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Conserved domains on  [gi|2462526534|ref|XP_054225407|]
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BRCA2-interacting transcriptional repressor EMSY isoform X48 [Homo sapiens]

Protein Classification

ENT and PHA03247 domain-containing protein( domain architecture ID 10509883)

ENT and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 4.26e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


:

Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 4.26e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462526534  17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735   1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
COG3889 super family cl28569
Extracellular solute-binding protein, contains Ig-fold domain [General function prediction ...
 484-585 4.08e-03

Extracellular solute-binding protein, contains Ig-fold domain [General function prediction only];


The actual alignment was detected with superfamily member COG3889:

Pssm-ID: 443097 [Multi-domain]  Cd Length: 878  Bit Score: 41.17  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526534 484 LPKPVTATLPTSSNSPIMVVSSNGAIM----TTKLVTTPTGTQATYTRP-----------TVSPSIGRMAATPGAATYVK 548
Cdd:COG3889   758 LPAEVTAKLSPGSYTLVVIAYSELVALpaiyTTSFIVTPAVTIAVSTTIqtltdtdttttTSAKTTPSLTTAATTTTTST 837

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462526534 549 TTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTI 585
Cdd:COG3889   838 TTSTTSVTTTAAALASAATAAIVVGVVAVAVAIATAI 874
 
Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 4.26e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 4.26e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462526534  17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735   1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
COG3889 COG3889
Extracellular solute-binding protein, contains Ig-fold domain [General function prediction ...
 484-585 4.08e-03

Extracellular solute-binding protein, contains Ig-fold domain [General function prediction only];


Pssm-ID: 443097 [Multi-domain]  Cd Length: 878  Bit Score: 41.17  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526534 484 LPKPVTATLPTSSNSPIMVVSSNGAIM----TTKLVTTPTGTQATYTRP-----------TVSPSIGRMAATPGAATYVK 548
Cdd:COG3889   758 LPAEVTAKLSPGSYTLVVIAYSELVALpaiyTTSFIVTPAVTIAVSTTIqtltdtdttttTSAKTTPSLTTAATTTTTST 837

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462526534 549 TTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTI 585
Cdd:COG3889   838 TTSTTSVTTTAAALASAATAAIVVGVVAVAVAIATAI 874
 
Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 4.26e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 4.26e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462526534  17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735   1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
COG3889 COG3889
Extracellular solute-binding protein, contains Ig-fold domain [General function prediction ...
 484-585 4.08e-03

Extracellular solute-binding protein, contains Ig-fold domain [General function prediction only];


Pssm-ID: 443097 [Multi-domain]  Cd Length: 878  Bit Score: 41.17  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462526534 484 LPKPVTATLPTSSNSPIMVVSSNGAIM----TTKLVTTPTGTQATYTRP-----------TVSPSIGRMAATPGAATYVK 548
Cdd:COG3889   758 LPAEVTAKLSPGSYTLVVIAYSELVALpaiyTTSFIVTPAVTIAVSTTIqtltdtdttttTSAKTTPSLTTAATTTTTST 837

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462526534 549 TTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTI 585
Cdd:COG3889   838 TTSTTSVTTTAAALASAATAAIVVGVVAVAVAIATAI 874
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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