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Conserved domains on  [gi|2462602083|ref|XP_054208353|]
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cytoplasmic FMR1-interacting protein 2 isoform X3 [Homo sapiens]

Protein Classification

FragX_IP domain-containing protein( domain architecture ID 10532330)

FragX_IP domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 266-1099 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


:

Pssm-ID: 461799  Cd Length: 842  Bit Score: 1421.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  266 ELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRM 345
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  346 ESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGgFDIKVP 425
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPKG-FDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  426 RRAVGPSSTQLYMVRTMLESLIADKSG--SKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREF 503
Cdd:pfam05994  160 RRAVGPSSTQLYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFFFPYLLNLSETLQECCDLSQLWFREF 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  504 FLEltMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKL 583
Cdd:pfam05994  240 YLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTKLKSQFLYDEIEAEVNLCFDQFVYKL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  584 ADQIFAYYKAMAGSVLLDKRFRAECKNYGV-IIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAIS 662
Cdd:pfam05994  318 SEQIFTYYKTLAASILLDKRFRAELKNAGIlIPPYPPANRYETLLQQRHVQLLGRSIDLNRLIAQRLNAAFRKSLDIAIG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  663 RFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVS--APYGRITLHVFWELNFDFLPNYCYNGSTNR 740
Cdd:pfam05994  398 RFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGRITLHVFSELNYDFLPNYCYNSTTQR 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  741 FVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQG 820
Cdd:pfam05994  478 FVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIVRLLGYGGIAVLIEELLKIVSNKIQG 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  821 TILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLL 900
Cdd:pfam05994  558 FLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFRELGNIILFCLLLDQALSQEEVTDLL 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  901 HAAPFQNILPRVYiKEGERLEVR------MKRLEAKYAPLH-LVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVI 973
Cdd:pfam05994  638 QAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQSAIAEEADLLTKERLCCGLSLFEVV 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  974 LTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL 1053
Cdd:pfam05994  717 LARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEELFGDGLMWAGCAIIALLGQQRRFEA 796

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 2462602083 1054 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAIL 1099
Cdd:pfam05994  797 LDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
 
Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 266-1099 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


Pssm-ID: 461799  Cd Length: 842  Bit Score: 1421.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  266 ELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRM 345
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  346 ESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGgFDIKVP 425
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPKG-FDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  426 RRAVGPSSTQLYMVRTMLESLIADKSG--SKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREF 503
Cdd:pfam05994  160 RRAVGPSSTQLYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFFFPYLLNLSETLQECCDLSQLWFREF 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  504 FLEltMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKL 583
Cdd:pfam05994  240 YLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTKLKSQFLYDEIEAEVNLCFDQFVYKL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  584 ADQIFAYYKAMAGSVLLDKRFRAECKNYGV-IIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAIS 662
Cdd:pfam05994  318 SEQIFTYYKTLAASILLDKRFRAELKNAGIlIPPYPPANRYETLLQQRHVQLLGRSIDLNRLIAQRLNAAFRKSLDIAIG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  663 RFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVS--APYGRITLHVFWELNFDFLPNYCYNGSTNR 740
Cdd:pfam05994  398 RFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGRITLHVFSELNYDFLPNYCYNSTTQR 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  741 FVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQG 820
Cdd:pfam05994  478 FVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIVRLLGYGGIAVLIEELLKIVSNKIQG 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  821 TILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLL 900
Cdd:pfam05994  558 FLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFRELGNIILFCLLLDQALSQEEVTDLL 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  901 HAAPFQNILPRVYiKEGERLEVR------MKRLEAKYAPLH-LVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVI 973
Cdd:pfam05994  638 QAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQSAIAEEADLLTKERLCCGLSLFEVV 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  974 LTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL 1053
Cdd:pfam05994  717 LARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEELFGDGLMWAGCAIIALLGQQRRFEA 796

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 2462602083 1054 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAIL 1099
Cdd:pfam05994  797 LDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
PIR PLN03099
Protein PIR; Provisional
 6-1099 0e+00

Protein PIR; Provisional


Pssm-ID: 215574 [Multi-domain]  Cd Length: 1232  Bit Score: 573.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083    6 FQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRA-AQFLRKMADPQSIQE 84
Cdd:PLN03099   123 WQSSAASKLAADMQRFSRPERRINGPTVTHMWSMLKLLDVLLQLDHLKNAKASIPNDFSWYKRTfTQVSTQWPDTDTMRE 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083   85 S-QNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLM---DGNVSNIY 160
Cdd:PLN03099   203 ElDDLQIFLSTRWAILLNLQAEMFRVNNVEDILQVLIVFCLESLESDFVLLYSERHILLRVLPVLVVLAtssEKEGESLF 282

