|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
1-310 |
3.24e-134 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
:
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 400.06 E-value: 3.24e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 1 MATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDP 80
Cdd:cd00186 68 EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRTDSTRLSEEAILEAREYIQAIYG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 81 RWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 154
Cdd:cd00186 148 KEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYELIWRRFLASQMADAKYEETTVTLEIG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 155 QERFVAHGLMILARNYLDVYPYDHWSDK-ILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAE 233
Cdd:cd00186 226 GEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQPPPRYTEASLIKLMEKRGIGRPSTYAS 305
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462557217 234 HIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVF 310
Cdd:cd00186 306 IIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
588-632 |
1.41e-18 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
:
Pssm-ID: 462017 Cd Length: 45 Bit Score: 79.37 E-value: 1.41e-18
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2462557217 588 TSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 632
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
504-545 |
8.22e-17 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
:
Pssm-ID: 462017 Cd Length: 45 Bit Score: 74.36 E-value: 8.22e-17
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2462557217 504 VTCNCGQEAVLLTVRKEGPNRGRQFFKCNGG---SCNFFLWADSP 545
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
348-387 |
6.16e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
:
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 60.35 E-value: 6.16e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462557217 348 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAVWLPDS 387
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
1-310 |
3.24e-134 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 400.06 E-value: 3.24e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 1 MATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDP 80
Cdd:cd00186 68 EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRTDSTRLSEEAILEAREYIQAIYG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 81 RWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 154
Cdd:cd00186 148 KEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYELIWRRFLASQMADAKYEETTVTLEIG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 155 QERFVAHGLMILARNYLDVYPYDHWSDK-ILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAE 233
Cdd:cd00186 226 GEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQPPPRYTEASLIKLMEKRGIGRPSTYAS 305
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462557217 234 HIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVF 310
Cdd:cd00186 306 IIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
8-261 |
7.72e-110 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 332.67 E-value: 7.72e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 8 RSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR-WGAFA 86
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKeYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 87 QSILERGGptPRNGNKSDQAHPPIHPTKYTN------NLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA 160
Cdd:smart00437 81 VVLLKPRK--PRKGKKAQGAHEAIRPTKPIFtpelekELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 161 HGLMILARNYLDVYPYDHW-SDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 239
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKKeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLL 238
|
250 260
....*....|....*....|..
gi 2462557217 240 ARMYVGLTPdKRFLPGHLGMGL 261
Cdd:smart00437 239 DRGYVTKKK-KKLIPTELGIAV 259
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
1-295 |
9.40e-100 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 312.25 E-value: 9.40e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 1 MATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GYISYPRTETNIFPRDLNLTVLVEQQTPD 79
Cdd:pfam01131 107 TAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGLITYPRTDSTYLSDDATLKAILEYLTKN 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 80 P-RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY---TNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQ 155
Cdd:pfam01131 187 YgKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDipvLPELSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGG 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 156 ERFVAHGLMILARNYLDVYPYDHWSD-KILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEH 234
Cdd:pfam01131 267 EEFRASGKVILEDGWLKVYPYEKKEDeEELPELKEGEELKVTQVEVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRATI 346
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462557217 235 IETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMgYEMSKPDLRAELEADLKLICDGKKDK 295
Cdd:pfam01131 347 IETLLERGYVERKK-KSLVPTELGKALVEALEKF-PDLVDPELTAELEEKLDEIAEGKLDW 405
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
2-404 |
3.05e-98 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 320.41 E-value: 3.05e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR 81
Cdd:PRK07219 266 ATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKE 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 82 WGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY--TNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFV 159
Cdd:PRK07219 346 YGPYAESILEQENIKPTEGKKETTDHPPIHPVDVpkREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFK 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 160 AHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 239
Cdd:PRK07219 426 ASGSRLVEEGWHEVYPYEKFDEKELPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLY 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 240 ARMYVglTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKK 319
Cdd:PRK07219 506 KRGYV--IEGDPPRPTDLGIAVIEALEKYAPEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKE 583
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 320 LdealaqyfgnGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPD----SVLeasrdS 395
Cdd:PRK07219 584 I----------GDHLAGSLKAENRSLKTIGKCPECGGDLIIIRTDKGSRFVGCSGYPDCRNTFPLPStgriKVL-----D 648
|
....*....
gi 2462557217 396 SVCPVCQPH 404
Cdd:PRK07219 649 EVCEKCGLP 657
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
2-301 |
1.52e-62 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 217.66 E-value: 1.52e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKwRPQAL-DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE-TNIfPRDLNltvlveqqtpd 79
Cdd:COG0550 231 FTVTSVEKKPKKR-NPPPPfTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDsVRL-SEDAV----------- 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 80 prwGAFAQSILERGGP-----TPR--NGNKSDQ-AHPPIHPT---KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETT 148
Cdd:COG0550 298 ---AAAREYIEALYGKeylpeKPRvyKTSKNAQeAHEAIRPTgvtRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTT 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 149 VEIDIAQERFVAHGLMILARNYLDVYPYDH-----WSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKH 223
Cdd:COG0550 375 VTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEEL 454
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 224 GIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGM---GLVEGYDSmgyEMSKPDLRAELEADLKLICDGKKDKFVVLR 300
Cdd:COG0550 455 GIGRPSTYASIIETLQDRGYVERE-GKRLVPTELGFiviDLLEEHFP---DLVDYEFTAKMEEKLDEIAEGKLDWKDVLE 530
|
.
gi 2462557217 301 Q 301
Cdd:COG0550 531 E 531
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
2-378 |
4.03e-61 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 215.85 E-value: 4.03e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR 81
Cdd:TIGR01057 257 AAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQSIAQELYEEALISYPRTSSQKLPPSINYRAILDNLAKGPL 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 82 WGAFAQSILERGGPTPRNGNKSDQAHPPIHPT--KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFV 159
Cdd:TIGR01057 337 YREAAERLLETGVLKPVEGKKEDPAHPAIHPTgeIPSQELSKDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFR 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 160 AHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 239
Cdd:TIGR01057 417 LSGLRVVKLGWLEYYHYSKFEEKELPPLDRGDKIKVVRVDVRVKETQPPARYDKASLIREMESRGLGTKATRARIIETLY 496
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 240 ARMYVGLTPDKRFLPghLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAvakAKK 319
Cdd:TIGR01057 497 KRGYIEGKKSIKVTP--LGEAVIETLQRYCPEIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEEF---KKR 571
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462557217 320 LDEAlaqyfgnGTELA---QQEDIypampepIRKCPQCNKDMVLKTKKNGGFYLsCMGFPEC 378
Cdd:TIGR01057 572 LDDI-------GIELGkslGSVEV-------VGKCPKCGGKLVSKYAKKGRFVG-CSNYPEC 618
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
588-632 |
1.41e-18 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 79.37 E-value: 1.41e-18
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2462557217 588 TSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 632
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
504-545 |
8.22e-17 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 74.36 E-value: 8.22e-17
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2462557217 504 VTCNCGQEAVLLTVRKEGPNRGRQFFKCNGG---SCNFFLWADSP 545
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
348-387 |
6.16e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 60.35 E-value: 6.16e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462557217 348 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAVWLPDS 387
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
1-310 |
3.24e-134 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 400.06 E-value: 3.24e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 1 MATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDP 80
Cdd:cd00186 68 EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRTDSTRLSEEAILEAREYIQAIYG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 81 RWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 154
Cdd:cd00186 148 KEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYELIWRRFLASQMADAKYEETTVTLEIG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 155 QERFVAHGLMILARNYLDVYPYDHWSDK-ILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAE 233
Cdd:cd00186 226 GEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQPPPRYTEASLIKLMEKRGIGRPSTYAS 305
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462557217 234 HIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVF 310
Cdd:cd00186 306 IIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
8-261 |
7.72e-110 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 332.67 E-value: 7.72e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 8 RSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR-WGAFA 86
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKeYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 87 QSILERGGptPRNGNKSDQAHPPIHPTKYTN------NLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA 160
Cdd:smart00437 81 VVLLKPRK--PRKGKKAQGAHEAIRPTKPIFtpelekELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 161 HGLMILARNYLDVYPYDHW-SDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 239
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKKeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLL 238
|
250 260
....*....|....*....|..
