NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|406601116|ref|NP_001258349|]
View 

tetratricopeptide repeat protein 19, mitochondrial isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 120-241 4.51e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 4.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 120 EEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 199
Cdd:COG3914   68 AAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRAL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 406601116 200 DLArqinhPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQA 241
Cdd:COG3914  140 ALN-----PDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 120-241 4.51e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 4.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 120 EEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 199
Cdd:COG3914   68 AAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRAL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 406601116 200 DLArqinhPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQA 241
Cdd:COG3914  140 ALN-----PDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 136-242 1.49e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 52.23  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 136 CARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAY------IYMQRASDLARQiNHPE 209
Cdd:NF040586 398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                         90       100       110
                 ....*....|....*....|....*....|...
gi 406601116 210 LHMVLSNLAAVLMHRERYTQAKEIYQEALKQAK 242
Cdd:NF040586 477 TLMTAGGLGADLRALGRFREALELDEETLERHR 509
TPR_12 pfam13424
Tetratricopeptide repeat;
123-204 1.64e-07

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 47.77  E-value: 1.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  123 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 202
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 406601116  203 RQ 204
Cdd:pfam13424  76 EK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 145-238 1.73e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 45.68  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 145 QPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN---HPELHMVLSNLAAVL 221
Cdd:NF040586 620 RLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLgedHPFTLACRNNLAVLL 699

                         90
                 ....*....|....*..
gi 406601116 222 MHRERYTQAKEIYQEAL 238
Cdd:NF040586 700 RALGDPEEARELAEAAL 716
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 148-238 1.02e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 43.37  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 148 QAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI----NHPELHMVLSNLAAVLMH 223
Cdd:NF040586 538 EALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlggpDHPDTLRAAKSLAVALRR 617

                         90
                 ....*....|....*
gi 406601116 224 RERYTQAKEIYQEAL 238
Cdd:NF040586 618 AGRLEEALELAEDTY 632
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 137-240 3.38e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 41.83  E-value: 3.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 137 ARYLLFSKQPSQAQRMYEKALQ-ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHM 212
Cdd:NF040586 569 ARDLRELGRYAEALDLLEEALErYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRfgpDHPDTLA 648

                         90       100
                 ....*....|....*....|....*...
gi 406601116 213 VLSNLAAVLMHRERYTQAKEIYQEALKQ 240
Cdd:NF040586 649 AALSLANDLRALGDADEARELAREVLDR 676
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 147-238 3.52e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 38.75  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 147 SQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVL---SNLAavLMH 223
Cdd:NF040586 495 REALELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLlsaNNLA--RDL 572

                         90
                 ....*....|....*..
gi 406601116 224 RE--RYTQAKEIYQEAL 238
Cdd:NF040586 573 RElgRYAEALDLLEEAL 589
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 2-240 7.57e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 37.76  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116    2 KDEPEEAELILHDALRLayQTDNKKAITYtydlMANLAFIRGQLENAEQLFKAtmsyllgggMKQEDNAIIEISLKLASI 81
Cdd:TIGR02917 478 KGDLAKAREAFEKALSI--EPDFFPAAAN----LARIDIQEGNPDDAIQRFEK---------VLTIDPKNLRAILALAGL 542

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116   82 YAAQNRQEFAVAGYEFCIS----------TLEEKIEREKELAEDIMSVEEKANTHLLLGMCLDACARYLLFSKQPSQAQR 151
Cdd:TIGR02917 543 YLRTGNEEEAVAWLEKAAElnpqeiepalALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVS 622

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  152 MYEKALqiseeiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPELHMVLSNLaavLMHRERYTQAK 231
Cdd:TIGR02917 623 SFKKLL--------ALQPDSALALLLLADAYAVMKNYAKAITSLKRA--LELKPDNTEAQIGLAQL---LLAAKRTESAK 689


                  ....*....
gi 406601116  232 EIYQEALKQ 240
Cdd:TIGR02917 690 KIAKSLQKQ 698
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 120-241 4.51e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 4.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 120 EEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 199
Cdd:COG3914   68 AAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRAL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 406601116 200 DLArqinhPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQA 241
Cdd:COG3914  140 ALN-----PDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 136-242 1.49e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 52.23  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 136 CARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAY------IYMQRASDLARQiNHPE 209
Cdd:NF040586 398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                         90       100       110
                 ....*....|....*....|....*....|...
gi 406601116 210 LHMVLSNLAAVLMHRERYTQAKEIYQEALKQAK 242
Cdd:NF040586 477 TLMTAGGLGADLRALGRFREALELDEETLERHR 509
TPR_12 pfam13424
Tetratricopeptide repeat;
123-204 1.64e-07

