YLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADRevqRILLELLNQMDGF-DQTTTVKVIMATNRADTL 307
Cdd:cd19521    80 WMGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASR---RIKTELLVQMNGVgNDSQGVLVLGATNIPWQL 156
                         170
                  ....*....|....
gi 1275378735 308 DPALLRpgRLDRKI 321
Cdd:cd19521   157 DSAIRR--RFEKRI 168
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
156-323 8.30e-44

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 150.35  E-value: 8.30e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 156 DIGGMDIQKQEIREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTA-----TFIRVVGSEFVQKYL 230
Cdd:cd19517     1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKggqkvSFFMRKGADCLSKWV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 231 GEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQtgaDREVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPA 310
Cdd:cd19517    81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQ---EQIHASIVSTLLALMDGLDNRGQVVVIGATNRPDALDPA 157
                         170
                  ....*....|...
gi 1275378735 311 LLRPGRLDRKIEF 323
Cdd:cd19517   158 LRRPGRFDREFYF 170
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
164-319 5.30e-43

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 148.04  E-value: 5.30e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 164 KQEIREAVELPLTCPELYQQiGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPRMVRDVFRL 243
Cdd:cd19527     2 KKEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1275378735 244 ARENSPAIVFIDEVDAIATKRfDAQTGADREVQRILLELLNQMDGFDQTTT-VKVIMATNRADTLDPALLRPGRLDR 319
Cdd:cd19527    81 ARDAKPCVIFFDELDSLAPSR-GNSGDSGGVMDRVVSQLLAELDGMSSSGQdVFVIGATNRPDLLDPALLRPGRFDK 156
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
135-321 2.22e-40

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 142.05  E-value: 2.22e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 135 PEADSTIQTLQMQEKPDVTYSDIGGMDIQKQEIREAVELPLTCPELYQQIGiDPPTGVLLYGPPGTGKTMLAKAVANNTT 214
Cdd:cd19525     2 PKMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLIGKCIASQSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 215 ATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADRevqRILLELLNQMDGFDQTTT 294
Cdd:cd19525    81 ATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSR---RIKTEFLVQLDGATTSSE 157
                         170       180
                  ....*....|....*....|....*....
gi 1275378735 295 VKVIM--ATNRADTLDPALLRpgRLDRKI 321
Cdd:cd19525   158 DRILVvgATNRPQEIDEAARR--RLVKRL 184
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
156-321 4.16e-39

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 138.19  E-value: 4.16e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 156 DIGGMDIQKQEIREAVELPLTCPELYQqiGIDPP-TGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGP 234
Cdd:cd19522     1 DIADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 235 RMVRDVFRLARENSPAIVFIDEVDAIATKRfdaQTGADREV-QRILLELLNQMDGF-------DQTTTVKVIMATNRADT 306
Cdd:cd19522    79 KLVRLLFEMARFYAPTTIFIDEIDSICSRR---GTSEEHEAsRRVKSELLVQMDGVggasendDPSKMVMVLAATNFPWD 155
                         170
                  ....*....|....*
gi 1275378735 307 LDPALLRpgRLDRKI 321
Cdd:cd19522   156 IDEALRR--RLEKRI 168
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
156-313 8.02e-39

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 137.17  E-value: 8.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 156 DIGGMDIQKQEIREAVELPLTCPELYQQIGI-DPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGP 234
Cdd:cd19520     1 DIGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 235 RMVRDVFRLARENSPAIVFIDEVDAIATKRfdaqTGADREVQRIL-LELLNQMDGF--DQTTTVKVIMATNRADTLDPAL 311
Cdd:cd19520    81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR----SSTDHEATAMMkAEFMSLWDGLstDGNCRVIVMGATNRPQDLDEAI 156

                  ..
gi 1275378735 312 LR 313
Cdd:cd19520   157 LR 158
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
156-321 8.15e-38

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 134.59  E-value: 8.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 156 DIGGMDIQKQEIREAVELPLTCPELYQQIGIdPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPR 235
Cdd:cd19524     1 DIAGQDLAKQALQEMVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 236 MVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTGADRevqRILLELLNQMDGFDQTTT--VKVIMATNRADTLDPALLR 313
Cdd:cd19524    80 LVRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASR---RLKTEFLIEFDGVQSNGDdrVLVMGATNRPQELDDAVLR 156