gi 2462557217 240 ARMYVGLTPdKRFLPGHLGMGL 261
Cdd:smart00437 239 DRGYVTKKK-KKLIPTELGIAV 259
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
1-295 |
9.40e-100 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 312.25 E-value: 9.40e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 1 MATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GYISYPRTETNIFPRDLNLTVLVEQQTPD 79
Cdd:pfam01131 107 TAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGLITYPRTDSTYLSDDATLKAILEYLTKN 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 80 P-RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY---TNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQ 155
Cdd:pfam01131 187 YgKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDipvLPELSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGG 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 156 ERFVAHGLMILARNYLDVYPYDHWSD-KILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEH 234
Cdd:pfam01131 267 EEFRASGKVILEDGWLKVYPYEKKEDeEELPELKEGEELKVTQVEVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRATI 346
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462557217 235 IETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMgYEMSKPDLRAELEADLKLICDGKKDK 295
Cdd:pfam01131 347 IETLLERGYVERKK-KSLVPTELGKALVEALEKF-PDLVDPELTAELEEKLDEIAEGKLDW 405
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
2-404 |
3.05e-98 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 320.41 E-value: 3.05e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR 81
Cdd:PRK07219 266 ATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKE 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 82 WGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY--TNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFV 159
Cdd:PRK07219 346 YGPYAESILEQENIKPTEGKKETTDHPPIHPVDVpkREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFK 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 160 AHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 239
Cdd:PRK07219 426 ASGSRLVEEGWHEVYPYEKFDEKELPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLY 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 240 ARMYVglTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKK 319
Cdd:PRK07219 506 KRGYV--IEGDPPRPTDLGIAVIEALEKYAPEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKE 583
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 320 LdealaqyfgnGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPD----SVLeasrdS 395
Cdd:PRK07219 584 I----------GDHLAGSLKAENRSLKTIGKCPECGGDLIIIRTDKGSRFVGCSGYPDCRNTFPLPStgriKVL-----D 648
|
....*....
gi 2462557217 396 SVCPVCQPH 404
Cdd:PRK07219 649 EVCEKCGLP 657
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
2-419 |
1.45e-68 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 238.50 E-value: 1.45e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKWRPQALDTVELEKLASrKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPr 81
Cdd:PRK07220 260 AEVTEVEKGTKTDKPPTPFNTTEFISAAN-SIGFSAANAMRIAESLYTNGYISYPRTDNTVYPESLDLREQIEIFAEGP- 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 82 WGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT--NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFV 159
Cdd:PRK07220 338 FGEYAQKLLEKGELVPTRGKKETTDHPPIYPASLAkkSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFR 417
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 160 AHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 239
Cdd:PRK07220 418 ANGSRLTEPGWRWYYPYNAPEDRLLPELSEGEELKVKKKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLY 497
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 240 ARMYVGLTPdkrFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKK 319
Cdd:PRK07220 498 SRAYIHGNP---IQPTNTAFAVVDALEKYAPTITKPDMTSRLEEDMDKIAEGKIKEDAVLEESREMLEQVFDELDKNREK 574
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 320 LDEALAqyfgNGTelaqQEDiypampEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDS----VLEAsrds 395
Cdd:PRK07220 575 IRESLR----EGL----RED------KIIGKCPLCGSDLMVRRSKRGSRFIGCEGYPECTFSLPLPKSgqiiVTDK---- 636
|
410 420
....*....|....*....|....
gi 2462557217 396 svcpVCQPHPVYRLKLKfKRGSLP 419
Cdd:PRK07220 637 ----VCEAHGLNHIRII-NGGKRP 655
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
2-301 |
1.52e-62 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 217.66 E-value: 1.52e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKwRPQAL-DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE-TNIfPRDLNltvlveqqtpd 79
Cdd:COG0550 231 FTVTSVEKKPKKR-NPPPPfTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDsVRL-SEDAV----------- 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 80 prwGAFAQSILERGGP-----TPR--NGNKSDQ-AHPPIHPT---KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETT 148
Cdd:COG0550 298 ---AAAREYIEALYGKeylpeKPRvyKTSKNAQeAHEAIRPTgvtRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTT 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 149 VEIDIAQERFVAHGLMILARNYLDVYPYDH-----WSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKH 223
Cdd:COG0550 375 VTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEEL 454
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 224 GIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGM---GLVEGYDSmgyEMSKPDLRAELEADLKLICDGKKDKFVVLR 300
Cdd:COG0550 455 GIGRPSTYASIIETLQDRGYVERE-GKRLVPTELGFiviDLLEEHFP---DLVDYEFTAKMEEKLDEIAEGKLDWKDVLE 530
|
.
