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Conserved domains on  [gi|28461129|ref|NP_064715|]
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ankyrin repeat and MYND domain-containing protein 2 [Homo sapiens]

Protein Classification

ankyrin repeat and MYND domain-containing protein( domain architecture ID 12122226)

ankyrin repeat and MYND domain-containing protein similar to ANKMY2 that may be involved in the trafficking of signaling proteins to the cilia

Gene Ontology:  GO:0008270
PubMed:  32702291|34235289|15152081|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-132 2.43e-25

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 2.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVN-ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        90       100
                ....*....|....*....|..
gi 28461129 111 SVGRTAAQMAAFVGQHDCVTII 132
Cdd:COG0666 217 NDGKTALDLAAENGNLEIVKLL 238
zf-MYND pfam01753
MYND finger;
320-357 5.69e-11

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 57.04  E-value: 5.69e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28461129   320 CTTCGEKGAS-KRCSVCKMVIYCDQTCQKTHWFTHKKIC 357
Cdd:pfam01753   1 CAVCGKEALKlLRCSRCKSVYYCSKECQKADWPYHKKEC 39
PHA03100 super family cl39094
ankyrin repeat protein; Provisional
 30-236 2.96e-06

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA03100:

Pssm-ID: 476869 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 2.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   30 TLLSSKNVRVNCLDENGMTPLmHAAYKG---KLDMCKLLLRHGADVN------------CH---QHEHGYTALMFAALSG 91
Cdd:PHA03100 125 EYLLDNGANVNIKNSDGENLL-HLYLESnkiDLKILKLLIDKGVDINaknrvnyllsygVPiniKDVYGFTPLHYAVYNN 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   92 NKDITWVMLEAGAETDVVNSVGRTAAQMAAfvgqHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPPklagplhKIITTT 171
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAI----LNNNKEIFKLLLNNGPSIKTIIETLLYFKDKDL-------NTITKI 272

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28461129  172 NLHPVKIVMLVNENPLLTEEAALNKCYRVMDLICEKCMKqrdmnEVLAMKMHYIS------CIFQKCINFL 236
Cdd:PHA03100 273 KMLKKSIMYMFLLDPGFYKNRKLIENSKSLKDVINECEK-----EIERMKEIKLNkvtvydIIFNKNINFL 338
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-132 2.43e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 2.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVN-ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        90       100
                ....*....|....*....|..
gi 28461129 111 SVGRTAAQMAAFVGQHDCVTII 132
Cdd:COG0666 217 NDGKTALDLAAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-110 6.52e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 6.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129    31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHgADVNChqHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:pfam12796  15 LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNL--KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
zf-MYND pfam01753
MYND finger;
320-357 5.69e-11

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 57.04  E-value: 5.69e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28461129   320 CTTCGEKGAS-KRCSVCKMVIYCDQTCQKTHWFTHKKIC 357
Cdd:pfam01753   1 CAVCGKEALKlLRCSRCKSVYYCSKECQKADWPYHKKEC 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 31-111 8.80e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 8.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNChQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:PHA03100 177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNL-VNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255


                 .
gi 28461129  111 S 111
Cdd:PHA03100 256 E 256
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 45-74 2.75e-07

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 46.43  E-value: 2.75e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 28461129     45 NGMTPLMHAAYKGKLDMCKLLLRHGADVNC 74
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 30-236 2.96e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 2.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   30 TLLSSKNVRVNCLDENGMTPLmHAAYKG---KLDMCKLLLRHGADVN------------CH---QHEHGYTALMFAALSG 91
Cdd:PHA03100 125 EYLLDNGANVNIKNSDGENLL-HLYLESnkiDLKILKLLIDKGVDINaknrvnyllsygVPiniKDVYGFTPLHYAVYNN 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   92 NKDITWVMLEAGAETDVVNSVGRTAAQMAAfvgqHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPPklagplhKIITTT 171
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAI----LNNNKEIFKLLLNNGPSIKTIIETLLYFKDKDL-------NTITKI 272