                  ....*...
gi 1275378735 314 pgRLDRKI 321
Cdd:cd19524   157 --RFTKRV 162
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
157-322 4.25e-32

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 119.52  E-value: 4.25e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 157 IGGMDIQKQEI-REAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVV-GSEFVQKYLGEGP 234
Cdd:cd19504     2 IGGLDKEFSDIfRRAFASRVFPPEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMLNAREPKIVnGPEILNKYVGESE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 235 RMVRDVFRLARENSPA--------IVFIDEVDAIATKRfdAQTGADREV-QRILLELLNQMDGFDQTTTVKVIMATNRAD 305
Cdd:cd19504    82 ANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQR--GSMAGSTGVhDTVVNQLLSKIDGVEQLNNILVIGMTNRKD 159
                         170
                  ....*....|....*..
gi 1275378735 306 TLDPALLRPGRLDRKIE 322
Cdd:cd19504   160 LIDEALLRPGRLEVQME 176
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
158-325 6.96e-27

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 104.92  E-value: 6.96e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 158 GGMDIQKQEIREAVELPltcpelyqqigidPPTGVLLYGPPGTGKTMLAKAVANNTT---ATFIRVVGSEFVQKYLGE-- 232
Cdd:cd00009     1 VGQEEAIEALREALELP-------------PPKNLLLYGPPGTGKTTLARAIANELFrpgAPFLYLNASDLLEGLVVAel 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 233 -GPRMVRDVFRLARENSPAIVFIDEVDAIAtkrfdaqtgadREVQRILLELLNQ-MDGFDQTTTVKVIMATNRADTLDPA 310
Cdd:cd00009    68 fGHFLVRLLFELAEKAKPGVLFIDEIDSLS-----------RGAQNALLRVLETlNDLRIDRENVRVIGATNRPLLGDLD 136
                         170
                  ....*....|....*
gi 1275378735 311 LLRPGRLDRKIEFPL 325
Cdd:cd00009   137 RALYDRLDIRIVIPL 151
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
156-313 8.20e-27

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 104.97  E-value: 8.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 156 DIGGMDIQKQEIREAVELPLTCPELYQQIgIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEGPR 235
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGL-LRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 236 MVRDVFRLARENSPAIVFIDEVDAIATKRFDAQTgadrEVQRILLELLNQMDGF-----DQtttVKVIMATNRADTLDPA 310
Cdd:cd19523    80 ILQASFLAARCRQPSVLFISDLDALLSSQDDEAS----PVGRLQVELLAQLDGVlgsgeDG---VLVVCTTSKPEEIDES 152

                  ...
gi 1275378735 311 LLR 313
Cdd:cd19523   153 LRR 155
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
156-319 1.72e-21

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 90.51  E-value: 1.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 156 DIGGMDIQKQ--EIREAVELPLTcpelyQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEG 233
Cdd:cd19507     1 DVGGLDNLKDwlKKRKAAFSKQA-----SAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGES 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 234 PRMVRDVFRLARENSPAIVFIDEVD-AIATKRFDAQTGADRevqRILLELLNQMDgfDQTTTVKVIMATNRADTLDPALL 312
Cdd:cd19507    76 ESRLRQMIQTAEAIAPCVLWIDEIEkGFSNADSKGDSGTSS---RVLGTFLTWLQ--EKKKPVFVVATANNVQSLPPELL 150

                  ....*..
gi 1275378735 313 RPGRLDR 319
Cdd:cd19507   151 RKGRFDE 157
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
188-327 7.35e-20

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 85.50  E-value: 7.35e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  188 PPTGVLLYGPPGTGKTMLAKAVANN---TTATFIRVVGSEF--------------VQKYLGEGPRMVRDVFRLARENSPA 250
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARElgpPGGGVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1275378735  251 IVFIDEVDAIATKRFdaqtgadrEVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPALLRPgRLDRKIEFPLPD 327
Cdd:smart00382  81 VLILDEITSLLDAEQ--------EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
167-323 2.92e-17

