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Conserved domains on  [gi|1864245103|ref|NP_001371902|]
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protein NLRC5 isoform 21 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Atypical_Card pfam18461
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ...
 1-95 6.96e-54

Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.


:

Pssm-ID: 436519  Cd Length: 95  Bit Score: 182.54  E-value: 6.96e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103    1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461    1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80

                           90
                   ....*....|....*
gi 1864245103   81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461   81 EVPLDLEVPLLSTWG 95
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 222-383 8.06e-47

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 165.17  E-value: 8.06e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159


                   ....*..
gi 1864245103  377 NHFFSAQ 383
Cdd:pfam05729  160 RKYFSDE 166
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
173-530 8.03e-25

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 112.21  E-value: 8.03e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635    131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635    211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635    284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635    362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1864245103  480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635    436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 751-1069 5.38e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 84.84  E-value: 5.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238     69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238    147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238    221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245103  991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238    281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
NLRC4_HD2 super family cl39284
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 514-628 1.83e-09

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


The actual alignment was detected with superfamily member pfam17776:

Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 56.53  E-value: 1.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRWVQRT---KARLGLSDHLP---TFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776    1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKRESLKSlldKALKSKNGHLDlflRFLFGLLNEENQRLLEGL-LGCKL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1864245103  587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776   80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
649-782 1.03e-05

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 1.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886    153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1864245103  729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886    220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
 
Name Accession Description Interval E-value
Atypical_Card pfam18461
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ...
 1-95 6.96e-54

Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.


Pssm-ID: 436519  Cd Length: 95  Bit Score: 182.54  E-value: 6.96e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103    1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461    1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80

                           90
                   ....*....|....*
gi 1864245103   81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461   81 EVPLDLEVPLLSTWG 95
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 222-383 8.06e-47

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 165.17  E-value: 8.06e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159


                   ....*..
gi 1864245103  377 NHFFSAQ 383
Cdd:pfam05729  160 RKYFSDE 166
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
173-530 8.03e-25

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 112.21  E-value: 8.03e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635    131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635    211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635    284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635    362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1864245103  480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635    436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 751-1069 5.38e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 84.84  E-value: 5.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238     69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238    147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238    221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245103  991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238    281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 745-1069 5.47e-14

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 74.31  E-value: 5.47e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  745 KEVSFRDNQLSDQVVLnivEVLPHLPRLRKLDLSSNSICVSTLLCLARvavtcptvrMLQAREADLIFLLSpptetTAEL 824
Cdd:cd00116      1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLS-----LNET 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  825 QRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQeGPHLEEVDLSGNQLEDEGCRLMAEAASQL-HIARKL 903
Cdd:cd00116     64 GRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKL 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  904 DLSNNGLSVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepeeQKGPQERAAFLDSLMLQMPSELplssRRMRLTH 983
Cdd:cd00116    143 VLGRNRLEGASCEALAKALRANRDLKELNLA----------------NNGIGDAGIRALAEGLKANCNL----EVLDLNN 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  984 CGLQEKHLEQLCKALGGSCHLghLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWL 1062
Cdd:cd00116    203 NGLTDEGASALAETLASLKSL--EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280


                   ....*..
gi 1864245103 1063 FRLDISF 1069
Cdd:cd00116    281 LELDLRG 287
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 514-628 1.83e-09

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 56.53  E-value: 1.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRWVQRT---KARLGLSDHLP---TFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776    1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKRESLKSlldKALKSKNGHLDlflRFLFGLLNEENQRLLEGL-LGCKL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1864245103  587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776   80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
649-782 1.03e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 1.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886    153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1864245103  729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886    220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 705-783 1.64e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340    117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 221-365 5.69e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.51  E-value: 5.69e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103   221 PRVTVLLGKAGMGKTTLAHRLCqkwaeGHLNCFQALFLF---EFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEK 297
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALA-----RELGPPGGGVIYidgEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARK 76

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103   298 NADQVLLIfdglDEA--LQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKlpacLPAEAAMVHML 365
Cdd:smart00382   77 LKPDVLIL----DEItsLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEK----DLGPALLRRRF 138
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 742-780 7.77e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 7.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1864245103  742 PQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSN 780
Cdd:pfam12799    1 PNLEVLDLSNNQITD------IPPLAKLPNLETLDLSGN 33
 
Name Accession Description Interval E-value
Atypical_Card pfam18461
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ...
 1-95 6.96e-54

Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.


