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Conserved domains on  [gi|530413540|ref|XP_005256434|]
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WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-230 3.14e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 3.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540  46 KQVMIWDDLKKKTVIEIE-FSTEVKAVKLRRD-RIVVV--LDSMIKVF---------TFTHnpHQLHVFETCYNPKGlcv 112
Cdd:COG2319  142 GTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDgKLLASgsDDGTVRLWdlatgkllrTLTG--HTGAVRSVAFSPDG--- 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 113 lcpnsnnSLLAFpGTHTGHVQLVDLAsTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRR 192
Cdd:COG2319  217 -------KLLAS-GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTG 286

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 530413540 193 GSQAanIYCINFNQDASLICVSSDHGTVHIFAAEDPKR 230
Cdd:COG2319  287 HSGG--VNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-230 3.14e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 3.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540  46 KQVMIWDDLKKKTVIEIE-FSTEVKAVKLRRD-RIVVV--LDSMIKVF---------TFTHnpHQLHVFETCYNPKGlcv 112
Cdd:COG2319  142 GTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDgKLLASgsDDGTVRLWdlatgkllrTLTG--HTGAVRSVAFSPDG--- 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 113 lcpnsnnSLLAFpGTHTGHVQLVDLAsTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRR 192
Cdd:COG2319  217 -------KLLAS-GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTG 286

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 530413540 193 GSQAanIYCINFNQDASLICVSSDHGTVHIFAAEDPKR 230
Cdd:COG2319  287 HSGG--VNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-223 9.51e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 9.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540  46 KQVMIWDDLKKKTVIEIE-FSTEVKAVKLRRDRIVVV---LDSMIKVFTFTHNPhQLHVFETCynPKGLCVLCPNSNNSL 121
Cdd:cd00200   73 KTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGRILSsssRDKTIKVWDVETGK-CLTTLRGH--TDWVNSVAFSPDGTF 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 122 LAFpGTHTGHVQLVDLaSTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRrgSQAANIYC 201
Cdd:cd00200  150 VAS-SSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLR--GHENGVNS 224

                        170       180
                 ....*....|....*....|..
gi 530413540 202 INFNQDASLICVSSDHGTVHIF 223
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVW 246
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-230 3.14e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 3.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540  46 KQVMIWDDLKKKTVIEIE-FSTEVKAVKLRRD-RIVVV--LDSMIKVF---------TFTHnpHQLHVFETCYNPKGlcv 112
Cdd:COG2319  142 GTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDgKLLASgsDDGTVRLWdlatgkllrTLTG--HTGAVRSVAFSPDG--- 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 113 lcpnsnnSLLAFpGTHTGHVQLVDLAsTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRR 192
Cdd:COG2319  217 -------KLLAS-GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTG 286

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 530413540 193 GSQAanIYCINFNQDASLICVSSDHGTVHIFAAEDPKR 230
Cdd:COG2319  287 HSGG--VNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
126-243 1.72e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 126 GTHTGHVQLVDLAsTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRRGSQAanIYCINFN 205
Cdd:COG2319  180 GSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLTGHSGS--VRSVAFS 255

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530413540 206 QDASLICVSSDHGTVHIFAAEDPKRNK-----QSSLASASFLP 243
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRtltghSGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-223 9.51e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 9.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540  46 KQVMIWDDLKKKTVIEIE-FSTEVKAVKLRRDRIVVV---LDSMIKVFTFTHNPhQLHVFETCynPKGLCVLCPNSNNSL 121
Cdd:cd00200   73 KTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGRILSsssRDKTIKVWDVETGK-CLTTLRGH--TDWVNSVAFSPDGTF 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 122 LAFpGTHTGHVQLVDLaSTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRrgSQAANIYC 201
Cdd:cd00200  150 VAS-SSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLR--GHENGVNS 224

                        170       180
                 ....*....|....*....|..
gi 530413540 202 INFNQDASLICVSSDHGTVHIF 223
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-224 1.45e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540  46 KQVMIWDDLKKKTVIEIEFSTE-VKAVKLRRDRIVVV---LDSMIKVF---------TFTHnpHQLHVFETCYNPKGLCV 112
Cdd:cd00200  115 KTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTFVAsssQDGTIKLWdlrtgkcvaTLTG--HTGEVNSVAFSPDGEKL 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 113 LCpnsnnsllafpGTHTGHVQLVDLaSTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRr 192
Cdd:cd00200  193 LS-----------SSSDGTIKLWDL-STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLS- 258

                        170       180       190
                 ....*....|....*....|....*....|..
gi 530413540 193 GSQAAnIYCINFNQDASLICVSSDHGTVHIFA 224
Cdd:cd00200  259 GHTNS-VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
126-243 1.63e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 126 GTHTGHVQLVDLAsTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRRGSQAanIYCINFN 205
Cdd:COG2319   96 ASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGA--VTSVAFS 171

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530413540 206 QDASLICVSSDHGTVHIFAAEDPK-----RNKQSSLASASFLP 243
Cdd:COG2319  172 PDGKLLASGSDDGTVRLWDLATGKllrtlTGHTGAVRSVAFSP 214
WD40 COG2319
WD40 repeat [General function prediction only];
118-227 1.76e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 118 NNSLLAFpGTHTGHVQLVDLAsTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRRGSQAa 197
Cdd:COG2319  299 DGKLLAS-GSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGA- 374

                         90       100       110
                 ....*....|....*....|....*....|
gi 530413540 198 nIYCINFNQDASLICVSSDHGTVHIFAAED 227
Cdd:COG2319  375 -VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 107-229 2.87e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 2.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 107 PKGLCVLCPNSNNSLLAFpGTHTGHVQLVDLaSTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHL 186
Cdd:cd00200    9 TGGVTCVAFSPDGKLLAT-GSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGEC 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530413540 187 IQELRrGSQAAnIYCINFNQDASLICVSSDHGTVHIFAAEDPK 229
Cdd:cd00200   86 VRTLT-GHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-282 1.39e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540  83 DSMIKVFTFTHNpHQLHVFETCYNPKGLCVLCPNSNnSLLA--FPGThtghVQLVDLaSTEKPPVDIPAHEGVLSCIALN 160
Cdd:cd00200   30 DGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGT-YLASgsSDKT----IRLWDL-ETGECVRTLTGHTSYVSSVAFS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413540 161 LQGTRIATASEKGTlIRIFDTSSGHLIQELRrgSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKRNK-----QSS 235
Cdd:cd00200  103 PDGRILSSSSRDKT-IKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAtltghTGE 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530413540 236 LASASFLP---KYFSS-------KWSFSKFQvpsgspCICAFGTEPNAVIAICADGS 282
Cdd:cd00200  180 VNSVAFSPdgeKLLSSssdgtikLWDLSTGK------CLGTLRGHENGVNSVAFSPD 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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