NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|149274617|ref|NP_150376|]
View 

zinc finger protein 479 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
16-76 8.54e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.54  E-value: 8.54e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149274617    16 LTFRDIAIEFSLEEWQCLDCAQRNLYRDVMLENYRNLVSLGIAVSKPDLITCLEQNKESQN 76
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-372 2.55e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 170 SNSNRDKTRYTGNKHFKCNKYgKSFCMLSHLNQHQVIHTR-EKSYKCKECGKSFNCSSNHTTHK--IIHTGE--KPYRCE 244
Cdd:COG5048  247 SLSSSDSSSSASESPRSSLPT-ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCP 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 245 E--CGKAFSWSANLTRHKRTHTGEKPYTC--EECGQAFRRSS-----ALTNHKRIHTGERPYKCE--ECGKAFSVSSTLT 313
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149274617 314 DHKRIHTGEKP--CRCEECGKAFSWSSNLTRHKRIHTREKPYACEECGqaFSLSSNLMRHR 372
Cdd:COG5048  406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK--SFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-479 9.48e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 323 KPCRCEECGKAFSWSSNLTRHKR--IHTRE--KPYACEE--CGQAFSLSSNLMRHRRIHTGEKPYTC--EECGQDFRRSS 394
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 395 -----ALTIHKRIHTGERPYKCE--ECGKVFSLSSTLTDHKRIHTGERP--YKCEECGKAFSLSSTLTDHKRIHTGERPY 465
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....
gi 149274617 466 TCEECGKAFNCSST 479
Cdd:COG5048  448 LCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-503 5.00e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.00e-04
                          10        20
                  ....*....|....*....|....
gi 149274617  480 LMQHKRIHTGEKPYKCEECEQAFK 503
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
16-76 8.54e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.54  E-value: 8.54e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149274617    16 LTFRDIAIEFSLEEWQCLDCAQRNLYRDVMLENYRNLVSLGIAVSKPDLITCLEQNKESQN 76
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-56 4.90e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 4.90e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 149274617   15 LLTFRDIAIEFSLEEWQCLDCAQRNLYRDVMLENYRNLVSLG 56
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-55 1.86e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 1.86e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 149274617  16 LTFRDIAIEFSLEEWQCLDCAQRNLYRDVMLENYRNLVSL 55
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-372 2.55e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 170 SNSNRDKTRYTGNKHFKCNKYgKSFCMLSHLNQHQVIHTR-EKSYKCKECGKSFNCSSNHTTHK--IIHTGE--KPYRCE 244
Cdd:COG5048  247 SLSSSDSSSSASESPRSSLPT-ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCP 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 245 E--CGKAFSWSANLTRHKRTHTGEKPYTC--EECGQAFRRSS-----ALTNHKRIHTGERPYKCE--ECGKAFSVSSTLT 313
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149274617 314 DHKRIHTGEKP--CRCEECGKAFSWSSNLTRHKRIHTREKPYACEECGqaFSLSSNLMRHR 372
Cdd:COG5048  406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK--SFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-479 9.48e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 323 KPCRCEECGKAFSWSSNLTRHKR--IHTRE--KPYACEE--CGQAFSLSSNLMRHRRIHTGEKPYTC--EECGQDFRRSS 394
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 395 -----ALTIHKRIHTGERPYKCE--ECGKVFSLSSTLTDHKRIHTGERP--YKCEECGKAFSLSSTLTDHKRIHTGERPY 465
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....
gi 149274617 466 TCEECGKAFNCSST 479
Cdd:COG5048  448 LCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-280 3.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 149274617  255 NLTRHKRTHTGEKPYTCEECGQAFRR 280
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-392 4.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.76e-04
                          10        20
                  ....*....|....*....|....*.
gi 149274617  367 NLMRHRRIHTGEKPYTCEECGQDFRR 392
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-503 5.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.00e-04
                          10        20
                  ....*....|....*....|....
