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Conserved domains on  [gi|2217276831|ref|XP_047281057|]
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fucose mutarotase isoform X5 [Homo sapiens]

Protein Classification

RbsD/FucU family protein( domain architecture ID 10008334)

RbsD/FucU family protein similar to Streptococcus pneumoniae fucose mutarotase, a component of the fucose-utilization pathway, which catalyzes the interconversion between alpha-L-fucose and beta-L-fucose

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FucU COG4154
L-fucose mutarotase/ribose pyranase, RbsD/FucU family [Carbohydrate transport and metabolism];
3-127 8.07e-44

L-fucose mutarotase/ribose pyranase, RbsD/FucU family [Carbohydrate transport and metabolism];


:

Pssm-ID: 443323  Cd Length: 143  Bit Score: 140.30  E-value: 8.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276831   3 IRADGLGIPQLLEAVLKLLPLDTYVESPAAVMELVPSDKERglqTPVWTEYESILRRAGcvgslqpchfVFQRALAKIER 82
Cdd:COG4154    43 VRLDGHSAPELLEAILSLFPLDTFVDDPVVRMEVVGGPDEV---PPVWAEYQAIIAKAE----------GRPVPIERLER 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217276831  83 FEFYERAKKAFAVVATGpaqcwawllcrETALYGNLILRKGVLAL 127
Cdd:COG4154   110 FAFYERAKKAYAVVATG-----------ETRLYGNIILKKGVIPP 143
 
Name Accession Description Interval E-value
FucU COG4154
L-fucose mutarotase/ribose pyranase, RbsD/FucU family [Carbohydrate transport and metabolism];
3-127 8.07e-44

L-fucose mutarotase/ribose pyranase, RbsD/FucU family [Carbohydrate transport and metabolism];


Pssm-ID: 443323  Cd Length: 143  Bit Score: 140.30  E-value: 8.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276831   3 IRADGLGIPQLLEAVLKLLPLDTYVESPAAVMELVPSDKERglqTPVWTEYESILRRAGcvgslqpchfVFQRALAKIER 82
Cdd:COG4154    43 VRLDGHSAPELLEAILSLFPLDTFVDDPVVRMEVVGGPDEV---PPVWAEYQAIIAKAE----------GRPVPIERLER 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217276831  83 FEFYERAKKAFAVVATGpaqcwawllcrETALYGNLILRKGVLAL 127
Cdd:COG4154   110 FAFYERAKKAYAVVATG-----------ETRLYGNIILKKGVIPP 143
RbsD_FucU pfam05025
RbsD / FucU transport protein family; The Escherichia coli high-affinity ribose-transport ...
 3-124 1.48e-28

RbsD / FucU transport protein family; The Escherichia coli high-affinity ribose-transport system consists of six proteins encoded by the rbs operon (rbsD, rbsA, rbsC, rbsB, rbsK and rbsR). RbsD was originally thought to be a high affinity ribose transport protein, but further analysis shows that it is a D-ribose pyranase. It catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. It also catalyzes the conversion between beta-allofuranose and beta-allopyranose. This family also includes FucU a component of the fucose operon and is a L-fucose mutarotase, involved in the anomeric conversion of L-fucose. It also exhibits a pyranase activity for D-ribose. Both have been classified in the RbsD/FucU family of proteins. Members of this family are ubiquitous having been found in organizms from eubacteria to mammals.


Pssm-ID: 428264  Cd Length: 132  Bit Score: 100.95  E-value: 1.48e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276831   3 IRADGLGIPQLLEAVLKLLPLD-TYVESPAavmelVPSDkerglqTPVWTEYESILRRAGCvgslqpchfvfqrALAKIE 81
Cdd:pfam05025  44 LRAGGPSFLDVLDAVLSELPVEkVYVAEEI-----VEGN------PEVWAEYLALLPKAEG-------------EIEYVE 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2217276831  82 RFEFYERAKKAFAVVATGpaqcwawllcrETALYGNLILRKGV 124
Cdd:pfam05025 100 HEAFKERAKKAKAVVRTG-----------ETTPYANIILKKGV 131
fucU PRK15420
L-fucose mutarotase; Provisional
 3-124 3.87e-19

L-fucose mutarotase; Provisional


Pssm-ID: 185318  Cd Length: 140  Bit Score: 77.22  E-value: 3.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276831   3 IRADGLGIPQLLEAVLKLLPLDTYVeSPAAVMELVPSDKergLQTPVWTEYESILRRAGcvgslqPChfvfqRALAKIER 82
Cdd:PRK15420   43 IRADGLLVSDLLQAIIPLFELDSYA-PPLVMMAAVEGDT---LDPEVERRYRNALSLQA------PC-----PDIIRINR 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2217276831  83 FEFYERAKKAFAVVATGpaqcwawllcrETALYGNLILRKGV 124
Cdd:PRK15420  108 FAFYERAQKAFAIVITG-----------ERAKYGNILLKKGV 138
 
Name Accession Description Interval E-value
FucU COG4154
L-fucose mutarotase/ribose pyranase, RbsD/FucU family [Carbohydrate transport and metabolism];
3-127 8.07e-44

L-fucose mutarotase/ribose pyranase, RbsD/FucU family [Carbohydrate transport and metabolism];


Pssm-ID: 443323  Cd Length: 143  Bit Score: 140.30  E-value: 8.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276831   3 IRADGLGIPQLLEAVLKLLPLDTYVESPAAVMELVPSDKERglqTPVWTEYESILRRAGcvgslqpchfVFQRALAKIER 82
Cdd:COG4154    43 VRLDGHSAPELLEAILSLFPLDTFVDDPVVRMEVVGGPDEV---PPVWAEYQAIIAKAE----------GRPVPIERLER 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217276831  83 FEFYERAKKAFAVVATGpaqcwawllcrETALYGNLILRKGVLAL 127
Cdd:COG4154   110 FAFYERAKKAYAVVATG-----------ETRLYGNIILKKGVIPP 143
RbsD_FucU pfam05025
RbsD / FucU transport protein family; The Escherichia coli high-affinity ribose-transport ...
 3-124 1.48e-28

RbsD / FucU transport protein family; The Escherichia coli high-affinity ribose-transport system consists of six proteins encoded by the rbs operon (rbsD, rbsA, rbsC, rbsB, rbsK and rbsR). RbsD was originally thought to be a high affinity ribose transport protein, but further analysis shows that it is a D-ribose pyranase. It catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. It also catalyzes the conversion between beta-allofuranose and beta-allopyranose. This family also includes FucU a component of the fucose operon and is a L-fucose mutarotase, involved in the anomeric conversion of L-fucose. It also exhibits a pyranase activity for D-ribose. Both have been classified in the RbsD/FucU family of proteins. Members of this family are ubiquitous having been found in organizms from eubacteria to mammals.


Pssm-ID: 428264  Cd Length: 132  Bit Score: 100.95  E-value: 1.48e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276831   3 IRADGLGIPQLLEAVLKLLPLD-TYVESPAavmelVPSDkerglqTPVWTEYESILRRAGCvgslqpchfvfqrALAKIE 81
Cdd:pfam05025  44 LRAGGPSFLDVLDAVLSELPVEkVYVAEEI-----VEGN------PEVWAEYLALLPKAEG-------------EIEYVE 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2217276831  82 RFEFYERAKKAFAVVATGpaqcwawllcrETALYGNLILRKGV 124
Cdd:pfam05025 100 HEAFKERAKKAKAVVRTG-----------ETTPYANIILKKGV 131
fucU PRK15420
L-fucose mutarotase; Provisional
 3-124 3.87e-19

L-fucose mutarotase; Provisional


Pssm-ID: 185318  Cd Length: 140  Bit Score: 77.22  E-value: 3.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217276831   3 IRADGLGIPQLLEAVLKLLPLDTYVeSPAAVMELVPSDKergLQTPVWTEYESILRRAGcvgslqPChfvfqRALAKIER 82
Cdd:PRK15420   43 IRADGLLVSDLLQAIIPLFELDSYA-PPLVMMAAVEGDT---LDPEVERRYRNALSLQA------PC-----PDIIRINR 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2217276831  83 FEFYERAKKAFAVVATGpaqcwawllcrETALYGNLILRKGV 124
Cdd:PRK15420  108 FAFYERAQKAFAIVITG-----------ERAKYGNILLKKGV 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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