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Conserved domains on  [gi|527122094|ref|NP_001268370|]
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RCC1-like G exchanging factor-like protein isoform 3 [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-353 1.31e-24

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 102.36  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094  55 AARAD-RVFVWGFSFSGALGVPSfvvpssgpgpragarprRRIQPVPYRLELDQKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184   62 ALKADgTVWCWGNNSYGQLGDGT-----------------TTDRTTPVKVPGLTGVVAVAAGYYHScaLKSDGT-----V 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 132 WGMGLNKDSQLGfhrsrkdkTRGYEYVLEPSPVSLPLdrpqeTRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGrkvv 211
Cdd:COG5184  120 WCWGDNSSGQLG--------DGTTTNRLTPVQVDAGL-----SGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLG---- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 212 eNEIYSESHRVHRMQDFDGqVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGdlaGVNVIQVATY 291
Cdd:COG5184  183 -DGTTTDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG---LTGVVAIAAG 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 527122094 292 GDCCLAVSADGGLFGWGNSEYLQLASVTdSTQVNVPRCLhfSGVGKVRQAACGG-TGCAVLND 353
Cdd:COG5184  258 GSHTCALKSDGTVWCWGDNSYGQLGDGT-TTDRSTPVKV--PGLSGVVAVAAGSsHTCALLTD 317
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-353 1.31e-24

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 102.36  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094  55 AARAD-RVFVWGFSFSGALGVPSfvvpssgpgpragarprRRIQPVPYRLELDQKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184   62 ALKADgTVWCWGNNSYGQLGDGT-----------------TTDRTTPVKVPGLTGVVAVAAGYYHScaLKSDGT-----V 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 132 WGMGLNKDSQLGfhrsrkdkTRGYEYVLEPSPVSLPLdrpqeTRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGrkvv 211
Cdd:COG5184  120 WCWGDNSSGQLG--------DGTTTNRLTPVQVDAGL-----SGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLG---- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 212 eNEIYSESHRVHRMQDFDGqVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGdlaGVNVIQVATY 291
Cdd:COG5184  183 -DGTTTDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG---LTGVVAIAAG 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 527122094 292 GDCCLAVSADGGLFGWGNSEYLQLASVTdSTQVNVPRCLhfSGVGKVRQAACGG-TGCAVLND 353
Cdd:COG5184  258 GSHTCALKSDGTVWCWGDNSYGQLGDGT-TTDRSTPVKV--PGLSGVVAVAAGSsHTCALLTD 317
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
232-261 1.32e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.03  E-value: 1.32e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 527122094  232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQ 261
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-353 1.31e-24

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 102.36  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094  55 AARAD-RVFVWGFSFSGALGVPSfvvpssgpgpragarprRRIQPVPYRLELDQKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184   62 ALKADgTVWCWGNNSYGQLGDGT-----------------TTDRTTPVKVPGLTGVVAVAAGYYHScaLKSDGT-----V 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 132 WGMGLNKDSQLGfhrsrkdkTRGYEYVLEPSPVSLPLdrpqeTRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGrkvv 211
Cdd:COG5184  120 WCWGDNSSGQLG--------DGTTTNRLTPVQVDAGL-----SGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLG---- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 212 eNEIYSESHRVHRMQDFDGqVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGdlaGVNVIQVATY 291
Cdd:COG5184  183 -DGTTTDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG---LTGVVAIAAG 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 527122094 292 GDCCLAVSADGGLFGWGNSEYLQLASVTdSTQVNVPRCLhfSGVGKVRQAACGG-TGCAVLND 353
Cdd:COG5184  258 GSHTCALKSDGTVWCWGDNSYGQLGDGT-TTDRSTPVKV--PGLSGVVAVAAGSsHTCALLTD 317
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-353 2.44e-24

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 101.98  E-value: 2.44e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094  55 AARAD-RVFVWGFSFSGALGVPSfvvpssgpgpragarprRRIQPVPYRLELDQKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184   12 ALKSDgTVWCWGDNSYGQLGDGT-----------------TTDRSTPVRVPGLSNVVAVAAGGDHTcaLKADGT-----V 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 132 WGMGLNKDSQLGfhrsrkDKTRGYeyvlEPSPVSLPLDrpqeTRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVV 211
Cdd:COG5184   70 WCWGNNSYGQLG------DGTTTD----RTTPVKVPGL----TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 212 ENEIYSEshrvhRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLagvNVIQVATY 291
Cdd:COG5184  136 TNRLTPV-----QVDAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS---GVVAVAAG 207