gi 2462557217 301 Q 301
Cdd:COG0550 531 E 531
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
2-378 |
4.03e-61 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 215.85 E-value: 4.03e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR 81
Cdd:TIGR01057 257 AAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQSIAQELYEEALISYPRTSSQKLPPSINYRAILDNLAKGPL 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 82 WGAFAQSILERGGPTPRNGNKSDQAHPPIHPT--KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFV 159
Cdd:TIGR01057 337 YREAAERLLETGVLKPVEGKKEDPAHPAIHPTgeIPSQELSKDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFR 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 160 AHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 239
Cdd:TIGR01057 417 LSGLRVVKLGWLEYYHYSKFEEKELPPLDRGDKIKVVRVDVRVKETQPPARYDKASLIREMESRGLGTKATRARIIETLY 496
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 240 ARMYVGLTPDKRFLPghLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAvakAKK 319
Cdd:TIGR01057 497 KRGYIEGKKSIKVTP--LGEAVIETLQRYCPEIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEEF---KKR 571
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462557217 320 LDEAlaqyfgnGTELA---QQEDIypampepIRKCPQCNKDMVLKTKKNGGFYLsCMGFPEC 378
Cdd:TIGR01057 572 LDDI-------GIELGkslGSVEV-------VGKCPKCGGKLVSKYAKKGRFVG-CSNYPEC 618
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
2-379 |
1.04e-55 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 201.76 E-value: 1.04e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR 81
Cdd:PRK05776 260 LKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPYKTQSIAEDLYLDGLISYPRTNSQKLPPTLNIRNILKGLSRSPQ 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 82 WGAFAQSILERGGP--TPRNGNKSDQAHPPIHPT-KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDI--AQE 156
Cdd:PRK05776 340 YRPLVNLLLKETKGvlKPVQGPKDDPAHPAIYPTgEPPKNLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVpgFPL 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 157 RFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIE 236
Cdd:PRK05776 420 VFSASGQRIEERGWLKYYPFHKFDEEELPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIE 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 237 TIKARMYvgLTPDKRFL-PGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKkdkfvVLRQQVqkykqvfieaVA 315
Cdd:PRK05776 500 TLFKRGY--LTSNGKYIeVTPLGFGVAEVLEKYFPDIVSVELTRDFEEKLEMIRTGK-----ATREEV----------IE 562
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462557217 316 KAKK-LDEALAQYFGN----GTELAQqediYPAMPEPIRKCPQCNKDMV--------LKTKKNggfYLSCMGFPECR 379
Cdd:PRK05776 563 EAKEtLNKLLEEFKKNkdeiGEELAK----ALGLIKPVGKCKICGREAYkdglckyhYEAKKR---LVKAYEEWKER 632
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
4-419 |
1.72e-53 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 198.53 E-value: 1.72e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 4 VVEVRSKPKSKWRPQALDTVELEKLASRkLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVE--QQTPDPR 81
Cdd:PRK14973 261 VTEVKEGHKVDRAPTPFDTTTFIVAASR-LGFSAANAMRIAEDLYMNGYISYPRTDNTIYPKSLDLNGVLAtlAKGAFSK 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 82 WGAFAQSILErggPTPRNGNKSDQAHPPIHPTKYTNNLQ-GDEQ-RLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFV 159
Cdd:PRK14973 340 DVAWVKDNRR---PVPTRGKKSSTDHPPIHPTGVATREElGDDRwKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYT 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 160 AHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 239
Cdd:PRK14973 417 ATGGRLLEAGWRTVYPYSEAKENILPAFALGEKLPILAVNLEEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLV 496
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 240 ARMYVGLTPDKrflPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFieavakaKK 319
Cdd:PRK14973 497 SRKYIEGNPLR---PTLVGRAVTESLEEHAGTITEPDMTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAF-------DE 566
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 320 LDEALAQYfgnGTELAQQEdiypAMPEPIRKCPQCNKDMVLKtKKNGGFYLSCMGFPECRSAVWLPDSVL-EASRDSSVC 398
Cdd:PRK14973 567 LEANEAVI---GRDIMERT----AEELTIGPCPVCGKDLRIK-HIGSSQFIGCSGYPDCTFNIGLPGTTWgWAIRTDEVC 638
|
410 420
....*....|....*....|.
gi 2462557217 399 PVcqpHPVYRLKLkFKRGSLP 419
Cdd:PRK14973 639 PI---HHLNHVRL-IRKGARP 655
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
2-378 |
3.25e-42 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 162.64 E-value: 3.25e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLY-TQGYISYPRTETNIFPRDLNLTVlveqqtPD- 79
Cdd:PRK07726 263 AKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYeTHKLITYPRTDSRYLPEDMVATL------PEv 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 80 ----PRWGAFAQSILERGGPTPRNG---NKSDQAHPPIHPTKYT---NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTV 149
Cdd:PRK07726 337 lnaiSKVDPYLLLAPPVLDPSIRSRawnDKKVTAHHAIIPTEQPpnlSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTI 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 150 EIDIAQERFVAHGLMILARNYLDVYPYDHWSDK---ILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALM------ 220
Cdd:PRK07726 417 ELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEkeqPLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMeniarf 496
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 221 -----------EKHGIGTDATHAEHIETIKARMYvgLTPDKRFL-PGHLGMGLVegyDSMGYEMSKPDLRAELEADLKLI 288
Cdd:PRK07726 497 vqdkelkktlkETDGLGTEATRAGIIEKLFKRGY--LEKKGKYIhATDKGKQLI---DALPEELTSPDMTAKWEQALDQI 571
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 289 CDGKKDkfvvlrqqvqkyKQVFI-EAVAKAKKLdeaLAQYfgngtelAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGG 367
Cdd:PRK07726 572 SEGQLS------------YQDFMqPLKQWLKQL---VEQA-------KQSSEKYKFDNLTGPKCPDCGKPMLKVKGKNGK 629
|
410
....*....|.
gi 2462557217 368 FyLSCMGFPEC 378
Cdd:PRK07726 630 M-LVCQDRECG 639
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
3-431 |
1.19e-39 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 156.49 E-value: 1.19e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 3 TVVEVRSKPKSKwRPQA-LDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE-TNIFP------RDLnltvlve 74
Cdd:PRK07561 254 SVASVEDKPTTR-KPSApFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYITYMRTDsTNLSQeainaaRGY------- 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 75 qqtpdprwgafaqsILERGG-----PTPRN-GNKSD---QAHPPIHPT------KYTNNLQGDEQRLYEFIVRHFLACCS 139
Cdd:PRK07561 326 --------------IGDNYGkkylpEKPRQySSKAKnaqEAHEAIRPSdvfrtpDQLKGLEGDAQRLYELIWKRFVASQM 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 140 QDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYP-----YDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEA 214
Cdd:PRK07561 392 APARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVegrddALDDEDRRLPALKVGDALTLEKLDPTQHFTKPPARYSEA 471
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 215 DLIALMEKHGIGTDATHAEHIETIKARMYVglTPDK-RFLPGHLGM---GLVEGY--DSMGYemskpDLRAELEADLKLI 288
Cdd:PRK07561 472 SLVKELEKLGIGRPSTYASIISTIQDRGYV--RLENrRFYPEKMGRivtDRLEEFfpRLVDY-----DFTARMEEELDDI 544
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 289 CDGKKDKFVVLRqqvQKYKQvFIEAVAKAKKLDEAlaqyfgNGTELAQqediypaMPEPIRKCPQCNKDMVLKTKKNGGF 368
Cdd:PRK07561 545 ANGEADWKPVLD---DFYKD-FSQQLEKAEELREE------GGMRPNQ-------MVITDRDCPTCGRGMGIRTGKTGVF 607
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 369 yLSCMGF---PECR---------SAVWLPDSVLEASRDSSVCPVCQpHPVYRLKLKF------------KRGSLPPTMPL 424
Cdd:PRK07561 608 -LGCSGYalkERCKttrnltpeeETLNVLEGEDAETRALGADPECG-TAMVLRSGRFgpyvqegegdkpRRLSLPKGNNP 685
|
....*..
