|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
427-844 |
1.10e-29 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 122.71 E-value: 1.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 427 LRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVIS 506
Cdd:COG2319 16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 507 SDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQi 583
Cdd:COG2319 96 ASADGTVRLWDLATGLLLRTLTG-HTGA-VRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGAvtSVAFSP- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 584 lilKKKILVTG-WERAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNSTENAHHVL 661
Cdd:COG2319 173 ---DGKLLASGsDDGTVRLWDLATGKLLR----TLTG---HTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 662 ------------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFLKarkntavtG 729
Cdd:COG2319 243 tghsgsvrsvafSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHS--------------GGVNSVAFSP--------D 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 730 GANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIEeyclnssknkitkAPTL 808
Cdd:COG2319 300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPD--GKTLASGSDDGTVRLWDLA-------------TGEL 364
|
410 420 430
....*....|....*....|....*....|....*.
gi 1150273469 809 IRSFQPHEDRISSLEMCePGGQLLiISSSADCSICV 844
Cdd:COG2319 365 LRTLTGHTGAVTSVAFS-PDGRTL-ASGSADGTVRL 398
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
482-842 |
4.57e-29 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 118.21 E-value: 4.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 482 SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 562 FN-GYCHHTLnVGQDGAV---DISQililKKKILVT-GWERAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPPQ 636
Cdd:cd00200 80 LEtGECVRTL-TGHTSYVssvAFSP----DGRILSSsSRDKTIKVWDVETGKCLT----TLRG---HTDWVNSVAFSPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 637 TLVT-GSYDGEIVLWNNSTEnahhvlhpdyqrllkskldtKPQKLLSAgrsqpshpmadHsttgvrnfeidtegKNAVMR 715
Cdd:cd00200 148 TFVAsSSQDGTIKLWDLRTG--------------------KCVATLTG-----------H--------------TGEVNS 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 716 LCFLKarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHS-GVGSIIMSTDkmNRYLTTGDLDGWLKIWNieeyc 794
Cdd:cd00200 183 VAFSP--------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPD--GYLLASGSEDGTIRVWD----- 247
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1150273469 795 lnssknkiTKAPTLIRSFQPHEDRISSLeMCEPGGQLLiISSSADCSI 842
Cdd:cd00200 248 --------LRTGECVQTLSGHTNSVTSL-AWSPDGKRL-ASGSADGTI 285
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
246-564 |
6.95e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.52 E-value: 6.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319 172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319 320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397
|
....*.
gi 1150273469 559 IWDFNG 564
Cdd:COG2319 398 LWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
139-431 |
1.06e-10 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 63.89 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 139 HKDTIQKVIFLKNSSHYLTISKEGLLAIWgehlKLQETFPITSDatKLKHLWVTSLVSLENVNKIAVAFTSKEVCFYDLl 218
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW----DLETGELLRTL--KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 219 skEEFACQYKLQGLKGTPICMDY-----------------WYDpLDANESILSFGDITGKVQAIAF--TAALIslferpA 279
Cdd:cd00200 81 --ETGECVRTLTGHTSYVSSVAFspdgrilssssrdktikVWD-VETGKCLTTLRGHTDWVNSVAFspDGTFV------A 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 280 SACEDGeaTMTInWaELLSGchKCCHILEHklHQGdWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLN-MTSFN 358
Cdd:cd00200 152 SSSQDG--TIKL-W-DLRTG--KCVATLTG--HTG-EVNSVAFSPDGEKLLSSSSDGT---IKLWDLSTGKCLGtLRGHE 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1150273469 359 iaQGIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:cd00200 220 --NGVNSVAFSPDGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
520-561 |
5.71e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.14 E-value: 5.71e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1150273469 520 TGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:smart00320 1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
521-561 |
2.82e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.25 E-value: 2.82e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1150273469 521 GQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:pfam00400 1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
394-431 |
8.79e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.68 E-value: 8.79e-04
10 20 30
....*....|....*....|....*....|....*...
gi 1150273469 394 KPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
393-431 |
3.21e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 3.21e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1150273469 393 SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
427-844 |
1.10e-29 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 122.71 E-value: 1.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 427 LRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVIS 506
Cdd:COG2319 16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 507 SDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQi 583
Cdd:COG2319 96 ASADGTVRLWDLATGLLLRTLTG-HTGA-VRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGAvtSVAFSP- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 584 lilKKKILVTG-WERAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNSTENAHHVL 661
Cdd:COG2319 173 ---DGKLLASGsDDGTVRLWDLATGKLLR----TLTG---HTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 662 ------------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFLKarkntavtG 729
Cdd:COG2319 243 tghsgsvrsvafSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHS--------------GGVNSVAFSP--------D 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 730 GANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIEeyclnssknkitkAPTL 808
Cdd:COG2319 300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPD--GKTLASGSDDGTVRLWDLA-------------TGEL 364
|
410 420 430
....*....|....*....|....*....|....*.
gi 1150273469 809 IRSFQPHEDRISSLEMCePGGQLLiISSSADCSICV 844
Cdd:COG2319 365 LRTLTGHTGAVTSVAFS-PDGRTL-ASGSADGTVRL 398
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
482-842 |
4.57e-29 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 118.21 E-value: 4.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 482 SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 562 FN-GYCHHTLnVGQDGAV---DISQililKKKILVT-GWERAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPPQ 636
Cdd:cd00200 80 LEtGECVRTL-TGHTSYVssvAFSP----DGRILSSsSRDKTIKVWDVETGKCLT----TLRG---HTDWVNSVAFSPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 637 TLVT-GSYDGEIVLWNNSTEnahhvlhpdyqrllkskldtKPQKLLSAgrsqpshpmadHsttgvrnfeidtegKNAVMR 715
Cdd:cd00200 148 TFVAsSSQDGTIKLWDLRTG--------------------KCVATLTG-----------H--------------TGEVNS 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 716 LCFLKarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHS-GVGSIIMSTDkmNRYLTTGDLDGWLKIWNieeyc 794
Cdd:cd00200 183 VAFSP--------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPD--GYLLASGSEDGTIRVWD----- 247
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1150273469 795 lnssknkiTKAPTLIRSFQPHEDRISSLeMCEPGGQLLiISSSADCSI 842
Cdd:cd00200 248 --------LRTGECVQTLSGHTNSVTSL-AWSPDGKRL-ASGSADGTI 285
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
365-791 |
3.78e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 118.09 E-value: 3.78e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 365 AFDYHSRLNLIATAGINNKVCLWNPYVvSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIacs 444
Cdd:COG2319 41 SLAASPDGARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL--- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 445 fpksqdfrclfhfdeahgrlfisfnnqlallamkseaskrvKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKI 524
Cdd:COG2319 117 -----------------------------------------TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 525 KQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQililKKKILVTG-WERAIT 600
Cdd:COG2319 156 RTLTG-HSGA-VTSVAFSPDGKLLASGSDDGTVRLWDLaTGKLLRTLTGHTGAvrSVAFSP----DGKLLASGsADGTVR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 601 VFRPQNFNQffiqPEEWKGgiqHHDDILCAAFLP-PQTLVTGSYDGEIVLWNNSTENAHHVL------------HPDYQR 667
Cdd:COG2319 230 LWDLATGKL----LRTLTG---HSGSVRSVAFSPdGRLLASGSADGTVRLWDLATGELLRTLtghsggvnsvafSPDGKL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 668 LLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFlkarkntaVTGGANLVSCGGSGYVRFWDI 747
Cdd:COG2319 303 LASGSDDGTV-RLWDLATGKLLRTLTGHT--------------GAVRSVAF--------SPDGKTLASGSDDGTVRLWDL 359
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1150273469 748 YKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIE 791
Cdd:COG2319 360 ATGELLRTLTGHTGaVTSVAFSPD--GRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
362-651 |
7.32e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 108.58 E-value: 7.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 362 GIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRI 441
Cdd:cd00200 11 GVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 442 ACSfpkSQDFRCLfHFDeAHGRLFI--SFNNQLALLAMKSEASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMI 518
Cdd:cd00200 90 TGH---TSYVSSV-AFS-PDGRILSssSRDKTIKVWDVETGKCLTTlRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 519 DTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDG--AVDISQililKKKILVTG- 594
Cdd:cd00200 165 RTGKCVATLTG-H-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGvnSVAFSP----DGYLLASGs 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1150273469 595 WERAITVFRPQNFnqffiqpEEWKGGIQHHDDILCAAFLP-PQTLVTGSYDGEIVLWN 651
Cdd:cd00200 239 EDGTIRVWDLRTG-------ECVQTLSGHTNSVTSLAWSPdGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
311-654 |
1.35e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.77 E-value: 1.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 311 LHQGDWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLNmTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPy 390
Cdd:COG2319 75 LGHTAAVLSVAFSPDGRLLASASADGT---VRLWDLATGLLLR-TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL- 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 391 VVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQ----------HQLSIQRIACSfpksqdfrclfhfdeA 460
Cdd:COG2319 150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtgkllrtltgHTGAVRSVAFS---------------P 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 461 HGRLFIS--FNNQLALLAMKS-EASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGnaEIS 537
Cdd:COG2319 215 DGKLLASgsADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVN 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 538 TMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLN--VGQDGAVDISQililKKKILVTG-WERAITVFRPQNFNQffiq 613
Cdd:COG2319 293 SVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTghTGAVRSVAFSP----DGKTLASGsDDGTVRLWDLATGEL---- 364
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1150273469 614 PEEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNST 654
Cdd:COG2319 365 LRTLTG---HTGAVTSVAFSPDgRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
246-564 |
6.95e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.52 E-value: 6.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319 172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319 320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397
|
....*.
gi 1150273469 559 IWDFNG 564
Cdd:COG2319 398 LWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
139-431 |
1.06e-10 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 63.89 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 139 HKDTIQKVIFLKNSSHYLTISKEGLLAIWgehlKLQETFPITSDatKLKHLWVTSLVSLENVNKIAVAFTSKEVCFYDLl 218
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW----DLETGELLRTL--KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 219 skEEFACQYKLQGLKGTPICMDY-----------------WYDpLDANESILSFGDITGKVQAIAF--TAALIslferpA 279
Cdd:cd00200 81 --ETGECVRTLTGHTSYVSSVAFspdgrilssssrdktikVWD-VETGKCLTTLRGHTDWVNSVAFspDGTFV------A 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 280 SACEDGeaTMTInWaELLSGchKCCHILEHklHQGdWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLN-MTSFN 358
Cdd:cd00200 152 SSSQDG--TIKL-W-DLRTG--KCVATLTG--HTG-EVNSVAFSPDGEKLLSSSSDGT---IKLWDLSTGKCLGtLRGHE 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1150273469 359 iaQGIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:cd00200 220 --NGVNSVAFSPDGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
733-848 |
3.81e-05 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 46.94 E-value: 3.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150273469 733 LVSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKMNRYLTTGDlDGWLKIWNIEeyclnssknkitkAPTLIRSF 812
Cdd:cd00200 24 LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS-DKTIRLWDLE-------------TGECVRTL 89
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1150273469 813 QPHEDRISSLeMCEPGGQlLIISSSADCSICV----TGVC 848
Cdd:cd00200 90 TGHTSYVSSV-AFSPDGR-ILSSSSRDKTIKVwdveTGKC 127
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
520-561 |
5.71e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.14 E-value: 5.71e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1150273469 520 TGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:smart00320 1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
521-561 |
2.82e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.25 E-value: 2.82e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1150273469 521 GQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:pfam00400 1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
394-431 |
8.79e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.68 E-value: 8.79e-04
10 20 30
....*....|....*....|....*....|....*...
gi 1150273469 394 KPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
393-431 |
3.21e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 3.21e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1150273469 393 SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
623-651 |
8.99e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 34.98 E-value: 8.99e-03
10 20 30
....*....|....*....|....*....|
gi 1150273469 623 HHDDILCAAFLP-PQTLVTGSYDGEIVLWN 651
Cdd:smart00320 11 HTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
|
|
| |
