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Conserved domains on  [gi|530390139|ref|XP_005251634|]
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DDB1- and CUL4-associated factor 10 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-521 2.91e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnryTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 327 DLDltkslevgsypilrarrttsssgvsprnslevvTPEVLGE-SDHGNCITSLQLHPKGwATLLrcsSNSDDEEcTCVY 405
Cdd:COG2319  232 DLA---------------------------------TGKLLRTlTGHSGSVRSVAFSPDG-RLLA---SGSADGT-VRLW 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 406 EFQEGAPVRpvsprcslRLTHyieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkqcselvdclpkEASPLRVI 484
Cdd:COG2319  274 DLATGELLR--------TLTG-------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW---------------DLATGKLL 323

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 530390139 485 RSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 521
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-521 2.91e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnryTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 327 DLDltkslevgsypilrarrttsssgvsprnslevvTPEVLGE-SDHGNCITSLQLHPKGwATLLrcsSNSDDEEcTCVY 405
Cdd:COG2319  232 DLA---------------------------------TGKLLRTlTGHSGSVRSVAFSPDG-RLLA---SGSADGT-VRLW 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 406 EFQEGAPVRpvsprcslRLTHyieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkqcselvdclpkEASPLRVI 484
Cdd:COG2319  274 DLATGELLR--------TLTG-------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW---------------DLATGKLL 323

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 530390139 485 RSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 521
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-519 9.30e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 9.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 169 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 247
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLET-GECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 248 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHkkfFHTRFLMRMRLTPDcsKMLISTSS--GYLLIl 325
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR---GHTDWVNSVAFSPD--GTFVASSSqdGTIKL- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 326 hdLDLTKSLEVGSYpilrarrttsssgvsprnslevvtpevlgeSDHGNCITSLQLHPKGwATLLRCSSNSddeeCTCVY 405
Cdd:cd00200  162 --WDLRTGKCVATL------------------------------TGHTGEVNSVAFSPDG-EKLLSSSSDG----TIKLW 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 406 EFQEGAPVrpvsprCSLRlTHyieeanvgRGYIKELCFSPDGRMISSPHGYG-IRLlgFDKQCSELVDCLPkeasplrvi 484
Cdd:cd00200  205 DLSTGKCL------GTLR-GH--------ENGVNSVAFSPDGYLLASGSEDGtIRV--WDLRTGECVQTLS--------- 258

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 530390139 485 rslySHNDVVLTTKFSPTHCQIASGCLSGRVSLYQ 519
Cdd:cd00200  259 ----GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-281 3.22e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 530390139   244 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
243-281 1.19e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530390139  243 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 224-281 1.03e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530390139 224 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 281
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
168-521 2.91e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKV 246
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 247 CTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnryTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILH 326
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 327 DLDltkslevgsypilrarrttsssgvsprnslevvTPEVLGE-SDHGNCITSLQLHPKGwATLLrcsSNSDDEEcTCVY 405
Cdd:COG2319  232 DLA---------------------------------TGKLLRTlTGHSGSVRSVAFSPDG-RLLA---SGSADGT-VRLW 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 406 EFQEGAPVRpvsprcslRLTHyieeanvGRGYIKELCFSPDGRMI-SSPHGYGIRLLgfdkqcselvdclpkEASPLRVI 484
Cdd:COG2319  274 DLATGELLR--------TLTG-------HSGGVNSVAFSPDGKLLaSGSDDGTVRLW---------------DLATGKLL 323

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 530390139 485 RSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 521
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-519 9.30e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 9.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 169 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 247
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLET-GECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 248 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHkkfFHTRFLMRMRLTPDcsKMLISTSS--GYLLIl 325
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR---GHTDWVNSVAFSPD--GTFVASSSqdGTIKL- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 326 hdLDLTKSLEVGSYpilrarrttsssgvsprnslevvtpevlgeSDHGNCITSLQLHPKGwATLLRCSSNSddeeCTCVY 405
Cdd:cd00200  162 --WDLRTGKCVATL------------------------------TGHTGEVNSVAFSPDG-EKLLSSSSDG----TIKLW 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 406 EFQEGAPVrpvsprCSLRlTHyieeanvgRGYIKELCFSPDGRMISSPHGYG-IRLlgFDKQCSELVDCLPkeasplrvi 484
Cdd:cd00200  205 DLSTGKCL------GTLR-GH--------ENGVNSVAFSPDGYLLASGSEDGtIRV--WDLRTGECVQTLS--------- 258

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 530390139 485 rslySHNDVVLTTKFSPTHCQIASGCLSGRVSLYQ 519
Cdd:cd00200  259 ----GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-319 3.01e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 3.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 164 STRTH-GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRK 241
Cdd:cd00200  130 TLRGHtDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLST 208

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530390139 242 LnTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDtnryTEDGCPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 319
Cdd:cd00200  209 G-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
169-283 1.55e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 1.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 169 GAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSeAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVC 247
Cdd:COG2319  289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLAT-GELLR 366

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530390139 248 TLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTN 283
Cdd:COG2319  367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 246-521 2.31e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 2.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 246 VCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnryteDGCPHKKFF--HTRFLMRMRLTPDcSKMLISTSSGYLL 323
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-----ETGELLRTLkgHTGPVRDVAASAD-GTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 324 ILHDLDltkslevgsypilrarrttsssgvsprnslevvTPEVLGE-SDHGNCITSLQLHPKGwatLLRCSSNSDdeeCT 402
Cdd:cd00200   76 RLWDLE---------------------------------TGECVRTlTGHTSYVSSVAFSPDG---RILSSSSRD---KT 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530390139 403 C-VYEFQEGapvrpvspRCSLRLT-HyieeanvgRGYIKELCFSPDGRMISSPHGYG-IRLlgFDkqcselvdclpkeAS 479
Cdd:cd00200  117 IkVWDVETG--------KCLTTLRgH--------TDWVNSVAFSPDGTFVASSSQDGtIKL--WD-------------LR 165

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 530390139 480 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 521
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
168-240 6.03e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 6.03e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530390139 168 HGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLR 240
Cdd:COG2319  330 TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSpDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-281 3.22e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 530390139   244 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
243-281 1.19e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530390139  243 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 281
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 224-281 1.03e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530390139 224 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 281
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-238 2.79e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530390139   199 SSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 238
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
200-238 1.48e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 530390139  200 SKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 238
Cdd:pfam00400   1 GKLLKTL-EGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 480-518 4.94e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 530390139   480 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 518
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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