|
Name |
Accession |
Description |
Interval |
E-value |
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
346-785 |
6.20e-125 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 380.44 E-value: 6.20e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 346 LAGVYALIIFEIVHRTLAAMLGSLAALAALaVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRL 425
Cdd:cd01116 1 FIITYALIIFEKVHRTVAALAGALWLVILG-LATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 426 SRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqe 505
Cdd:cd01116 80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 506 lrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllg 585
Cdd:cd01116 157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 586 kvlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVpgiHLDLGWIAILG 665
Cdd:cd01116 202 ------------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPL---GVSLGWIALLG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 666 AIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKmvpeeQRLIAAIVLVVWVSALASS 745
Cdd:cd01116 249 ALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVIL-----GRIAVAVILILWISALLSA 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1034590834 746 LIDNIPFTATMAGL------PNDGCVLHCWDVLSPCGSCGGGMELI 785
Cdd:cd01116 324 FIDNIPVTATMIPIvkdlasQLGIPLLPLWWALALGACLGGNGTLI 369
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
338-759 |
8.70e-77 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 254.28 E-value: 8.70e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 338 QVTIATAILAGVYALIIFEI--VHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFF 415
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVV-----SLEDALEAIDWNTILFLLGMMIIVAILDESGFF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 416 DYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDP 495
Cdd:COG1055 76 EWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 496 PNVIIVSnqelrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKLYNKEPSEIVELKHEIHVWRltaqrispasre 575
Cdd:COG1055 156 TNIMIAS-----AGGLSFLDFLANLFPPSLVSLLVTLLVLYLLF--RKELPAAPDLEDDPKEAIKDRR------------ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 576 etavrrlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrisdgiLLAKCLTVLGFVIFMFFLNSFvpgIH 655
Cdd:COG1055 217 ------------------------------------------------------LLRISLLVLALLLVGFVLHSF---LG 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 656 LDLGWIAILGAIWLLILADIHDFEiILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIkmvpeEQRLIAAIVL 735
Cdd:COG1055 240 LPPALIALLGAAVLLLLARVDVRE-VLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLT-----GGNLLLAALL 313
|
410 420
....*....|....*....|....
gi 1034590834 736 VVWVSALASSLIDNIPFTATMAGL 759
Cdd:COG1055 314 ILWLSAILSAVVDNVPLVAALLPL 337
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
350-757 |
7.79e-65 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 219.88 E-value: 7.79e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 350 YALIIFEIVHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR 429
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVL-----TPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 430 VWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNqelrkM 509
Cdd:pfam03600 76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASA-----L 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 510 GLDFAGFTAHMFIGICLVLLV-CFPLLRLLYWNRKLYNKEPSEIVELKheihvwrltaqrispasreetavrrlllgkvl 588
Cdd:pfam03600 151 GLSFGDFGFFMFPPVGVALLLvGLLPLLLIFRKLLPVRKEEEAELEEL-------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 589 alehllarrlhtfhrqisqedknwetniqelqKKHRISDGILLAKCLTVLGFVIFMFFLNSfvpgihldlgwIAILGAIW 668
Cdd:pfam03600 199 --------------------------------RKRAIKDKLLLAISALVLALVILGFLLLS-----------VLALAGAL 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 669 LLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEqtallikMVPEEQRLIAAIVLVVWVSALASSLID 748
Cdd:pfam03600 236 LLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALAD-------ALGGLSGLLVALALILWLSALLSAFIS 308
|
....*....
gi 1034590834 749 NIPFTATMA 757
Cdd:pfam03600 309 NVPTAALMA 317
|
|
| PLN00136 |
PLN00136 |
silicon transporter; Provisional |
391-785 |
3.65e-17 |
|
silicon transporter; Provisional
Pssm-ID: 215070 [Multi-domain] Cd Length: 482 Bit Score: 85.05 E-value: 3.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 391 IDFETLALLFGMMILVAIFSETGFFDYCA-VKAYRLSRGRvwAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLN 469
Cdd:PLN00136 61 IDLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCRVCVVTALASALFTNDTCCVVLTEFVLELAAERN 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 470 LDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLdFAGFTAHMFIG--ICLVLLVCfpllrlLYWNRKLYNK 547
Cdd:PLN00136 139 LPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKITFPKF-LLGILPAMLAGmaVNMVMLLC------MYWKDLDGGA 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 548 EPSEIVELKHEIHVWRLTAQRIS-PASREETAVRRLLLGKVLALEHLLARRLHTFHRqisqedknWETNIQELQKKHRIS 626
Cdd:PLN00136 212 ELSVDGKQMEAVEEGRSPASAKStKQQSPALLQAGLNGDGNGDMSSMMSENISTKHP--------WFMQCTEHRRKLFLK 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 627 DgilLAKCLTVLGFVIFMFFLNsfvpgihldLGWIAILGAIwLLILADIHDFEIILHRVEWATLLFFAALFVLMEALahl 706
Cdd:PLN00136 284 S---FAYVVTVGMVVAYMVGLN---------MSWTAITTAI-ALVVVDFRDAEPCLDTVSYSLLVFFSGMFITVSGF--- 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 707 hliEYVGEQTALLIKMVPEEQ-RLIAAIVLVVWVSALASSLIDNIPF-------TATMAGLPNDGCVLHCWDVLSPCGSC 778
Cdd:PLN00136 348 ---NKTGLPGAIWNFMAPYSKvNSVGGISVLSVIILLLSNLASNVPTvllmgdeVAAAAALISPAAVTRSWLLLAWVSTV 424
|
....*..
gi 1034590834 779 GGGMELI 785
Cdd:PLN00136 425 AGNLSLL 431
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
384-535 |
2.62e-05 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 47.34 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 384 LTHVVEW-------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIM--LCLIAAVLSAFLDNVTTM 454
Cdd:TIGR00785 285 FLGIVTWkdiqknkVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLvlVVLFYIILYFFASNTAHT 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 455 LLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFAgftahmFIGICLVLL 529
Cdd:TIGR00785 365 AALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyVKIKDMWRVGAIIG------IVGLIVLLL 438
|
....*.
gi 1034590834 530 VCFPLL 535
Cdd:TIGR00785 439 VGTLWW 444
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
346-785 |
6.20e-125 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 380.44 E-value: 6.20e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 346 LAGVYALIIFEIVHRTLAAMLGSLAALAALaVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRL 425
Cdd:cd01116 1 FIITYALIIFEKVHRTVAALAGALWLVILG-LATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 426 SRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqe 505
Cdd:cd01116 80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 506 lrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIvelkheihvwrltaqrispasreetavrrlllg 585
Cdd:cd01116 157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 586 kvlalehllarrlhtfhrqisqedknwetnIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVpgiHLDLGWIAILG 665
Cdd:cd01116 202 ------------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPL---GVSLGWIALLG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 666 AIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKmvpeeQRLIAAIVLVVWVSALASS 745
Cdd:cd01116 249 ALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVIL-----GRIAVAVILILWISALLSA 323
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1034590834 746 LIDNIPFTATMAGL------PNDGCVLHCWDVLSPCGSCGGGMELI 785
Cdd:cd01116 324 FIDNIPVTATMIPIvkdlasQLGIPLLPLWWALALGACLGGNGTLI 369
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
338-759 |
8.70e-77 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 254.28 E-value: 8.70e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 338 QVTIATAILAGVYALIIFEI--VHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFF 415
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVV-----SLEDALEAIDWNTILFLLGMMIIVAILDESGFF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 416 DYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDP 495
Cdd:COG1055 76 EWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 496 PNVIIVSnqelrKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKLYNKEPSEIVELKHEIHVWRltaqrispasre 575
Cdd:COG1055 156 TNIMIAS-----AGGLSFLDFLANLFPPSLVSLLVTLLVLYLLF--RKELPAAPDLEDDPKEAIKDRR------------ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 576 etavrrlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrisdgiLLAKCLTVLGFVIFMFFLNSFvpgIH 655
Cdd:COG1055 217 ------------------------------------------------------LLRISLLVLALLLVGFVLHSF---LG 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 656 LDLGWIAILGAIWLLILADIHDFEiILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIkmvpeEQRLIAAIVL 735
Cdd:COG1055 240 LPPALIALLGAAVLLLLARVDVRE-VLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLT-----GGNLLLAALL 313
|
410 420
....*....|....*....|....
