|
Name |
Accession |
Description |
Interval |
E-value |
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
10-343 |
7.46e-55 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 193.57 E-value: 7.46e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 10 KYSDTLKKMDpDHLVALVTEVIP-NYSCLVFCPSKKNCENVAEMICKFLsKEYLKHKEKEKC-EVIKNLKNIGNGN-LCP 86
Cdd:COG1204 216 RFDDGSRRSK-DPTLALALDLLEeGGQVLVFVSSRRDAESLAKKLADEL-KRRLTPEEREELeELAEELLEVSEEThTNE 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 87 VLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPY-VAKEFLKRNQYKQMIGRAG 165
Cdd:COG1204 294 KLADCLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKrGGMVPIPVLEFKQMAGRAG 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 166 RAGIDTIGESILIlqEKDKQQVLELITKPL----ENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQ 241
Cdd:COG1204 374 RPGYDPYGEAILV--AKSSDEADELFERYIlgepEPIRSKLANE--SALRTHLLALIASGFANSREELLDFLENTFYAYQ 449
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 242 QkvllKEKSLWEITVESLRYLTEKGLLQKDTIYkseeevqynFHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLES 321
Cdd:COG1204 450 Y----DKGDLEEVVDDALEFLLENGFIEEDGDR---------LRATKLGKLVSRLYIDPLTAAELVDGLRKADEEFTDLG 516
|
330 340
....*....|....*....|..
gi 663071085 322 LLHLIYLTTpydlvsqcnpDWM 343
Cdd:COG1204 517 LLHLILILR----------DWI 528
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
20-522 |
3.82e-48 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 178.61 E-value: 3.82e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 20 PDHLVALVTEVI-PNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAY 98
Cdd:PRK02362 229 KDDTLNLVLDTLeEGGQCLVFVSSRRNAEGFAKRAASALKKTLTAAERAELAELAEEIREVSDTETSKDLADCVAKGAAF 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 99 HHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILR-----------APYVAKEflkrnqYKQMIGRAGRA 167
Cdd:PRK02362 309 HHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRdyrrydggagmQPIPVLE------YHQMAGRAGRP 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 168 GIDTIGESILIlqEKDKQQVLEL----ITKPLENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQK 243
Cdd:PRK02362 383 GLDPYGEAVLL--AKSYDELDELferyIWADPEDVRSKLATE--PALRTHVLSTIASGFARTRDGLLEFLEATFYATQTD 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 244 vllKEKSLWEITVESLRYLTEKGLLQKDtiyksEEEVqynfHITKLGRasfkgTIDLAYCDILY-RDLKKGLEGLVLES- 321
Cdd:PRK02362 459 ---DTGRLERVVDDVLDFLERNGMIEED-----GETL----EATELGH-----LVSRLYIDPLSaAEIIDGLEAAKKPTd 521
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 322 --LLHLIYLTtpydlvsqcnPD-WMIYFRqfsqlSPAEQNVAAILGVSES-FIGKKASgqaigkkVDKNVVNRLYLSFVL 397
Cdd:PRK02362 522 lgLLHLVCST----------PDmYELYLR-----SGDYEWLNEYLYEHEDeLLGDVPS-------EFEDDEFEDFLSAVK 579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 398 YTLLKETNIWTVSE-----KFNMPRGYIQN-------LLTGTASFSScvlhfceELEEFWVYRAllVELTKKLTYCVKAE 465
Cdd:PRK02362 580 TALLLEDWIDEVDEeriteRYGVGPGDIRGkvetaewLLHAAERLAS-------ELDLDLARAA--RELEKRVEYGVREE 650
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 663071085 466 LIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTidhLSRRQAKQIVSSAK 522
Cdd:PRK02362 651 LLDLVGLRGVGRVRARRLYNAGIESRADLRAADKSVVLAI---LGEKIAENILEQAG 704
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
3-178 |
1.19e-41 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 146.93 E-value: 1.19e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 3 FSRLLNYKYSDTLKKMDPDHLVALVTEVIPNY-SCLVFCPSKKNCENVAEMIckflskeylkhkekekceviknlknign 81
Cdd:cd18795 12 FNGLGIKLRVDVMNKFDSDIIVLLKIETVSEGkPVLVFCSSRKECEKTAKDL---------------------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 82 gnlcpvlkrtipFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAK----EFLKRNQY 157
Cdd:cd18795 64 ------------AGIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDgkgyRELSPLEY 131
|
170 180
....*....|....*....|.
gi 663071085 158 KQMIGRAGRAGIDTIGESILI 178
Cdd:cd18795 132 LQMIGRAGRPGFDTRGEAIIM 152
|
|
| HTH_61 |
pfam20470 |
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA ... |
173-269 |
2.59e-30 |
|
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA polymerase theta.
Pssm-ID: 466619 [Multi-domain] Cd Length: 92 Bit Score: 113.80 E-value: 2.59e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 173 GESILILQEKDKQQVLELITKPLENCYSHLVQEfTKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQKVLLKEKSlw 252
Cdd:pfam20470 1 GESILICKEKDLEKVAELLRAELPPVYSCLLPE-KRGIKRALLEIIALGLATSPEDVDEYMSCTLLSVQQKELDVEKS-- 77
|
90
....*....|....*..
gi 663071085 253 eiTVESLRYLTEKGLLQ 269
Cdd:pfam20470 78 --IESSLEELVENGLIT 92
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
90-168 |
6.71e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.16 E-value: 6.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 90 RTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLP-ARRVILRAPYVAKEflkrnQYKQMIGRAGRAG 168
Cdd:smart00490 8 KELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDLPWSPA-----SYIQRIGRAGRAG 82
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
469-522 |
2.28e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 36.31 E-value: 2.28e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 663071085 469 LMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDhLSRRQAKQIVSSAK 522
Cdd:pfam14520 4 LLSISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPG-IGEKTAQRIILELR 56
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
10-343 |
7.46e-55 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 193.57 E-value: 7.46e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 10 KYSDTLKKMDpDHLVALVTEVIP-NYSCLVFCPSKKNCENVAEMICKFLsKEYLKHKEKEKC-EVIKNLKNIGNGN-LCP 86
Cdd:COG1204 216 RFDDGSRRSK-DPTLALALDLLEeGGQVLVFVSSRRDAESLAKKLADEL-KRRLTPEEREELeELAEELLEVSEEThTNE 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 87 VLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPY-VAKEFLKRNQYKQMIGRAG 165
Cdd:COG1204 294 KLADCLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKrGGMVPIPVLEFKQMAGRAG 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 166 RAGIDTIGESILIlqEKDKQQVLELITKPL----ENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQ 241
Cdd:COG1204 374 RPGYDPYGEAILV--AKSSDEADELFERYIlgepEPIRSKLANE--SALRTHLLALIASGFANSREELLDFLENTFYAYQ 449
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 242 QkvllKEKSLWEITVESLRYLTEKGLLQKDTIYkseeevqynFHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLES 321
Cdd:COG1204 450 Y----DKGDLEEVVDDALEFLLENGFIEEDGDR---------LRATKLGKLVSRLYIDPLTAAELVDGLRKADEEFTDLG 516
|
330 340
....*....|....*....|..
gi 663071085 322 LLHLIYLTTpydlvsqcnpDWM 343
Cdd:COG1204 517 LLHLILILR----------DWI 528
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
20-522 |
3.82e-48 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 178.61 E-value: 3.82e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 20 PDHLVALVTEVI-PNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAY 98
Cdd:PRK02362 229 KDDTLNLVLDTLeEGGQCLVFVSSRRNAEGFAKRAASALKKTLTAAERAELAELAEEIREVSDTETSKDLADCVAKGAAF 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 99 HHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILR-----------APYVAKEflkrnqYKQMIGRAGRA 167
Cdd:PRK02362 309 HHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRdyrrydggagmQPIPVLE------YHQMAGRAGRP 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 168 GIDTIGESILIlqEKDKQQVLEL----ITKPLENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQK 243
Cdd:PRK02362 383 GLDPYGEAVLL--AKSYDELDELferyIWADPEDVRSKLATE--PALRTHVLSTIASGFARTRDGLLEFLEATFYATQTD 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 244 vllKEKSLWEITVESLRYLTEKGLLQKDtiyksEEEVqynfHITKLGRasfkgTIDLAYCDILY-RDLKKGLEGLVLES- 321
Cdd:PRK02362 459 ---DTGRLERVVDDVLDFLERNGMIEED-----GETL----EATELGH-----LVSRLYIDPLSaAEIIDGLEAAKKPTd 521
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 322 --LLHLIYLTtpydlvsqcnPD-WMIYFRqfsqlSPAEQNVAAILGVSES-FIGKKASgqaigkkVDKNVVNRLYLSFVL 397
Cdd:PRK02362 522 lgLLHLVCST----------PDmYELYLR-----SGDYEWLNEYLYEHEDeLLGDVPS-------EFEDDEFEDFLSAVK 579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 398 YTLLKETNIWTVSE-----KFNMPRGYIQN-------LLTGTASFSScvlhfceELEEFWVYRAllVELTKKLTYCVKAE 465
Cdd:PRK02362 580 TALLLEDWIDEVDEeriteRYGVGPGDIRGkvetaewLLHAAERLAS-------ELDLDLARAA--RELEKRVEYGVREE 650
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 663071085 466 LIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTidhLSRRQAKQIVSSAK 522
Cdd:PRK02362 651 LLDLVGLRGVGRVRARRLYNAGIESRADLRAADKSVVLAI---LGEKIAENILEQAG 704
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
3-178 |
1.19e-41 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 146.93 E-value: 1.19e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 3 FSRLLNYKYSDTLKKMDPDHLVALVTEVIPNY-SCLVFCPSKKNCENVAEMIckflskeylkhkekekceviknlknign 81
Cdd:cd18795 12 FNGLGIKLRVDVMNKFDSDIIVLLKIETVSEGkPVLVFCSSRKECEKTAKDL---------------------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 82 gnlcpvlkrtipFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAK----EFLKRNQY 157
Cdd:cd18795 64 ------------AGIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDgkgyRELSPLEY 131
|
170 180
....*....|....*....|.
gi 663071085 158 KQMIGRAGRAGIDTIGESILI 178
Cdd:cd18795 132 LQMIGRAGRPGFDTRGEAIIM 152
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
11-528 |
2.75e-31 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 128.85 E-value: 2.75e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 11 YSDTLKKMDPDHLVALVTEVIPNYSCLVFCPSKKNCENVAEMICKFLSKeylkhkekekcevIKNLK-NIGNGNLCP-VL 88
Cdd:PRK01172 214 ILDGYERSQVDINSLIKETVNDGGQVLVFVSSRKNAEDYAEMLIQHFPE-------------FNDFKvSSENNNVYDdSL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 89 KRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVIL----RAPYVAKEFLKRNQYKQMIGRA 164
Cdd:PRK01172 281 NEMLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVrditRYGNGGIRYLSNMEIKQMIGRA 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 165 GRAGIDTIGESILILQEKDKQQVL-ELITKPLENCYSHLVQEFTKGIQTlfLSLIGLKIATNLDDIYHFMNGTFFGVQQK 243
Cdd:PRK01172 361 GRPGYDQYGIGYIYAASPASYDAAkKYLSGEPEPVISYMGSQRKVRFNT--LAAISMGLASSMEDLILFYNETLMAIQNG 438
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 244 VLLKEKSLweitVESLRYLTEKGLLQKDTIYKSeeevqynfhiTKLGRAsfkgTIDLaYCDIlyrdlkkgleglvlESLL 323
Cdd:PRK01172 439 VDEIDYYI----ESSLKFLKENGFIKGDVTLRA----------TRLGKL----TSDL-YIDP--------------ESAL 485
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 324 HLI-YLTTPYDLvsqcnpDWMIYFRQFS-QLSPAE-QNVAAILGVSESfIGkkasgqaigkKVDKNvVNRLYLSFVLYTL 400
Cdd:PRK01172 486 ILKsAFDHDYDE------DLALYYISLCrEIIPANtRDDYYAMEFLED-IG----------VIDGD-ISAAKTAMVLRGW 547
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 401 LKETNIWTVSEKFNMPRGYIQNLLTGTASFSSCVLHFCEeleefwVY----RALLVELTKKLTYCVKAELIPLMEVTGVL 476
Cdd:PRK01172 548 ISEASMQKITDTYGIAPGDVQARASSADWISYSLARLSS------IYkpemRRKLEILNIRIKEGIREDLIDLVLIPKVG 621
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 663071085 477 EGRAKQLYSAGYKSLMHLANANPEvLVRTIDHLSRRQAKQIVSSAKMLLHEK 528
Cdd:PRK01172 622 RVRARRLYDAGFKTVDDIARSSPE-RIKKIYGFSDTLANAIVNRAMKISSMY 672
|
|
| HTH_61 |
pfam20470 |
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA ... |
173-269 |
2.59e-30 |
|
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA polymerase theta.
Pssm-ID: 466619 [Multi-domain] Cd Length: 92 Bit Score: 113.80 E-value: 2.59e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 173 GESILILQEKDKQQVLELITKPLENCYSHLVQEfTKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQKVLLKEKSlw 252
Cdd:pfam20470 1 GESILICKEKDLEKVAELLRAELPPVYSCLLPE-KRGIKRALLEIIALGLATSPEDVDEYMSCTLLSVQQKELDVEKS-- 77
|
90
....*....|....*..
gi 663071085 253 eiTVESLRYLTEKGLLQ 269
Cdd:pfam20470 78 --IESSLEELVENGLIT 92
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
37-504 |
1.25e-29 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 123.77 E-value: 1.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 37 LVFCPSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLK-NIGNGNLcpvlKRTIPFGVAYHHSGLTSDERKLLEEAY 115
Cdd:PRK00254 242 LVFVNTRRSAEKEALELAKKIKRFLTKPELRALKELADSLEeNPTNEKL----KKALRGGVAFHHAGLGRTERVLIEDAF 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 116 STGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEF----LKRNQYKQMIGRAGRAGIDTIGESILILQEKDKQQVLE-- 189
Cdd:PRK00254 318 REGLIKVITATPTLSAGINLPAFRVIIRDTKRYSNFgwedIPVLEIQQMMGRAGRPKYDEVGEAIIVATTEEPSKLMEry 397
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 190 LITKPlENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQkvllKEKSLWEITVESLRYLtekgLLQ 269
Cdd:PRK00254 398 IFGKP-EKLFSMLSNE--SAFRSQVLALITNFGVSNFKELVNFLERTFYAHQR----KDLYSLEEKAKEIVYF----LLE 466
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 270 KDTIyksEEEVQYNFHITKLGRASFKGTIDlaycDILYRDLKKGLEGLVLE----SLLHLIYLT---TPYDLVSQCNPDW 342
Cdd:PRK00254 467 NEFI---DIDLEDRFIPLPLGIRTSQLYID----PLTAKKFKDAFPKIEKNpnplGIFQLIASTpdmTPLNYSRKEMEDL 539
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 343 MIYFRQFsqlspaEQNVAAILGVSESFIGKKASGQAIGKKvdknvvnrlylsfVLYTLLKETNIWTVSEKFNMPRGYIQN 422
Cdd:PRK00254 540 LDEAYEM------EDRLYFNIPYWEDYKFQKFLRAFKTAK-------------VLLDWINEVPEGEIVETYNIDPGDLYR 600
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 423 LLtgtasfsscvlhfceELEEFWVYRalLVELTK-----------------KLTYCVKAELIPLMEVTGVLEGRAKQLYS 485
Cdd:PRK00254 601 IL---------------ELADWLMYS--LIELYKlfepkqevldyletlhlRVKHGVREELLELMRLPMIGRKRARALYN 663
|
490
....*....|....*....
gi 663071085 486 AGYKSLMHLANANPEVLVR 504
Cdd:PRK00254 664 AGFRSIEDIVNAKPSELLK 682
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
13-196 |
8.53e-19 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 90.38 E-value: 8.53e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 13 DTLKKMDPDHLValvteviPNYsclVFCPSKKNCENVAEMIckfLSKEYLKHKEKEK-CEVIKNLKNIGNGNLCPVLKRT 91
Cdd:COG4581 231 EVIEELDRGGLL-------PAI---VFIFSRRGCDEAAQQL---LSARLTTKEERAEiREAIDEFAEDFSVLFGKTLSRL 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 92 IPFGVAYHHSGLTSDERKLLEEAYSTG---VLClftCTSTLAAGVNLPARRVIL----------RAPYVAKEFLkrnqyk 158
Cdd:COG4581 298 LRRGIAVHHAGMLPKYRRLVEELFQAGllkVVF---ATDTLAVGINMPARTVVFtklskfdgerHRPLTAREFH------ 368
|
170 180 190
....*....|....*....|....*....|....*....
gi 663071085 159 QMIGRAGRAGIDTIGESILILQE-KDKQQVLELITKPLE 196
Cdd:COG4581 369 QIAGRAGRRGIDTEGHVVVLAPEhDDPKKFARLASARPE 407
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
90-168 |
6.71e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.16 E-value: 6.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 90 RTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLP-ARRVILRAPYVAKEflkrnQYKQMIGRAGRAG 168
Cdd:smart00490 8 KELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDLPWSPA-----SYIQRIGRAGRAG 82
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
85-184 |
1.14e-10 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 64.53 E-value: 1.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 85 CPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIGRA 164
Cdd:COG1202 440 CHEIARALGYKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPASQVIFDSLAMGIEWLSVQEFHQMLGRA 519
|
90 100
....*....|....*....|
gi 663071085 165 GRAGIDTIGEsILILQEKDK 184
Cdd:COG1202 520 GRPDYHDRGK-VYLLVEPGK 538
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
59-168 |
3.21e-10 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 57.61 E-value: 3.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 59 KEYLKHKEKEKCEVIKNLKNIGNGNLcpvLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLP-A 137
Cdd:pfam00271 7 LELLKKERGGKVLIFSQTKKTLEAEL---LLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdV 83
|
90 100 110
....*....|....*....|....*....|..
gi 663071085 138 RRVI-LRAPYvakeflKRNQYKQMIGRAGRAG 168
Cdd:pfam00271 84 DLVInYDLPW------NPASYIQRIGRAGRAG 109
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
35-166 |
3.52e-06 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 46.87 E-value: 3.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 35 SCLVFCPSKKNCENVAEmickflskeylkhkekekcevikNLKNigngnLCPvlKRTIPFGVAYHHSGLTSDERKLLEEA 114
Cdd:cd18796 40 STLVFTNTRSQAERLAQ-----------------------RLRE-----LCP--DRVPPDFIALHHGSLSRELREEVEAA 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 663071085 115 YSTGVLCLFTCTSTLAAGVNLPA-RRVI-LRAPYVAKEFLKRnqykqmIGRAGR 166
Cdd:cd18796 90 LKRGDLKVVVATSSLELGIDIGDvDLVIqIGSPKSVARLLQR------LGRSGH 137
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
23-181 |
1.03e-05 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 48.29 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 23 LVALVTEvipNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKekekceviknlknigngnlcpvlkrtipfgVAYHHSG 102
Cdd:COG1205 281 LADLVRE---GLRTLVFTRSRRGAELLARYARRALREPDLADR------------------------------VAAYRAG 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 103 LTSDERKLLEEAYSTG-VLCLFTcTSTLAAGVNLP---ArrVILRA-PYvakeflKRNQYKQMIGRAGRAGIDtiGESIL 177
Cdd:COG1205 328 YLPEERREIERGLRSGeLLGVVS-TNALELGIDIGgldA--VVLAGyPG------TRASFWQQAGRAGRRGQD--SLVVL 396
|
....
gi 663071085 178 ILQE 181
Cdd:COG1205 397 VAGD 400
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
469-522 |
2.28e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 36.31 E-value: 2.28e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 663071085 469 LMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDhLSRRQAKQIVSSAK 522
Cdd:pfam14520 4 LLSISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPG-IGEKTAQRIILELR 56
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
21-179 |
3.46e-03 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 37.87 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 21 DHLVALVTEVIPNYSCLVFCPSKKNCENVAEMICKFlskeylkhkeKEKCEVIknlknigngnlcpvlkrtipfgvayhH 100
Cdd:cd18787 15 LLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEEL----------GIKVAAL--------------------------H 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 101 SGLTSDERKLLEEAYSTG-VLCLFtCTSTLAAGVNLPA-RRVI-LRAPYVAKEFLKRnqykqmIGRAGRAGidTIGESIL 177
Cdd:cd18787 59 GDLSQEERERALKKFRSGkVRVLV-ATDVAARGLDIPGvDHVInYDLPRDAEDYVHR------IGRTGRAG--RKGTAIT 129
|
..
gi 663071085 178 IL 179
Cdd:cd18787 130 FV 131
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
36-168 |
3.63e-03 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 38.01 E-value: 3.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071085 36 CLVFCPSKKNCENVAEMIckflsKEYLKHKEkekceviknlknigngnlcPVLKRtipfgVAYHHSGLTSDERKLLEEAY 115
Cdd:cd18797 38 TIVFCRSRKLAELLLRYL-----KARLVEEG-------------------PLASK-----VASYRAGYLAEDRREIEAEL 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 663071085 116 STGVLCLFTCTSTLAAGVNLPARRVILRAPY---VAKeflkrnqYKQMIGRAGRAG 168
Cdd:cd18797 89 FNGELLGVVATNALELGIDIGGLDAVVLAGYpgsLAS-------LWQQAGRAGRRG 137
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
108-178 |
4.04e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 36.14 E-value: 4.04e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 663071085 108 RKLLEEAYStgVLCLFTCTSTLAAGVNLP-ARRVILRAPYVAKeflkrNQYKQMIGRAGRAGiDTIGESILI 178
Cdd:cd18785 13 IEHAEEIAS--SLEILVATNVLGEGIDVPsLDTVIFFDPPSSA-----ASYIQRVGRAGRGG-KDEGEVILF 76
|
|
| |