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 78.16  E-value: 2.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 167 IREAVELPLTCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFirvvgsefvqkYLGEGPRMVRDVFRLAR- 245
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDI-----------CDLNLSEVVLTDDRLNHl 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 246 -ENSP--AIVFIDEVD-AIATKRFDAQTGADRE-VQRILLE-LLNQMDGFDQTTTVKVIMATNRADTLDPALLRPGRLDR 319
Cdd:cd19510    70 lNTAPkqSIILLEDIDaAFESREHNKKNPSAYGgLSRVTFSgLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDM 149

                  ....
gi 1275378735 320 KIEF 323
Cdd:cd19510   150 KIYM 153
ycf46 CHL00195
Ycf46; Provisional
126-336 3.33e-16

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 80.06  E-value: 3.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 126 SHSVVDILPPEADSTIQTLQMQE--KPDVTYSDIGGMDIQKQEIREAVElplTCPELYQQIGIDPPTGVLLYGPPGTGKT 203
Cdd:CHL00195  197 DENSIPLILEEKKQIISQTEILEfySVNEKISDIGGLDNLKDWLKKRST---SFSKQASNYGLPTPRGLLLVGIQGTGKS 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 204 MLAKAVANNTTATFIRV-VGSEFvQKYLGEGPRMVRDVFRLARENSPAIVFIDEVD-AIATKRFDAQTGADREVQRILLE 281
Cdd:CHL00195  274 LTAKAIANDWQLPLLRLdVGKLF-GGIVGESESRMRQMIRIAEALSPCILWIDEIDkAFSNSESKGDSGTTNRVLATFIT 352
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1275378735 282 LLNQmdgfdQTTTVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQ 336
Cdd:CHL00195  353 WLSE-----KKSPVFVVATANNIDLLPLEILRKGRFDEIFFLDLPSLEEREKIFK 402
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
183-323 2.83e-12

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 64.32  E-value: 2.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 183 QIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQK--------------YLGEGPRMVRDVFRLARENS 248
Cdd:cd19505     6 RLGLSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYNkpdfgnddwidgmlILKESLHRLNLQFELAKAMS 85
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1275378735 249 PAIVFIDEVDAIATKRFDAQTGADRevqRILLELLNQM--DGFDQTTTVK--VIMATNRADTLDPALLRPGRLDRKIEF 323
Cdd:cd19505    86 PCIIWIPNIHELNVNRSTQNLEEDP---KLLLGLLLNYlsRDFEKSSTRNilVIASTHIPQKVDPALIAPNRLDTCINI 161
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
192-311 7.65e-12

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 64.00  E-value: 7.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTT---------ATFIRVVGSEFVQKYLGEGPRMVRDVFR-----LARENSPAIVFIDEV 257
Cdd:cd19508    55 VLLHGPPGTGKTSLCKALAQKLSirlssryryGQLIEINSHSLFSKWFSESGKLVTKMFQkiqelIDDKDALVFVLIDEV 134
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1275378735 258 DAIATKRFDAQTGAD-REVQRILLELLNQMDGFDQTTTVKVIMATNRADTLDPAL 311
Cdd:cd19508   135 ESLAAARSASSSGTEpSDAIRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAF 189
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
192-323 2.85e-11

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 61.39  E-value: 2.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEfVQKYLGEGPRMVRDVFRLA-RENSPAIVFIDEVDAIATKRfdAQTG 270
Cdd:cd19512    25 ILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAIHKVFDWAnTSRRGLLLFVDEADAFLRKR--STEK 101
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1275378735 271 ADREVQRILLELLNQMDgfDQTTTVKVIMATNRADTLDPALlrPGRLDRKIEF 323
Cdd:cd19512   102 ISEDLRAALNAFLYRTG--EQSNKFMLVLASNQPEQFDWAI--NDRIDEMVEF 150
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
189-283 1.89e-10

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 59.70  E-value: 1.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 189 PTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQ-KYLGegprmvRDVFRLARENSPAIVFIDEVDAIATKRFDA 267
Cdd:cd19498    46 PKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEvGYVG------RDVESIIRDLVEGIVFIDEIDKIAKRGGSS 119
                          90
                  ....*....|....*..
gi 1275378735 268 QTGADRE-VQRILLELL 283
Cdd:cd19498   120 GPDVSREgVQRDLLPIV 136
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
188-323 8.73e-10

