NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767903554|ref|XP_011539468|]
View 

serine/threonine-protein kinase mTOR isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
TEL1 super family cl34875
Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
363-1587 1.47e-117

Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5032:

Pssm-ID: 227365 [Multi-domain]  Cd Length: 2105  Bit Score: 411.10  E-value: 1.47e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  363 RDLMEEKFDQVCQWVLKCRNSKNSLIQMtILNLLPRLAAFRPSAFTdtQYLQDTMNHVLSCVKKEKERTAAFQALGllsv 442
Cdd:COG5032    47 DERLSNVNDLVRNSTQSLLNTISNLIKI-VKFVLPLKSFFLSPIFA--KLRALPMTKILCISADTYCLSLSIKALA---- 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  443 avrseFKVYLPRVLDIIRAALppKDFAHKRQkamqvdaTVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLY 522
Cdd:COG5032   120 -----DDESLTTILKTIRELL--SKFLLRLR-------LLFLFIGLLAQKFSEAQSKLFFKLLLSILKEILSDAYEALLN 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  523 DLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAH-------QLASPGLTTLPEASDVGSITLALRTLGSFEFE 595
Cdd:COG5032   186 DLLENLKSLKETLQNRLLPLLFNISDGNYFKVEIGRKLLDHlnalgqiLDCQKIAKITKSFRSLPVIIKKFLNLLLIKVS 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  596 GhSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHvvsqtAVQVVADVLSKLLVVGITDPDPDIRYCV 675
Cdd:COG5032   266 Y-YLPSFFRLSLLSYLDHFETDLFKTFLVTSCFLFFVDEICKPESEH-----LAEEVSEKLSKFLTIEIIDSFPEIRISA 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  676 LASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSAR 755
Cdd:COG5032   340 LSSLLVIFDYHLALPDAVRLLFGESNDKVFLISELALDSTGRLLRVLPARVLPSLFEFLLSLLTVLKISGLILEFEISAQ 419
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  756 MLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDpnpgVINNVLATIGELAQVSGLE-MRKWVDELFIIIMDMLQDSSLL 834
Cdd:COG5032   420 LLCNLIRSSNQLLTSLISPYFLFILPKCIDSSNS----EISYRVENLGELKDILGLDrITDYQALSLRLIIVSIQLRSFV 495
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  835 AKRQVALWTLGQLvasTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSrDASA 914
Cdd:COG5032   496 FKREAINQIFKQL---ASIVIKPFLDYPKRLDLPIKIVTVVYVALLRRPTEKLSGVLGSIDKYSHIESEEMSSSD-FPWT 571
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  915 VSLSESKSSqdssdystseMLVNMGNLpLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQvM 994
Cdd:COG5032   572 KNPVGLQLL----------AVYGFIRS-IDDLYFTVSDPTLIEILKLPVLSIVHSAIIEAIMLIKLSLGSESSQFEDL-N 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  995 PTFLNVIRVCDGAIREFLFQQ-LGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQ 1073
Cdd:COG5032   640 PSFLYIFSNNSISDILFYFQNfLELIVIAFFPLIRSEIIGIVLISSLFSKTWILLKLLLIAFISKLISALQGELKMLAPT 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1074 LIPHMLRVFMH--DNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSrKAALETVDRLTESLDFTDY 1151
Cdd:COG5032   720 LFTLFLVLVERylDVEYSSVSFKLLLVILVYFGGNLESLVLLILDLIVMLVEYTELGLQE-SIFIERLSQFFKFKNLSEN 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1152 ASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQI-FIPMVNKVL-VRHRINHQRYDVLICRIVKgytladeeEDP 1229
Cdd:COG5032   799 ASRLLPPLMDNLSKSHELRCVSEDDVSALLIQLLTDRVIcFIPVINSSLgDSRRIFLSLLAQLLDDSLK--------EES 870
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1230 LIYQHRMLR-SGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQ 1308
Cdd:COG5032   871 LPYNLNVDRgTDLREFFQTVKSKAEVLSMLPFVQSILFEAWNRVDFLLKDFWQEELDNLLVALLKELPFMALRDCSILSD 950
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1309 AYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIA-EVTQTLL---NLAEFMEHSDKG-PLPLRDdngivlL 1383
Cdd:COG5032   951 LYFMLGRELWNSVSFECWLELMNSYKRLLIKSLKSKLHLPTIPiLILQMLLdskNLTEFTEHQLKNlPLPSLS------I 1024
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1384 GERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFgELEIQATWYEKLHEWEDALVAY 1463
Cdd:COG5032  1025 GFYESLCSFLAKLLHDEELYFFPLLFVSSLETLLSVNYHINQLDLRPNILKHFGSFV-RFQLKPHLVKYLQRWYEALNRY 1103
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1464 DKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDG 1543
Cdd:COG5032  1104 FELLSKGDRLFAISFTKLRNVDALGKLELYSSLAEIDMFLSLHRRRKLLETLVATAYEQVGEWYKAQQLYEVAQRKARSK 1183
                        1210      1220      1230      1240      1250
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767903554 1544 AFY--RAVLALHQDLFslaqQCIDK-----ARDLLDAELTAMA-GESYSRAY 1587
Cdd:COG5032  1184 EFPfsLQYLYWHINDI----DCADKlqsvlAELSLVTGISELLlEESWRRAL 1231
 
Name Accession Description Interval E-value
TEL1 COG5032
Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
363-1587 1.47e-117

Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];


Pssm-ID: 227365 [Multi-domain]  Cd Length: 2105  Bit Score: 411.10  E-value: 1.47e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  363 RDLMEEKFDQVCQWVLKCRNSKNSLIQMtILNLLPRLAAFRPSAFTdtQYLQDTMNHVLSCVKKEKERTAAFQALGllsv 442
Cdd:COG5032    47 DERLSNVNDLVRNSTQSLLNTISNLIKI-VKFVLPLKSFFLSPIFA--KLRALPMTKILCISADTYCLSLSIKALA---- 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  443 avrseFKVYLPRVLDIIRAALppKDFAHKRQkamqvdaTVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLY 522
Cdd:COG5032   120 -----DDESLTTILKTIRELL--SKFLLRLR-------LLFLFIGLLAQKFSEAQSKLFFKLLLSILKEILSDAYEALLN 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  523 DLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAH-------QLASPGLTTLPEASDVGSITLALRTLGSFEFE 595
Cdd:COG5032   186 DLLENLKSLKETLQNRLLPLLFNISDGNYFKVEIGRKLLDHlnalgqiLDCQKIAKITKSFRSLPVIIKKFLNLLLIKVS 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  596 GhSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHvvsqtAVQVVADVLSKLLVVGITDPDPDIRYCV 675
Cdd:COG5032   266 Y-YLPSFFRLSLLSYLDHFETDLFKTFLVTSCFLFFVDEICKPESEH-----LAEEVSEKLSKFLTIEIIDSFPEIRISA 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  676 LASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSAR 755
Cdd:COG5032   340 LSSLLVIFDYHLALPDAVRLLFGESNDKVFLISELALDSTGRLLRVLPARVLPSLFEFLLSLLTVLKISGLILEFEISAQ 419
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  756 MLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDpnpgVINNVLATIGELAQVSGLE-MRKWVDELFIIIMDMLQDSSLL 834
Cdd:COG5032   420 LLCNLIRSSNQLLTSLISPYFLFILPKCIDSSNS----EISYRVENLGELKDILGLDrITDYQALSLRLIIVSIQLRSFV 495
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  835 AKRQVALWTLGQLvasTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSrDASA 914
Cdd:COG5032   496 FKREAINQIFKQL---ASIVIKPFLDYPKRLDLPIKIVTVVYVALLRRPTEKLSGVLGSIDKYSHIESEEMSSSD-FPWT 571
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  915 VSLSESKSSqdssdystseMLVNMGNLpLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQvM 994
Cdd:COG5032   572 KNPVGLQLL----------AVYGFIRS-IDDLYFTVSDPTLIEILKLPVLSIVHSAIIEAIMLIKLSLGSESSQFEDL-N 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  995 PTFLNVIRVCDGAIREFLFQQ-LGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQ 1073
Cdd:COG5032   640 PSFLYIFSNNSISDILFYFQNfLELIVIAFFPLIRSEIIGIVLISSLFSKTWILLKLLLIAFISKLISALQGELKMLAPT 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1074 LIPHMLRVFMH--DNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSrKAALETVDRLTESLDFTDY 1151
Cdd:COG5032   720 LFTLFLVLVERylDVEYSSVSFKLLLVILVYFGGNLESLVLLILDLIVMLVEYTELGLQE-SIFIERLSQFFKFKNLSEN 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1152 ASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQI-FIPMVNKVL-VRHRINHQRYDVLICRIVKgytladeeEDP 1229
Cdd:COG5032   799 ASRLLPPLMDNLSKSHELRCVSEDDVSALLIQLLTDRVIcFIPVINSSLgDSRRIFLSLLAQLLDDSLK--------EES 870
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1230 LIYQHRMLR-SGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQ 1308
Cdd:COG5032   871 LPYNLNVDRgTDLREFFQTVKSKAEVLSMLPFVQSILFEAWNRVDFLLKDFWQEELDNLLVALLKELPFMALRDCSILSD 950
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1309 AYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIA-EVTQTLL---NLAEFMEHSDKG-PLPLRDdngivlL 1383
Cdd:COG5032   951 LYFMLGRELWNSVSFECWLELMNSYKRLLIKSLKSKLHLPTIPiLILQMLLdskNLTEFTEHQLKNlPLPSLS------I 1024
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1384 GERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFgELEIQATWYEKLHEWEDALVAY 1463
Cdd:COG5032  1025 GFYESLCSFLAKLLHDEELYFFPLLFVSSLETLLSVNYHINQLDLRPNILKHFGSFV-RFQLKPHLVKYLQRWYEALNRY 1103
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1464 DKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDG 1543
Cdd:COG5032  1104 FELLSKGDRLFAISFTKLRNVDALGKLELYSSLAEIDMFLSLHRRRKLLETLVATAYEQVGEWYKAQQLYEVAQRKARSK 1183
                        1210      1220      1230      1240      1250
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767903554 1544 AFY--RAVLALHQDLFslaqQCIDK-----ARDLLDAELTAMA-GESYSRAY 1587
Cdd:COG5032  1184 EFPfsLQYLYWHINDI----DCADKlqsvlAELSLVTGISELLlEESWRRAL 1231
DUF3385 pfam11865
Domain of unknown function (DUF3385); This domain is functionally uncharacterized. This domain ...
854-1024 1.68e-75

