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Conserved domains on  [gi|1477052705|ref|NP_003398|]
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mRNA decay activator protein ZFP36 [Homo sapiens]

Protein Classification

CTH1 family zinc finger protein( domain architecture ID 1004917)

CTH1 family zinc finger protein similar to Homo sapiens mRNA decay activator protein ZFP36 that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|11179890
SCOP:  4003893

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTH1 super family cl34885
CCCH-type Zn-finger protein [General function prediction only];
104-200 1.74e-12

CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5063:

Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 67.38  E-value: 1.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477052705 104 YKTELCRTFSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPSEDLAAPGHPPVLRQ 183
Cdd:COG5063   113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFISLPLTDINLQPLSQRKPK 192

                          90
                  ....*....|....*...
gi 1477052705 184 SISFS-GLPSGRRTSPPP 200
Cdd:COG5063   193 SGKNCtSYTLGKESDAHP 210
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
104-200 1.74e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 67.38  E-value: 1.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477052705 104 YKTELCRTFSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPSEDLAAPGHPPVLRQ 183
Cdd:COG5063   113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFISLPLTDINLQPLSQRKPK 192

                          90
                  ....*....|....*...
gi 1477052705 184 SISFS-GLPSGRRTSPPP 200
Cdd:COG5063   193 SGKNCtSYTLGKESDAHP 210
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
104-129 6.25e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 50.65  E-value: 6.25e-09
                          10        20
                  ....*....|....*....|....*.
gi 1477052705 104 YKTELCRTFSESGRCRYGAKCQFAHG 129
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
ZnF_C3H1 smart00356
zinc finger;
141-168 6.25e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 44.93  E-value: 6.25e-07
                           10        20
                   ....*....|....*....|....*...
gi 1477052705  141 KYKTELChKFYLQGRCPYGSRCHFIHNP 168
Cdd:smart00356   1 KYKTELC-KFFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
104-200 1.74e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 67.38  E-value: 1.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477052705 104 YKTELCRTFSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPSEDLAAPGHPPVLRQ 183
Cdd:COG5063   113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFISLPLTDINLQPLSQRKPK 192

                          90
                  ....*....|....*...
gi 1477052705 184 SISFS-GLPSGRRTSPPP 200
Cdd:COG5063   193 SGKNCtSYTLGKESDAHP 210
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
104-184 7.47e-11

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 62.38  E-value: 7.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477052705 104 YKT--ELCRTFSESGRCRY---GAKCQFA---HGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPSEDLAAP 175
Cdd:COG5063   226 YKTnpELCESFTRKGTCPYwisGVKCQFAcrgHGLNELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMY 305


                  ....*....
gi 1477052705 176 GHPPVLRQS 184
Cdd:COG5063   306 EEASLGYLD 314
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
104-169 3.51e-10

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 60.45  E-value: 3.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1477052705 104 YKTELCRTFSESGRCRYGAKCQFAHGLGELRQANRHP--KYKTELCHKFYLQGRCPYGSRCHFIHNPS 169
Cdd:COG5063   272 FRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKGGAFPSGGAVCKSFDKK 339
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
104-129 6.25e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 50.65  E-value: 6.25e-09
                          10        20
                  ....*....|....*....|....*.
gi 1477052705 104 YKTELCRTFSESGRCRYGAKCQFAHG 129
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
142-168 1.38e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.80  E-value: 1.38e-07
                          10        20
                  ....*....|....*....|....*..
gi 1477052705 142 YKTELCHKFYLQGRCPYGSRCHFIHNP 168
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
141-168 6.25e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 44.93  E-value: 6.25e-07
                           10        20
                   ....*....|....*....|....*...
gi 1477052705  141 KYKTELChKFYLQGRCPYGSRCHFIHNP 168
Cdd:smart00356   1 KYKTELC-KFFKRGYCPRGDRCKFAHPL 27
ZnF_C3H1 smart00356
zinc finger;
103-130 1.86e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.77  E-value: 1.86e-06
                           10        20
                   ....*....|....*....|....*...
gi 1477052705  103 RYKTELCRTFsESGRCRYGAKCQFAHGL 130
Cdd:smart00356   1 KYKTELCKFF-KRGYCPRGDRCKFAHPL 27
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 149-166 1.19e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 38.55  E-value: 1.19e-04
                          10
                  ....*....|....*...
gi 1477052705 149 KFYLQGRCPYGSRCHFIH 166
Cdd:pfam18345   2 KFFLKGRCRYGDKCRFAH 19
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 109-128 1.02e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 35.86  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|
gi 1477052705 109 CRTFSEsGRCRYGAKCQFAH 128
Cdd:pfam18345   1 CKFFLK-GRCRYGDKCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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