Pssm-ID: 436519  Cd Length: 95  Bit Score: 182.54  E-value: 6.96e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103    1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461    1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80

                           90
                   ....*....|....*
gi 1864245103   81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461   81 EVPLDLEVPLLSTWG 95
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 222-383 8.06e-47

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 165.17  E-value: 8.06e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159


                   ....*..
gi 1864245103  377 NHFFSAQ 383
Cdd:pfam05729  160 RKYFSDE 166
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
173-530 8.03e-25

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 112.21  E-value: 8.03e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635    131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635    211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635    284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635    362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1864245103  480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635    436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 751-1069 5.38e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 84.84  E-value: 5.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238     69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238    147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238    221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245103  991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238    281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 687-915 4.09e-15

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 79.06  E-value: 4.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  687 QIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVL 766
Cdd:COG5238    181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  767 PHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFllspptETTAELqrAPDLQESDGQRkgaqsrslT 846
Cdd:COG5238    261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGD------EGAIAL--AEGLQGNKTLH--------T 324

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245103  847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGV 915
Cdd:COG5238    325 LNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 715-1052 1.10e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 77.91  E-value: 1.10e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  715 RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVa 794
Cdd:COG5238    181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA- 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  795 vtcptvrmLQareadlifllsppTETTAElqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEE 874
Cdd:COG5238    260 --------LK-------------NNTTVE----------------------TLYLSGNQIGAEGAIALAKALQGNTTLTS 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  875 VDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAVsacWTLAELHIslqhktvifmfaqepeeqkgp 954
Cdd:COG5238    297 LDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL---QENTTLHS--------------------- 352

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  955 qeraafldslmlqmpselplssrrmrlthcglqekhleqlckalggschlghlhLDFSGNALGDEGAARLAQLLPGLGAL 1034
Cdd:COG5238    353 ------------------------------------------------------LDLSDNQIGDEGAIALAKYLEGNTTL 378

                          330
                   ....*....|....*...
gi 1864245103 1035 QSLNLSENGLSLDAVLGL 1052
Cdd:COG5238    379 RELNLGKNNIGKQGAEAL 396
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 745-1069 5.47e-14

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 74.31  E-value: 5.47e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  745 KEVSFRDNQLSDQVVLnivEVLPHLPRLRKLDLSSNSICVSTLLCLARvavtcptvrMLQAREADLIFLLSpptetTAEL 824
Cdd:cd00116      1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLS-----LNET 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  825 QRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQeGPHLEEVDLSGNQLEDEGCRLMAEAASQL-HIARKL 903
Cdd:cd00116     64 GRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKL 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  904 DLSNNGLSVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepeeQKGPQERAAFLDSLMLQMPSELplssRRMRLTH 983
Cdd:cd00116    143 VLGRNRLEGASCEALAKALRANRDLKELNLA----------------NNGIGDAGIRALAEGLKANCNL----EVLDLNN 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  984 CGLQEKHLEQLCKALGGSCHLghLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWL 1062
Cdd:cd00116    203 NGLTDEGASALAETLASLKSL--EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280


                   ....*..
gi 1864245103 1063 FRLDISF 1069
Cdd:cd00116    281 LELDLRG 287
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 661-893 3.19e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 68.92  E-value: 3.19e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  661 REAPIHLDFDGCPLePHCPEAL--VGCGQienlsfksRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKAL 738
Cdd:cd00116    119 GLGDRGLRLLAKGL-KDLPPALekLVLGR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGL 189

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  739 PLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvsTLLCLARVAvtcptvrmlqareadlifllsppt 818
Cdd:cd00116    190 KANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNL---TDAGAAALA------------------------ 242

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245103  819 ettaelqrapdlqesDGQRKGAQSRsLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEA 893
Cdd:cd00116    243 ---------------SALLSPNISL-LTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 680-910 3.31e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 70.20  E-value: 3.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238    230 EALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  760 LNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavtcptvrmlqaREADLIFLLspptettAELQRAPDLQesdgqrkg 839
Cdd:COG5238    310 IALAEGLQGNKTLHTLNLAYNGI-----------------------GAQGAIALA-------KALQENTTLH-------- 351

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245103  840 aqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAeAASQLHIARKLDLSNNGL 910
Cdd:COG5238    352 ------SLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALI-DALQTNRLHTLILDGNLI 415
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 514-628 1.83e-09

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 56.53  E-value: 1.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRWVQRT---KARLGLSDHLP---TFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776    1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKRESLKSlldKALKSKNGHLDlflRFLFGLLNEENQRLLEGL-LGCKL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1864245103  587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776   80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 666-914 3.18e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.59  E-value: 3.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  666 HLDFDGCPLEPHCPEALVGCGQI---ENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLC 741
Cdd:cd00116     85 ELDLSDNALGPDGCGVLESLLRSsslQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRAN 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  742 PQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavTCPTVRMLQAREADLIFLLspptett 821
Cdd:cd00116    165 RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGL-------------TDEGASALAETLASLKSLE------- 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  822 aelqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALI-ALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA 900
Cdd:cd00116    225 ------------------------VLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280

                          250
                   ....*....|....
gi 1864245103  901 RKLDLSNNGLSVAG 914
Cdd:cd00116    281 LELDLRGNKFGEEG 294
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
704-911 1.38e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 1.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  704 EALSRSLPTMGRLQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSIc 783
Cdd:COG4886    126 TDLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQI- 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  784 vSTL-LCLARvavtCPTVRMLQAREADLifllsppTETTAELQRAPDLQesdgqrkgaqsrslTLRLQKCQLQVhdaeal 862
Cdd:COG4886    195 -TDLpEPLGN----LTNLEELDLSGNQL-------TDLPEPLANLTNLE--------------TLDLSNNQLTD------ 242

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1864245103  863 IALLQEGPHLEEVDLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886    243 LPELGNLTNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
716-911 1.10e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 1.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  716 LQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSICVstllcLARVAV 795
Cdd:COG4886    115 LESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELG 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  796 TCPTVRMLQAREADLifllsppTETTAELQRAPDLQEsdgqrkgaqsrsltLRLQKCQLQvhDAEALIALLqegPHLEEV 875
Cdd:COG4886    180 NLTNLKELDLSNNQI-------TDLPEPLGNLTNLEE--------------LDLSGNQLT--DLPEPLANL---TNLETL 233

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1864245103  876 DLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886    234 DLSNNQLTD------LPELGNLTNLEELDLSNNQLT 263
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 845-1141 2.31e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 2.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  845 LTLRLQKCQLQVHDAEALIALLQegpHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNN--GLSVAGVHCVLRAV 922
Cdd:cd00116      1 LQLSLKGELLKTERATELLPKLL---CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  923 SACWTLAELHISlqhktvifmfaqepeeqkgpqeRAAFLDSLMLQMPSELPLSS-RRMRLTHCGLQEKHLEQLCKALGG- 1000
Cdd:cd00116     78 TKGCGLQELDLS----------------------DNALGPDGCGVLESLLRSSSlQELKLNNNGLGDRGLRLLAKGLKDl 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103 1001 SCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDisfesqhillrgdk 1080
Cdd:cd00116    136 PPALEKLVL--GRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLD-------------- 199

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245103 1081 tsrdmwatgslpdfpaaakflgfrqrciprslcLSECPLEPPSLTRLCATLKDCPGPLELH 1141
Cdd:cd00116    200 ---------------------------------LNNNGLTDEGASALAETLASLKSLEVLN 227
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
649-782 1.03e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 1.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886    153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1864245103  729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886    220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
650-782 1.17e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 1.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  650 DLATLTNIlehreapIHLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITAr 729
Cdd:COG4886    131 ELANLTNL-------KELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD- 196

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1864245103  730 gishLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886    197 ----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQL 240
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 680-772 1.14e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALpLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238    342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQ 420

                           90
                   ....*....|...
gi 1864245103  760 LNIVEVLPHLPRL 772
Cdd:COG5238    421 QRLEQLLERIKSV 433
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 705-783 1.64e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103  705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340    117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 221-365 5.69e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.51  E-value: 5.69e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103   221 PRVTVLLGKAGMGKTTLAHRLCqkwaeGHLNCFQALFLF---EFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEK 297
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALA-----RELGPPGGGVIYidgEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARK 76

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245103   298 NADQVLLIfdglDEA--LQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKlpacLPAEAAMVHML 365
Cdd:smart00382   77 LKPDVLIL----DEItsLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEK----DLGPALLRRRF 138
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 742-780 7.77e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 7.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1864245103  742 PQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSN 780
Cdd:pfam12799    1 PNLEVLDLSNNQITD------IPPLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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