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Conserved domains on  [gi|1383484541|ref|NP_001349666|]
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WD repeat-containing protein 91 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
407-765 4.59e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 4.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 485
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 486 LCEININDNmpriqpqdqsapslcgqaegltqahvccRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvp 565
Cdd:COG2319   155 LRTLTGHSG----------------------------AVTSVAFSPDGKLLA------------------SGSDD----- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 566 GRLLLWDTKTmkQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTV 645
Cdd:COG2319   184 GTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 646 YSIGEDGKFIQWNIhKSGLKVSEYSLPSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFD 701
Cdd:COG2319   262 ASGSADGTVRLWDL-ATGELLRTLTGHSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFS 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1383484541 702 SEGNYMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 765
Cdd:COG2319   340 PDGKTLASGSDDGTVrLWDLATGELLRT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
407-765 4.59e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 4.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 485
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 486 LCEININDNmpriqpqdqsapslcgqaegltqahvccRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvp 565
Cdd:COG2319   155 LRTLTGHSG----------------------------AVTSVAFSPDGKLLA------------------SGSDD----- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 566 GRLLLWDTKTmkQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTV 645
Cdd:COG2319   184 GTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 646 YSIGEDGKFIQWNIhKSGLKVSEYSLPSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFD 701
Cdd:COG2319   262 ASGSADGTVRLWDL-ATGELLRTLTGHSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFS 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1383484541 702 SEGNYMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 765
Cdd:COG2319   340 PDGKTLASGSDDGTVrLWDLATGELLRT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-765 2.19e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.19e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNL 486
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 487 CEInindnmpriqpqdqsapslcgqaegltQAHvCCRILSLACSPNGaSFVCSaaapsltSQVDfsapdigskgmnqvpG 566
Cdd:cd00200    87 RTL---------------------------TGH-TSYVSSVAFSPDG-RILSS-------SSRD---------------K 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 567 RLLLWDTKTMKQQlqFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVY 646
Cdd:cd00200   116 TIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLL 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 647 SIGEDGKFIQWNIhKSGLKVSEYSLPSDatgpFVLSGysgykqvqvprgrlfAFDSEGNYMLTCSATGGV-IYKLGGDEK 725
Cdd:cd00200   194 SSSSDGTIKLWDL-STGKCLGTLRGHEN----GVNSV---------------AFSPDGYLLASGSEDGTIrVWDLRTGEC 253

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1383484541 726 VLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 765
Cdd:cd00200   254 VQT----LSGHTNSVTSLAWSP--DGKRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 590-616 8.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.22e-05
                           10        20
                   ....*....|....*....|....*..
gi 1383484541  590 AINCTAFNHNGNLLVTGAADGVIRLFD 616
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 581-641 4.86e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 4.86e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1383484541 581 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD 641
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
407-765 4.59e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 4.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 485
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 486 LCEININDNmpriqpqdqsapslcgqaegltqahvccRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvp 565
Cdd:COG2319   155 LRTLTGHSG----------------------------AVTSVAFSPDGKLLA------------------SGSDD----- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 566 GRLLLWDTKTmkQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTV 645
Cdd:COG2319   184 GTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 646 YSIGEDGKFIQWNIhKSGLKVSEYSLPSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFD 701
Cdd:COG2319   262 ASGSADGTVRLWDL-ATGELLRTLTGHSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFS 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1383484541 702 SEGNYMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 765
Cdd:COG2319   340 PDGKTLASGSDDGTVrLWDLATGELLRT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-765 2.19e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.19e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNL 486
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 487 CEInindnmpriqpqdqsapslcgqaegltQAHvCCRILSLACSPNGaSFVCSaaapsltSQVDfsapdigskgmnqvpG 566
Cdd:cd00200    87 RTL---------------------------TGH-TSYVSSVAFSPDG-RILSS-------SSRD---------------K 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 567 RLLLWDTKTMKQQlqFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVY 646
Cdd:cd00200   116 TIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLL 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 647 SIGEDGKFIQWNIhKSGLKVSEYSLPSDatgpFVLSGysgykqvqvprgrlfAFDSEGNYMLTCSATGGV-IYKLGGDEK 725
Cdd:cd00200   194 SSSSDGTIKLWDL-STGKCLGTLRGHEN----GVNSV---------------AFSPDGYLLASGSEDGTIrVWDLRTGEC 253