gi 2462557217 425 EfvcCIG 431
Cdd:PRK07561 686 E---CVG 689
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
3-401 |
3.20e-35 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 141.92 E-value: 3.20e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 3 TVVEVRSKPKSKwRPQA-LDTVELEKLASRKLRINAKETMRIAEKLY--------TQGYISYPRTETnifprdlnlTVLV 73
Cdd:PRK06599 244 TVDKIEKKERKR-NPPPpFITSTLQQEASRKLGFSAKKTMRIAQKLYegidlgegTVGLITYMRTDS---------VRLS 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 74 EQQTPDPRwgafaQSILERGGP-----TPR---NGNKSDQ-AHPPIHPT--KYT-----NNLQGDEQRLYEFIVRHFLAC 137
Cdd:PRK06599 314 NEALDEAR-----KYITKKYGKeylpaKPRvykKKSKNAQeAHEAIRPTsiNRTpeslkPYLTPDQFKLYELIWKRTVAS 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 138 CSQDAQGQETTVEIDIAQERFV--AHGLMILARNYLDVYPYD-----HWSDKILPVYEQGSHFQPSTVEMVDGETSPPKL 210
Cdd:PRK06599 389 QMAPAILDQTSVDIASENGKYVfrATGSVILFPGFLKVYGESkddeeEDDEKLLPPLKEGEKLKLDELLPEQHFTEPPPR 468
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 211 LTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGMG----LVEGY-DSMGYemskpDLRAELEADL 285
Cdd:PRK06599 469 YSEASLVKKLEEYGIGRPSTYASIISTLQDREYVELE-KKRFIPTDLGRIvndfLVEHFpKYVDY-----DFTAGLEDEL 542
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 286 KLICDGKKDKFVVLRQQVQKykqvFIEAVAKAKKLDEalaqyfgngTELAQQEDIYpampepiRKCPQCN-KDMVLKTKK 364
Cdd:PRK06599 543 DEIAEGKKDWKPVLREFWEP----FISNLEKVEEDVR---------TEKVTQEETD-------ETCPKCGgGPLVLKLGK 602
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2462557217 365 NGGFyLSCMGFPECRSAVWLPDS-----VLEASRDSSVCPVC 401
Cdd:PRK06599 603 NGKF-LGCSGYPECKYTKNITRDedepiEEEEIVEEEKCPKC 643
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
3-408 |
4.54e-23 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 104.90 E-value: 4.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 3 TVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLY---------TQGYISYPRTET-NIFPRDLNLTVL 72
Cdd:PRK06319 254 TVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQTLYegvdldsegATGLITYMRTDSvRTDPEALKQVRK 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 73 VEQQTpdprwgaFAQSILERGgPTPRNGNKSDQ-AHPPIHPT-------KYTNNLQGDEQRLYEFIVRHFLAccSQDAQG 144
Cdd:PRK06319 334 YIEGT-------FGKEFLPSS-PNVYTTKKMAQdAHEAIRPTditltpeKLRSKLTEDQYKLYSLIWKRFVA--SQMIPA 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 145 QETTVEIDIAQERFV---AHGLMILARNYLDVYP------YDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEAD 215
Cdd:PRK06319 404 IYDTLAIRITTNKGIdlrATGSLLKFKGFLAVYEekrddeGDEEENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEAS 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 216 LIALMEKHGIGTDATHAEHIETIKARMYVgLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDK 295
Cdd:PRK06319 484 LVKELEKSGIGRPSTYATIMNKIQSREYT-LKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKPW 562
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 296 FVVLRQQVQKYKQVFIEAVAKA----------------KKLDEALAQ---YFG-----------NGTELAQQEDIYPAMP 345
Cdd:PRK06319 563 KLLLQEFWELFLPVVVTAEKEAfiprivteidcpkchkGKLVKIWAKnryFYGcseypecdyktSEEELTFNKEDYAEDT 642
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462557217 346 EPIRKCPQCNKDMVLKTKKNGGFyLSCMGFPECRSAVWLPDSVLEAS--RDSSVCPV--CQPHPVYR 408
Cdd:PRK06319 643 PWDSPCPLCGGEMKVRHGRFGTF-LGCENYPECRGIINIHKKGEEGIepEETVPCPAigCTGHIVKR 708
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
4-322 |
1.77e-22 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 102.82 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 4 VVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GYISYPRTETNIFPRDLNLTVL--VEQQTPDP 80
Cdd:PRK08173 275 TVTEESKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVKqtLEMLKESN 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 81 RWGAFAQSILERG--GPTPR---NGNKSDqaHPPIHPTKYT-NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIA 154
Cdd:PRK08173 355 NYLPHAKQILDKGwvKPNKRifdNSKISD--HFAIIPTLQApKSLSEPEQKLYDLVVKRFLAVFFPAAEFLVTTRITEVA 432
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 155 QERFVAHGLMILARNYLDVYPYD-HWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALME------------ 221
Cdd:PRK08173 433 GHHFKTEGKVLVNPGWLAVYGKEaQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklveddelr 512
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 222 ----KHGIGTDATHAEHIETIKARMYV-----GLTPD-KRFlpgHLgMGLVEGYDSMgyEMSKPDLRAELEADLKLICDG 291
Cdd:PRK08173 513 eamaEKGLGTPATRAAIIEGLLGEKYLvregrELIPTaKAF---QL-MTLLRGLGVE--ELTSPELTGEWEYKLSQIERG 586
|
330 340 350
....*....|....*....|....*....|.
gi 2462557217 292 KKDKFVVLRQQVQKYKQVfieaVAKAKKLDE 322
Cdd:PRK08173 587 KLSRDAFMQEIAQMTQQI----VKRAKEYDS 613
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
29-416 |
1.56e-21 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 99.55 E-value: 1.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 29 ASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPrWGAFAQSILERGGPTPRNGNKSDQAHP 108
Cdd:COG0551 284 AAAASALAAALLEEEGELLYTGGYIRYTRTPKSSEADALAALEALKKIAEEP-PDERAKKKKKKAKKKKASEAKETTDHP 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 109 PIHPTKYTNN---LQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILP 185
Cdd:COG0551 363 PIPPTTAAALlelLEDRKLLLELLVRRRFAAAADLAKVEELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLP 442
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 186 VYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGY 265
Cdd:COG0551 443 PLEEGEPLLLEELLLEKQTTTPPPRYTTELLLKKLEEEGGGGRGTTATIIILILKRRYVVLEEKKTTPTELLVEVVLLLL 522
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 266 DSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRqqvqKYKQVFIEAVAKAKKldealaqyfgngtelaQQEDIYPAMP 345
Cdd:COG0551 523 LPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIRE----EEYPFFKKLLEIAEE----------------EGEEELSEED 582
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462557217 346 EPI-RKCPQCNKDMVLKTKKNGGFyLSCMGFPECRSAvwLPdsvLEASRDSSV-CPVCQphpVYRLKLKFKRG 416
Cdd:COG0551 583 EVLgEKCPKCGKPLVIKKGRYGKF-LGCSNYPECKYT--KP---LPKPEVTGVkCPKCG---KKLVLRKSKKG 646
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
3-301 |
7.71e-21 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 97.53 E-value: 7.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 3 TVVEVRSKPKsKWRPQA-LDTVELEKLASRKLRINAKETMRIAEKLY---------TQGYISYPRTETnifprdLNLTVL 72
Cdd:PRK08780 247 HVTDVESKER-KRNPAPpFTTSTLQQEASRKLGFTTRRTMQVAQKLYegvdlgdegSVGLITYMRTDS------VNLSQD 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 73 VEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQ-AHPPIHPT-------KYTNNLQGDEQRLYEFIVRHFLACCSQDAQG 144
Cdd:PRK08780 320 ALAEIRDVIARDYGTASLPDQPNTYKTKSKNAQeAHEAVRPTsalrtpaQVARFLSDDQRRLYELIWKRAVACQMIPATL 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 145 QETTVEIDIAQER-FVAHGLMILARNYLDVY--------PYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEAD 215
Cdd:PRK08780 400 NTVSVDLAAGSEHvFRATGSTVVVPGFLAVYeegkddksAEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEAS 479
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 216 LIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGMG----LVEGYDS-MGYemskpDLRAELEADLKLICD 290
Cdd:PRK08780 480 LVKALEEYGIGRPSTYASIISTLQFRKYVEME-GRRFRPTDVGRAvnkfLTGHFTRyVDY-----DFTARLEDDLDAVSR 553
|
330
....*....|.
