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2-oxoglutarate dehydrogenase complex component E1 isoform X1 [Homo sapiens]
Protein Classification
2-oxoglutarate dehydrogenase family protein ( domain architecture ID 11426267 )
2-oxoglutarate dehydrogenase family protein, such as 2-oxoglutarate dehydrogenase subunit E1 that catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
SucA
COG0567
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1031
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
:Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1317.77
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL D E S DLD K VF H lp T TTF 208
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRERP --- Y VP -------- E LD P A ------------- FYGL T E A DLD T VF N -- T GSL 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 209 I G GQE sa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K W 287
Cdd:COG0567 143 L G LET -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K Y 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 288 SSE KRF G LEG C E V LIPAL KTI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG 367
Cdd:COG0567 221 VGQ KRF S LEG G E S LIPAL DEL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 368 m YHR ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS 446
Cdd:COG0567 301 - FSS -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG 377
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 447 Y T T H GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N 526
Cdd:COG0567 378 Y R T G GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H 457
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 527 GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PG 606
Cdd:COG0567 458 GHNE G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SP 536
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 607 FFT L d G QPRSMSCP s TG LTEDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IH 685
Cdd:COG0567 537 YRR L - G EDWDDPVD - TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YP 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 686 I RLSGQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF 765
Cdd:COG0567 614 V RLSGQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 766 H N T AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V 845
Cdd:COG0567 693 A N G AQ VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C 752
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 846 N CS TP GNF FH V LRRQ ILL PFRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYY 925
Cdd:COG0567 753 N PT TP AQY FH L LRRQ MKR PFRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYY 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 926 DL T --- RER KAR D mvgq VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YA 1001
Cdd:COG0567 830 DL L eer RER GRD D ---- VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YA 905
970 980 990
....*....|....*....|....*....|
gi 767945521 1002 GR DPA A A PATG NKKT H LT E LQR L LDT A FDL 1031
Cdd:COG0567 906 GR PAS A S PATG YMSV H KA E QKA L VEE A LGI 935
Name
Accession
Description
Interval
E-value
SucA
COG0567
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1031
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1317.77
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL D E S DLD K VF H lp T TTF 208
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRERP --- Y VP -------- E LD P A ------------- FYGL T E A DLD T VF N -- T GSL 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 209 I G GQE sa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K W 287
Cdd:COG0567 143 L G LET -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K Y 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 288 SSE KRF G LEG C E V LIPAL KTI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG 367
Cdd:COG0567 221 VGQ KRF S LEG G E S LIPAL DEL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 368 m YHR ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS 446
Cdd:COG0567 301 - FSS -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG 377
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 447 Y T T H GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N 526
Cdd:COG0567 378 Y R T G GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H 457
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 527 GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PG 606
Cdd:COG0567 458 GHNE G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SP 536
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 607 FFT L d G QPRSMSCP s TG LTEDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IH 685
Cdd:COG0567 537 YRR L - G EDWDDPVD - TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YP 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 686 I RLSGQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF 765
Cdd:COG0567 614 V RLSGQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 766 H N T AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V 845
Cdd:COG0567 693 A N G AQ VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C 752
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 846 N CS TP GNF FH V LRRQ ILL PFRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYY 925
Cdd:COG0567 753 N PT TP AQY FH L LRRQ MKR PFRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYY 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 926 DL T --- RER KAR D mvgq VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YA 1001
Cdd:COG0567 830 DL L eer RER GRD D ---- VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YA 905
970 980 990
....*....|....*....|....*....|
gi 767945521 1002 GR DPA A A PATG NKKT H LT E LQR L LDT A FDL 1031
Cdd:COG0567 906 GR PAS A S PATG YMSV H KA E QKA L VEE A LGI 935
sucA
PRK09404
2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1030
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1271.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplplsrgs L A AVAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL D E S DLD KV F H lp T TTF 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG LWKRP --- D VP -------- E LD P A ------------- FYGL T E A DLD RT F N -- T GSL 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 209 IG G Q E S A l P LREII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WS 288
Cdd:PRK09404 136 AL G K E T A - T LREII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FV 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 289 SE KRF G LEG C E V LIP A L KT II DKSSEN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG 367
Cdd:PRK09404 214 GQ KRF S LEG G E S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG 293
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 368 m YHR ri N R V TD - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L P 445
Cdd:PRK09404 294 - FSS -- D R E TD g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L R 370
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 446 S Y T T H GT V H V V V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDVV V DLVCYRR 525
Cdd:PRK09404 371 G Y R T G GT I H I V I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 526 N GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F ARS K DEK ilh IKH WL DSP W P 605
Cdd:PRK09404 451 H GHNE G DEP S FTQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W S 527
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 606 GFFTLDGQPR smsc PS TG LTEDI L THIGNVASS VP v E N F TI H GGLSR IL KT R G EM VK - NRTV DW AL AE YM AF G SLL K EG I 684
Cdd:PRK09404 528 PYLGHEWDDP ---- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GM AE AL AF A SLL D EG Y 602
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 685 HI RLSGQD VE RGTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGD 764
Cdd:PRK09404 603 PV RLSGQD SG RGTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGD 681
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 765 F H N T AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V 844
Cdd:PRK09404 682 F A N G AQ VV IDQFI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V 741
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 845 V N CS TP GNF FH V LRRQ I L L PFRKPL IIF TPKSLLRHP E A R SS FD E MLP G T h FQ R VI PE dg PAAQN P EN VKR LLF C T GKVY 924
Cdd:PRK09404 742 C N PT TP AQY FH L LRRQ A L R PFRKPL VVM TPKSLLRHP L A V SS LE E LAE G S - FQ P VI GD -- IDELD P KK VKR VVL C S GKVY 818
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 925 YDL TRE R KA R D m VGQ VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTISRAKPVW YAGR 1003
Cdd:PRK09404 819 YDL LEA R RK R G - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR 897
970 980
....*....|....*....|....*..
gi 767945521 1004 DPA A A PA T G NKKT H LTELQR L LDT A FD 1030
Cdd:PRK09404 898 PAS A S PA V G YMSL H KKQQEA L VED A LG 924
2oxo_dh_E1
TIGR00239
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1029
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 987.83
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LPLSRGS LA AV A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 129 AV Q s LIRAY QI RGH HV A Q LDPLG ILDA D ldss VPAD iisstdk LDL A vfkerlrmltvgg FYGL D E S DL DKV F HLPTTTF 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG LKQQ D ---- KVPE ------- LDL S ------------- FYGL T E A DL QET F NIGSFVS 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 209 IGGQESA L PLR E IIRR L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WS 288
Cdd:TIGR00239 134 GKDATMK L SNL E LLQA L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FP 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 289 SE KRF G LEG CEV L I P A LK T II DK S SEN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G 367
Cdd:TIGR00239 214 GA KRF S LEG LDA L V P M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G 293
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 368 MYHRRIN r VTDRNIT L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS 446
Cdd:TIGR00239 294 RFSSDFT - TDGKLVH L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG 372
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 447 Y TTH GT V H VVV NNQIGFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W R S TF HK DV VV DLV C YRR N 526
Cdd:TIGR00239 373 Y SVG GT I H III NNQIGFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H 452
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 527 GHNE M DEP MF TQPLMY KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FARSKD e KILHIKHWLDSPWPG 606
Cdd:TIGR00239 453 GHNE A DEP SA TQPLMY QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTW 527
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 607 FFT L D g QPRSMSC P ST g LTEDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R GEMVK -- NRTV DW AL AE YM AF GS L LKE GI 684
Cdd:TIGR00239 528 SPE L N - HEWDEEY P NK - VEMKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI 604
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 685 HI RLSG Q D V ERGTF SH RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGD 764
Cdd:TIGR00239 605 PV RLSG E D S ERGTF FQ RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGD 683
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 765 F H N T AQ CI IDQFI CP G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlkeanfdinqlydc N WV V 844
Cdd:TIGR00239 684 F A N G AQ VV IDQFI SS G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V 743
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 845 VNCS TP GNF FH V LRRQ I L LPF R K PL IIFT PKSLLRHP E A R SS FD E MLP GT h FQ R VI P -- E DGPAAQN PE N VKRL LF C T GK 922
Cdd:TIGR00239 744 CVPT TP AQV FH I LRRQ A L RGM R R PL VVMS PKSLLRHP L A V SS LE E LAE GT - FQ P VI G ei E ESGLSLD PE G VKRL VL C S GK 822
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 923 VYYDL t R E RKARDMVGQ VAI T RIEQL S PFP FDLLLKEV Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I SRAKP V W YA 1001
Cdd:TIGR00239 823 VYYDL - H E QRRKNGQKD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YA 901
970 980
....*....|....*....|....*...
