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Conserved domains on  [gi|282721077|ref|NP_001164222|]
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sushi repeat-containing protein SRPX isoform 3 precursor [Homo sapiens]

Protein Classification

beta-2-glycoprotein 1( domain architecture ID 10034342)

beta-2-glycoprotein 1 is a heavily glycosylated plasma membrane-adhesion protein, which plays a role in blood coagulation and removal of apoptotic bodies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 273-392 1.11e-41

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


:

Pssm-ID: 463980  Cd Length: 120  Bit Score: 142.77  E-value: 1.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721077  273 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPL 352
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPDLIEELRKELGIPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 282721077  353 YSFSMVLVDKHGMDKERYVSLVMPVALFNLIDTFPLRKEE 392
Cdd:pfam13778  81 NYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 118-198 4.13e-33

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


:

Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 119.03  E-value: 4.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721077  118 MEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGilTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVK 197
Cdd:pfam02494   3 TTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQ--AILVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFTVT 80


                  .
gi 282721077  198 V 198
Cdd:pfam02494  81 V 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 203-258 1.83e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 70.18  E-value: 1.83e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721077 203 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 258
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 57-116 1.08e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 1.08e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 282721077  57 CS-PIKVKYGDVYCRAPqggyyKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICK 116
Cdd:cd00033    1 CPpPPVPENGTVTGSKG-----SYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPpTCE 57
 
Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 273-392 1.11e-41

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 142.77  E-value: 1.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721077  273 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPL 352
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPDLIEELRKELGIPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 282721077  353 YSFSMVLVDKHGMDKERYVSLVMPVALFNLIDTFPLRKEE 392
Cdd:pfam13778  81 NYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 118-198 4.13e-33

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 119.03  E-value: 4.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721077  118 MEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGilTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVK 197
Cdd:pfam02494   3 TTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQ--AILVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFTVT 80


                  .
gi 282721077  198 V 198
Cdd:pfam02494  81 V 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 203-258 1.83e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 70.18  E-value: 1.83e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721077 203 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 258
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 203-258 8.59e-14

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 65.63  E-value: 8.59e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721077   203 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 258
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
203-258 2.96e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 64.06  E-value: 2.96e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721077  203 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 258
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 57-116 1.08e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 1.08e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 282721077  57 CS-PIKVKYGDVYCRAPqggyyKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICK 116
Cdd:cd00033    1 CPpPPVPENGTVTGSKG-----SYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPpTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 59-115 2.57e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 2.57e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 282721077    59 PIKVKYGDVYCRapqGGYYKTalGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-IC 115
Cdd:smart00032   4 PPDIENGTVTSS---SGTYSY--GDTVTYSCDPGYTLIGSSTITCLENGTWSPPPpTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 202-269 9.26e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 37.66  E-value: 9.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 282721077 202 RCgKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAMNVNVGVRT 269
Cdd:PHA02831 140 RC-KYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKCVKDKVHNEIQP 206
 
Name Accession Description Interval E-value
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 273-392 1.11e-41

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 142.77  E-value: 1.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721077  273 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPL 352
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAECGLAERDLTVIELVGSGPNETGKIEHEQLSPDLIEELRKELGIPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 282721077  353 YSFSMVLVDKHGMDKERYVSLVMPVALFNLIDTFPLRKEE 392
Cdd:pfam13778  81 NYFSMVLIGKDGGVKERYPAPVSLEALFDLIDAMPMRQQE 120
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 118-198 4.13e-33

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 119.03  E-value: 4.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721077  118 MEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGilTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVK 197
Cdd:pfam02494   3 TTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQ--AILVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFTVT 80


                  .
gi 282721077  198 V 198
Cdd:pfam02494  81 V 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 203-258 1.83e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 70.18  E-value: 1.83e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721077 203 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 258
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 203-258 8.59e-14

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 65.63  E-value: 8.59e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721077   203 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 258
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
203-258 2.96e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 64.06  E-value: 2.96e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721077  203 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 258
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 57-116 1.08e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 1.08e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 282721077  57 CS-PIKVKYGDVYCRAPqggyyKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICK 116
Cdd:cd00033    1 CPpPPVPENGTVTGSKG-----SYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPpTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 59-115 2.57e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 2.57e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 282721077    59 PIKVKYGDVYCRapqGGYYKTalGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-IC 115
Cdd:smart00032   4 PPDIENGTVTSS---SGTYSY--GDTVTYSCDPGYTLIGSSTITCLENGTWSPPPpTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 202-269 9.26e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 37.66  E-value: 9.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 282721077 202 RCgKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAMNVNVGVRT 269
Cdd:PHA02831 140 RC-KYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKCVKDKVHNEIQP 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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