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  161 KldakkRINLSKIDKFFKQlqvvplfgdmqielaryiktsahyeenkskwtctqssispQYNICEQMVQIRDDH----IR 236
Cdd:PLN03099   283 K-----RIKINRLINIFQR----------------------------------------EYLIVNHMGAIRAEHddfcIR 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  237 FISELARYSNSEVVTGsgLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPT-DKFCNKDCPGTAEEYERA 315
Cdd:PLN03099   318 FASAMNQLQLLKSADG--VDTAWSREIKENMYDVVVEGFQLLSEWTGRIWEQCAWKFSRPAkDATPDPERSGSVTDYEKV 395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  316 TRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNvLISVLQAIRKTI 395
Cdd:PLN03099   396 VRCNYTAEERKALVELIGYIKGVGSMLERCDTLVADALWETIHAQVQDFVQNKLATMLRTTFRKKKE-LSRILSDMRTIA 474

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  396 CDWEGgreppNDPCLRGEKDPKGGFDIKVPR----RAVGPSSTQLYMVRTMLESLIADKS--------GSKKTLRSSLDg 463
Cdd:PLN03099   475 ADWMA-----NTRPEEKMPSRQRENDESRPNffypRPVAPTAAQLHCLQFLIHELVSGGSpkkpggffGNNGSEIPVND- 548

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  464 piVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTmgRRIQFPIEMSMPWILTDHILETKEPSMMEYVLY 543
Cdd:PLN03099   549 --LKQLETFFNKLAFFPHILDYRATIGHLTDLGFLWFREFYLETS--RVIQFPIECSLPWMLVDYILESQDAGLLESVLL 624

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  544 PLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKN---YGViipypPS 620
Cdd:PLN03099   625 PFDIYNDSAQHALRVLKQRFLYDEIEAEVDLCFDQLVSKLSESIFTYYKSRAASKLLDPSFLAAVDNgekFSV-----QP 699

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  621 NRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDA 700
Cdd:PLN03099   700 KRYDALFKMRRVKILGRTIDLASLIAQRMNKIFRENLDFLFERFESQDLCSVVELQRLVEILRLTHELLSEHLSIDPFSL 779

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  701 MFREANHNVS--APYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHI 778
Cdd:PLN03099   780 MLGEMQENISlvSFSSRLASQIWSEMQNDFLPNFILCNTTQRFVRSSKVPQRPTRRPSVPSAKPSFLCGTQDLNMAHQSF 859

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  779 YSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGtILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLK 858
Cdd:PLN03099   860 AELHSKFFGLPHMFAIVKLLGSRSLPWLIRALLDHLSQKITT-LEPMIEDLREAMPKAIGLPSFDGGVAGCMKIFREQLQ 938

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  859 DIIEYaELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRvyiKEGErlevrMKRLEAKYAPL---- 934
Cdd:PLN03099   939 WGTKY-EGKSEVLRGLKEIGSLIFWMSLLDIAMREVETVQFMQVAPWLGLVPG---KEGQ-----LQQADDNESPLvslf 1009

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  935 -----HLVPLIERLGTPQQIAIAREG---DLLTKERLCCG------LSMFEVILTRIRSYlqdpiWRGPPPTnGVMHVDE 1000
Cdd:PLN03099  1010 keatsAVVSSPGCLNPSAFVSMSKQAevaDLLYKSNLNTGsvleytLAFTSAVLDRHRSK-----WSAPPKT-GFIDITT 1083

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083 1001 CVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQ---RQDGKDEIIK--- 1074
Cdd:PLN03099  1084 SKDFYRIYSGLQYVYLEEISAEGSAFHERLGDSVAWGGCTIVYLLGQQLRFELLDFIYHVLSVSeveSASASHTHRNerl 1163

                         1130      1140      1150
                   ....*....|....*....|....*....|
gi 2462602083 1075 -----NVPLKKMADRIRKYQILNNEVFAIL 1099
Cdd:PLN03099  1164 kspsyHQGWEGFLENARKARRLNNHVFSLL 1193
 
Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 266-1099 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


Pssm-ID: 461799  Cd Length: 842  Bit Score: 1421.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  266 ELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRM 345
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  346 ESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGgFDIKVP 425
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPKG-FDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  426 RRAVGPSSTQLYMVRTMLESLIADKSG--SKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREF 503
Cdd:pfam05994  160 RRAVGPSSTQLYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFFFPYLLNLSETLQECCDLSQLWFREF 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  504 FLEltMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKL 583
Cdd:pfam05994  240 YLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTKLKSQFLYDEIEAEVNLCFDQFVYKL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  584 ADQIFAYYKAMAGSVLLDKRFRAECKNYGV-IIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAIS 662
Cdd:pfam05994  318 SEQIFTYYKTLAASILLDKRFRAELKNAGIlIPPYPPANRYETLLQQRHVQLLGRSIDLNRLIAQRLNAAFRKSLDIAIG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  663 RFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVS--APYGRITLHVFWELNFDFLPNYCYNGSTNR 740
Cdd:pfam05994  398 RFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGRITLHVFSELNYDFLPNYCYNSTTQR 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  741 FVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQG 820
Cdd:pfam05994  478 FVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIVRLLGYGGIAVLIEELLKIVSNKIQG 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  821 TILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLL 900
Cdd:pfam05994  558 FLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFRELGNIILFCLLLDQALSQEEVTDLL 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  901 HAAPFQNILPRVYiKEGERLEVR------MKRLEAKYAPLH-LVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVI 973
Cdd:pfam05994  638 QAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQSAIAEEADLLTKERLCCGLSLFEVV 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  974 LTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDL 1053
Cdd:pfam05994  717 LARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEELFGDGLMWAGCAIIALLGQQRRFEA 796

