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Conserved domains on  [gi|749569489|ref|WP_040199164|]
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HEAT repeat domain-containing protein [Geoalkalibacter subterraneus]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 12151680)

HEAT repeat domain-containing protein may function as a scaffold, anchoring and/or adaptor protein

CATH:  1.25.10.10
Gene Ontology:  GO:0005515
PubMed:  35552740|10378263
SCOP:  4001283

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
359-507 2.40e-24

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 98.55  E-value: 2.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 359 VVRNAATILGEIRDPETAGHLAALLGHEDERVRREAIRALTRLGTTEAMDVLLVAVEEGDPDLQRQALLFLGAMKQTKAI 438
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749569489 439 PYLLRFLERSDPFVRalelkRGAVRALGDMGAAEAVPALRALLQQRKfffprrfQEIQIACCLALARIG 507
Cdd:COG1413   81 PALIAALKDEDPEVR-----RAAAEALGRLGDPAAVPALLEALKDPD-------WEVRRAAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 317-398 1.46e-07

HEAT repeats; This family includes multiple HEAT repeats.


:

Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 49.26  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489  317 LGERLAEEKEAKRRKILAQALTAFG-RSALATLDRLLGDSRWYVVRNAATILGEIRDPETAGHLAALLGHE-DERVRREA 394
Cdd:pfam13646   4 LLQALLRDPDPEVRAAAIRALGRIGdPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDdDDVVRAAA 83


                  ....
gi 749569489  395 IRAL 398
Cdd:pfam13646  84 AEAL 87
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
359-507 2.40e-24

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 98.55  E-value: 2.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 359 VVRNAATILGEIRDPETAGHLAALLGHEDERVRREAIRALTRLGTTEAMDVLLVAVEEGDPDLQRQALLFLGAMKQTKAI 438
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749569489 439 PYLLRFLERSDPFVRalelkRGAVRALGDMGAAEAVPALRALLQQRKfffprrfQEIQIACCLALARIG 507
Cdd:COG1413   81 PALIAALKDEDPEVR-----RAAAEALGRLGDPAAVPALLEALKDPD-------WEVRRAAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 379-466 2.57e-11

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 60.04  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489  379 LAALLGHEDERVRREAIRALTRLGTTEAMDVLLVAVEEGDPDLQRQALLFLGAMKQTKAIPYLLRFLERSDPFVRalelK 458
Cdd:pfam13646   5 LQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDDDDVV----R 80


                  ....*...
gi 749569489  459 RGAVRALG 466
Cdd:pfam13646  81 AAAAEALA 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 317-398 1.46e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 49.26  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489  317 LGERLAEEKEAKRRKILAQALTAFG-RSALATLDRLLGDSRWYVVRNAATILGEIRDPETAGHLAALLGHE-DERVRREA 394
Cdd:pfam13646   4 LLQALLRDPDPEVRAAAIRALGRIGdPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDdDDVVRAAA 83


                  ....
gi 749569489  395 IRAL 398
Cdd:pfam13646  84 AEAL 87
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
359-535 1.76e-06

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 51.00  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 359 VVRNAATILGEIRDPETAGHLAALLGHEDERVRREAIRALTRLGtteamDVLLVAVEEGDPDLQ-----RQALLFLGAmK 433
Cdd:PRK13800 699 VVRAAALDVLRALRAGDAALFAAALGDPDHRVRIEAVRALVSVD-----DVESVAGAATDENREvriavAKGLATLGA-G 772

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 434 QTKAIPYLLRFLERSDPFVRALEL---------------------------KRGAVRALGDMGAAEAVPALRALLQQRKF 486
Cdd:PRK13800 773 GAPAGDAVRALTGDPDPLVRAAALaalaelgcppddvaaataalrasawqvRQGAARALAGAAADVAVPALVEALTDPHL 852

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 749569489 487 ffprrfqEIQIACCLALARI-GTDECRRILEITTQRGHGPVSRSASRALR 535
Cdd:PRK13800 853 -------DVRKAAVLALTRWpGDPAARDALTTALTDSDADVRAYARRALA 895
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
359-507 2.40e-24