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 527122094 292 GDCCLAVSADGGLFGWGNSEYLQL---ASVTDSTQVNVPrclhfsGVGKVRQAACGGT-GCAVLND 353
Cdd:COG5184  208 GDHSCALKSDGTVWCWGSNSSGQLgdgTTTDRATPVQVA------GLTGVVAIAAGGShTCALKSD 267
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 178-353 3.09e-21

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 93.12  E-value: 3.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 178 QVSCGRAHSLVLTDREGVFSMGNNSYGQCGrkvveNEIYSESHRVHRMQDFDGqVVQVACGQDHSLFLTDKGEVYSCGWG 257
Cdd:COG5184    2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLG-----DGTTTDRSTPVRVPGLSN-VVAVAAGGDHTCALKADGTVWCWGNN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 258 ADGQTGLGHYNITSSPTKLGGdlaGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASvTDSTQVNVPRcLHFSGVGK 337
Cdd:COG5184   76 SYGQLGDGTTTDRTTPVKVPG---LTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTPV-QVDAGLSG 150

                        170
                 ....*....|....*..
gi 527122094 338 VRQAACGG-TGCAVLND 353
Cdd:COG5184  151 VVAIAAGGyHTCALKSD 167
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-315 9.68e-21

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 91.58  E-value: 9.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094  55 AARAD-RVFVWGFSFSGALGVPSFVVPSSgpgpragarprrriqPVPYRLELDqKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184  112 ALKSDgTVWCWGDNSSGQLGDGTTTNRLT---------------PVQVDAGLS-GVVAIAAGGYHTcaLKSDGT-----V 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 132 WGMGLNKDSQLGfhrsrkDKTrgyeyvlePSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVV 211
Cdd:COG5184  171 WCWGANSYGQLG------DGT--------TTDRPTPVQVGGLSGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTT 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 212 ENEIYSEshRVHRMQDfdgqVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGdlaGVNVIQVATY 291
Cdd:COG5184  237 TDRATPV--QVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPG---LSGVVAVAAG 307

                        250       260
                 ....*....|....*....|....
gi 527122094 292 GDCCLAVSADGGLFGWGNSEYLQL 315
Cdd:COG5184  308 SSHTCALLTDGTVWCWGDNAYGQL 331
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-274 1.66e-14

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 73.47  E-value: 1.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094  55 AARAD-RVFVWGFSFSGALGVPSFVVpssgpgpragarprrriQPVPYRLELDQKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184  163 ALKSDgTVWCWGANSYGQLGDGTTTD-----------------RPTPVQVGGLSGVVAVAAGGDHScaLKSDGT-----V 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 132 WGMGLNKDSQLGfhrsrkdkTRGYEYVLEPSPVSLPldrpqeTRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKvv 211
Cdd:COG5184  221 WCWGSNSSGQLG--------DGTTTDRATPVQVAGL------TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-- 284

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 527122094 212 eneiySESHRVHRMQ-DFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPT 274
Cdd:COG5184  285 -----TTTDRSTPVKvPGLSGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 233-353 5.63e-14

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 71.93  E-value: 5.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGdlaGVNVIQVATYGDCCLAVSADGGLFGWGNSEY 312
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG---LSNVVAVAAGGDHTCALKADGTVWCWGNNSY 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 527122094 313 LQL--ASVTDSTQ-VNVPrclhfsGVGKVRQAACGG-TGCAVLND 353
Cdd:COG5184   78 GQLgdGTTTDRTTpVKVP------GLTGVVAVAAGYyHSCALKSD 116
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
232-261 1.32e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.03  E-value: 1.32e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 527122094  232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQ 261
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
301-351 3.77e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 43.66  E-value: 3.77e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 527122094  301 DGGLFGWGNSEYLQLASVTDSTQvNVPRCLHFSGVGKVRQAACGGTGCAVL 351
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENV-LVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
195-245 1.14e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 42.12  E-value: 1.14e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 527122094  195 VFSMGNNSYGQCGRKVVENEIYSEshrvhRMQDFDGQ-VVQVACGQDHSLFL 245
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTTENVLVPQ-----KVEGLSGNkVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
176-205 1.75e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 41.26  E-value: 1.75e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 527122094  176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQ 205
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
248-298 4.44e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.58  E-value: 4.44e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 527122094  248 KGEVYSCGWGADGQTGLGHYNITSSPTKLGGdLAGVNVIQVATYGDCCLAV 298
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG-LSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
130-189 1.87e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 35.96  E-value: 1.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 527122094  130 KVWGMGLNKDSQLGfHRSRKDktrgyeyVLEPSPVSLPLDRpqetRVLQVSCGRAHSLVL 189
Cdd:pfam00415   3 RVYTWGRNDYGQLG-LGTTEN-------VLVPQKVEGLSGN----KVVQVACGGDHTVAL 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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