gi 149274617  480 LMQHKRIHTGEKPYKCEECEQAFK 503
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
16-76 8.54e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.54  E-value: 8.54e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149274617    16 LTFRDIAIEFSLEEWQCLDCAQRNLYRDVMLENYRNLVSLGIAVSKPDLITCLEQNKESQN 76
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-56 4.90e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 4.90e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 149274617   15 LLTFRDIAIEFSLEEWQCLDCAQRNLYRDVMLENYRNLVSLG 56
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-55 1.86e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 1.86e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 149274617  16 LTFRDIAIEFSLEEWQCLDCAQRNLYRDVMLENYRNLVSL 55
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-372 2.55e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 170 SNSNRDKTRYTGNKHFKCNKYgKSFCMLSHLNQHQVIHTR-EKSYKCKECGKSFNCSSNHTTHK--IIHTGE--KPYRCE 244
Cdd:COG5048  247 SLSSSDSSSSASESPRSSLPT-ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCP 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 245 E--CGKAFSWSANLTRHKRTHTGEKPYTC--EECGQAFRRSS-----ALTNHKRIHTGERPYKCE--ECGKAFSVSSTLT 313
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149274617 314 DHKRIHTGEKP--CRCEECGKAFSWSSNLTRHKRIHTREKPYACEECGqaFSLSSNLMRHR 372
Cdd:COG5048  406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK--SFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-523 3.04e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 211 KSYKCKECGKSFNCSSNHTTHKIIHTGEKPYRC--EECGKAFSWSANLTRHKRTHTGEKPYTCEECG---QAFRRSSALT 285
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 286 NHkrIHTGERPYKCEECGKAFSVSSTLTDHKRIHTGEKPCRCEEC-----------------------GKAFSWSSNLTR 342
Cdd:COG5048  112 SS--SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 343 HKRIHTREKPYACEECGQA------------FSLSSNLMRHRRIHTGEKPYTCE-----------ECGQDFRRSSALTIH 399
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQspsslsssdssSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 400 KRIHTGER-----------PYKCEECGKVFSLSSTLTDHKR--IHTGE--RPYKCEE--CGKAFSLSSTLTDHKRIHTGE 462
Cdd:COG5048  270 SQSSSPNEsdsssekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 463 RPYTCEEC-------GKAFNCSSTLMQHKRIHTGEKPYKCE--ECEQAFKWHSSLAKHKIIHTGEKPYKC 523
Cdd:COG5048  350 SPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-479 9.48e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 323 KPCRCEECGKAFSWSSNLTRHKR--IHTRE--KPYACEE--CGQAFSLSSNLMRHRRIHTGEKPYTC--EECGQDFRRSS 394
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149274617 395 -----ALTIHKRIHTGERPYKCE--ECGKVFSLSSTLTDHKRIHTGERP--YKCEECGKAFSLSSTLTDHKRIHTGERPY 465
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....
gi 149274617 466 TCEECGKAFNCSST 479
Cdd:COG5048  448 LCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-280 3.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 149274617  255 NLTRHKRTHTGEKPYTCEECGQAFRR 280
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-392 4.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.76e-04
                          10        20
                  ....*....|....*....|....*.
gi 149274617  367 NLMRHRRIHTGEKPYTCEECGQDFRR 392
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-503 5.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.00e-04
                          10        20
                  ....*....|....*....|....
gi 149274617  480 LMQHKRIHTGEKPYKCEECEQAFK 503
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-307 7.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.12e-04
                          10        20
                  ....*....|....*....|....*
gi 149274617  283 ALTNHKRIHTGERPYKCEECGKAFS 307
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-447 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....
gi 149274617  424 LTDHKRIHTGERPYKCEECGKAFS 447
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-476 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*
gi 149274617  452 LTDHKRIHTGERPYTCEECGKAFNC 476
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-363 2.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.63e-03
                          10        20
                  ....*....|....*....|....*
gi 149274617  339 NLTRHKRIHTREKPYACEECGQAFS 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-419 2.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.96e-03
                          10        20
                  ....*....|....*....|....*
gi 149274617  395 ALTIHKRIHTGERPYKCEECGKVFS 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-224 4.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.88e-03
                          10        20
                  ....*....|....*....|....*.
gi 149274617  199 HLNQHQVIHTREKSYKCKECGKSFNC 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-251 7.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.89e-03
                          10        20
                  ....*....|....*....|.
gi 149274617  231 HKIIHTGEKPYRCEECGKAFS 251
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH