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Conserved domains on  [gi|320202942|ref|NP_001188512|]
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ankyrin repeat and SOCS box protein 11 isoform c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-265 1.79e-30

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 1.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  12 NIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQACLG 91
Cdd:COG0666   18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  92 GHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLANNV 170
Cdd:COG0666   98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 171 NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALD 249
Cdd:COG0666  178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257

                        250
                 ....*....|....*.
gi 320202942 250 LAAPKSSVEQALLLRE 265
Cdd:COG0666  258 LAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 265-306 4.96e-20

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239698  Cd Length: 42  Bit Score: 81.38  E-value: 4.96e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 320202942 265 EGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-265 1.79e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 1.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  12 NIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQACLG 91
Cdd:COG0666   18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  92 GHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLANNV 170
Cdd:COG0666   98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 171 NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALD 249
Cdd:COG0666  178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257

                        250
                 ....*....|....*.
gi 320202942 250 LAAPKSSVEQALLLRE 265
Cdd:COG0666  258 LAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 265-306 4.96e-20

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 81.38  E-value: 4.96e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 320202942 265 EGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-241 1.43e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  150 IHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLElGASVDHGQWLDTPLHAAARQSNVEVIHL 229
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 320202942  230 LTDYGANLKRRN 241
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 98-256 6.04e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 6.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  98 KALLENGAHVNGVTVH-GATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILLANNVNIDHE 175
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 176 VPQLGTPLYVACTY-QRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSnvEVIHLLTDYGANLKRRNAQGKSALDLAA 252
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 320202942 253 PKSS 256
Cdd:PHA02878 309 KQYL 312
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 266-304 3.27e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.18  E-value: 3.27e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 320202942  266 GPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLL 304
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 268-306 1.67e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.94  E-value: 1.67e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 320202942   268 PALSQLCRLCVRKCLGrachqAIHKLHLPEPLERFLLYQ 306
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 148-244 4.06e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.84  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 148 SPIHEAVKRGHRECMEILLANNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLE---------LGASVDHGQwldTPLHA 217
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGeTALHVAALYDNLEAAVVLMEaapelvnepMTSDLYQGE---TALHI 95

                         90       100
                 ....*....|....*....|....*..
gi 320202942 218 AARQSNVEVIHLLTDYGANLKRRNAQG 244
Cdd:cd22192   96 AVVNQNLNLVRELIARGADVVSPRATG 122
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 212-237 4.76e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 4.76e-03
                           10        20
                   ....*....|....*....|....*.
gi 320202942   212 DTPLHAAARQSNVEVIHLLTDYGANL 237
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-265 1.79e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 1.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  12 NIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQACLG 91
Cdd:COG0666   18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  92 GHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLANNV 170
Cdd:COG0666   98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 171 NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALD 249
Cdd:COG0666  178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257

                        250
                 ....*....|....*.
gi 320202942 250 LAAPKSSVEQALLLRE 265
Cdd:COG0666  258 LAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-265 1.56e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.90  E-value: 1.56e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  28 IKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQACLGGHVACAKALLENGAHV 107
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 108 NGVTVHGATPLFNACCSGSAACVNVLLEFGAK-AQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA 186
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 187 CTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 265
Cdd:COG0666  161 AANGNLEIVKLLLEAGADVNArDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-248 7.99e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.79  E-value: 7.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  32 LALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQ-----------------ACLGGHV 94
Cdd:COG0666   54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAgadvnardkdgetplhlAAYNGNL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  95 ACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHL-ASPIHEAVKRGHRECMEILLANNVNID 173
Cdd:COG0666  134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDgETPLHLAAENGHLEIVKLLLEAGADVN 213

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320202942 174 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 248
Cdd:COG0666  214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAkDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 265-306 4.96e-20

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 81.38  E-value: 4.96e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 320202942 265 EGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 265-306 4.82e-15

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 67.91  E-value: 4.82e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 320202942 265 EGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-241 1.43e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  150 IHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLElGASVDHGQWLDTPLHAAARQSNVEVIHL 229
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 320202942  230 LTDYGANLKRRN 241
Cdd:pfam12796  80 LLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-173 1.76e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 1.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942   87 QACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEVHLASPIHEAVKRGHRECMEILL 166
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLL 81


                  ....*..
gi 320202942  167 ANNVNID 173
Cdd:pfam12796  82 EKGADIN 88
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 98-256 6.04e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 6.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  98 KALLENGAHVNGVTVH-GATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILLANNVNIDHE 175
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 176 VPQLGTPLYVACTY-QRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSnvEVIHLLTDYGANLKRRNAQGKSALDLAA 252
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 320202942 253 PKSS 256
Cdd:PHA02878 309 KQYL 312
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 97-267 6.77e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 6.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  97 AKALLENGAHVNGVTVHGATPLFNA--CCSGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGHR--ECMEILLANNVN 171
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLIDKGVD 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 172 IDhevpqlgtplyvACTyqRVDCvkkLLELGASVD----HGqwlDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSA 247
Cdd:PHA03100 169 IN------------AKN--RVNY---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                        170       180
                 ....*....|....*....|.
gi 320202942 248 LDLAAPKSSVE-QALLLREGP 267
Cdd:PHA03100 229 LHIAILNNNKEiFKLLLNNGP 249
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 267-306 1.09e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 61.33  E-value: 1.09e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 320202942 267 PPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 81-251 6.24e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 65.76  E-value: 6.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  81 LKTLIAQACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGHR 159
Cdd:PHA02874 124 LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVkDNNGESPLHNAAEYGDY 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 160 ECMEILLANNVNIDHEVPQLGTPLYVACTYQRvdCVKKLLELGASVDHgQWLD--TPLHAAAR-QSNVEVIHLLTDYGAN 236
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASIND-QDIDgsTPLHHAINpPCDIDIIDILLYHKAD 280

                        170
                 ....*....|....*
gi 320202942 237 LKRRNAQGKSALDLA 251
Cdd:PHA02874 281 ISIKDNKGENPIDTA 295
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 88-258 1.98e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.24  E-value: 1.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  88 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 166
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpDIESELHDAVEEGDVKAVEELL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 167 ANNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQwLD--TPLHAAARQSNVEVIHLLTDYGANLKRRNAQ 243
Cdd:PHA02875  89 DLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPN-TDkfSPLHLAVMMGDIKGIELLIDHKACLDIEDCC 167

                        170
                 ....*....|....*
gi 320202942 244 GKSALDLAAPKSSVE 258
Cdd:PHA02875 168 GCTPLIIAMAKGDIA 182
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 266-304 3.27e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.18  E-value: 3.27e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 320202942  266 GPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLL 304
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 100-251 4.56e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.54  E-value: 4.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 100 LLENGAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-VHLASPIHEAVKRGH-RECMEILLANNVNIDHEV 176
Cdd:PHA02876 259 LYDAGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYLMAKNGYdTENIRTLIMLGADVNAAD 338

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320202942 177 PQLGTPLYVACTYQRV-DCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLA 251
Cdd:PHA02876 339 RLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-207 4.25e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.57  E-value: 4.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  66 RSPLHEAAAQGrllalktliaqaclggHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAqlEVH 145
Cdd:PLN03192 559 RTPLHIAASKG----------------YEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASIS--DPH 620

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320202942 146 LASPIH-EAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH 207
Cdd:PLN03192 621 AAGDLLcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 98-262 4.42e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.38  E-value: 4.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  98 KALLENGAHVNGVTVHGATPLFNACC-SGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGHRECMEILLANNVNIDHE 175
Cdd:PHA02876 325 RTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNArDYCDKTPIHYAAVRNNVVIINTLLDYGADIEAL 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 176 VPQLGTPLYVA-CTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQS-NVEVIHLLTDYGANLKRRNAQGKSALDLAA 252
Cdd:PHA02876 405 SQKIGTALHFAlCGTNPYMSVKTLIDRGANVNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL 484

                        170
                 ....*....|
gi 320202942 253 PKSSVEQALL 262
Cdd:PHA02876 485 EYHGIVNILL 494
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 45-166 2.69e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  45 RKEAARIAEEIYGGISDCWADRSPLHEAAAQGRL--LALKTLIAQAC---LGGHVACAKALLENGAHVNGVTVHGATPLF 119
Cdd:PTZ00322  41 QEEIARIDTHLEALEATENKDATPDHNLTTEEVIdpVVAHMLTVELCqlaASGDAVGARILLTGGADPNCRDYDGRTPLH 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 320202942 120 NACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILL 166
Cdd:PTZ00322 121 IACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLS 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 66-236 4.08e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 4.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  66 RSPLHEAAAQGRLLALKTliaqaclgghvacakaLLENGAHVNGVTVH-GATPLFNACCSGSAACVNVLLEFGAKAQL-E 143
Cdd:PHA02875  69 ESELHDAVEEGDVKAVEE----------------LLDLGKFADDVFYKdGMTPLHLATILKKLDIMKLLIARGADPDIpN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 144 VHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQS 222
Cdd:PHA02875 133 TDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYfGKNGCVAALCYAIEN 212

                        170
                 ....*....|....*
gi 320202942 223 N-VEVIHLLTDYGAN 236
Cdd:PHA02875 213 NkIDIVRLFIKRGAD 227
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 118-263 8.10e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.07  E-value: 8.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 118 LFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVK 196
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320202942 197 KLLELGASVDHGQWLD--TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 263
Cdd:PHA02875  86 ELLDLGKFADDVFYKDgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 83-252 2.34e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 2.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  83 TLIAQACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLevhLASPIHEavkrghRECM 162
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI---LPIPCIE------KDMI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 163 EILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV----DHGQWldtPLHAAARQSNVEVIHLLTDYGANLK 238
Cdd:PHA02874 108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVniedDNGCY---PIHIAIKHNFFDIIKLLLEKGAYAN 184

                        170
                 ....*....|....
gi 320202942 239 RRNAQGKSALDLAA 252
Cdd:PHA02874 185 VKDNNGESPLHNAA 198
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 116-265 5.55e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.73  E-value: 5.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 116 TPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLANNVNIdhevpqlgTPLYVACTYQrvDC 194
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDT--------SILPIPCIEK--DM 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320202942 195 VKKLLELGASVD-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 265
Cdd:PHA02874 107 IKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 267-306 6.57e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 45.37  E-value: 6.57e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 320202942 267 PPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 267-306 7.19e-07

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 45.25  E-value: 7.19e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 320202942 267 PPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 268-306 1.67e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.94  E-value: 1.67e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 320202942   268 PALSQLCRLCVRKCLGrachqAIHKLHLPEPLERFLLYQ 306
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
PHA03095 PHA03095
ankyrin-like protein; Provisional
 98-249 4.94e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.71  E-value: 4.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  98 KALLENGAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAkaqlevhlaspiheavkrghrecmeillanNVNIDHEV 176
Cdd:PHA03095  67 RLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGA------------------------------DVNAKDKV 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320202942 177 PQlgTPLYVACTYQRVD--CVKKLLELGASV-DHGQWLDTPLHAAARQSN--VEVIHLLTDYGANLKRRNAQGKSALD 249
Cdd:PHA03095 117 GR--TPLHVYLSGFNINpkVIRLLLRKGADVnALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFRSLLH 192
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 265-306 1.14e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 41.77  E-value: 1.14e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 320202942 265 EGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 69-199 2.11e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.72  E-value: 2.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  69 LHEAAAQGRLLALKTLIA----------QACLGGHVACA-------KALLENGAHVNGVTVHGATPLFNACCSGSAACVN 131
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEygadvnieddNGCYPIHIAIKhnffdiiKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 132 VLLEFGAKAQLEVHLA-SPIHEAVKRgHRECMEiLLANNVNIDHEVPQLGTPLYVACTYQ-RVDCVKKLL 199
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGfTPLHNAIIH-NRSAIE-LLINNASINDQDIDGSTPLHHAINPPcDIDIIDILL 275
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 267-304 2.80e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 40.89  E-value: 2.80e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 320202942 267 PPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLL 304
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
PHA03095 PHA03095
ankyrin-like protein; Provisional
 98-252 3.00e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 3.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  98 KALLENGAHVNGVTVHGATPLfNACCSG---SAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRgHRECMEIL--LANNVN 171
Cdd:PHA03095 101 KLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRKGADVNaLDLYGMTPLAVLLKS-RNANVELLrlLIDAGA 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 172 IDHEVPQLG-TPLYVACTY--QRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHL--LTDYGANLKRRNAQGK 245
Cdd:PHA03095 179 DVYAVDDRFrSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGnTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQ 258