gi 1034590834 736 VVWVSALASSLIDNIPFTATMAGL 759
Cdd:COG1055 314 ILWLSAILSAVVDNVPLVAALLPL 337
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
350-759 |
4.64e-68 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 230.21 E-value: 4.64e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 350 YALIIFEIVHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR 429
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVV-----SPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 430 VWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQelrkm 509
Cdd:cd00625 76 RRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIASLS----- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 510 GLDFAGFTAHMFIGICLVLLVCFPLLRLLYWnrklynkepseivelkheihvwrltaqrispasreetavrrlllgkvla 589
Cdd:cd00625 151 GLGFLDFLAFMAPPALGLLLLLLGLLYLLFR------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 590 lehllarrlhtfhRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLnsfvpgihLDLGWIAILGAIWL 669
Cdd:cd00625 182 -------------KKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFL--------IPLGLIALLGALLL 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 670 LILADI-HDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIkmvpeEQRLIAAIVLVVWVSALASSLID 748
Cdd:cd00625 241 LLLLVRgLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALV-----GLPPLAALLLIGLLSALLSNFIS 315
|
410
....*....|.
gi 1034590834 749 NIPFTATMAGL 759
Cdd:cd00625 316 NVPTVALLLPI 326
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
350-757 |
7.79e-65 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 219.88 E-value: 7.79e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 350 YALIIFEIVHRTLAAMLGSLAALAALAVigdrpSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR 429
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVL-----TPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 430 VWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNqelrkM 509
Cdd:pfam03600 76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASA-----L 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 510 GLDFAGFTAHMFIGICLVLLV-CFPLLRLLYWNRKLYNKEPSEIVELKheihvwrltaqrispasreetavrrlllgkvl 588
Cdd:pfam03600 151 GLSFGDFGFFMFPPVGVALLLvGLLPLLLIFRKLLPVRKEEEAELEEL-------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 589 alehllarrlhtfhrqisqedknwetniqelqKKHRISDGILLAKCLTVLGFVIFMFFLNSfvpgihldlgwIAILGAIW 668
Cdd:pfam03600 199 --------------------------------RKRAIKDKLLLAISALVLALVILGFLLLS-----------VLALAGAL 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 669 LLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEqtallikMVPEEQRLIAAIVLVVWVSALASSLID 748
Cdd:pfam03600 236 LLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALAD-------ALGGLSGLLVALALILWLSALLSAFIS 308
|
....*....
gi 1034590834 749 NIPFTATMA 757
Cdd:pfam03600 309 NVPTAALMA 317
|
|
| YbiR_permease |
cd01117 |
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ... |
382-754 |
9.44e-34 |
|
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.
Pssm-ID: 238537 [Multi-domain] Cd Length: 384 Bit Score: 133.94 E-value: 9.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 382 PSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGrVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVT 461
Cdd:cd01117 30 ISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGS-PRRLLFLLVLLSGILSALLTNDTACLVFTPIV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 462 IRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSnqelrKMGLDFAGFTAHM--FIGICLVLLVCfpLLRLLY 539
