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Conserved domains on  [gi|573459698|ref|NP_001275981|]
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GPI ethanolamine phosphate transferase 2 isoform 4 [Homo sapiens]

Protein Classification

alkaline phosphatase family protein( domain architecture ID 1908206)

alkaline phosphatase (ALP) family protein may catalyze the hydrolysis of substrates; the ALP superfamily includes alkaline phosphatases and sulfatases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ALP_like super family cl23718
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ...
 62-202 2.55e-44

alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.


The actual alignment was detected with superfamily member cd16024:

Pssm-ID: 474031 [Multi-domain]  Cd Length: 274  Bit Score: 161.19  E-value: 2.55e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  62 PPLFSKVVIVLIDALRDDFVFGSKgvKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIK--------------------- 120
Cdd:cd16024    1 KPAFDKLVFMVIDALRADFVFGPD--SNMPFTQSLINSGSALAFTAKAQPPTVTMPRIKalttgsipsfldvvlnfassl 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698     --------------------------------------------------------------------------------
Cdd:cd16024   79 leednwlsqlkaagkkivfygddtwlklfpgsftrsdgttsffvsdftevdnnvtrhldselsrddwdvlilhylgldhi 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 121 ------------------------------ERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKP--- 167
Cdd:cd16024  159 ghlegpksplmppklkemddvikriyesleEQSSNNPTLLVVCGDHGMTDAGNHGGSSPGETSVPLLFISPKFSSKPsna 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 573459698 168 -GDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLL 202
Cdd:cd16024  239 dGELSYYETVQQVDLAPTLALLLGLPIPKNSVGVLI 274
PIGO_PIGG super family cl44747
GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the ...
 670-832 4.03e-19

GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the transmembrane region of the GPI ethanolamine phosphate transferase enzymes. The family includes the PIGO and PIGG proteins from human. These proteins are involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis.


The actual alignment was detected with superfamily member pfam19316:

Pssm-ID: 437148  Cd Length: 423  Bit Score: 90.72  E-value: 4.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  670 LLAALLF---RPHNLPVLAFSLLIQTLMTkfiwkPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYv 746
Cdd:pfam19316 242 LLTLFLItqsRATNIPLFLLFRLQLEFLS-----SLDLSPTEITTTSLLLQYASFFAFGGSNAISSVDLSNAYNGVSGY- 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  747 EIPAV-LLTAFGTYAGPVLWASHLVHFLSSETRSGSAlSHACFCYALICSipVFTYIVLV------TSLRYHLFIWSVFS 819
Cdd:pfam19316 316 NVVAVgVLTFVSNWAGPIWWTSATNLLLLRKRRRGEG-RGVFFQHLALLT--LFVAASLVsvmaacTALRTHLFIWTVFS 392

                         170
                  ....*....|....*...
gi 573459698  820 PKLLYE-----GMHLLIT 832
Cdd:pfam19316 393 PKYLYTmawslGQHLLVN 410
 
Name Accession Description Interval E-value
GPI_EPT_2 cd16024
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is ...
 62-202 2.55e-44

GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.


Pssm-ID: 293748 [Multi-domain]  Cd Length: 274  Bit Score: 161.19  E-value: 2.55e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  62 PPLFSKVVIVLIDALRDDFVFGSKgvKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIK--------------------- 120
Cdd:cd16024    1 KPAFDKLVFMVIDALRADFVFGPD--SNMPFTQSLINSGSALAFTAKAQPPTVTMPRIKalttgsipsfldvvlnfassl 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698     --------------------------------------------------------------------------------
Cdd:cd16024   79 leednwlsqlkaagkkivfygddtwlklfpgsftrsdgttsffvsdftevdnnvtrhldselsrddwdvlilhylgldhi 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 121 ------------------------------ERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKP--- 167
Cdd:cd16024  159 ghlegpksplmppklkemddvikriyesleEQSSNNPTLLVVCGDHGMTDAGNHGGSSPGETSVPLLFISPKFSSKPsna 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 573459698 168 -GDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLL 202
Cdd:cd16024  239 dGELSYYETVQQVDLAPTLALLLGLPIPKNSVGVLI 274
PIGO_PIGG pfam19316
GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the ...
 670-832 4.03e-19

GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the transmembrane region of the GPI ethanolamine phosphate transferase enzymes. The family includes the PIGO and PIGG proteins from human. These proteins are involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis.


Pssm-ID: 437148  Cd Length: 423  Bit Score: 90.72  E-value: 4.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  670 LLAALLF---RPHNLPVLAFSLLIQTLMTkfiwkPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYv 746
Cdd:pfam19316 242 LLTLFLItqsRATNIPLFLLFRLQLEFLS-----SLDLSPTEITTTSLLLQYASFFAFGGSNAISSVDLSNAYNGVSGY- 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  747 EIPAV-LLTAFGTYAGPVLWASHLVHFLSSETRSGSAlSHACFCYALICSipVFTYIVLV------TSLRYHLFIWSVFS 819
Cdd:pfam19316 316 NVVAVgVLTFVSNWAGPIWWTSATNLLLLRKRRRGEG-RGVFFQHLALLT--LFVAASLVsvmaacTALRTHLFIWTVFS 392

                         170
                  ....*....|....*...
gi 573459698  820 PKLLYE-----GMHLLIT 832
Cdd:pfam19316 393 PKYLYTmawslGQHLLVN 410
AslA COG3119
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
129-210 9.72e-04

Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 442353 [Multi-domain]  Cd Length: 393  Bit Score: 42.56  E-value: 9.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 129 LLVLCGDHGMSeTGSHG-----ASSTEE-VNTPLIlISSAFERKPGDIRHpKHVQQTDVAATLAIALGLPIPKDSVG-SL 201
Cdd:COG3119  230 IVVFTSDNGPS-LGEHGlrggkGTLYEGgIRVPLI-VRWPGKIKAGSVSD-ALVSLIDLLPTLLDLAGVPIPEDLDGrSL 306


                 ....*....
gi 573459698 202 LfPVVEGRP 210
Cdd:COG3119  307 L-PLLTGEK 314
 
Name Accession Description Interval E-value
GPI_EPT_2 cd16024
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is ...
 62-202 2.55e-44

GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.


Pssm-ID: 293748 [Multi-domain]  Cd Length: 274  Bit Score: 161.19  E-value: 2.55e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  62 PPLFSKVVIVLIDALRDDFVFGSKgvKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIK--------------------- 120
Cdd:cd16024    1 KPAFDKLVFMVIDALRADFVFGPD--SNMPFTQSLINSGSALAFTAKAQPPTVTMPRIKalttgsipsfldvvlnfassl 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698     --------------------------------------------------------------------------------
Cdd:cd16024   79 leednwlsqlkaagkkivfygddtwlklfpgsftrsdgttsffvsdftevdnnvtrhldselsrddwdvlilhylgldhi 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 121 ------------------------------ERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKP--- 167
Cdd:cd16024  159 ghlegpksplmppklkemddvikriyesleEQSSNNPTLLVVCGDHGMTDAGNHGGSSPGETSVPLLFISPKFSSKPsna 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 573459698 168 -GDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLL 202
Cdd:cd16024  239 dGELSYYETVQQVDLAPTLALLLGLPIPKNSVGVLI 274
PIGO_PIGG pfam19316
GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the ...
 670-832 4.03e-19

GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the transmembrane region of the GPI ethanolamine phosphate transferase enzymes. The family includes the PIGO and PIGG proteins from human. These proteins are involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis.


Pssm-ID: 437148  Cd Length: 423  Bit Score: 90.72  E-value: 4.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  670 LLAALLF---RPHNLPVLAFSLLIQTLMTkfiwkPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYv 746
Cdd:pfam19316 242 LLTLFLItqsRATNIPLFLLFRLQLEFLS-----SLDLSPTEITTTSLLLQYASFFAFGGSNAISSVDLSNAYNGVSGY- 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  747 EIPAV-LLTAFGTYAGPVLWASHLVHFLSSETRSGSAlSHACFCYALICSipVFTYIVLV------TSLRYHLFIWSVFS 819
Cdd:pfam19316 316 NVVAVgVLTFVSNWAGPIWWTSATNLLLLRKRRRGEG-RGVFFQHLALLT--LFVAASLVsvmaacTALRTHLFIWTVFS 392

                         170
                  ....*....|....*...
gi 573459698  820 PKLLYE-----GMHLLIT 832
Cdd:pfam19316 393 PKYLYTmawslGQHLLVN 410
GPI_EPT_3 cd16023
GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is ...
 62-201 2.93e-17

GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.


Pssm-ID: 293747  Cd Length: 289  Bit Score: 82.99  E-value: 2.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698  62 PPLFSKVVIVLIDALRDDFVF-------GSKGVKF---MPYTTYLVEKGASHS----FVAEakPPTVTMPRIK------- 120
Cdd:cd16023    1 PPRFDKVVLLLIDALRYDFVLpddenppSENSLYYhnkLPVLEELLKSQPNNSrlfkFIAD--PPTTTLQRLKglttgsl 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 121 -----------------------------------------------ERETPLPN------------------------- 128
Cdd:cd16023   79 ptfidagsnfassaivednllkqlklagkrivfmgddtwtslfpnqfDRSYPFPSfnvkdldtvdngvlkhlfpelqsed 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 129 ------------------------------------------------LLVLCGDHGMSETGSHGASSTEEVNTPLILIS 160
Cdd:cd16023  159 dwdlliahflgvdhvghrygpnhpemarkltqmdqfirdiierldddtLLLVFGDHGMTETGDHGGDSDEEVDAALFAYS 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 573459698 161 ---------SAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSL 201
Cdd:cd16023  239 krpfnnsdePIESNGPGDPSKVRSVPQIDLVPTLSLLLGLPIPFSNLGTV 288
GPI_EPT_1 cd16020
GPI ethanolamine phosphate transferase 1; PIG-N; Ethanolamine phosphate transferase is ...
 135-201 7.33e-12

GPI ethanolamine phosphate transferase 1; PIG-N; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.