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 2462602083 1054 FDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAIL 1099
Cdd:pfam05994  797 LDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
PIR PLN03099
Protein PIR; Provisional
 6-1099 0e+00

Protein PIR; Provisional


Pssm-ID: 215574 [Multi-domain]  Cd Length: 1232  Bit Score: 573.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083    6 FQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRA-AQFLRKMADPQSIQE 84
Cdd:PLN03099   123 WQSSAASKLAADMQRFSRPERRINGPTVTHMWSMLKLLDVLLQLDHLKNAKASIPNDFSWYKRTfTQVSTQWPDTDTMRE 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083   85 S-QNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLM---DGNVSNIY 160
Cdd:PLN03099   203 ElDDLQIFLSTRWAILLNLQAEMFRVNNVEDILQVLIVFCLESLESDFVLLYSERHILLRVLPVLVVLAtssEKEGESLF 282

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  161 KldakkRINLSKIDKFFKQlqvvplfgdmqielaryiktsahyeenkskwtctqssispQYNICEQMVQIRDDH----IR 236
Cdd:PLN03099   283 K-----RIKINRLINIFQR----------------------------------------EYLIVNHMGAIRAEHddfcIR 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  237 FISELARYSNSEVVTGsgLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPT-DKFCNKDCPGTAEEYERA 315
Cdd:PLN03099   318 FASAMNQLQLLKSADG--VDTAWSREIKENMYDVVVEGFQLLSEWTGRIWEQCAWKFSRPAkDATPDPERSGSVTDYEKV 395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  316 TRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNvLISVLQAIRKTI 395
Cdd:PLN03099   396 VRCNYTAEERKALVELIGYIKGVGSMLERCDTLVADALWETIHAQVQDFVQNKLATMLRTTFRKKKE-LSRILSDMRTIA 474

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  396 CDWEGgreppNDPCLRGEKDPKGGFDIKVPR----RAVGPSSTQLYMVRTMLESLIADKS--------GSKKTLRSSLDg 463
Cdd:PLN03099   475 ADWMA-----NTRPEEKMPSRQRENDESRPNffypRPVAPTAAQLHCLQFLIHELVSGGSpkkpggffGNNGSEIPVND- 548

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  464 piVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTmgRRIQFPIEMSMPWILTDHILETKEPSMMEYVLY 543
Cdd:PLN03099   549 --LKQLETFFNKLAFFPHILDYRATIGHLTDLGFLWFREFYLETS--RVIQFPIECSLPWMLVDYILESQDAGLLESVLL 624

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  544 PLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKN---YGViipypPS 620
Cdd:PLN03099   625 PFDIYNDSAQHALRVLKQRFLYDEIEAEVDLCFDQLVSKLSESIFTYYKSRAASKLLDPSFLAAVDNgekFSV-----QP 699

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  621 NRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDA 700
Cdd:PLN03099   700 KRYDALFKMRRVKILGRTIDLASLIAQRMNKIFRENLDFLFERFESQDLCSVVELQRLVEILRLTHELLSEHLSIDPFSL 779

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  701 MFREANHNVS--APYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHI 778
Cdd:PLN03099   780 MLGEMQENISlvSFSSRLASQIWSEMQNDFLPNFILCNTTQRFVRSSKVPQRPTRRPSVPSAKPSFLCGTQDLNMAHQSF 859

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  779 YSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGtILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLK 858
Cdd:PLN03099   860 AELHSKFFGLPHMFAIVKLLGSRSLPWLIRALLDHLSQKITT-LEPMIEDLREAMPKAIGLPSFDGGVAGCMKIFREQLQ 938

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  859 DIIEYaELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRvyiKEGErlevrMKRLEAKYAPL---- 934
Cdd:PLN03099   939 WGTKY-EGKSEVLRGLKEIGSLIFWMSLLDIAMREVETVQFMQVAPWLGLVPG---KEGQ-----LQQADDNESPLvslf 1009

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083  935 -----HLVPLIERLGTPQQIAIAREG---DLLTKERLCCG------LSMFEVILTRIRSYlqdpiWRGPPPTnGVMHVDE 1000
Cdd:PLN03099  1010 keatsAVVSSPGCLNPSAFVSMSKQAevaDLLYKSNLNTGsvleytLAFTSAVLDRHRSK-----WSAPPKT-GFIDITT 1083

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602083 1001 CVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQ---RQDGKDEIIK--- 1074
Cdd:PLN03099  1084 SKDFYRIYSGLQYVYLEEISAEGSAFHERLGDSVAWGGCTIVYLLGQQLRFELLDFIYHVLSVSeveSASASHTHRNerl 1163

                         1130      1140      1150
                   ....*....|....*....|....*....|
gi 2462602083 1075 -----NVPLKKMADRIRKYQILNNEVFAIL 1099
Cdd:PLN03099  1164 kspsyHQGWEGFLENARKARRLNNHVFSLL 1193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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