Cdd:cd01117 109 LELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIAS-----ESGISFPFFLAAMapLALLGLLLLLI--LLLVLF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 540 WnRKLYNKEPSEIVELKHEIHVWRltaqrispasreetAVRRLLLgkvlalehllarrlhtfhrqisqedknwetniqel 619
Cdd:cd01117 182 P-GELKGLPLDKATKEEGVGARKL--------------AVKLLVL----------------------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 620 qkkhrisdgillakCLTVLGFVIFMFFLNSFvpgihldlgWIAILGAIWLLILADIHDFEIILhRVEWATLLFFAALFVL 699
Cdd:cd01117 212 --------------ILLLLVAFLALLGVIPL---------WTAALVAAVLLLLTRLKPRRVLK-KVDWGLLLFFAGLFIL 267
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1034590834 700 MEALAHLHLIEYVgeqTALLIkmvpeeqrLIAAIVLVVWVSALASSLIDNIPFTA 754
Cdd:cd01117 268 VGGFAQGLPLEGL---SRLLP--------LLDSVLSLFLVSIGLSQLISNVPAVL 311
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
400-757 |
1.28e-24 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 106.39 E-value: 1.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 400 FGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLD-----PRQ 474
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 475 VLIAEVIFTNIGGAATAIGDPPNVIIVSN-QELRKMGLDFAGFTAHMF-IGICLVLLVCFPLLRLLywnrklynkePSEI 552
Cdd:COG0471 81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLlEEATGIPISFFEWMLVGLpVALVGLLLLWLVLYRLL----------PPEI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 553 VELKHEIHVWRLTAQRISPASREETAVrrlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrisdgilla 632
Cdd:COG0471 151 KEVPGSKEVIREELAELGPLSRREKIA----------------------------------------------------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 633 kcLTVLGFVIFMFFLNSFvpgIHLDLGWIAILGAIwLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYV 712
Cdd:COG0471 178 --LAIFALTVLLWITGSL---HGIPIAVVALLGAV-LLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWL 251
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1034590834 713 GEQTALLIKMVPeeqrLIAAIVLVVWVSALASSLIDNIPFTATMA 757
Cdd:COG0471 252 ADALLPLLGGLS----PLLLLLLLALLTLLLTEFASNTATAALLL 292
|
|
| PLN00136 |
PLN00136 |
silicon transporter; Provisional |
391-785 |
3.65e-17 |
|
silicon transporter; Provisional
Pssm-ID: 215070 [Multi-domain] Cd Length: 482 Bit Score: 85.05 E-value: 3.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 391 IDFETLALLFGMMILVAIFSETGFFDYCA-VKAYRLSRGRvwAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLN 469
Cdd:PLN00136 61 IDLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCRVCVVTALASALFTNDTCCVVLTEFVLELAAERN 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 470 LDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLdFAGFTAHMFIG--ICLVLLVCfpllrlLYWNRKLYNK 547
Cdd:PLN00136 139 LPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKITFPKF-LLGILPAMLAGmaVNMVMLLC------MYWKDLDGGA 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 548 EPSEIVELKHEIHVWRLTAQRIS-PASREETAVRRLLLGKVLALEHLLARRLHTFHRqisqedknWETNIQELQKKHRIS 626
Cdd:PLN00136 212 ELSVDGKQMEAVEEGRSPASAKStKQQSPALLQAGLNGDGNGDMSSMMSENISTKHP--------WFMQCTEHRRKLFLK 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 627 DgilLAKCLTVLGFVIFMFFLNsfvpgihldLGWIAILGAIwLLILADIHDFEIILHRVEWATLLFFAALFVLMEALahl 706
Cdd:PLN00136 284 S---FAYVVTVGMVVAYMVGLN---------MSWTAITTAI-ALVVVDFRDAEPCLDTVSYSLLVFFSGMFITVSGF--- 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 707 hliEYVGEQTALLIKMVPEEQ-RLIAAIVLVVWVSALASSLIDNIPF-------TATMAGLPNDGCVLHCWDVLSPCGSC 778
Cdd:PLN00136 348 ---NKTGLPGAIWNFMAPYSKvNSVGGISVLSVIILLLSNLASNVPTvllmgdeVAAAAALISPAAVTRSWLLLAWVSTV 424
|
....*..
gi 1034590834 779 GGGMELI 785
Cdd:PLN00136 425 AGNLSLL 431
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
399-760 |
1.73e-16 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 82.70 E-value: 1.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 399 LFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIA 478
Cdd:cd01118 58 LIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPF 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 479 EVIFTNIGGAATA---IGDPPNVIIVSNqelrkMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYwnRKlynkepseivEL 555
Cdd:cd01118 138 LYACAFIADAASLplpISNLVNIVTAGY-----FGIGFTEYAALMFLPSIVSILATYVVLYLFF--RR----------AL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 556 KHEIHVWRLTAQRISpasreetavrrlllgkvlalehllarrlhtfhrqisqedknwetniqelqkkhrISDGILLAKCL 635
Cdd:cd01118 201 PKRLETASVKKPSLA------------------------------------------------------IKDPLLFGLAW 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 636 TVLGFVIFMFFlnsfvpGIHLDLGWIAILGAIW---LLILADIHDFE---IILHRVEWATLLFFAALFVLMEALAHLHLI 709
Cdd:cd01118 227 TLLVLLVVSAF------GVDILLIPPSFIAGVLaliFLLLARRGGAInplKVLKEAPWGVLLFSLGLYVVVFGLKNAGLT 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1034590834 710 EYVGEQTALLIkmvpeEQRLIAAIVLVVWVSALASSLIDNIPftATMAGLP 760
Cdd:cd01118 301 AILADLLNWLV-----SQGLLAAILGVGLLAAFLSNVMNNLP--AVLIGAL 344
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
398-539 |
8.49e-14 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 73.77 E-value: 8.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 398 LLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLI 477
Cdd:cd01115 51 LFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLM 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034590834 478 AEVIFTNIGGAATAIGDPPNVIIVSnqELRKMGLDFAGFTAHMFIGIcLVLLVCFPLLRLLY 539
Cdd:cd01115 131 PLAFAASIGGMLTLIGTPPNLVASG--YLESLGGQGFSFFEFTPIGL-PLLIIGLLYLWFIF 189
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
381-540 |
1.38e-13 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 73.62 E-value: 1.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 381 RPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPV 460
Cdd:COG1055 258 RVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPL 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 461 TIRLCEVLNLDPrqVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYW 540
Cdd:COG1055 338 IPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
386-535 |
1.34e-12 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 70.36 E-value: 1.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 386 HVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLc 465
Cdd:cd00625 252 EVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASL- 330
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 466 evlnLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLL 535
Cdd:cd00625 331 ----APPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
384-537 |
1.39e-11 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 67.10 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 384 LTHVVEW------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRG-RVWAMIIMLCLIAAVLSAFLDNVTTMLL 456
Cdd:COG0471 211 LTGVLTWkdayksIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGlSPLLLLLLLALLTLLLTEFASNTATAAL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 457 FTPVTIRLCEVLNLDPRQVLIAeVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFagftahMFIGICLVLLVC 531
Cdd:COG0471 291 LLPIAISLAQALGVNPLPLALA-VAFAASCAFLLPVGTPPNAIVygsgyYKFKDFLKVGLPL------NLIGLVVLLLLG 363
|
....*.
gi 1034590834 532 FPLLRL 537
Cdd:COG0471 364 PLWWPL 369
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
378-516 |
7.03e-09 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 58.80 E-value: 7.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 378 IGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLF 457
Cdd:cd01116 255 LADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATM 334
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1034590834 458 TPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGF 516
Cdd:cd01116 335 IPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEF 393
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
341-477 |
3.70e-08 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 56.17 E-value: 3.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 341 IATAILAGVYALIIFEIVhrtlaAMLGSLAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAV 420
Cdd:pfam03600 207 LLLAISALVLALVILGFL-----LLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALAD 281
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034590834 421 KAYRLSrgRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLI 477
Cdd:pfam03600 282 ALGGLS--GLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
391-539 |
4.07e-07 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 52.97 E-value: 4.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 391 IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRG-RVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLN 469
Cdd:cd01115 239 IDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGlPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLG 318
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034590834 470 LDPRQVLIAEVIftnIGGAA--TAIGDPPNVIIVSNQELRKMglDFagFTAHMFIGIcLVLLVCFPLLRLLY 539
Cdd:cd01115 319 LPPEALLLAVAI---GASCAfmLPVGTPPNAIVLGPGGYKFS--DF--AKVGLPLSI-LSLVVSVTMIPLIW 382
|
|
| PRK15445 |
PRK15445 |
arsenical efflux pump membrane protein ArsB; |
378-476 |
6.93e-07 |
|
arsenical efflux pump membrane protein ArsB;
Pssm-ID: 185342 Cd Length: 427 Bit Score: 52.48 E-value: 6.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 378 IGDRPSLTHVVeWidFETLALLfGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLF 457
Cdd:PRK15445 42 LGDVPVVWGIV-W--NATLTFI-AIIIISLLLDEAGFFEWAALHVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALIL 117
|
90
....*....|....*....
gi 1034590834 458 TPVTIRLCEVLNLDPRQVL 476
Cdd:PRK15445 118 TPIVLAMLLALGFSKKATL 136
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
654-760 |
1.56e-06 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 51.28 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 654 IHLDLGWIAILGAIwLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVgeqTALLIKMVPEEQRLIaaI 733
Cdd:COG1055 21 RGLNRAVAALLGAA-LLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWL---AIKLARRAKGSPRRL--L 94
|
90 100
....*....|....*....|....*..
gi 1034590834 734 VLVVWVSALASSLIDNIpfTATMAGLP 760
Cdd:COG1055 95 WLLGLLTALLSAFLDND--TTALLLTP 119
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
384-535 |
2.62e-05 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 47.34 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 384 LTHVVEW-------IDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIM--LCLIAAVLSAFLDNVTTM 454
Cdd:TIGR00785 285 FLGIVTWkdiqknkVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLvlVVLFYIILYFFASNTAHT 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 455 LLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVII-----VSNQELRKMGLDFAgftahmFIGICLVLL 529
Cdd:TIGR00785 365 AALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyVKIKDMWRVGAIIG------IVGLIVLLL 438
|
....*.
gi 1034590834 530 VCFPLL 535
Cdd:TIGR00785 439 VGTLWW 444
|
|
| PLN00137 |
PLN00137 |
NHAD transporter family protein; Provisional |
639-785 |
1.82e-03 |
|
NHAD transporter family protein; Provisional
Pssm-ID: 215071 Cd Length: 424 Bit Score: 41.60 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 639 GFVIFMFFLNS--FVP------GIHLDLGWIAILGAIWLLILAdIHDFEII---------LHRVEWATLLFFaaLFVLMe 701
Cdd:PLN00137 225 GQLVFGVGVGAllFVPvfkaltGLPPYMGMLLGLGVLWILTDA-IHYGESErqalkvpqaLSRIDTQGILFF--LGILL- 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 702 ALAHLHLIEYVGEQTALLIKMVPEeQRLIAAIVlvvwvsALASSLIDNIPFTAT---MAGLPNDGCVLHCWDVLSPCGSC 778
Cdd:PLN00137 301 SVGSLDAAGILRELANYLDANIPN-VELIASAI------GVASAIIDNVPLVAAtmgMYDLTDYPMDSELWQLIALCAGT 373
|
....*..
gi 1034590834 779 GGGMELI 785
Cdd:PLN00137 374 GGSLLVI 380
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
384-500 |
2.68e-03 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 41.20 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 384 LTHVVEWID-------FETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAM--IIMLCLIAAVLSAFLDNVTTM 454
Cdd:pfam00939 306 LLRILDWKDivknkgaWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMafIIILSLFYLSHYLFASATAHT 385
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1034590834 455 LLFTPVTIRLCEVLNLDPRQVLIAEVIF-TNIGGAATAIGDPPNVII 500
Cdd:pfam00939 386 AAMLPIFAAVAQAIPGAPPLLAALLLGFaISLGGFLTPYGTGPGPIY 432
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
395-757 |
3.68e-03 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 40.41 E-value: 3.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 395 TLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGR-----VWAMIIMLCLIAAVLSaflDNVTTMLLFTPVTIRLCEVLN 469
Cdd:TIGR00785 65 TIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGTtlglgYFLVFLETLLAPMWPS---NTARAGGILLPIIKSLLPLLG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 470 LDP-------RQVLIAEVIF-TNIGGAATAIGDPPNVIIVSNqeLRKMGLDFAGFTAHMFIGICLVlLVCFPLLRLLywn 541
Cdd:TIGR00785 142 SKPeksprkiGKYLMLGIAYsASIGSSGFLTGSAPNALAAGI--LSKILGIQISWGDWFLAGLPLG-IILLLLVPLL--- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 542 rkLYNKEPSEIvELKHEIHVWrltaqrispASREETAVRRLLLgkvlalehllarrlhtfhrqisqedknwetniqelqk 621
Cdd:TIGR00785 216 --LYVLFPPEL-KLKDEVDLW---------AKEELEEMGPMSF------------------------------------- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590834 622 KHRISDGILLakcLTVLGFVifmfflnsFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLME 701
Cdd:TIGR00785 247 REKALLGIFL---LALLLWI--------FGGSLGINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLILFGGLIGLAG 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034590834 702 ALAHLHLIEYVGEqtaLLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMA 757
Cdd:TIGR00785 316 GLKKSGFIKWFSE---KLVGILDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALV 368
|
|
| |