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28461129  172 NLHPVKIVMLVNENPLLTEEAALNKCYRVMDLICEKCMKqrdmnEVLAMKMHYIS------CIFQKCINFL 236
Cdd:PHA03100 273 KMLKKSIMYMFLLDPGFYKNRKLIENSKSLKDVINECEK-----EIERMKEIKLNkvtvydIIFNKNINFL 338
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 46-115 1.50e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.31  E-value: 1.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  46 GMTPLMHAAYKGKLDMCKLLLRHGADVN----------------CHQHEHgytALMFAALSGNKDITWVMLEAGAETDVV 109
Cdd:cd22192  89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffrpgpknlIYYGEH---PLSFAACVGNEEIVRLLIEHGADIRAQ 165


                ....*.
gi 28461129 110 NSVGRT 115
Cdd:cd22192 166 DSLGNT 171
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-132 2.43e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 2.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVN-ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        90       100
                ....*....|....*....|..
gi 28461129 111 SVGRTAAQMAAFVGQHDCVTII 132
Cdd:COG0666 217 NDGKTALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-129 7.65e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.50  E-value: 7.65e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  16 LLEVIGKGTVQEAGTLLSsKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMFAALSGNKDI 95
Cdd:COG0666  91 LHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN-AQDNDGNTPLHLAAANGNLEI 168

                        90       100       110
                ....*....|....*....|....*....|....
gi 28461129  96 TWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
Cdd:COG0666 169 VKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-129 2.41e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.70  E-value: 2.41e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  16 LLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMFAALSGNKDI 95
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEI 135

                        90       100       110
                ....*....|....*....|....*....|....
gi 28461129  96 TWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
Cdd:COG0666 136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-129 2.66e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.92  E-value: 2.66e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:COG0666 171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN-AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249

                        90
                ....*....|....*....
gi 28461129 111 SVGRTAAQMAAFVGQHDCV 129
Cdd:COG0666 250 KDGLTALLLAAAAGAALIV 268
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-110 6.52e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 6.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129    31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHgADVNChqHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:pfam12796  15 LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNL--KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
50-132 4.48e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 4.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129    50 LMHAAYKGKLDMCKLLLRHGADVNCHQHEhGYTALMFAALSGNKDITWVMLEaGAETDVVNSvGRTAAQMAAFVGQHDCV 129
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77


                  ...
gi 28461129   130 TII 132
Cdd:pfam12796  78 KLL 80
zf-MYND pfam01753
MYND finger;
320-357 5.69e-11

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 57.04  E-value: 5.69e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28461129   320 CTTCGEKGAS-KRCSVCKMVIYCDQTCQKTHWFTHKKIC 357
Cdd:pfam01753   1 CAVCGKEALKlLRCSRCKSVYYCSKECQKADWPYHKKEC 39
Ank_5 pfam13857
Ankyrin repeats (many copies);
31-87 4.38e-10

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 55.05  E-value: 4.38e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 28461129    31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQhEHGYTALMFA 87
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKD-EEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
46-95 4.54e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 4.54e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 28461129    46 GMTPLMHAAYKGKLDMCKLLLRHGADVNChQHEHGYTALMFAALSGNKDI 95
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEV 49
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-129 5.24e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.27  E-value: 5.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:COG0666  39 LLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN-AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD 117

                        90
                ....*....|....*....
gi 28461129 111 SVGRTAAQMAAFVGQHDCV 129
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIV 136
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 31-111 8.80e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 8.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNChQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:PHA03100 177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNL-VNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255


                 .
gi 28461129  111 S 111
Cdd:PHA03100 256 E 256
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 45-74 2.75e-07