gi 767945521 1002 GR DPA A A PA T G NKKT H LTEL Q R LL DT A F 1029
Cdd:TIGR00239 902 GR PAS A S PA V G YMSL H QKQQ Q D LL ND A L 929
TPP_E1_OGDC_like
cd02016
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
279-542
2.13e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 522.47
E-value: 2.13e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 279 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID KSS E N GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 356
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAA E L GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 357 EGSGDVKYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 436
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 437 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDV 516
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 767945521 517 V V DLVCYRR N GHNE M DEP M FTQPLMY 542
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
271-597
9.35e-112
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 348.16
E-value: 9.35e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 271 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DKSS E N G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 350
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 351 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 430
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 431 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRS 510
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 511 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF ARSK 589
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 767945521 590 DEKIL H IK 597
Cdd:pfam00676 293 SAPEP H PE 300
Transket_pyr
smart00861
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
732-879
4.51e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.93
E-value: 4.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 732 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 810
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 811 E - RFLQM cnddpdvlpdlkeanfdinqlyd CNWV VV NC S T P GNFFHV LR RQ I LLP f RKPL I IFTP KSL L R 879
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
Name
Accession
Description
Interval
E-value
SucA
COG0567
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1031
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1317.77
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL D E S DLD K VF H lp T TTF 208
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRERP --- Y VP -------- E LD P A ------------- FYGL T E A DLD T VF N -- T GSL 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 209 I G GQE sa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K W 287
Cdd:COG0567 143 L G LET -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K Y 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 288 SSE KRF G LEG C E V LIPAL KTI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG 367
Cdd:COG0567 221 VGQ KRF S LEG G E S LIPAL DEL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 368 m YHR ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS 446
Cdd:COG0567 301 - FSS -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG 377
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 447 Y T T H GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N 526
Cdd:COG0567 378 Y R T G GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H 457
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 527 GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PG 606
Cdd:COG0567 458 GHNE G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SP 536
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 607 FFT L d G QPRSMSCP s TG LTEDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IH 685
Cdd:COG0567 537 YRR L - G EDWDDPVD - TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YP 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 686 I RLSGQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF 765