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 47.77  E-value: 1.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  123 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 202
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 406601116  203 RQ 204
Cdd:pfam13424  76 EK 77
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 137-260 6.14e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 47.69  E-value: 6.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 137 ARYLLFSKQPSQAQRMYEKALQISeeiqgerhPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPElhmVLSN 216
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALRLD--------PDNADALLDLAEALLAAGDTEEAEELLERA--LALDPDNPE---ALYL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 406601116 217 LAAVLMHRERYTQAKEIYQEALKQAklkKDEISVQHIREELAEL 260
Cdd:COG4235   91 LGLAAFQQGDYAEAIAAWQKLLALL---PADAPARLLEASIAEA 131
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 36-249 3.60e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.07  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  36 ANLAFIRGQLENAEQLFKATMsyllgggmkQEDNAIIEISLKLASIYAAQNRQEFAVAgyefcisTLEEKIEREKELAEd 115
Cdd:COG3914   85 ALLLQALGRYEEALALYRRAL---------ALNPDNAEALFNLGNLLLALGRLEEALA-------ALRRALALNPDFAE- 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 116 imsveekanTHLLLGMCLDACaryllfsKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYM 195
Cdd:COG3914  148 ---------AYLNLGEALRRL-------GRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAY 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 406601116 196 QRASDLArqinhPELHMVLSNLAAVLMHRERYTQAkEIYQEALKQAKLKKDEIS 249
Cdd:COG3914  204 RRALELD-----PDNADAHSNLLFALRQACDWEVY-DRFEELLAALARGPSELS 251
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 145-238 1.73e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 45.68  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 145 QPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN---HPELHMVLSNLAAVL 221
Cdd:NF040586 620 RLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLgedHPFTLACRNNLAVLL 699

                         90
                 ....*....|....*..
gi 406601116 222 MHRERYTQAKEIYQEAL 238
Cdd:NF040586 700 RALGDPEEARELAEAAL 716
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 27-241 2.27e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  27 AITYTYDLMANLAFIRGQLENAEQLFKAtmsyllgggMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKI 106
Cdd:COG2956    6 AAALGWYFKGLNYLLNGQPDKAIDLLEE---------ALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 107 EREKELAEDIMSVEEKANTHLLLGMCL-----DACARYLLFSKQpsQAQRMYEKALQISEEIQgERHPQTIVLMSDLATT 181
Cdd:COG2956   77 EALLELAQDYLKAGLLDRAEELLEKLLeldpdDAEALRLLAEIY--EQEGDWEKAIEVLERLL-KLGPENAHAYCELAEL 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 182 LDAQGRFDEAYIYMQRASDLarqinHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQA 241
Cdd:COG2956  154 YLEQGDYDEAIEALEKALKL-----DPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208
TPR_12 pfam13424
Tetratricopeptide repeat;
170-242 2.73e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.60  E-value: 2.73e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 406601116  170 QTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAK 242
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgpDHPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 4-204 5.14e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.21  E-value: 5.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116   4 EPEEAELILHDALRLayQTDNKKAitytYDLMANLAFIRGQLENAEQLFKATMSYllgggmkQEDNAiiEISLKLASIYA 83
Cdd:COG3914   93 RYEEALALYRRALAL--NPDNAEA----LFNLGNLLLALGRLEEALAALRRALAL-------NPDFA--EAYLNLGEALR 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  84 AQNRQEFAVAGYEFCIstleekierekELAEDimsveeKANTHLLLGMCLDACARYllfskqpSQAQRMYEKALQIseei 163
Cdd:COG3914  158 RLGRLEEAIAALRRAL-----------ELDPD------NAEALNNLGNALQDLGRL-------EEAIAAYRRALEL---- 209

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 406601116 164 qgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQ 204
Cdd:COG3914  210 ----DPDNADAHSNLLFALRQACDWEVYDRFEELLAALARG 246
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 137-241 6.23e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 6.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 137 ARYLLFSKQPSQAQRMYEKALqiseeiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSN 216
Cdd:COG4783   11 AQALLLAGDYDEAEALLEKAL--------ELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL-----DPDEPEARLN 77