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 57.57  E-value: 8.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 188 PPTGVLLYGPPGTGKTMLAKAVA---NNTTATFIRVVGSEFVQK------------YLG--EGPRMVRDVfrlaRENSPA 250
Cdd:cd19499    40 PIGSFLFLGPTGVGKTELAKALAellFGDEDNLIRIDMSEYMEKhsvsrligappgYVGytEGGQLTEAV----RRKPYS 115
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1275378735 251 IVFIDEVDAiatkrfdaqtgADREVQRILLELLNQ---MDGFDQTTTVK---VIMATNradTLDPALLrpGRLDRKIEF 323
Cdd:cd19499   116 VVLLDEIEK-----------AHPDVQNLLLQVLDDgrlTDSHGRTVDFKntiIIMTSN---HFRPEFL--NRIDEIVVF 178
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
187-334 2.07e-09

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 56.05  E-value: 2.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 187 DPPTGVLLYGPPGTGKTMLAKAVAN---NTTATFIRVVGSEFVQKYL-----GEGPRMVR-----DVFRLARENSPAIVF 253
Cdd:pfam07724   1 RPIGSFLFLGPTGVGKTELAKALAEllfGDERALIRIDMSEYMEEHSvsrliGAPPGYVGyeeggQLTEAVRRKPYSIVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 254 IDEVDAIAtkrfdaqtgadREVQRILLELL----------NQMDgFDQTTtvkVIMATNR--ADTLDPALLRPGRLDRKI 321
Cdd:pfam07724  81 IDEIEKAH-----------PGVQNDLLQILeggtltdkqgRTVD-FKNTL---FIMTGNFgsEKISDASRLGDSPDYELL 145
                         170
                  ....*....|...
gi 1275378735 322 EFPLPDRRQRRLI 334
Cdd:pfam07724 146 KEEVMDLLKKGFI 158
Prot_ATP_ID_OB pfam16450
Proteasomal ATPase OB C-terminal domain; This is the interdomain (ID) or oligonucleotide ...
79-134 7.70e-09

Proteasomal ATPase OB C-terminal domain; This is the interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase


Pssm-ID: 465118 [Multi-domain]  Cd Length: 56  Bit Score: 51.35  E-value: 7.70e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1275378735  79 IGQFMELINANEGIVASTAGSSYVVRILSTLNRELLKTGCSVALHRHSHSVVDILP 134
Cdd:pfam16450   1 VATVVEVLDDGRALVKSSGGEERVVRLAGSLDEEKLRPGDRVLLDPRSGYALEVLP 56
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
191-313 2.92e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 52.29  E-value: 2.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 191 GVLLYGPPGTGKTMLAKAVANNTT-ATFIRVVGS------EFVQKYL--GEGPRMVRDVF-RLAREnsPAIVFIDEVDAi 260
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSnRPVFYVQLTrdtteeDLFGRRNidPGGASWVDGPLvRAARE--GEIAVLDEINR- 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1275378735 261 atkrfdaqtgADREVQRILLELLN-----QMDGF----DQTTTVKVIMATNRADT----LDPALLR 313
Cdd:pfam07728  78 ----------ANPDVLNSLLSLLDerrllLPDGGelvkAAPDGFRLIATMNPLDRglneLSPALRS 133
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
180-257 3.71e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 55.06  E-value: 3.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 180 LYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRV--VGSefvqkylgeGPRMVRDVFRLARENS----PAIVF 253
Cdd:COG2256    40 LRRAIEAGRLSSMILWGPPGTGKTTLARLIANATDAEFVALsaVTS---------GVKDIREVIEEARERRaygrRTILF 110

                  ....
gi 1275378735 254 IDEV 257
Cdd:COG2256   111 VDEI 114
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
347-391 5.33e-08

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 48.69  E-value: 5.33e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1275378735 347 EVDLEDYVSRPEKVSAADIAAICQEAGMQAVRKNRYVILPKDFEK 391
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQEDLEE 45
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
180-257 1.41e-07

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 53.16  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 180 LYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEF-VQKylgegprmVRDVFRLARENSPA----IVFI 254
Cdd:PRK13342   27 LRRMIEAGRLSSMILWGPPGTGKTTLARIIAGATDAPFEALSAVTSgVKD--------LREVIEEARQRRSAgrrtILFI 98

                  ...
gi 1275378735 255 DEV 257
Cdd:PRK13342   99 DEI 101
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
192-283 2.32e-07

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 52.09  E-value: 2.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTTATFIRV-----------VGSE-FVQK----YLGEGPrmvrdVFRlarenspAIVFID 255
Cdd:COG0714    34 LLLEGVPGVGKTTLAKALARALGLPFIRIqftpdllpsdiLGTYiYDQQtgefEFRPGP-----LFA-------NVLLAD 101
                          90       100
                  ....*....|....*....|....*...
gi 1275378735 256 EVDaiatkRfdaqtgADREVQRILLELL 283
Cdd:COG0714   102 EIN-----R------APPKTQSALLEAM 118
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
192-308 2.13e-06

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 46.34  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLgegpRMVRDvfrLARENSPAIVFIDEVDAIATKRfdaQTGA 271
Cdd:cd01120     1 ILITGPPGSGKTTLLLQFAEQALLSDEPVIFISFLDTIL----EAIED---LIEEKKLDIIIIDSLSSLARAS---QGDR 70
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1275378735 272 DREVQRILLELLNqmdgfDQTTTVKVIMATNRADTLD 308
Cdd:cd01120    71 SSELLEDLAKLLR-----AARNTGITVIATIHSDKFD 102
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
192-303 3.26e-06

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 46.75  E-value: 3.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQKYLGEG--PRMVRDVFRLARENSPAIVFIDEVDAIATKRF---D 266
Cdd:cd19506    29 LLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTFYKKVpktE 108
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1275378735 267 AQTGADReVQRILLELLNQMDGFDQtttVKVIMATNR 303
Cdd:cd19506   109 KQLDPKR-LKKDLPKILKSLKPEDR---VLIVGTTSR 141
ycf2 CHL00206
Ycf2; Provisional
183-288 6.06e-06

Ycf2; Provisional


Pssm-ID: 214396 [Multi-domain]  Cd Length: 2281  Bit Score: 48.75  E-value: 6.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735  183 QIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVvgseFVQKYLgegprmvrdvfrlarENSPAIVFIDEVDAIAT 262
Cdd:CHL00206  1624 RLALSPSRGILVIGSIGTGRSYLVKYLATNSYVPFITV----FLNKFL---------------DNKPKGFLIDDIDIDDS 1684
                           90       100
                   ....*....|....*....|....*.
gi 1275378735  263 KRFDAQTGADREVQRILLELLNQMDG 288
Cdd:CHL00206  1685 DDIDDSDDIDRDLDTELLTMMNALTM 1710
PRK04195 PRK04195
replication factor C large subunit; Provisional
188-279 1.19e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 47.22  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 188 PPTGVLLYGPPGTGKTMLAKAVAN---------NT----TATFI-RVVGSEFVQKYLGEGPRMvrdvfrlarenspaIVF 253
Cdd:PRK04195   38 PKKALLLYGPPGVGKTSLAHALANdygwevielNAsdqrTADVIeRVAGEAATSGSLFGARRK--------------LIL 103
                          90       100
                  ....*....|....*....|....*.
gi 1275378735 254 IDEVDAIATKrfdAQTGADREVQRIL 279
Cdd:PRK04195  104 LDEVDGIHGN---EDRGGARAILELI 126
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
187-324 2.84e-05

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 45.99  E-value: 2.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 187 DPPTGVLLYGPPGTGKTMLAKAVA---------NNTTATFIRV----------VGSEFVQKyLGEGPRMVR------DVF 241
Cdd:COG1474    49 ERPSNVLIYGPTGTGKTAVAKYVLeeleeeaeeRGVDVRVVYVncrqastryrVLSRILEE-LGSGEDIPStglstdELF 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 242 -----RLARENSPAIVFIDEVDAIatkrfdaqtgADREVQRILLELLNQMDGFDqTTTVKVIMATNRA---DTLDPALLR 313
Cdd:COG1474   128 drlyeALDERDGVLVVVLDEIDYL----------VDDEGDDLLYQLLRANEELE-GARVGVIGISNDLeflENLDPRVKS 196
                         170
                  ....*....|..
gi 1275378735 314 pgRL-DRKIEFP 324
Cdd:COG1474   197 --SLgEEEIVFP 206
PRK13341 PRK13341
AAA family ATPase;
193-257 3.60e-05