Pssm-ID: 293744  Cd Length: 294  Bit Score: 67.23  E-value: 7.33e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 573459698 135 DHGMSETGSHGASSTEEVNTPLIL-----------ISSAFERKPGDIRHPKH-VQQTDVAATLAIALGLPIPKDSVGSL 201
Cdd:cd16020  215 DHGMTDWGSHGDGSPDETETPFIAwgagikhptpgRGPSFSANWGGLRLPRHdLDQADLAPLMSALLGLPPPVNSVGIL 293
GPI_EPT cd16019
GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in ...
 129-199 3.14e-11

GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.


Pssm-ID: 293743 [Multi-domain]  Cd Length: 292  Bit Score: 65.07  E-value: 3.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 129 LLVLCGDHGMSETGSHGASSTEEVNTPLILIS-SAFERKPGDIRHPKHVQ-----------------QTDVAATLAIALG 190
Cdd:cd16019  201 LLVVVSDHGMNNDGNHGGSSTEETSSFFFFISkKGFFKKRPIDQIEKIKQnneqqkidpseyiriiyQIDILPTICYLLG 280


                 ....*....
gi 573459698 191 LPIPKDSVG 199
Cdd:cd16019  281 IPIPFNNIG 289
sulfatase_like cd16148
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 129-204 2.78e-07

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293767 [Multi-domain]  Cd Length: 271  Bit Score: 52.94  E-value: 2.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 129 LLVLCGDHGMS-----ETGSHGASSTEE-VNTPLILissAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLL 202
Cdd:cd16148  193 LVIVTSDHGEEfgehgLYWGHGSNLYDEqLHVPLII---RWPGKEPGKRVDALVSHIDIAPTLLDLLGVEPPDYSDGRSL 269


                 ..
gi 573459698 203 FP 204
Cdd:cd16148  270 LP 271
AslA COG3119
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
129-210 9.72e-04

Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 442353 [Multi-domain]  Cd Length: 393  Bit Score: 42.56  E-value: 9.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 129 LLVLCGDHGMSeTGSHG-----ASSTEE-VNTPLIlISSAFERKPGDIRHpKHVQQTDVAATLAIALGLPIPKDSVG-SL 201
Cdd:COG3119  230 IVVFTSDNGPS-LGEHGlrggkGTLYEGgIRVPLI-VRWPGKIKAGSVSD-ALVSLIDLLPTLLDLAGVPIPEDLDGrSL 306


                 ....*....
gi 573459698 202 LfPVVEGRP 210
Cdd:COG3119  307 L-PLLTGEK 314
sulfatase_like cd16153
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 129-193 1.02e-03

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293772 [Multi-domain]  Cd Length: 282  Bit Score: 41.98  E-value: 1.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 129 LLVLCGDHGmSETGSHGASST-----EEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPI 193
Cdd:cd16153  201 IVYVTGDHG-WHLGEQGILAKftfwpQSHRVPLIVVSSDKLKAPAGKVRHDFVEFVDLAPTLLAAAGVDV 269
sulfatase_like cd16156
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ...
 126-213 1.42e-03

uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293775 [Multi-domain]  Cd Length: 468  Bit Score: 41.98  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 126 LPNLLVL-CGDHGMSeTGSH-----GASSTEEV-NTPLILISSAFERKPGDIRHPkhVQQTDVAATLAIALGLPIPKDSV 198
Cdd:cd16156  265 AEDAWVIyTSDHGDM-LGAHklwakGPAVYDEItNIPLIIRGKGGEKAGTVTDTP--VSHIDLAPTILDYAGIPQPKVLE 341

                         90
                 ....*....|....*
gi 573459698 199 GSLLFPVVEGRPMRE 213
Cdd:cd16156  342 GESILATIEDPEIPE 356
AtaC COG1524
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ...
 142-192 2.68e-03

c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];


Pssm-ID: 441133 [Multi-domain]  Cd Length: 370  Bit Score: 40.89  E-value: 2.68e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 573459698 142 GSHGASSTEEVNTPLILISSAFerkpgdirhPKHVQQTDVAATLAIALGLP 192
Cdd:COG1524  327 GSHGGLPDEEMRVPLLASGPGF---------RPGVRNVDVAPTIARLLGLP 368
sulfatase_like cd16155
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 129-224 6.03e-03

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293774 [Multi-domain]  Cd Length: 372  Bit Score: 39.86  E-value: 6.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459698 129 LLVLCGDHGMSeTGSHG---ASSTEE--VNTPLILISsaferkPG-----DIRHPkhVQQTDVAATLAIALGLPIPKDSV 198
Cdd:cd16155  222 IIVFTSDHGLA-VGSHGlmgKQNLYEhsMRVPLIISG------PGipkgkRRDAL--VYLQDVFPTLCELAGIEIPESVE 292

                         90       100
                 ....*....|....*....|....*...
gi 573459698 199 GSLLFPVVEG--RPMREQLrFLHLNTVQ 224
Cdd:cd16155  293 GKSLLPVIRGekKAVRDTL-YGAYRDGQ 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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