                         90       100
                 ....*....|....*....|....*
gi 406601116 217 LAAVLMHRERYTQAKEIYQEALKQA 241
Cdd:COG4783   78 LGLALLKAGDYDEALALLEKALKLD 102
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
123-239 6.61e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 6.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 123 ANTHLLLGMCLDACARYllfskqpSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLa 202
Cdd:COG0457    8 AEAYNNLGLAYRRLGRY-------EEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL- 71

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 406601116 203 rqinHPELHMVLSNLAAVLMHRERYTQAKEIYQEALK 239
Cdd:COG0457   72 ----DPDDAEALNNLGLALQALGRYEEALEDYDKALE 104
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
123-239 8.32e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 8.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 123 ANTHLLLGMCLDACARYllfskqpSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLa 202
Cdd:COG0457   42 AEALYNLGLAYLRLGRY-------EEALADYEQALEL--------DPDDAEALNNLGLALQALGRYEEALEDYDKALEL- 105

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 406601116 203 rqinHPELHMVLSNLAAVLMHRERYTQAKEIYQEALK 239
Cdd:COG0457  106 ----DPDDAEALYNLGLALLELGRYDEAIEAYERALE 138
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 137-241 8.42e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 8.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 137 ARYLLFSKQPSQAQRMYEKALQISEEIQgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSN 216
Cdd:COG3914   44 ALLLLAALAEAAAAALLALAAGEAAAAA-AALLLLAALLELAALLLQALGRYEEALALYRRALAL-----NPDNAEALFN 117

                         90       100
                 ....*....|....*....|....*
gi 406601116 217 LAAVLMHRERYTQAKEIYQEALKQA 241
Cdd:COG3914  118 LGNLLLALGRLEEALAALRRALALN 142
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
139-241 8.66e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.54  E-value: 8.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 139 YLLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYmQRASDLarqinHPELHMVLSNLA 218
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALEL--------DPDNADALNNLGLLLLEQGRYDEAIAL-EKALKL-----DPNNAEALLNLA 66

                         90       100
                 ....*....|....*....|...
gi 406601116 219 AVLMHRERYTQAKEIYQEALKQA 241
Cdd:COG3063   67 ELLLELGDYDEALAYLERALELD 89
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 148-238 1.02e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 43.37  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 148 QAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI----NHPELHMVLSNLAAVLMH 223
Cdd:NF040586 538 EALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlggpDHPDTLRAAKSLAVALRR 617

                         90
                 ....*....|....*
gi 406601116 224 RERYTQAKEIYQEAL 238
Cdd:NF040586 618 AGRLEEALELAEDTY 632
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 137-241 1.90e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 137 ARYLLFSKQPSQAQRMYEKALqiseeiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPELHMvlsN 216
Cdd:COG4783   45 GEILLQLGDLDEAIVLLHEAL--------ELDPDEPEARLNLGLALLKAGDYDEALALLEKA--LKLDPEHPEAYL---R 111

                         90       100
                 ....*....|....*....|....*
gi 406601116 217 LAAVLMHRERYTQAKEIYQEALKQA 241
Cdd:COG4783  112 LARAYRALGRPDEAIAALEKALELD 136
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 145-242 3.09e-04

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 41.53  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  145 QPSQAQRMYEKALQISEEiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMV-LSNLAAVLMH 223
Cdd:pfam17874  16 DAERALELAEQALALLPE---DDLLARGLATFVLGEAYLCLGDLDAALQAMREAEALARRADSPHVTLWaLLQQGEILRA 92

                          90
                  ....*....|....*....
gi 406601116  224 RERYTQAKEIYQEALKQAK 242
Cdd:pfam17874  93 QGRLHQALETYQQALQLAR 111
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 137-240 3.38e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 41.83  E-value: 3.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 137 ARYLLFSKQPSQAQRMYEKALQ-ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHM 212
Cdd:NF040586 569 ARDLRELGRYAEALDLLEEALErYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRfgpDHPDTLA 648

                         90       100
                 ....*....|....*....|....*...
gi 406601116 213 VLSNLAAVLMHRERYTQAKEIYQEALKQ 240
Cdd:NF040586 649 AALSLANDLRALGDADEARELAREVLDR 676
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 140-244 5.89e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.56  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 140 LLFSKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLArqinhPELHMVLSNLAA 219
Cdd:COG5010   64 YNKLGDFEESLALLEQALQL--------DPNNPELYYNLALLYSRSGDKDEAKEYYEKALALS-----PDNPNAYSNLAA 130