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 45.82  E-value: 3.60e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1275378735 193 LLYGPPGTGKTMLAKAVANNTTATFIR----VVGSEFVQKYLGEGPRmvrdvfRLARENSPAIVFIDEV 257
Cdd:PRK13341   56 ILYGPPGVGKTTLARIIANHTRAHFSSlnavLAGVKDLRAEVDRAKE------RLERHGKRTILFIDEV 118
44 PHA02544
clamp loader, small subunit; Provisional
193-327 1.49e-04

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 43.44  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 193 LLYGP-PGTGKTMLAKAVANNTTATFIRVVGS----EFVQKylgegprmvrDVFRLARENS----PAIVFIDEVDAIATK 263
Cdd:PHA02544   46 LLHSPsPGTGKTTVAKALCNEVGAEVLFVNGSdcriDFVRN----------RLTRFASTVSltggGKVIIIDEFDRLGLA 115
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1275378735 264 rfdaqtgadrEVQRILLELLNQMDGfdqttTVKVIMATNRADTLDPALLrpGRLdRKIEFPLPD 327
Cdd:PHA02544  116 ----------DAQRHLRSFMEAYSK-----NCSFIITANNKNGIIEPLR--SRC-RVIDFGVPT 161
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
192-256 1.86e-04

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 43.60  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTTAT---FIRVV-------GSEFVQKY---LGEG-----PRMVRDVFRLARENS--PAI 251
Cdd:COG1401   224 VILAGPPGTGKTYLARRLAEALGGEdngRIEFVqfhpswsYEDFLLGYrpsLDEGkyeptPGIFLRFCLKAEKNPdkPYV 303

                  ....*
gi 1275378735 252 VFIDE 256
Cdd:COG1401   304 LIIDE 308
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
186-285 1.98e-04

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 42.46  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 186 IDPPTGVLLYGPPGTGKTMLA-----KAVANNTTATFIRVvgSEFVQKY---LGEG--PRMVRdvfRLARensPAIVFID 255
Cdd:COG1484    96 IERGENLILLGPPGTGKTHLAialghEACRAGYRVRFTTA--PDLVNELkeaRADGrlERLLK---RLAK---VDLLILD 167
                          90       100       110
                  ....*....|....*....|....*....|
gi 1275378735 256 EvdaIATKRFDAQTGADrevqriLLELLNQ 285
Cdd:COG1484   168 E---LGYLPLDAEGAEL------LFELISD 188
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
193-261 2.41e-04

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 41.78  E-value: 2.41e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1275378735 193 LLYGPPGTGKTMLAKAVANNTTATFIRV-VG-----SEFV---QKYLGEGP-RMVRDVfRLARENSPAIVfIDEVDAIA 261
Cdd:cd19500    41 CLVGPPGVGKTSLGKSIARALGRKFVRIsLGgvrdeAEIRghrRTYVGAMPgRIIQAL-KKAGTNNPVFL-LDEIDKIG 117
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
192-263 3.14e-04

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 42.20  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAK----------AVANNTTATFIRVVGSE---FVQKYLGEGPrmvRDVFRLARenspAIVFIDEVD 258
Cdd:cd19497    53 ILLIGPTGSGKTLLAQtlakildvpfAIADATTLTEAGYVGEDvenILLKLLQAAD---YDVERAQR----GIVYIDEID 125

                  ....*
gi 1275378735 259 AIATK 263
Cdd:cd19497   126 KIARK 130
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
193-324 3.58e-04