gi 2462557217 291 GKKDKFVVLRQ 301
Cdd:PRK08780 554 GEKEWIPLMEK 564
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
2-321 |
2.41e-19 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 93.10 E-value: 2.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEvRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GYISYPRTETNIFPRDLnltVLVEQQTPDP 80
Cdd:PRK14724 282 ATVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDY---LPVAKQTFEM 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 81 RWGA-------FAQSILERG--GPTPR---NGNKSDqaHPPIHPT-KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQET 147
Cdd:PRK14724 358 LATSgmrhlapFAQQALDGNyvRPSKRifdNSKVSD--HFAIIPTtQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVT 435
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 148 TVEIDIAQERFVAHGLMILARNYLDVYPYDHWSD-----------KILPVyEQGSHFQPSTVEMVDGETSPPKLLTEADL 216
Cdd:PRK14724 436 TRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEvedakdgdkgqPLVPV-KPGEMVRTEFAEAKGLKTKPPARYSEATL 514
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 217 IALME----------------KHGIGTDATHAEHIETIKARMYVgLTPDKRFLPGHLG---MGLVEGYDSMgyEMSKPDL 277
Cdd:PRK14724 515 LGAMEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEKYM-LREGRELIPTAKAfqlMTLLRGLGVE--ELSRAEL 591
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2462557217 278 RAELEADLKLICDGK--KDKFVvlrQQVQKYKQvfiEAVAKAKKLD 321
Cdd:PRK14724 592 TGEWEYKLAQMEKGQlsREAFM---QQIAAMTE---KLVKKAKEYD 631
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
588-632 |
1.41e-18 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 79.37 E-value: 1.41e-18
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2462557217 588 TSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 632
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
504-545 |
8.22e-17 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 74.36 E-value: 8.22e-17
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2462557217 504 VTCNCGQEAVLLTVRKEGPNRGRQFFKCNGG---SCNFFLWADSP 545
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
348-387 |
6.16e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 60.35 E-value: 6.16e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462557217 348 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAVWLPDS 387
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
2-425 |
4.94e-04 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 43.65 E-value: 4.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 2 ATVVEVRSKPKSKWRPQAldtvelEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR 81
Cdd:COG1754 256 AAAAAVREPPTPTTTTTA------QAATTTTTRAAAARTTRSAQQAARRTRLGGEGTYTTTTTTTTTTSAAAAAAAAAAA 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 82 WGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT----------NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEI 151
Cdd:COG1754 330 ALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAaarrppaaraALLSDDRLLLELLLLRRTAAAAAAAAAATATTTAA 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 152 DIAQE----------RFVAHGLMILARNYLDVYPYDHwSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALME 221
Cdd:COG1754 410 AAAAGagavgtaaagAVFFFGGFLLFAEEEDDDEEDD-DDDDLPALEEGLPLLKEGVLADQHFTQPPPRYTEAPLVKRME 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 222 KHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGhlGMGLV------------EGYdsmgyemskpDLRAELEADLKLIC 289
Cdd:COG1754 489 ELGIGRPSTYASILSTLADRIYVRLD-KRRLIPE--DKGRLvtaflfsffrryVEY----------DFTADLEEFLDDVS 555
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 290 DGKKDKFVVLRQQVQKYKQvFIEAVAKAKKLDEALAqyfgngteLAQQEDIypaMPEPIRKCPQCNKDMVLKTKKNGGfY 369
Cdd:COG1754 556 DGELDWKAVLRRFWRDFSA-AYDETGDLRISEVLDA--------LEDLGEI---DPREINSCPLGTGGLSLRVGRYGP-F 622
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462557217 370 LSCMG-------FPECRSavwlPDS-VLEASRDSSVCPVCQP----------HPVYRLKLKF-----------------K 414
Cdd:COG1754 623 IECSNyeprrasIPECLA----PDElTPEKAEELLEAPADGPrvlgtdpetgKPIVLKDGRFgpyvqlgepekedkpkpK 698
|
490
....*....|.
gi 2462557217 415 RGSLPPTMPLE 425
Cdd:COG1754 699 RASLPKGMSPE 709
|
|
| |