                         90       100
                 ....*....|....*....|....*
gi 406601116 220 VLMHRERYTQAKEIYQEALKQAKLK 244
Cdd:COG5010  131 LLLSLGQDDEAKAALQRALGTSPLK 155
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1-241 1.37e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.33  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116   1 MKDEPEEAELILHDALRLAYQTdnkkaiTYTYDLMANLAFIRGQLENAEQLFKATMSYllgggmkqeDNAIIEISLKLAS 80
Cdd:COG2956   20 LNGQPDKAIDLLEEALELDPET------VEAHLALGNLYRRRGEYDRAIRIHQKLLER---------DPDRAEALLELAQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  81 IYAAQNRQEFAVAGYEFCISTLEEKIEREKELAE---------------DIMSVEEKANTHLLLGMcldacARYLLFSKQ 145
Cdd:COG2956   85 DYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEiyeqegdwekaievlERLLKLGPENAHAYCEL-----AELYLEQGD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 146 PSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSNLAAVLMHRE 225
Cdd:COG2956  160 YDEAIEALEKALKL--------DPDCARALLLLAELYLEQGDYEEAIAALERALEQ-----DPDYLPALPRLAELYEKLG 226

                        250
                 ....*....|....*.
gi 406601116 226 RYTQAKEIYQEALKQA 241
Cdd:COG2956  227 DPEEALELLRKALELD 242
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
123-263 2.41e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.45  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 123 ANTHLLLGMCLDACARYllfskqpSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 202
Cdd:COG0457   76 AEALNNLGLALQALGRY-------EEALEDYDKALEL--------DPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 406601116 203 rqinhPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEISVQHIREELAELSKK 263
Cdd:COG0457  141 -----PDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVL 196
COG3899 COG3899
Predicted ATPase [General function prediction only];
111-241 3.18e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 39.07  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  111 ELAEDIMSVEEKANTHLLLGMCLDACARYllfskqpSQAQRMYEKALQ--ISEEIQGERHPQTIVLMSDLATTLDAQ-GR 187
Cdd:COG3899   733 ELLPPDPEEEYRLALLLELAEALYLAGRF-------EEAEALLERALAarALAALAALRHGNPPASARAYANLGLLLlGD 805

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 406601116  188 FDEAYIYMQRASDLARQINHPELH-MVLSNLAAVLMHRERYTQAKEIYQEALKQA 241
Cdd:COG3899   806 YEEAYEFGELALALAERLGDRRLEaRALFNLGFILHWLGPLREALELLREALEAG 860
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 147-238 3.52e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 38.75  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116 147 SQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVL---SNLAavLMH 223
Cdd:NF040586 495 REALELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLlsaNNLA--RDL 572

                         90
                 ....*....|....*..
gi 406601116 224 RE--RYTQAKEIYQEAL 238
Cdd:NF040586 573 RElgRYAEALDLLEEAL 589
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 2-240 7.57e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 37.76  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116    2 KDEPEEAELILHDALRLayQTDNKKAITYtydlMANLAFIRGQLENAEQLFKAtmsyllgggMKQEDNAIIEISLKLASI 81
Cdd:TIGR02917 478 KGDLAKAREAFEKALSI--EPDFFPAAAN----LARIDIQEGNPDDAIQRFEK---------VLTIDPKNLRAILALAGL 542

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116   82 YAAQNRQEFAVAGYEFCIS----------TLEEKIEREKELAEDIMSVEEKANTHLLLGMCLDACARYLLFSKQPSQAQR 151
Cdd:TIGR02917 543 YLRTGNEEEAVAWLEKAAElnpqeiepalALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVS 622

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406601116  152 MYEKALqiseeiqgERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPELHMVLSNLaavLMHRERYTQAK 231
Cdd:TIGR02917 623 SFKKLL--------ALQPDSALALLLLADAYAVMKNYAKAITSLKRA--LELKPDNTEAQIGLAQL---LLAAKRTESAK 689


                  ....*....
gi 406601116  232 EIYQEALKQ 240
Cdd:TIGR02917 690 KIAKSLQKQ 698
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
166-239 8.87e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 36.91  E-value: 8.87e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 406601116 166 ERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLarqinHPELHMVLSNLAAVLMHRERYTQAKEIYQEALK 239
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL-----DPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH