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Conserved domains on  [gi|194018433|ref|NP_001123465|]
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SANT and BTB domain regulator of class switch recombination isoform a [Homo sapiens]

Protein Classification

KIAA1841 family protein( domain architecture ID 12111642)

KIAA1841 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANBR_BTB pfam11822
SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the ...
 147-248 9.22e-44

SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR.


:

Pssm-ID: 432102  Cd Length: 97  Bit Score: 152.63  E-value: 9.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018433  147 MVIHVCDEAKNLKEDFTCPRDLLISEMKYFAEYLS---MDAQRWEEVDISVHCDVHIFNWLIKYIKRNTkenkdcemPTL 223
Cdd:pfam11822   1 VEITVCDEAKNLKRDFRCPLDLLETEMRYFEPYISryiSEAQRWPPVDIRVHCDVSIFDWLMNYVSGKA--------PKL 72

                          90       100
                  ....*....|....*....|....*
gi 194018433  224 EPGNVISILISSEFLKMDSLVEQCI 248
Cdd:pfam11822  73 TPSNVVSILLSSNFLKMDQLVDNCL 97
 
Name Accession Description Interval E-value
SANBR_BTB pfam11822
SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the ...
 147-248 9.22e-44

SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR.


Pssm-ID: 432102  Cd Length: 97  Bit Score: 152.63  E-value: 9.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018433  147 MVIHVCDEAKNLKEDFTCPRDLLISEMKYFAEYLS---MDAQRWEEVDISVHCDVHIFNWLIKYIKRNTkenkdcemPTL 223
Cdd:pfam11822   1 VEITVCDEAKNLKRDFRCPLDLLETEMRYFEPYISryiSEAQRWPPVDIRVHCDVSIFDWLMNYVSGKA--------PKL 72

                          90       100
                  ....*....|....*....|....*
gi 194018433  224 EPGNVISILISSEFLKMDSLVEQCI 248
Cdd:pfam11822  73 TPSNVVSILLSSNFLKMDQLVDNCL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 166-256 5.13e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.22  E-value: 5.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018433 166 RDLLISEMKYFAeylSMDAQRWEEVDISVHCDVHIFNWLIKYIkrNTKenkdceMPTLEPGNVISILISSEFLKMDSLVE 245
Cdd:PHA03098  27 KIILSSSSEYFK---KMFKNNFKENEINLNIDYDSFNEVIKYI--YTG------KINITSNNVKDILSIANYLIIDFLIN 95

                         90
                 ....*....|.
gi 194018433 246 QCIQYCHKNMN 256
Cdd:PHA03098  96 LCINYIIKIID 106
 
Name Accession Description Interval E-value
SANBR_BTB pfam11822
SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the ...
 147-248 9.22e-44

SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR.


Pssm-ID: 432102  Cd Length: 97  Bit Score: 152.63  E-value: 9.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018433  147 MVIHVCDEAKNLKEDFTCPRDLLISEMKYFAEYLS---MDAQRWEEVDISVHCDVHIFNWLIKYIKRNTkenkdcemPTL 223
Cdd:pfam11822   1 VEITVCDEAKNLKRDFRCPLDLLETEMRYFEPYISryiSEAQRWPPVDIRVHCDVSIFDWLMNYVSGKA--------PKL 72

                          90       100
                  ....*....|....*....|....*
gi 194018433  224 EPGNVISILISSEFLKMDSLVEQCI 248
Cdd:pfam11822  73 TPSNVVSILLSSNFLKMDQLVDNCL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 166-256 5.13e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.22  E-value: 5.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018433 166 RDLLISEMKYFAeylSMDAQRWEEVDISVHCDVHIFNWLIKYIkrNTKenkdceMPTLEPGNVISILISSEFLKMDSLVE 245
Cdd:PHA03098  27 KIILSSSSEYFK---KMFKNNFKENEINLNIDYDSFNEVIKYI--YTG------KINITSNNVKDILSIANYLIIDFLIN 95

                         90
                 ....*....|.
gi 194018433 246 QCIQYCHKNMN 256
Cdd:PHA03098  96 LCINYIIKIID 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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