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Conserved domains on  [gi|2217378907|ref|XP_047279820|]
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DDB1- and CUL4-associated factor 10 isoform X4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-334 1.12e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLW 315


                  ....*...
gi 2217378907 327 DLDLTKSL 334
Cdd:COG2319   316 DLATGKLL 323
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-334 1.12e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLW 315


                  ....*...
gi 2217378907 327 DLDLTKSL 334
Cdd:COG2319   316 DLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-319 3.68e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 3.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 164 STRTH-GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRK 241
Cdd:cd00200   130 TLRGHtDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217378907 242 LnTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnryTEDGCPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 319
Cdd:cd00200   209 G-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-281 3.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2217378907  244 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
243-281 1.44e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.44e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217378907 243 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 224-281 1.01e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217378907 224 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 281
Cdd:PTZ00420   89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-334 1.12e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLW 315


                  ....*...
gi 2217378907 327 DLDLTKSL 334
Cdd:COG2319   316 DLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-319 3.68e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 3.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 164 STRTH-GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRK 241
Cdd:cd00200   130 TLRGHtDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217378907 242 LnTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnryTEDGCPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 319
Cdd:cd00200   209 G-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-319 1.52e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 1.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 169 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 247
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLET-GECVR 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217378907 248 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHkkfFHTRFLMRMRLTPDcsKMLISTSS 319
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR---GHTDWVNSVAFSPD--GTFVASSS 154
WD40 COG2319
WD40 repeat [General function prediction only];
168-329 4.50e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 4.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnryTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319   156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231


                  ...
gi 2217378907 327 DLD 329
Cdd:COG2319   232 DLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
169-283 5.94e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 5.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 169 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSeAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 247
Cdd:COG2319   289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLAT-GELLR 366

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2217378907 248 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTN 283
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-336 6.58e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 6.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 169 GAVFNLEYSPDG-SVLTVACEQTeVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:cd00200    52 GPVRDVAASADGtYLASGSSDKT-IRLWDLETGECVRTL-TGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVET-GKCL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNrytedGCPHKKFF--HTRFLMRMRLTPDcSKMLISTSSGYLLI 324
Cdd:cd00200   129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLtgHTGEVNSVAFSPD-GEKLLSSSSDGTIK 202

                         170
                  ....*....|..
gi 2217378907 325 LHDLDLTKSLEV 336
Cdd:cd00200   203 LWDLSTGKCLGT 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-281 5.39e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 5.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 169 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 247
Cdd:cd00200   178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRT-GECVQ 255

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2217378907 248 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:cd00200   256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
163-329 1.34e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 163 LSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKl 242
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 243 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnryTEDG-CPHKKFFHTRFLMRMRLTPDcSKMLISTSSGY 321
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD----LATGkLLRTLTGHSGAVTSVAFSPD-GKLLASGSDDG 184


                  ....*...
gi 2217378907 322 LLILHDLD 329
Cdd:COG2319   185 TVRLWDLA 192
WD40 COG2319
WD40 repeat [General function prediction only];
168-240 1.27e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.38  E-value: 1.27e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217378907 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLR 240
Cdd:COG2319   330 TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSpDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-281 3.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2217378907  244 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
243-281 1.44e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.44e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217378907 243 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 224-281 1.01e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217378907 224 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 281
Cdd:PTZ00420   89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 246-334 1.98e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217378907 246 VCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnryteDGCPHKKFF--HTRFLMRMRLTPDcSKMLISTSSGYLL 323
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-----ETGELLRTLkgHTGPVRDVAASAD-GTYLASGSSDKTI 75

                          90
                  ....*....|.
gi 2217378907 324 ILHDLDLTKSL 334
Cdd:cd00200    76 RLWDLETGECV 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-238 3.21e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.21e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2217378907  199 SSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 238
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
200-238 1.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2217378907 200 SKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 238
Cdd:pfam00400   1 GKLLKTL-EGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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