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Conserved domains on  [gi|767992561|ref|XP_011522319|]
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membrane-associated phosphatidylinositol transfer protein 3 isoform X3 [Homo sapiens]

Protein Classification

DDHD family phospholipase( domain architecture ID 10502158)

DDHD family phospholipase similar to Homo sapiens phospholipase DDHD1 that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid

EC:  3.1.1.-
Gene Ontology:  GO:0008970|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DDHD pfam02862
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ...
 390-495 3.35e-28

DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.


:

Pssm-ID: 460725  Cd Length: 241  Bit Score: 112.91  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992561  390 FDFDVSDFFLFGSPLGLVLAMR---RTVLPGLDGFQVRPACSQVYSFFHCADPSASRLEPLLEPKFHLVPPVSVPRYQRF 466
Cdd:pfam02862   1 LDFEVENFFLLGSPLGLFLALRgaqIAGRSRSDHIYGSPACKQLYNIFHPYDPVAYRLEPLIDPAYSNLKPVLIPYYKKR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767992561  467 P-----LGDGQSLLLADALHTHSPLFLEGSSRDS 495
Cdd:pfam02862  81 GlrhleLGEGLTRIGAAVGQSVSGLWSSLSSGAS 114
 
Name Accession Description Interval E-value
DDHD pfam02862
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ...
 390-495 3.35e-28

DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.


Pssm-ID: 460725  Cd Length: 241  Bit Score: 112.91  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992561  390 FDFDVSDFFLFGSPLGLVLAMR---RTVLPGLDGFQVRPACSQVYSFFHCADPSASRLEPLLEPKFHLVPPVSVPRYQRF 466
Cdd:pfam02862   1 LDFEVENFFLLGSPLGLFLALRgaqIAGRSRSDHIYGSPACKQLYNIFHPYDPVAYRLEPLIDPAYSNLKPVLIPYYKKR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767992561  467 P-----LGDGQSLLLADALHTHSPLFLEGSSRDS 495
Cdd:pfam02862  81 GlrhleLGEGLTRIGAAVGQSVSGLWSSLSSGAS 114
 
Name Accession Description Interval E-value
DDHD pfam02862
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ...
 390-495 3.35e-28

DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.


Pssm-ID: 460725  Cd Length: 241  Bit Score: 112.91  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767992561  390 FDFDVSDFFLFGSPLGLVLAMR---RTVLPGLDGFQVRPACSQVYSFFHCADPSASRLEPLLEPKFHLVPPVSVPRYQRF 466
Cdd:pfam02862   1 LDFEVENFFLLGSPLGLFLALRgaqIAGRSRSDHIYGSPACKQLYNIFHPYDPVAYRLEPLIDPAYSNLKPVLIPYYKKR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767992561  467 P-----LGDGQSLLLADALHTHSPLFLEGSSRDS 495
Cdd:pfam02862  81 GlrhleLGEGLTRIGAAVGQSVSGLWSSLSSGAS 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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