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 42.52  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 193 LLYGPPGTGKTMLAKAVANNTTA-------TFIRVVGSEFVQKYLGEGPRMVRDVFRLAREnspAIVFIDEVDAIATKRF 265
Cdd:TIGR03922 316 LFAGPPGTGKTTIARVVAKIYCGlgvlrkpLVREVSRADLIGQYIGESEAKTNEIIDSALG---GVLFLDEAYTLVETGY 392
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1275378735 266 DAQTGADRE-VQRILLELLNQMDGFdqtttvKVIMATNRADtLDPAL-----LRpGRLDRKIEFP 324
Cdd:TIGR03922 393 GQKDPFGLEaIDTLLARMENDRDRL------VVIGAGYRKD-LDKFLevnegLR-SRFTRVIEFP 449
PRK08116 PRK08116
hypothetical protein; Validated
191-221 4.32e-04

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 41.93  E-value: 4.32e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1275378735 191 GVLLYGPPGTGKTMLAKAVANNTTATFIRVV 221
Cdd:PRK08116  116 GLLLWGSVGTGKTYLAACIANELIEKGVPVI 146
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
192-211 4.85e-04

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 41.65  E-value: 4.85e-04
                          10        20
                  ....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVAN 211
Cdd:PRK00080   54 VLLYGPPGLGKTTLANIIAN 73
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
192-207 4.89e-04

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 42.33  E-value: 4.89e-04
                          10
                  ....*....|....*.
gi 1275378735 192 VLLYGPPGTGKTMLAK 207
Cdd:COG0606   214 LLMIGPPGSGKTMLAR 229
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
192-208 5.70e-04

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 40.98  E-value: 5.70e-04
                          10
                  ....*....|....*..
gi 1275378735 192 VLLYGPPGTGKTMLAKA 208
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKR 41
COG2842 COG2842
Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons]; ...
192-258 6.73e-04

Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons];


Pssm-ID: 442090 [Multi-domain]  Cd Length: 254  Bit Score: 41.09  E-value: 6.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVAN-NTTATFIRVVGS----EFVQK---YLG--EGPRMVRDVFRLARE---NSPAIVFIDEVD 258
Cdd:COG2842    53 GVVYGESGVGKTTAAREYANrNPNVIYVTASPSwtskELLEElaeELGipAPPGTIADLRDRILErlaGTGRLLIIDEAD 132
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
192-211 9.73e-04

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 39.41  E-value: 9.73e-04
                          10        20
                  ....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVAN 211
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIAN 55
AAA_22 pfam13401
AAA domain;
192-260 1.49e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.48  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVAN-----------------NTTATFIRVVGSEFVQKYLGEGP-----RMVRDVfrLARENSP 249
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEqlpevrdsvvfvdlpsgTSPKDLLRALLRALGLPLSGRLSkeellAALQQL--LLALAVA 85
                          90
                  ....*....|.
gi 1275378735 250 AIVFIDEVDAI 260
Cdd:pfam13401  86 VVLIIDEAQHL 96
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
162-261 2.39e-03

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 39.59  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 162 IQKQEIREAVELPLTCPELYQqigiDPPTGVLLYGPPGTGKTMLAKAVAnNTTATFIRVVGSEFVQKylgegPRMVRDVF 241
Cdd:TIGR00635   7 IGQEKVKEQLQLFIEAAKMRQ----EALDHLLLYGPPGLGKTTLAHIIA-NEMGVNLKITSGPALEK-----PGDLAAIL 76
                          90       100
                  ....*....|....*....|
gi 1275378735 242 RLARENSpaIVFIDEVDAIA 261
Cdd:TIGR00635  77 TNLEEGD--VLFIDEIHRLS 94
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
185-293 3.16e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 38.74  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 185 GIDPPTGVLLYGPPGTGKTMLA-----KAVANNTTATFI-------------RVVGSEFvQKYLGEGPRMVRDVFRLARE 246
Cdd:COG0467    16 GLPRGSSTLLSGPPGTGKTTLAlqflaEGLRRGEKGLYVsfeespeqllrraESLGLDL-EEYIESGLLRIIDLSPEELG 94
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1275378735 247 NSP---AIVFIDEVDAIATKR--------FDAQTGADREVQRILLELLNQMDGFDQTT 293
Cdd:COG0467    95 LDLeelLARLREAVEEFGAKRvvidslsgLLLALPDPERLREFLHRLLRYLKKRGVTT 152
hslU PRK05201
ATP-dependent protease ATPase subunit HslU;
251-280 3.61e-03

ATP-dependent protease ATPase subunit HslU;


Pssm-ID: 235364 [Multi-domain]  Cd Length: 443  Bit Score: 39.29  E-value: 3.61e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1275378735 251 IVFIDEVDAIATKrfDAQTGAD--RE-VQRILL 280
Cdd:PRK05201  252 IVFIDEIDKIAAR--GGSSGPDvsREgVQRDLL 282
DUF815 pfam05673
Protein of unknown function (DUF815); This family consists of several bacterial proteins of ...
192-255 4.52e-03

Protein of unknown function (DUF815); This family consists of several bacterial proteins of unknown function.


Pssm-ID: 428578 [Multi-domain]  Cd Length: 250  Bit Score: 38.67  E-value: 4.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTTATFIRVVgsEFVQKYLGEGPRMVRdvfRLARENSPAIVFID 255
Cdd:pfam05673  56 VLLWGARGTGKSSLVKALLNEYADQGLRLI--EVDKEDLGDLPDLVD---LLRDRPYRFILFCD 114
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
192-211 4.72e-03

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 38.91  E-value: 4.72e-03
                          10        20
                  ....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVAN 211
Cdd:COG2255    57 VLLYGPPGLGKTTLAHIIAN 76
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
192-256 4.79e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 38.62  E-value: 4.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANN---------------TTATFIRVVGSEFVQKYLGEGPRMVRDVF-----RLARENSPAI 251
Cdd:COG3267    46 VVLTGEVGTGKTTLLRRLLERlpddvkvayipnpqlSPAELLRAIADELGLEPKGASKADLLRQLqefllELAAAGRRVV 125

                  ....*
gi 1275378735 252 VFIDE 256
Cdd:COG3267   126 LIIDE 130
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
192-313 5.07e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 37.22  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANNTTAT--FIRVVGSEFVQKYLGEGPRMVRDVFRL----------ARE--NSPAIVFIDEV 257
Cdd:cd00267    28 VALVGPNGSGKSTLLRAIAGLLKPTsgEILIDGKDIAKLPLEELRRRIGYVPQLsggqrqrvalARAllLNPDLLLLDEP 107
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1275378735 258 DAiatkrfdaqtGADREVQRILLELLNQMdgFDQTTTvkVIMATNRADTLDPALLR 313
Cdd:cd00267   108 TS----------GLDPASRERLLELLREL--AEEGRT--VIIVTHDPELAELAADR 149
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
179-313 5.33e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 37.48  E-value: 5.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1275378735 179 ELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANNTTATFIRVVGSEFVQkYLGEGP----RMVRDVFRLARENSPAIVFI 254
Cdd:pfam13191  14 DALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALERDGGYFLRGKCDE-NLPYSPlleaLTREGLLRQLLDELESSLLE 92
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1275378735 255 DEVDAIATKRFDAQTGADREVQRILLELLNQMDGF--DQTTTVKVIMATNRADTLDPALLR 313
Cdd:pfam13191  93 AWRAALLEALAPVPELPGDLAERLLDLLLRLLDLLarGERPLVLVLDDLQWADEASLQLLA 153
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
191-225 5.83e-03

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 38.44  E-value: 5.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1275378735 191 GVLLYGPPGTGKTMLAKAVAN--NTTATFIRVVGSEF 225
Cdd:pfam06068  52 AVLIAGPPGTGKTALAIAISKelGEDTPFTSISGSEV 88
Parvo_NS1 pfam01057
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
192-212 6.71e-03

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


Pssm-ID: 426020  Cd Length: 271  Bit Score: 38.06  E-value: 6.71e-03
                          10        20
                  ....*....|....*....|.
gi 1275378735 192 VLLYGPPGTGKTMLAKAVANN 212
Cdd:pfam01057 116 VWFYGPASTGKTNLAQAIAHA 136
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
191-210 9.27e-03

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 38.03  E-value: 9.27e-03
                          10        20
                  ....*....|....*....|
gi 1275378735 191 GVLLYGPPGTGKTMLAKAVA 210
Cdd:COG1224    66 GILIVGPPGTGKTALAVAIA 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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