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 98.55  E-value: 2.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 359 VVRNAATILGEIRDPETAGHLAALLGHEDERVRREAIRALTRLGTTEAMDVLLVAVEEGDPDLQRQALLFLGAMKQTKAI 438
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749569489 439 PYLLRFLERSDPFVRalelkRGAVRALGDMGAAEAVPALRALLQQRKfffprrfQEIQIACCLALARIG 507
Cdd:COG1413   81 PALIAALKDEDPEVR-----RAAAEALGRLGDPAAVPALLEALKDPD-------WEVRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
330-469 9.65e-23

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 93.93  E-value: 9.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 330 RKILAQALTAFG-RSALATLDRLLGDSRWYVVRNAATILGEIRDPETAGHLAALLGHEDERVRREAIRALTRLGTTEAMD 408
Cdd:COG1413    2 RRAAARALGRLGdPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVP 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 749569489 409 VLLVAVEEGDPDLQRQALLFLGAMKQTKAIPYLLRFLERSDPFVRalelkRGAVRALGDMG 469
Cdd:COG1413   82 ALIAALKDEDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWEVR-----RAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
390-538 2.98e-17

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 78.52  E-value: 2.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 390 VRREAIRALTRLGTTEAMDVLLVAVEEGDPDLQRQALLFLGAMKQTKAIPYLLRFLERSDPFVRalelkRGAVRALGDMG 469
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVR-----AAAAEALGRIG 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749569489 470 AAEAVPALRALLQQRKFffprrfqEIQIACCLALARIGTDECRRILEITTQRGHGPVSRSASRALREIA 538
Cdd:COG1413   76 DPEAVPALIAALKDEDP-------EVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 379-466 2.57e-11

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 60.04  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489  379 LAALLGHEDERVRREAIRALTRLGTTEAMDVLLVAVEEGDPDLQRQALLFLGAMKQTKAIPYLLRFLERSDPFVRalelK 458
Cdd:pfam13646   5 LQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDDDDVV----R 80


                  ....*...
gi 749569489  459 RGAVRALG 466
Cdd:pfam13646  81 AAAAEALA 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 348-427 3.86e-11

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 59.27  E-value: 3.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489  348 LDRLLGDSRWYVVRNAATILGEIRDPETAGHLAALLGHEDERVRREAIRALTRLGTTEAMDVLLVAVEEGDPDLQRQALL 427
Cdd:pfam13646   5 LQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDDDDVVRAAAA 84
HEAT COG1413
HEAT repeat [General function prediction only];
421-541 3.61e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.41  E-value: 3.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 421 LQRQALLFLGAMKQTKAIPYLLRFLERSDPFVRALelkrgAVRALGDMGAAEAVPALRALLQQRKfffprrfQEIQIACC 500
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALADEDPDVRAA-----AARALGRLGDPRAVPALLEALKDPD-------PEVRAAAA 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 749569489 501 LALARIGTDECRRILEITTQRGHGPVSRSASRALREIARAE 541
Cdd:COG1413   69 EALGRIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPA 109
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 317-398 1.46e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 49.26  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489  317 LGERLAEEKEAKRRKILAQALTAFG-RSALATLDRLLGDSRWYVVRNAATILGEIRDPETAGHLAALLGHE-DERVRREA 394
Cdd:pfam13646   4 LLQALLRDPDPEVRAAAIRALGRIGdPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDdDDVVRAAA 83


                  ....
gi 749569489  395 IRAL 398
Cdd:pfam13646  84 AEAL 87
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
359-535 1.76e-06

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 51.00  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 359 VVRNAATILGEIRDPETAGHLAALLGHEDERVRREAIRALTRLGtteamDVLLVAVEEGDPDLQ-----RQALLFLGAmK 433
Cdd:PRK13800 699 VVRAAALDVLRALRAGDAALFAAALGDPDHRVRIEAVRALVSVD-----DVESVAGAATDENREvriavAKGLATLGA-G 772