Cdd:COG0567 614 V RLSGQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 766 H N T AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V 845
Cdd:COG0567 693 A N G AQ VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C 752
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 846 N CS TP GNF FH V LRRQ ILL PFRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYY 925
Cdd:COG0567 753 N PT TP AQY FH L LRRQ MKR PFRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYY 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 926 DL T --- RER KAR D mvgq VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YA 1001
Cdd:COG0567 830 DL L eer RER GRD D ---- VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YA 905
970 980 990
....*....|....*....|....*....|
gi 767945521 1002 GR DPA A A PATG NKKT H LT E LQR L LDT A FDL 1031
Cdd:COG0567 906 GR PAS A S PATG YMSV H KA E QKA L VEE A LGI 935
sucA
PRK09404
2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1030
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1271.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplplsrgs L A AVAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL D E S DLD KV F H lp T TTF 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG LWKRP --- D VP -------- E LD P A ------------- FYGL T E A DLD RT F N -- T GSL 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 209 IG G Q E S A l P LREII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WS 288
Cdd:PRK09404 136 AL G K E T A - T LREII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FV 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 289 SE KRF G LEG C E V LIP A L KT II DKSSEN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG 367
Cdd:PRK09404 214 GQ KRF S LEG G E S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG 293
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 368 m YHR ri N R V TD - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L P 445
Cdd:PRK09404 294 - FSS -- D R E TD g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L R 370
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 446 S Y T T H GT V H V V V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDVV V DLVCYRR 525
Cdd:PRK09404 371 G Y R T G GT I H I V I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 526 N GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F ARS K DEK ilh IKH WL DSP W P 605
Cdd:PRK09404 451 H GHNE G DEP S FTQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W S 527
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 606 GFFTLDGQPR smsc PS TG LTEDI L THIGNVASS VP v E N F TI H GGLSR IL KT R G EM VK - NRTV DW AL AE YM AF G SLL K EG I 684
Cdd:PRK09404 528 PYLGHEWDDP ---- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GM AE AL AF A SLL D EG Y 602
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 685 HI RLSGQD VE RGTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGD 764
Cdd:PRK09404 603 PV RLSGQD SG RGTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGD 681
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 765 F H N T AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V 844
Cdd:PRK09404 682 F A N G AQ VV IDQFI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V 741
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 845 V N CS TP GNF FH V LRRQ I L L PFRKPL IIF TPKSLLRHP E A R SS FD E MLP G T h FQ R VI PE dg PAAQN P EN VKR LLF C T GKVY 924
Cdd:PRK09404 742 C N PT TP AQY FH L LRRQ A L R PFRKPL VVM TPKSLLRHP L A V SS LE E LAE G S - FQ P VI GD -- IDELD P KK VKR VVL C S GKVY 818
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 925 YDL TRE R KA R D m VGQ VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTISRAKPVW YAGR 1003
Cdd:PRK09404 819 YDL LEA R RK R G - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR 897
970 980
....*....|....*....|....*..
gi 767945521 1004 DPA A A PA T G NKKT H LTELQR L LDT A FD 1030
Cdd:PRK09404 898 PAS A S PA V G YMSL H KKQQEA L VED A LG 924
kgd
PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
117-1031
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1014.81
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 117 QPNVDKL V EDHLA V QS LI R AY QI RGH HV A QL DPL GI --- LDA DLD ssvpad IIS stdkldlavfkerlrmltvggf Y GL D 193
Cdd:PRK12270 376 PADHEDE V DKNAR V ME LI H AY RV RGH LM A DT DPL EY rqr SHP DLD ------ VLT ---------------------- H GL T 427
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 194 ES DLD KV F hl P TTT F i GG Q E S a LP LR E I IRR L EMA YC QHI G V E F M F I N D L EQ CQ W IRQKF E T P g IMQF T N EE KRTL L AR L 273
Cdd:PRK12270 428 LW DLD RE F -- P VGG F - GG K E R - MK LR D I LGV L RDS YC RTV G I E Y M H I Q D P EQ RR W LQERV E R P - HEKP T R EE QKRI L SK L 502
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 274 VRSTR FE E FLQ R K WSSE KRF G LEG C E V LIP A L KTII D KSS E N G V D Y V IM GM P HRGRLNVLAN VIR K ELE QIF CQ F DSK L E 353
Cdd:PRK12270 503 NAAEA FE T FLQ T K YVGQ KRF S LEG G E S LIP L L DAVL D QAA E H G L D E V VI GM A HRGRLNVLAN IVG K PYS QIF RE F EGN L D 582
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 354 - AADE GSGDVKYHLG --- MYHR rinr VTDRN I TL SL V ANPSHLEA A DPV VM G KTK A E Q FYCGD - T EG KK V MS ILLHGDAA 428
Cdd:PRK12270 583 p RSAQ GSGDVKYHLG aeg TFTQ ---- MFGDE I KV SL A ANPSHLEA V DPV LE G IVR A K Q DRLDK g E EG FT V LP ILLHGDAA 658
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 429 FAGQG I V Y ET FH LS D L PS Y T T H GT V H V VVNNQ I GFTT D P RMA RSS P Y P TDVA RVVN APIFHVN S DDPEAV MY V CKV A A E W 508
Cdd:PRK12270 659 FAGQG V V A ET LN LS Q L RG Y R T G GT I H I VVNNQ V GFTT A P ESS RSS E Y A TDVA KMIQ APIFHVN G DDPEAV VR V ARL A F E Y 738
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 509 R ST FHKDVV V DLVCYRR N GHNE M D E P MF TQPLMY KQ I RKQKP V LQK Y A E L L VSQ G VVNQP E Y E EEISK Y DKIC E EA F ARS 588
Cdd:PRK12270 739 R QR FHKDVV I DLVCYRR R GHNE G D D P SM TQPLMY DL I DAKRS V RKL Y T E A L IGR G DITVE E A E QALRD Y QGQL E RV F NEV 818
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 589 KDEK ilhi K H wl DSPW P GFFTL D GQ P rs MSCPS T GLTEDI L TH IG NVASSV P v E N FT I H GG L SRI L KT R G EM VKNRTV DW 668
Cdd:PRK12270 819 REAE ---- K K -- PPEP P ESVES D QG P -- PAGVD T AVSAEV L ER IG DAHVNL P - E G FT V H PK L KPL L EK R R EM AREGGI DW 889
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 669 A LA E YM AFGSLL K EG IHI RLSGQD VE RGTFS H RH H VL H D QNVDKRTC i P MNH L WPN Q APYT V CN S S LSEY GVL GFE L G FA 748
Cdd:PRK12270 890 A FG E LL AFGSLL L EG TPV RLSGQD SR RGTFS Q RH A VL I D RETGEEYT - P LQN L SDD Q GKFL V YD S L LSEY AAM GFE Y G YS 968
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 749 MAS P N ALVLWEAQFGDF H N T AQ C IID Q FI CP G Q AKW VRQN G I VLLLPHG M EG M GP E HSSAR P ERFLQ M C NDD pdvlpdlk 828
Cdd:PRK12270 969 VER P D ALVLWEAQFGDF A N G AQ T IID E FI SS G E AKW GQRS G V VLLLPHG Y EG Q GP D HSSAR I ERFLQ L C AEG -------- 1040
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 829 eanfdinqlydc N WV V VNC STP G N F FH V LRRQ I L LPF R K PL II FTPKS L LR HPE A R S SFDEMLP G T h F QR VI PE dg P AAQ 908
Cdd:PRK12270 1041 ------------ N MT V AQP STP A N Y FH L LRRQ A L SGP R R PL VV FTPKS M LR LKA A V S DVEDFTE G K - F RP VI DD -- P TVD 1105
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 909 NPEN V K R L L F C T GK V YYDL TRE R KARD m VGQV AI T R I EQL S P F P FDL L LKEVQK YPNA - E LA W C QEE HK NQG YYDYVKPR 987
Cdd:PRK12270 1106 DGAK V R R V L L C S GK L YYDL AAR R EKDG - RDDT AI V R V EQL Y P L P RAE L REALAR YPNA t E VV W V QEE PA NQG AWPFMALN 1184
890 900 910 920
....*....|....*....|....*....|....*....|....