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 46.43  E-value: 2.75e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 28461129     45 NGMTPLMHAAYKGKLDMCKLLLRHGADVNC 74
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-145 4.78e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 4.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28461129    84 LMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTI-INNFFPRERLDYYT 145
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLlLEHADVNLKDNGRT 63
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 45-74 6.49e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 45.36  E-value: 6.49e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 28461129    45 NGMTPLMHAAYK-GKLDMCKLLLRHGADVNC 74
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-117 6.53e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.72  E-value: 6.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:COG0666 204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN-AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                ....*..
gi 28461129 111 SVGRTAA 117
Cdd:COG0666 283 LDLLTLL 289
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 45-74 1.70e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 44.17  E-value: 1.70e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 28461129    45 NGMTPLMHAAYKGKLDMCKLLLRHGADVNC 74
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 30-236 2.96e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 2.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   30 TLLSSKNVRVNCLDENGMTPLmHAAYKG---KLDMCKLLLRHGADVN------------CH---QHEHGYTALMFAALSG 91
Cdd:PHA03100 125 EYLLDNGANVNIKNSDGENLL-HLYLESnkiDLKILKLLIDKGVDINaknrvnyllsygVPiniKDVYGFTPLHYAVYNN 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   92 NKDITWVMLEAGAETDVVNSVGRTAAQMAAfvgqHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPPklagplhKIITTT 171
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAI----LNNNKEIFKLLLNNGPSIKTIIETLLYFKDKDL-------NTITKI 272

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28461129  172 NLHPVKIVMLVNENPLLTEEAALNKCYRVMDLICEKCMKqrdmnEVLAMKMHYIS------CIFQKCINFL 236
Cdd:PHA03100 273 KMLKKSIMYMFLLDPGFYKNRKLIENSKSLKDVINECEK-----EIERMKEIKLNkvtvydIIFNKNINFL 338
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-128 1.03e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.71  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   31 LLSSKNVRVNCLDENGMTPL-MHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMfAALSG---NKDITWVMLEAGAET 106
Cdd:PHA03095  68 LLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVN-AKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADV 145

                         90       100
                 ....*....|....*....|..
gi 28461129  107 DVVNSVGRTAaqMAAFVGQHDC 128
Cdd:PHA03095 146 NALDLYGMTP--LAVLLKSRNA 165
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 30-132 1.20e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   30 TLLSSkNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNChQHEHGYTALMFAALSGNKDITWVMLEAGAETDVV 109
Cdd:PHA02874 109 TILDC-GIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNI-EDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100
                 ....*....|....*....|...
gi 28461129  110 NSVGRTAAQMAAFVGQHDCVTII 132
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLL 209
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 13-115 1.24e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.29  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   13 EKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHgYTALMFAALSGN 92
Cdd:PHA02875  69 ESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK-FSPLHLAVMMGD 147

                         90       100
                 ....*....|....*....|...
gi 28461129   93 KDITWVMLEAGAETDVVNSVGRT 115
Cdd:PHA02875 148 IKGIELLIDHKACLDIEDCCGCT 170
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 46-115 1.50e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.31  E-value: 1.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129  46 GMTPLMHAAYKGKLDMCKLLLRHGADVN----------------CHQHEHgytALMFAALSGNKDITWVMLEAGAETDVV 109
Cdd:cd22192  89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffrpgpknlIYYGEH---PLSFAACVGNEEIVRLLIEHGADIRAQ 165


                ....*.
gi 28461129 110 NSVGRT 115
Cdd:cd22192 166 DSLGNT 171
Ank_4 pfam13637
Ankyrin repeats (many copies);
31-66 2.11e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 2.11e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 28461129    31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLL 66
Cdd:pfam13637  19 LLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-116 3.02e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.17  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   39 VNCLDENGMTPL---MHAAYKGKLDMCKLLLRHGADVN----ChqhehGYTALMFAALSGNK-DITWVMLEAGAETDVVN 110
Cdd:PHA03095  40 VNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNaperC-----GFTPLHLYLYNATTlDVIKLLIKAGADVNAKD 114


                 ....*.
gi 28461129  111 SVGRTA 116
Cdd:PHA03095 115 KVGRTP 120
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 31-112 1.10e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.21  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNcHQHEHGYTALMFAALSGNK-DITWVMLEAGAETDVV 109
Cdd:PHA02875 153 LLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID-YFGKNGCVAALCYAIENNKiDIVRLFIKRGADCNIM 231


                 ...
gi 28461129  110 NSV 112
Cdd:PHA02875 232 FMI 234
Ank_5 pfam13857
Ankyrin repeats (many copies);
65-120 1.80e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 1.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 28461129    65 LLRHG-ADVNcHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMA 120
Cdd:pfam13857   1 LLEHGpIDLN-RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 39-133 2.53e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 43.33  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   39 VNCLDENGMTPLMHA-AYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSgnKDITWVMLEAGAETDVVNSVGRTAA 117
Cdd:PHA02878 227 TDARDKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPL 304

                         90
                 ....*....|....*.
gi 28461129  118 QMAafVGQHDCVTIIN 133
Cdd:PHA02878 305 SSA--VKQYLCINIGR 318
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 50-156 5.67e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 5.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   50 LMHAAYKGKLDMCKLLLRHGADVNCHQHeHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDY-DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164

                         90       100
                 ....*....|....*....|....*...
gi 28461129  130 TIINNFFPRE-RLDYYTKPQGLDKEPKL 156
Cdd:PTZ00322 165 QLLSRHSQCHfELGANAKPDSFTGKPPS 192
Ank_4 pfam13637
Ankyrin repeats (many copies);
80-129 6.47e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 6.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 28461129    80 GYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVL 50
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 31-112 1.30e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   31 LLSSKNVRVNCLDENGMTPLMHAAYK--GKLDMCKLLLRHGADVNCHQHEhGYTALMfAALSGNK---DITWVMLEAGAE 105
Cdd:PHA03100  91 LLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSD-GENLLH-LYLESNKidlKILKLLIDKGVD 168


                 ....*..
gi 28461129  106 TDVVNSV 112
Cdd:PHA03100 169 INAKNRV 175
PHA02798 PHA02798
ankyrin-like protein; Provisional
 39-146 1.50e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   39 VNCLDENGMTPLMH-----AAYKGKLDMCKLLLRHGADVNcHQHEHGYTALmFAALS----GNKDITWVMLEAGAETDVV 109
Cdd:PHA02798  64 VNGLDNEYSTPLCTilsniKDYKHMLDIVKILIENGADIN-KKNSDGETPL-YCLLSngyiNNLEILLFMIENGADTTLL 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 28461129  110 NSVGRTAAQMAAFVGQHDCVTII-------------NNFFPRERLDYYTK 146
Cdd:PHA02798 142 DKDGFTMLQVYLQSNHHIDIEIIklllekgvdinthNNKEKYDTLHCYFK 191
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 50-110 1.58e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.01  E-value: 1.58e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28461129   50 LMHAAYKGKLDMCKLLLRHGADVNCHQHeHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
Cdd:PLN03192 626 LCTAAKRNDLTAMKELLKQGLNVDSEDH-QGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 6-115 2.93e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.86  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129    6 KGELTQEEKELLEVIGKGTVQEAGT-LLSSKNVRVNCLDEN-GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYtA 83
Cdd:PHA02878 126 KNIQTIDLVYIDKKSKDDIIEAEITkLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNS-P 204

                         90       100       110
                 ....*....|....*....|....*....|..
gi 28461129   84 LMFAALSGNKDITWVMLEAGAETDVVNSVGRT 115
Cdd:PHA02878 205 LHHAVKHYNKPIVHILLENGASTDARDKCGNT 236
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 48-148 6.48e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.43  E-value: 6.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28461129   48 TPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHD 127
Cdd:PHA02884  72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALMICNNF 151

                         90       100
                 ....*....|....*....|.
gi 28461129  128 CVTIINNffpRERLDYYTKPQ 148
Cdd:PHA02884 152 LAFMICD---NEISNFYKHPK 169
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 31-94 8.11e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.51  E-value: 8.11e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28461129   31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEhGYTALMFAALSGNKD 94
Cdd:PHA02876 163 MLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALD-DLSVLECAVDSKNID 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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