                 ....*..
gi 320202942 246 SALDLAA 252
Cdd:PHA03095 259 TPLHYAA 265
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 267-306 3.22e-05

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 40.48  E-value: 3.22e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 320202942 267 PPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03720    3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 103-263 3.66e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 3.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 103 NGAHVNGVTvhgATPLFNACCSGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGT 181
Cdd:PLN03192 517 GGEHDDPNM---ASNLLTVASTGNAALLEELLKAKLDPDIgDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNT 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 182 PLY--VACTYQRVdcvKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ 259
Cdd:PLN03192 594 ALWnaISAKHHKI---FRILYHFASISDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670


                 ....
gi 320202942 260 ALLL 263
Cdd:PLN03192 671 VRLL 674
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 267-306 4.50e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 39.96  E-value: 4.50e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 320202942 267 PPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 100-179 4.77e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 4.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 100 LLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA----KAQLEVhlaSPIHEAVKRGHRECMEILLANNVNIDHE 175
Cdd:PHA03100 178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGAnpnlVNKYGD---TPLHIAILNNNKEIFKLLLNNGPSIKTI 254


                 ....
gi 320202942 176 VPQL 179
Cdd:PHA03100 255 IETL 258
Ank_4 pfam13637
Ankyrin repeats (many copies);
181-230 6.77e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 6.77e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 320202942  181 TPLYVACTYQRVDCVKKLLELGASVDH--GQWlDTPLHAAARQSNVEVIHLL 230
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvdGNG-ETALHFAASNGNVEVLKLL 53
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 267-305 6.79e-05

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 39.77  E-value: 6.79e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 320202942 267 PPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLY 305
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
213-263 1.79e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 1.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 320202942  213 TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 263
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 267-306 2.46e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 38.01  E-value: 2.46e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 320202942 267 PPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 87-266 2.67e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.17  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  87 QACLGGHVACAKALLENGAHVNGVTVHGATPLFNAC-----------------CSGS----------------------- 126
Cdd:PHA02878  43 QAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnklgmkemirsinkCSVFytlvaikdafnnrnveifkiilt 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 127 ------------------------AACVNVLLEFGAKAQL--EVHLASPIHEAVKRGHRECMEILLANNVNIDheVPQLG 180
Cdd:PHA02878 123 nrykniqtidlvyidkkskddiieAEITKLLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANVN--IPDKT 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 181 --TPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLH-AAARQSNVEVIHLLTDYGANLkrrNAQ----GKSALDLAA 252
Cdd:PHA02878 201 nnSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHiSVGYCKDYDILKLLLEHGVDV---NAKsyilGLTALHSSI 277

                        250
                 ....*....|....
gi 320202942 253 pKSSVEQALLLREG 266
Cdd:PHA02878 278 -KSERKLKLLLEYG 290
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 265-306 4.25e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 37.31  E-value: 4.25e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 320202942 265 EGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03719    1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 181-256 7.05e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 7.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 181 TPLYVACTYQRVDCVKKLLELGASVdhgQWLD----TPLHAAARQSNVEVIHLLT-------DYGANLKRRNAQGKSALD 249
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADP---TLLDkdgkTPLELAEENGFREVVQLLSrhsqchfELGANAKPDSFTGKPPSL 193


                 ....*..
gi 320202942 250 LAAPKSS 256
Cdd:PTZ00322 194 EDSPISS 200
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 261-305 8.26e-04

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 36.51  E-value: 8.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 320202942   261 LLLREGPPALSQLCRLCVRKCLGRachQAIHKLHLPEPLERFLLY 305
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRT---DQIKTLPLPPKLKDYLSY 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 149-251 9.65e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.42  E-value: 9.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 149 PIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRV-----DCVKKLLELGASVDHGQWLD-TPLHAAARQS 222
Cdd:PHA03100  38 PLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGiTPLLYAISKK 117

                         90       100       110
                 ....*....|....*....|....*....|.
gi 320202942 223 --NVEVIHLLTDYGANLKRRNAQGKSALDLA 251
Cdd:PHA03100 118 snSYSIVEYLLDNGANVNIKNSDGENLLHLY 148
Ank_4 pfam13637
Ankyrin repeats (many copies);
83-134 1.03e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 1.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 320202942   83 TLIAQACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 134
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 63-216 1.39e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.05  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942  63 WADRSPLHEAAAQGRLLALKTliaqaclgghvacakaLLENGAHVNGVTVHGATPL-FNACCSGSAACVNVLLEFGAKAQ 141
Cdd:PHA02876 373 YCDKTPIHYAAVRNNVVIINT----------------LLDYGADIEALSQKIGTALhFALCGTNPYMSVKTLIDRGANVN 436

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320202942 142 LE-VHLASPIHEAVKRGHR-ECMEILLANNVNIDHEVPQLGTPLYVACTYQRVdcVKKLLELGASVDHGQWLDTPLH 216
Cdd:PHA02876 437 SKnKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPLLIALEYHGI--VNILLHYGAELRDSRVLHKSLN 511
Ank_4 pfam13637
Ankyrin repeats (many copies);
148-199 1.55e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 1.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 320202942  148 SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLL 199
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 265-306 1.59e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 35.98  E-value: 1.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 320202942 265 EGPPALSQLCRLCVRKCLGR---ACHQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 181-256 1.81e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.65  E-value: 1.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 181 TPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQ-----SNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 254
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNsTPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGITPLLYAISK 116


                 ..
gi 320202942 255 SS 256
Cdd:PHA03100 117 KS 118
PHA03095 PHA03095
ankyrin-like protein; Provisional
 184-266 2.73e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.24  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 184 YVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSN---VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ 259
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADVNFrGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLD 98


                 ....*....
gi 320202942 260 --ALLLREG 266
Cdd:PHA03095  99 viKLLIKAG 107
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 265-306 2.95e-03

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 34.88  E-value: 2.95e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 320202942 265 EGPPALSQLCRLCVRKCLGRachQAIHKLHLPEPLERFLLYQ 306
Cdd:cd03717    1 TSVRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLKEY 39
Ank_5 pfam13857
Ankyrin repeats (many copies);
209-251 4.06e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.01  E-value: 4.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 320202942  209 QWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLA 251
Cdd:pfam13857  14 GEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 148-244 4.06e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.84  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202942 148 SPIHEAVKRGHRECMEILLANNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLE---------LGASVDHGQwldTPLHA 217
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGeTALHVAALYDNLEAAVVLMEaapelvnepMTSDLYQGE---TALHI 95

                         90       100
                 ....*....|....*....|....*..
gi 320202942 218 AARQSNVEVIHLLTDYGANLKRRNAQG 244
Cdd:cd22192   96 AVVNQNLNLVRELIARGADVVSPRATG 122
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 212-237 4.76e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 4.76e-03
                           10        20
                   ....*....|....*....|....*.
gi 320202942   212 DTPLHAAARQSNVEVIHLLTDYGANL 237
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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