gi 767945521 988 L RTTISRAKPVWYAG R DPA A A PATG NK K T H LT E L Q R LLD T AF DL 1031
Cdd:PRK12270 1185 L PELLPDGRRLRRVS R PAS A S PATG SA K V H AV E Q Q E LLD E AF AR 1228
2oxo_dh_E1
TIGR00239
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1029
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 987.83
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LPLSRGS LA AV A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 129 AV Q s LIRAY QI RGH HV A Q LDPLG ILDA D ldss VPAD iisstdk LDL A vfkerlrmltvgg FYGL D E S DL DKV F HLPTTTF 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG LKQQ D ---- KVPE ------- LDL S ------------- FYGL T E A DL QET F NIGSFVS 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 209 IGGQESA L PLR E IIRR L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WS 288
Cdd:TIGR00239 134 GKDATMK L SNL E LLQA L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FP 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 289 SE KRF G LEG CEV L I P A LK T II DK S SEN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G 367
Cdd:TIGR00239 214 GA KRF S LEG LDA L V P M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G 293
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 368 MYHRRIN r VTDRNIT L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS 446
Cdd:TIGR00239 294 RFSSDFT - TDGKLVH L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG 372
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 447 Y TTH GT V H VVV NNQIGFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W R S TF HK DV VV DLV C YRR N 526
Cdd:TIGR00239 373 Y SVG GT I H III NNQIGFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H 452
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 527 GHNE M DEP MF TQPLMY KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FARSKD e KILHIKHWLDSPWPG 606
Cdd:TIGR00239 453 GHNE A DEP SA TQPLMY QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTW 527
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 607 FFT L D g QPRSMSC P ST g LTEDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R GEMVK -- NRTV DW AL AE YM AF GS L LKE GI 684
Cdd:TIGR00239 528 SPE L N - HEWDEEY P NK - VEMKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI 604
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 685 HI RLSG Q D V ERGTF SH RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGD 764
Cdd:TIGR00239 605 PV RLSG E D S ERGTF FQ RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGD 683
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 765 F H N T AQ CI IDQFI CP G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlkeanfdinqlydc N WV V 844
Cdd:TIGR00239 684 F A N G AQ VV IDQFI SS G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V 743
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 845 VNCS TP GNF FH V LRRQ I L LPF R K PL IIFT PKSLLRHP E A R SS FD E MLP GT h FQ R VI P -- E DGPAAQN PE N VKRL LF C T GK 922
Cdd:TIGR00239 744 CVPT TP AQV FH I LRRQ A L RGM R R PL VVMS PKSLLRHP L A V SS LE E LAE GT - FQ P VI G ei E ESGLSLD PE G VKRL VL C S GK 822
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 923 VYYDL t R E RKARDMVGQ VAI T RIEQL S PFP FDLLLKEV Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I SRAKP V W YA 1001
Cdd:TIGR00239 823 VYYDL - H E QRRKNGQKD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YA 901
970 980
....*....|....*....|....*...
gi 767945521 1002 GR DPA A A PA T G NKKT H LTEL Q R LL DT A F 1029
Cdd:TIGR00239 902 GR PAS A S PA V G YMSL H QKQQ Q D LL ND A L 929
TPP_E1_OGDC_like
cd02016
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
279-542
2.13e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 522.47
E-value: 2.13e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 279 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID KSS E N GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 356
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAA E L GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 357 EGSGDVKYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 436
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 437 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDV 516
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 767945521 517 V V DLVCYRR N GHNE M DEP M FTQPLMY 542
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
271-597
9.35e-112
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 348.16
E-value: 9.35e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 271 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DKSS E N G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 350