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 434 QTKAIPYLLRFLERSDPFVRALEL---------------------------KRGAVRALGDMGAAEAVPALRALLQQRKF 486
Cdd:PRK13800 773 GAPAGDAVRALTGDPDPLVRAAALaalaelgcppddvaaataalrasawqvRQGAARALAGAAADVAVPALVEALTDPHL 852

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 749569489 487 ffprrfqEIQIACCLALARI-GTDECRRILEITTQRGHGPVSRSASRALR 535
Cdd:PRK13800 853 -------DVRKAAVLALTRWpGDPAARDALTTALTDSDADVRAYARRALA 895
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
334-426 3.25e-04

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 43.69  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 334 AQALTAFGRSALATLDR-----LLGDSRWYVVRNAATILGEIRDPETAGHLAALLGHEDERVRREAIRALTRL-GTTEAM 407
Cdd:PRK13800 793 AAALAALAELGCPPDDVaaataALRASAWQVRQGAARALAGAAADVAVPALVEALTDPHLDVRKAAVLALTRWpGDPAAR 872

                         90       100
                 ....*....|....*....|..
gi 749569489 408 DVLLVAVEEGDPDLQ---RQAL 426
Cdd:PRK13800 873 DALTTALTDSDADVRayaRRAL 894
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
336-509 3.93e-04

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 43.30  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 336 ALTAFGRSALATLDRLLGDSRWYVVRNAATILGEIRDPETAGHLAALLGHEDERVRREAIRALTRL-GTTEAMDVLLVAV 414
Cdd:PRK13800 614 AVLALDAPSVAELAPYLADPDPGVRRTAVAVLTETTPPGFGPALVAALGDGAAAVRRAAAEGLRELvEVLPPAPALRDHL 693

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 415 EEGDPDLQRQALLFLGAMKQTKAIPYlLRFLERSDPFVRAlelkrGAVRALGDMGAAEAVpALRALLQQRkfffprrfqE 494
Cdd:PRK13800 694 GSPDPVVRAAALDVLRALRAGDAALF-AAALGDPDHRVRI-----EAVRALVSVDDVESV-AGAATDENR---------E 757

                        170
                 ....*....|....*
gi 749569489 495 IQIACCLALARIGTD 509
Cdd:PRK13800 758 VRIAVAKGLATLGAG 772
PRK09687 PRK09687
putative lyase; Provisional
 321-483 7.29e-04

putative lyase; Provisional


Pssm-ID: 170047 [Multi-domain]  Cd Length: 280  Bit Score: 41.65  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 321 LAEEKEAKRRKILAQALTAFGR-------SALATLDRLLGDSRWYVVRNAATILGEIRDPETAGHLAALLGHEDERVRRE 393
Cdd:PRK09687  99 ALEDKSACVRASAINATGHRCKknplyspKIVEQSQITAFDKSTNVRFAVAFALSVINDEAAIPLLINLLKDPNGDVRNW 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489 394 AIRALTRL--GTTEAMDVLLVAVEEGDPDLQRQALLFLGAMKQTKAIPYLLRFLERSDPFVRALElkrgavrALGDMGAA 471
Cdd:PRK09687 179 AAFALNSNkyDNPDIREAFVAMLQDKNEEIRIEAIIGLALRKDKRVLSVLIKELKKGTVGDLIIE-------AAGELGDK 251

                        170
                 ....*....|..
gi 749569489 472 EAVPALRALLQQ 483
Cdd:PRK09687 252 TLLPVLDTLLYK 263
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 438-535 3.22e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749569489  438 IPYLLRFLERSDPFvralELKRGAVRALGDMGAAEAVPALRALLQQRKFffprrfqEIQIACCLALARIGTDECRRILEI 517
Cdd:pfam13646   1 LPALLQALLRDPDP----EVRAAAIRALGRIGDPEAVPALLELLKDEDP-------AVRRAAAEALGKIGDPEALPALLE 69

                          90
                  ....*....|....*....
gi 749569489  518 TTQRGHGPVSRSAS-RALR 535
Cdd:pfam13646  70 LLRDDDDDVVRAAAaEALA 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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