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Conserved domains on  [gi|1677501901|ref|NP_001119579|]
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solute carrier family 12 member 3 isoform 2 [Homo sapiens]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
59-1028 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1597.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901   59 NTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFL-KEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGW 137
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLdKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  138 VKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGS 217
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  218 IGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPI-VDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSF 296
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSKImVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  297 ANYLVGTLIPPSeDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLM 376
Cdd:TIGR00930  241 LNIFVGTIIPAF-DKPAKGFFGLGNEIFSENFIPGIPGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  377 AIFWTTISYLAISATIGSCVVRDASGVLNDTVTPgwgACEGLACsygwnFTECTQQhSCHYGLINYYQTMSMVSGFAPLI 456
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHN-TCSYGLMNNLQVMSLVSPFPPLI 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  457 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFL 536
Cdd:TIGR00930  391 TAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFL 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  537 CSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQ 616
Cdd:TIGR00930  471 ASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQ 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  617 AGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHT 696
Cdd:TIGR00930  551 ALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQ 630
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  697 KWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMR 776
Cdd:TIGR00930  631 TWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNS 710
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  777 EGLNVSkMMQAHINPVFDPAEDGKEASARGArpsvsgaldPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPY 856
Cdd:TIGR00930  711 EGLPIS-VLQVQEELENDCSEDSIELNDGKI---------STQPDMHLEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPY 780
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  857 LLGRKRRWSKCKIRVFVGGQ-INRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDE 935
Cdd:TIGR00930  781 LLTTKKVWKKCKIRIFVGAQkDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDR 860
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  936 ATVN-EMRRDCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLrPPVI 1014
Cdd:TIGR00930  861 EAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDL-PPVL 939
                          970
                   ....*....|....
gi 1677501901 1015 LIRGNQENVLTFYC 1028
Cdd:TIGR00930  940 LVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
59-1028 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1597.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901   59 NTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFL-KEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGW 137
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLdKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  138 VKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGS 217
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  218 IGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPI-VDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSF 296
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSKImVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  297 ANYLVGTLIPPSeDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLM 376
Cdd:TIGR00930  241 LNIFVGTIIPAF-DKPAKGFFGLGNEIFSENFIPGIPGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  377 AIFWTTISYLAISATIGSCVVRDASGVLNDTVTPgwgACEGLACsygwnFTECTQQhSCHYGLINYYQTMSMVSGFAPLI 456
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHN-TCSYGLMNNLQVMSLVSPFPPLI 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  457 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFL 536
Cdd:TIGR00930  391 TAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFL 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  537 CSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQ 616
Cdd:TIGR00930  471 ASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQ 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  617 AGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHT 696
Cdd:TIGR00930  551 ALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQ 630
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  697 KWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMR 776
Cdd:TIGR00930  631 TWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNS 710
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  777 EGLNVSkMMQAHINPVFDPAEDGKEASARGArpsvsgaldPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPY 856
Cdd:TIGR00930  711 EGLPIS-VLQVQEELENDCSEDSIELNDGKI---------STQPDMHLEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPY 780
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  857 LLGRKRRWSKCKIRVFVGGQ-INRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDE 935
Cdd:TIGR00930  781 LLTTKKVWKKCKIRIFVGAQkDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDR 860
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  936 ATVN-EMRRDCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLrPPVI 1014
Cdd:TIGR00930  861 EAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDL-PPVL 939
                          970
                   ....*....|....
gi 1677501901 1015 LIRGNQENVLTFYC 1028
Cdd:TIGR00930  940 LVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
654-1028 6.07e-170

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 503.69  E-value: 6.07e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  654 RPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPElQLIANGHtKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMK 733
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRS-ELQKKAY-RWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  734 PNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQA----------HINPVFDPAEDGKEAS 803
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDqdteelglgdETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  804 ARG------------------------ARPSVSGALDPKALVKEE---------------QATTIFQSEQGKKTIDIYWL 844
Cdd:pfam03522  159 SNSkqdddksklskkdsnlslspdkstKNPSGKDSSKSDKLKKKSpsiilrtasnekeilNNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  845 FDDGGLTLLIPYLLGRKRRWSKCKIRVFVGG-QINRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMI 923
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  924 APFRLNDGFKDEATVnemrrdcpWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLE 1003
Cdd:pfam03522  319 EPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....*
gi 1677501901 1004 TLSQDLrPPVILIRGNQENVLTFYC 1028
Cdd:pfam03522  391 TLTKDL-PPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
124-606 1.08e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 135.41  E-value: 1.08e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  124 SSEKNPEEPVRFGWVKGVMIrCMLNIWGVILYLrLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNgKVKSGGTY 203
Cdd:COG0531      2 SRGESSELKRKLGLFDLVAL-GVGAIIGAGIFV-LPGLAAGLAGPAAILAWLIAGLLALLVALSYAELASA-FPRAGGAY 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  204 FLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLqeygapivdPINDIRIIAVVSVTVLLAISLAGMEWESK 283
Cdd:COG0531     79 TYARRALGPLLGFLAGWALLLSYVLAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAK 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  284 AQVLFFLVIMVSFANYLVGtlippsedkaskGFFSYRADIFvQNLVPDWRGPDGTFFGMFSIFFpSATGILAGANISGDL 363
Cdd:COG0531    150 VNNILTVLKLLVLLLFIVV------------GLFAFDPANF-TPFLPAGGGLSGVLAALALAFF-AFTGFEAIANLAEEA 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  364 KDPAIAIPKGTLMAIFWTTISYLAISATIGSCVvrdASGVLNDTVTPgwgaceglacsygwnftectqqhschyglinYY 443
Cdd:COG0531    216 KNPKRNIPRAIILSLLIVGVLYILVSLALTGVV---PYDELAASGAP-------------------------------LA 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  444 QTMSMVSG--FAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPliGFFGKGYGKNKEPVRGYLLAY--AIAVAFI 519
Cdd:COG0531    262 DAAEAVFGpwGAILIALGALLSLLGALNASILGASRLLYAMARDGLLP--KVFAKVHPRFGTPVNAILLTGviALLLLLL 339
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  520 IIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPsFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLF-L 598
Cdd:COG0531    340 GAASFTALASLASVGVLLAYLLVALAVIVLRRRRPDLPRP-FRVPLPLIPILGILLCLFLLYLLGPGALLIGLVLLAIgL 418

                   ....*...
gi 1677501901  599 LLYVIYKK 606
Cdd:COG0531    419 LLYLLYRR 426
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
59-1028 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1597.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901   59 NTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFL-KEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGW 137
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLdKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  138 VKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGS 217
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  218 IGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPI-VDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSF 296
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSKImVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  297 ANYLVGTLIPPSeDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLM 376
Cdd:TIGR00930  241 LNIFVGTIIPAF-DKPAKGFFGLGNEIFSENFIPGIPGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  377 AIFWTTISYLAISATIGSCVVRDASGVLNDTVTPgwgACEGLACsygwnFTECTQQhSCHYGLINYYQTMSMVSGFAPLI 456
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHN-TCSYGLMNNLQVMSLVSPFPPLI 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  457 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFL 536
Cdd:TIGR00930  391 TAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFL 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  537 CSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQ 616
Cdd:TIGR00930  471 ASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQ 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  617 AGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHT 696
Cdd:TIGR00930  551 ALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQ 630
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  697 KWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMR 776
Cdd:TIGR00930  631 TWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNS 710
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  777 EGLNVSkMMQAHINPVFDPAEDGKEASARGArpsvsgaldPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPY 856
Cdd:TIGR00930  711 EGLPIS-VLQVQEELENDCSEDSIELNDGKI---------STQPDMHLEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPY 780
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  857 LLGRKRRWSKCKIRVFVGGQ-INRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDE 935
Cdd:TIGR00930  781 LLTTKKVWKKCKIRIFVGAQkDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDR 860
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  936 ATVN-EMRRDCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLrPPVI 1014
Cdd:TIGR00930  861 EAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDL-PPVL 939
                          970
                   ....*....|....
gi 1677501901 1015 LIRGNQENVLTFYC 1028
Cdd:TIGR00930  940 LVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
654-1028 6.07e-170

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 503.69  E-value: 6.07e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  654 RPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPElQLIANGHtKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMK 733
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRS-ELQKKAY-RWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  734 PNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQA----------HINPVFDPAEDGKEAS 803
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDqdteelglgdETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  804 ARG------------------------ARPSVSGALDPKALVKEE---------------QATTIFQSEQGKKTIDIYWL 844
Cdd:pfam03522  159 SNSkqdddksklskkdsnlslspdkstKNPSGKDSSKSDKLKKKSpsiilrtasnekeilNNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  845 FDDGGLTLLIPYLLGRKRRWSKCKIRVFVGG-QINRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMI 923
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  924 APFRLNDGFKDEATVnemrrdcpWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLE 1003
Cdd:pfam03522  319 EPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....*
gi 1677501901 1004 TLSQDLrPPVILIRGNQENVLTFYC 1028
Cdd:pfam03522  391 TLTKDL-PPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
140-645 1.96e-116

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 366.65  E-value: 1.96e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  140 GVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVkSGGTYFLISRSLGPELGGSIG 219
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  220 L------IFAFANAVGVAMHTVGFAETVRDLLQEYgapivdpindirIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIM 293
Cdd:pfam00324   80 WnywlswITVLALELTAASILIQFWELVPDIPYLW------------VWGAVFLVLLTIINLVGVKWYGEAEFWFALIKI 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  294 VSFANYLVGTLIPPSEDKASKG--FFSYRADIFVQNLVPDWRGPdgtFFGMFSIFFPSATGILAGANISGDLKDPAIAIP 371
Cdd:pfam00324  148 IAIIGFIIVGIILLSGGNPNDGaiFRYLGDNGGKNNFPPGFGKG---FISVFVIAFFAFTGIELVGIAAGEVKNPEKSIP 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  372 KGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPgwgaceglacsygwnftectqqhschYGLINYYQTMSMVSG 451
Cdd:pfam00324  225 KAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASA--------------------------ASPFVIFFKFLGISG 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  452 FAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPligFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIapII 531
Cdd:pfam00324  279 LAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLALLLASLNPA--IV 353
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  532 SNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNW 611
Cdd:pfam00324  354 FNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNW 433
                          490       500       510
                   ....*....|....*....|....*....|....
gi 1677501901  612 GSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCL 645
Cdd:pfam00324  434 GAGSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
124-606 1.08e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 135.41  E-value: 1.08e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  124 SSEKNPEEPVRFGWVKGVMIrCMLNIWGVILYLrLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNgKVKSGGTY 203
Cdd:COG0531      2 SRGESSELKRKLGLFDLVAL-GVGAIIGAGIFV-LPGLAAGLAGPAAILAWLIAGLLALLVALSYAELASA-FPRAGGAY 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  204 FLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLqeygapivdPINDIRIIAVVSVTVLLAISLAGMEWESK 283
Cdd:COG0531     79 TYARRALGPLLGFLAGWALLLSYVLAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAK 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  284 AQVLFFLVIMVSFANYLVGtlippsedkaskGFFSYRADIFvQNLVPDWRGPDGTFFGMFSIFFpSATGILAGANISGDL 363
Cdd:COG0531    150 VNNILTVLKLLVLLLFIVV------------GLFAFDPANF-TPFLPAGGGLSGVLAALALAFF-AFTGFEAIANLAEEA 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  364 KDPAIAIPKGTLMAIFWTTISYLAISATIGSCVvrdASGVLNDTVTPgwgaceglacsygwnftectqqhschyglinYY 443
Cdd:COG0531    216 KNPKRNIPRAIILSLLIVGVLYILVSLALTGVV---PYDELAASGAP-------------------------------LA 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  444 QTMSMVSG--FAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPliGFFGKGYGKNKEPVRGYLLAY--AIAVAFI 519
Cdd:COG0531    262 DAAEAVFGpwGAILIALGALLSLLGALNASILGASRLLYAMARDGLLP--KVFAKVHPRFGTPVNAILLTGviALLLLLL 339
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  520 IIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPsFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLF-L 598
Cdd:COG0531    340 GAASFTALASLASVGVLLAYLLVALAVIVLRRRRPDLPRP-FRVPLPLIPILGILLCLFLLYLLGPGALLIGLVLLAIgL 418

                   ....*...
gi 1677501901  599 LLYVIYKK 606
Cdd:COG0531    419 LLYLLYRR 426
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
45-115 2.12e-30

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 114.46  E-value: 2.12e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1677501901   45 LTHSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKEGRHLhALAFDSRPSHEMTDG 115
Cdd:pfam08403    1 DTHGSTYYLQTFGHNTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKNSAL-AVAEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
165-603 5.35e-13

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 72.34  E-value: 5.35e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  165 AGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETvrdL 244
Cdd:pfam13520   27 SGGPALIVWGWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWFAYVLGLASSASVAASY---L 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  245 LQEYGAPIVDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPpsedKASKGFFSYRADIF 324
Cdd:pfam13520  104 LSALGPDLVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILGLV----TADGGGFNLLSGEW 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  325 VQNLVPDWrgpDGTFFGMFSIFFpSATGILAGANISGDLKDPaiAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVL 404
Cdd:pfam13520  180 HTFFPDGW---PGVFAGFLGVLW-SFTGFESAANVSEEVKKR--NVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEIALS 253
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  405 NDTVTPGwgaceGLacsygwnftectqqhschyglinyYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCE 484
Cdd:pfam13520  254 SGLGQVA-----AL------------------------LFQAVGGKWGAIIVVILLALSLLGAVNTAIVGASRLLYALAR 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677501901  485 DQLYPLIGFFGKgYGKNKEPVRGYLLAY-----AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRP 559
Cdd:pfam13520  305 DGVLPFSRFFAK-VNKFGSPIRAIILTAilsliLLLLFLLSPAAYNALLSLSAYGYLLSYLLPIIGLLILRKKRPDLGRI 383
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 1677501901  560 sfqYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVI 603
Cdd:pfam13520  384 ---PGRWPVAIFGILFSLFLIVALFFPPVGPATGSSLNYAIILI 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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