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1383484541 726 VLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 765
Cdd:cd00200   254 VQT----LSGHTNSVTSLAWSP--DGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
420-659 1.77e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 1.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 420 GRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKNLCEININDNMPR- 497
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS--PDgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRs 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 498 --IQPQDQ---SAPS--------LCGQAEGLTQAHVCCRILSLACSPNGASFVCsaaapsltsqvdfsapdiGSKGmnqv 564
Cdd:COG2319   252 vaFSPDGRllaSGSAdgtvrlwdLATGELLRTLTGHSGGVNSVAFSPDGKLLAS------------------GSDD---- 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 565 pGRLLLWDTKTmkQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENT 644
Cdd:COG2319   310 -GTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386

                         250
                  ....*....|....*
gi 1383484541 645 VYSIGEDGKFIQWNI 659
Cdd:COG2319   387 LASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-658 4.01e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 4.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNpiMQTKASSIS--KSPLLSLEWatKRDRLLLLGSGV-GTVRLYDTEAK 483
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLE--TGECVRTLTghTSYVSSVAF--SPDGRILSSSSRdKTIKVWDVETG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 484 KnlCEININD-----NMPRIQPQDQ----------------SAPSLCGQAEGltqaHVCCrILSLACSPNGASFVCSAAa 542
Cdd:cd00200   126 K--CLTTLRGhtdwvNSVAFSPDGTfvasssqdgtiklwdlRTGKCVATLTG----HTGE-VNSVAFSPDGEKLLSSSS- 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 543 psltsqvdfsapDigskgmnqvpGRLLLWDTKTMKQQLQFSLDPEPIaiNCTAFNHNGNLLVTGAADGVIRLFDMQQHEC 622
Cdd:cd00200   198 ------------D----------GTIKLWDLSTGKCLGTLRGHENGV--NSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1383484541 623 AMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 658
Cdd:cd00200   254 VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
420-618 5.56e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 420 GRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNmpriq 499
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG----- 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 500 pqdqsapslcgqaegltqahvccRILSLACSPNGaSFVCSAAApsltsqvdfsapDigskgmnqvpGRLLLWDTKTMKQQ 579
Cdd:COG2319   332 -----------------------AVRSVAFSPDG-KTLASGSD------------D----------GTVRLWDLATGELL 365

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1383484541 580 LQFSLDPEPIaiNCTAFNHNGNLLVTGAADGVIRLFDMQ 618
Cdd:COG2319   366 RTLTGHTGAV--TSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 626-773 1.37e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383484541 626 WRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhksglkvseyslpsdATGPFVLSGYSGYKQVQVprgrlFAFDSEGN 705
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL---------------ETGELLRTLKGHTGPVRD-----VAASADGT 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1383484541 706 YMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL---------TTLLAHKA 773
Cdd:cd00200    65 YLASGSSDKTIrLWDLETGECVRT----LTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVwdvetgkclTTLRGHTD 136
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 590-616 8.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.22e-05
                           10        20
                   ....*....|....*....|....*..
gi 1383484541  590 AINCTAFNHNGNLLVTGAADGVIRLFD 616
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 581-641 4.86e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 4.86e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1383484541 581 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD 641
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
590-616 8.41e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 8.41e-04
                          10        20
                  ....*....|....*....|....*..
gi 1383484541 590 AINCTAFNHNGNLLVTGAADGVIRLFD 616
Cdd:pfam00400  13 SVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 621-658 3.86e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1383484541  621 ECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 658
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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