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 351 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 430
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 431 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRS 510
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 511 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF ARSK 589
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 767945521 590 DEKIL H IK 597
Cdd:pfam00676 293 SAPEP H PE 300
OxoGdeHyase_C
pfam16870
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
884-1029
1.96e-80
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 258.14
E-value: 1.96e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 884 RSS FD E ML PGTHFQRVIP EDG P A a QN PE N VKR LLF C T GKVYYDL TR ER KA R DMVGQ VAI T RIEQL S PFPFDLL LK E VQ KY 963
Cdd:pfam16870 1 RSS LE E FT PGTHFQRVIP DPE P L - VD PE K VKR VVL C S GKVYYDL LK ER EE R GGIKD VAI V RIEQL Y PFPFDLL KE E LD KY 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767945521 964 PNA - E LA WCQEE H KNQG YYDY V K PRL R T TISRA - KPVW YAGR D P A A A PATG N K KT HL T E LQR LLD T AF 1029
Cdd:pfam16870 80 PNA a E IV WCQEE P KNQG AWSF V Q PRL E T VLNET g HRLR YAGR P P S A S PATG S K SV HL A E QEA LLD D AF 147
Transket_pyr
pfam02779
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
664-879
3.65e-53
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 183.52
E-value: 3.65e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 664 RTVDWAL A EYM A FGS L L K EGIHIRLS G Q D VER GTF SHRHHV LH D qnvdkrtcipmnhlwpn Q APYT V CNSSLS E YGVL GF 743
Cdd:pfam02779 1 KKIATRK A SGE A LAE L A K RDPRVVGG G A D LAG GTF TVTKGL LH P ----------------- Q GAGR V IDTGIA E QAMV GF 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 744 EL G F A MAS P N a L VLW EA Q F G DF H N taqc II D QF I CP G Q A KWVRQNG - I V LLL P H G MEGM GP E H S S ARPER FL QMCN ddpd 822
Cdd:pfam02779 64 AN G M A LHG P L - L PPV EA T F S DF L N ---- RA D DA I RH G A A LGKLPVP f V V TRD P I G VGED GP T H Q S VEDLA FL RAIP ---- 134
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 767945521 823 vlpdlkeanfdinqlydc NWV VV NC S TPGNFFHV LR RQ I LLPF RKP LIIFT P KS LLR 879
Cdd:pfam02779 135 ------------------ GLK VV RP S DAAETKGL LR AA I RRDG RKP VVLRL P RQ LLR 173
Transket_pyr
smart00861
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
732-879
4.51e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.93
E-value: 4.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 732 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 810
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 811 E - RFLQM cnddpdvlpdlkeanfdinqlyd CNWV VV NC S T P GNFFHV LR RQ I LLP f RKPL I IFTP KSL L R 879
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
2-oxogl_dehyd_N
pfam16078
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
47-87
1.27e-15
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 71.41
E-value: 1.27e-15
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 767945521 47 EP FLSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F R N TNA G A 87
Cdd:pfam16078 1 DS FLSG ANAA Y I EE L Y EQY L KD P S SV DP SW RAY F D N LDD G E 41
TPP_E1_PDC_ADC_BCADC
cd02000
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
415-587
1.13e-11
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 66.75
E-value: 1.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 415 G KKVMSILLH GD A A f AGQ G IVY E TFHLS --- D LP sytthg TVH V VV NN QIGFT T d P R m A R SSPYPTDVA R VVNA -- P IFH 489
Cdd:cd02000 124 G EDRVAVCFF GD G A - TNE G DFH E ALNFA alw K LP ------ VIF V CE NN GYAIS T - P T - S R QTAGTSIAD R AAAY gi P GIR 194
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945521 490 V NSD D PE AV MYVC K V A A E W - R ST f HKDVVVDL V C YR RN GH NEM D E P M ftqpl M Y K ----- QIR K QKPVLQKYAEL L VSQ G 563
Cdd:cd02000 195 V DGN D VL AV YEAA K E A V E R a R AG - GGPTLIEA V T YR LG GH STS D D P S ----- R Y R tkeev EEW K KRDPILRLRKY L IEA G 268
170 180
....*....|....*....|....
gi 767945521 564 VVNQP E YEEEISKYDKIC EEA FAR 587
Cdd:cd02000 269 ILTEE E LAAIEAEVKAEV EEA VEF 292
kgd
PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
57-112
1.91e-03
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 42.18
E-value: 1.91e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767945521 57 Y VEEMY CAW L EN P K SV HK SW DI FF RNTNA G APPGTAYQSPLPLSRG S LA A V A H A QS 112
Cdd:PRK12270 10 L VEEMY QQY L AD P N SV DP SW RE FF ADYGP G STAAPTAAAAAAAAAA S AP A A A P A AK 65
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01