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Conserved domains on  [gi|611435010|ref|NP_001278350|]
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lysine-specific demethylase 6A isoform 6 [Homo sapiens]

Protein Classification

KDM6 family histone demethylase( domain architecture ID 11421451)

KDM6 family histone demethylase, similar to lysine-specific demethylase 6A (KDM6A), also called UTX (ubiquitously-transcribed TPR protein on the X chromosome) that specifically demethylates 'Lys-27' of histone H3, and UTY (ubiquitously-transcribed TPR protein on the Y chromosome) that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3

CATH:  1.25.40.10|2.60.120.10
EC:  1.14.11.-
Gene Ontology:  GO:0005515|GO:0032452|GO:0031490|GO:0046872
PubMed:  26059336|21153002|10517866|30708253|22404999|11165500|14697267|19478949
SCOP:  4001344|3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 837-945 1.08e-36

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


:

Pssm-ID: 396791  Cd Length: 114  Bit Score: 133.96  E-value: 1.08e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   837 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNN-------LNFLMGSWWPnlEDLYEANV 909
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 611435010   910 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNV 945
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
18-127 4.31e-21

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 93.92  E-value: 4.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG0457    27 AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELD 106

                          90       100       110
                  ....*....|....*....|....*....|
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCYLNA 127
Cdd:COG0457   107 PDDAEALYNLGLALLELGRYDEAIEAYERA 136
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 803-867 4.86e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


:

Pssm-ID: 214721  Cd Length: 58  Bit Score: 50.33  E-value: 4.86e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 611435010    803 QLHELTKLPafvrvvSAGNLLSHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 867
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 837-945 1.08e-36

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 133.96  E-value: 1.08e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   837 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNN-------LNFLMGSWWPnlEDLYEANV 909
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 611435010   910 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNV 945
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
18-127 4.31e-21

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 93.92  E-value: 4.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG0457    27 AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELD 106

                          90       100       110
                  ....*....|....*....|....*....|
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCYLNA 127
Cdd:COG0457   107 PDDAEALYNLGLALLELGRYDEAIEAYERA 136
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 803-867 4.86e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 50.33  E-value: 4.86e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 611435010    803 QLHELTKLPafvrvvSAGNLLSHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 867
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
TPR_17 pfam13431
Tetratricopeptide repeat;
21-52 3.93e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 35.98  E-value: 3.93e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 611435010    21 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 52
Cdd:pfam13431    1 LYLKALELDPNNADAYYNLAVLLLELGQSETA 32
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 14-124 6.06e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 6.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010    14 KESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 93
Cdd:TIGR02917  412 DPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKA 491

                           90       100       110
                   ....*....|....*....|....*....|.
gi 611435010    94 VQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 124
Cdd:TIGR02917  492 LSIEPDFFPAAANLARIDIQEGNPDDAIQRF 522
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 837-945 1.08e-36

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 133.96  E-value: 1.08e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   837 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNN-------LNFLMGSWWPnlEDLYEANV 909
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 611435010   910 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNV 945
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
18-127 4.31e-21

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 93.92  E-value: 4.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG0457    27 AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELD 106

                          90       100       110
                  ....*....|....*....|....*....|
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCYLNA 127
Cdd:COG0457   107 PDDAEALYNLGLALLELGRYDEAIEAYERA 136
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 18-124 6.84e-20

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 86.60  E-value: 6.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG4235     2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                          90       100
                  ....*....|....*....|....*..
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCY 124
Cdd:COG4235    82 PDNPEALYLLGLAAFQQGDYAEAIAAW 108
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
18-124 1.00e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 86.98  E-value: 1.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG0457    61 ALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140

                          90       100
                  ....*....|....*....|....*..
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCY 124
Cdd:COG0457   141 PDDADALYNLGIALEKLGRYEEALELL 167
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
26-129 1.76e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 86.21  E-value: 1.76e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   26 LEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWM 105
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                          90       100
                  ....*....|....*....|....
gi 611435010  106 DLGTLYESCNQPQDAIKCYLNATR 129
Cdd:COG0457    81 NLGLALQALGRYEEALEDYDKALE 104
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 18-182 2.79e-18

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 90.44  E-value: 2.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG3914    97 ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCYLNATRsKSCSNTSALAARIKYLQNTSDnWSGGHAVSHPPVQQQAHSWCLTPQK 177
Cdd:COG3914   177 PDNAEALNNLGNALQDLGRLEEAIAAYRRALE-LDPDNADAHSNLLFALRQACD-WEVYDRFEELLAALARGPSELSPFA 254


                  ....*
gi 611435010  178 LQHLE 182
Cdd:COG3914   255 LLYLP 259
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 18-205 3.39e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 80.16  E-value: 3.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG2956    95 AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLD 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKscSNTSALAARIKYLQNTSDNWSGGHAVSHPPVQQQAhswclTPQK 177
Cdd:COG2956   175 PDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEALELLRKALELDP-----SDDL 247

                         170       180
                  ....*....|....*....|....*...
gi 611435010  178 LQHLEQLRANRNNLNPAQKLMLEQLESQ 205
Cdd:COG2956   248 LLALADLLERKEGLEAALALLERQLRRH 275
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 18-127 7.50e-15

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 72.53  E-value: 7.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG4783    23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                          90       100       110
                  ....*....|....*....|....*....|
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCYLNA 127
Cdd:COG4783   103 PEHPEAYLRLARAYRALGRPDEAIAALEKA 132
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 47-151 1.61e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 71.56  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   47 GKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLN 126
Cdd:COG3914    92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRR 171

                          90       100
                  ....*....|....*....|....*
gi 611435010  127 ATRSKScSNTSALAARIKYLQNTSD 151
Cdd:COG3914   172 ALELDP-DNAEALNNLGNALQDLGR 195
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 18-148 3.47e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 68.22  E-value: 3.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG2956    61 AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCYLNA-TRSKSCSNTSALAARIKYLQN 148
Cdd:COG2956   141 PENAHAYCELAELYLEQGDYDEAIEALEKAlKLDPDCARALLLLAELYLEQG 192
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 18-148 1.28e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.29  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG2956    27 AIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELD 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCYLNATR-SKSCSNTSALAARIKYLQN 148
Cdd:COG2956   107 PDDAEALRLLAEIYEQEGDWEKAIEVLERLLKlGPENAHAYCELAELYLEQG 158
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
18-97 1.21e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 59.03  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAfISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG3063    11 AEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELD 89
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 18-97 2.90e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.44  E-value: 2.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG4783    57 AIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
27-122 2.18e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.77  E-value: 2.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   27 EADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMD 106
Cdd:COG4785    67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                          90
                  ....*....|....*.
gi 611435010  107 LGTLYESCNQPQDAIK 122
Cdd:COG4785   147 RGIALYYLGRYELAIA 162
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 18-97 4.22e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 56.51  E-value: 4.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG5010    73 SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 34-129 7.79e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 7.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   34 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYES 113
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                          90
                  ....*....|....*.
gi 611435010  114 CNQPQDAIKCYLNATR 129
Cdd:COG4783    85 AGDYDEALALLEKALK 100
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 35-151 1.33e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.43  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   35 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESC 114
Cdd:COG2956    10 GWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 611435010  115 NQPQDAIKCYLNATRSKScSNTSALAARIKYLQNTSD 151
Cdd:COG2956    90 GLLDRAEELLEKLLELDP-DDAEALRLLAEIYEQEGD 125
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 18-127 2.42e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.58  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 97
Cdd:COG5010    39 EDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALS 118

                          90       100       110
                  ....*....|....*....|....*....|
gi 611435010   98 HGHAAAWMDLGTLYESCNQPQDAIKCYLNA 127
Cdd:COG5010   119 PDNPNAYSNLAALLLSLGQDDEAKAALQRA 148
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 803-867 4.86e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 50.33  E-value: 4.86e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 611435010    803 QLHELTKLPafvrvvSAGNLLSHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 867
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
42-124 5.27e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.71  E-value: 5.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   42 CYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQaYICAVQLDHGHAAAWMDLGTLYESCNQPQDAI 121
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79


                  ...
gi 611435010  122 KCY 124
Cdd:COG3063    80 AYL 82
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 18-90 3.45e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 46.91  E-value: 3.45e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 611435010   18 AIQYLQKSLEADPNS---GQSWYFLGRCYSSIGKVQDAFISYRQSID---KSEASADTWCSIGVLYQQQNQPMDALQAY 90
Cdd:COG1729    12 AIAAFKAFLKRYPNSplaPDALYWLGEAYYALGDYDEAAEAFEKLLKrypDSPKAPDALLKLGLSYLELGDYDKARATL 90
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 75-129 2.86e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 2.86e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 611435010   75 VLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATR 129
Cdd:COG5010    62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALA 116
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 65-127 8.25e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.88  E-value: 8.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 611435010   65 ASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 127
Cdd:COG2956     6 AAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKL 68
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 18-68 2.19e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.30  E-value: 2.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASAD 68
Cdd:COG4235    70 AEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
18-68 3.61e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.46  E-value: 3.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 611435010   18 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASAD 68
Cdd:COG0457   129 AIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALL 179
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 16-124 6.73e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 6.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010   16 SYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKsEASADTWCSIGVLYQQQNQPMDALQAYICAVQ 95
Cdd:COG3914   163 EEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL-DPDNADAHSNLLFALRQACDWEVYDRFEELLA 241

                          90       100
                  ....*....|....*....|....*....
gi 611435010   96 LDHGHAAAWMDLGTLYESCNQPQDAIKCY 124
Cdd:COG3914   242 ALARGPSELSPFALLYLPDDDPAELLALA 270
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 76-129 9.23e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.44  E-value: 9.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 611435010   76 LYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATR 129
Cdd:COG3914    87 LLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALA 140
TPR_17 pfam13431
Tetratricopeptide repeat;
21-52 3.93e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 35.98  E-value: 3.93e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 611435010    21 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 52
Cdd:pfam13431    1 LYLKALELDPNNADAYYNLAVLLLELGQSETA 32
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 14-124 6.06e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 6.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010    14 KESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 93
Cdd:TIGR02917  412 DPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKA 491

                           90       100       110
                   ....*....|....*....|....*....|.
gi 611435010    94 VQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 124
Cdd:TIGR02917  492 LSIEPDFFPAAANLARIDIQEGNPDDAIQRF 522
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 5-99 8.31e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 39.51  E-value: 8.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 611435010    5 VDLLGDKATKesyAIQYLQKSLEADPNSGQSWYFLGR-CYSS--IGKVQDAFisyRQSIdKSEASADTWCSIGVLYQQQN 81
Cdd:COG3071   233 GRLQGGDPAK---QLKRAEKWLKKHPNDPDLLLALGRlCLRNqlWGKAREYL---EAAL-ALRPSAEAYAELARLLEQLG 305

                          90
                  ....*....|....*...
gi 611435010   82 QPMDALQAYICAVQLDHG 99
Cdd:COG3071   306 DPEEAAEHYRKALALALG 323
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 64-129 9.18e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 9.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 611435010   64 EASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATR 129
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALE 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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