Domain of unknown function (DUF3385); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 160 to 172 amino acids in length. This domain is found associated with pfam00454, pfam02260, pfam02985, pfam02259 and pfam08771.


Pssm-ID: 463377  Cd Length: 160  Bit Score: 247.51  E-value: 1.68e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554   854 VVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSlseskssqdsSDYSTSE 933
Cdd:pfam11865    1 VIDPYLDYPQLLGILLNILKTEQSQSIRRETIRVLGILGALDPYKHKENEGKSEDSDSEEQNA----------PSTDVSL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554   934 MLVNMGNLPlDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLF 1013
Cdd:pfam11865   71 LMVGMSPSN-EEYYPTVVINSLMRILRDPSLSSHHTAVVQAIMFIFKTLGLKCVPFLPQVIPALLSVIRTCPPSLREFYF 149
                          170
                   ....*....|.
gi 767903554  1014 QQLGMLVSFVK 1024
Cdd:pfam11865  150 QQLATLVSIVK 160
 
Name Accession Description Interval E-value
TEL1 COG5032
Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
363-1587 1.47e-117

Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];


Pssm-ID: 227365 [Multi-domain]  Cd Length: 2105  Bit Score: 411.10  E-value: 1.47e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  363 RDLMEEKFDQVCQWVLKCRNSKNSLIQMtILNLLPRLAAFRPSAFTdtQYLQDTMNHVLSCVKKEKERTAAFQALGllsv 442
Cdd:COG5032    47 DERLSNVNDLVRNSTQSLLNTISNLIKI-VKFVLPLKSFFLSPIFA--KLRALPMTKILCISADTYCLSLSIKALA---- 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  443 avrseFKVYLPRVLDIIRAALppKDFAHKRQkamqvdaTVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLY 522
Cdd:COG5032   120 -----DDESLTTILKTIRELL--SKFLLRLR-------LLFLFIGLLAQKFSEAQSKLFFKLLLSILKEILSDAYEALLN 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  523 DLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAH-------QLASPGLTTLPEASDVGSITLALRTLGSFEFE 595
Cdd:COG5032   186 DLLENLKSLKETLQNRLLPLLFNISDGNYFKVEIGRKLLDHlnalgqiLDCQKIAKITKSFRSLPVIIKKFLNLLLIKVS 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  596 GhSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHvvsqtAVQVVADVLSKLLVVGITDPDPDIRYCV 675
Cdd:COG5032   266 Y-YLPSFFRLSLLSYLDHFETDLFKTFLVTSCFLFFVDEICKPESEH-----LAEEVSEKLSKFLTIEIIDSFPEIRISA 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  676 LASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSAR 755
Cdd:COG5032   340 LSSLLVIFDYHLALPDAVRLLFGESNDKVFLISELALDSTGRLLRVLPARVLPSLFEFLLSLLTVLKISGLILEFEISAQ 419
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  756 MLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDpnpgVINNVLATIGELAQVSGLE-MRKWVDELFIIIMDMLQDSSLL 834
Cdd:COG5032   420 LLCNLIRSSNQLLTSLISPYFLFILPKCIDSSNS----EISYRVENLGELKDILGLDrITDYQALSLRLIIVSIQLRSFV 495
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  835 AKRQVALWTLGQLvasTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSrDASA 914
Cdd:COG5032   496 FKREAINQIFKQL---ASIVIKPFLDYPKRLDLPIKIVTVVYVALLRRPTEKLSGVLGSIDKYSHIESEEMSSSD-FPWT 571
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  915 VSLSESKSSqdssdystseMLVNMGNLpLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQvM 994
Cdd:COG5032   572 KNPVGLQLL----------AVYGFIRS-IDDLYFTVSDPTLIEILKLPVLSIVHSAIIEAIMLIKLSLGSESSQFEDL-N 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  995 PTFLNVIRVCDGAIREFLFQQ-LGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQ 1073
Cdd:COG5032   640 PSFLYIFSNNSISDILFYFQNfLELIVIAFFPLIRSEIIGIVLISSLFSKTWILLKLLLIAFISKLISALQGELKMLAPT 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1074 LIPHMLRVFMH--DNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSrKAALETVDRLTESLDFTDY 1151
Cdd:COG5032   720 LFTLFLVLVERylDVEYSSVSFKLLLVILVYFGGNLESLVLLILDLIVMLVEYTELGLQE-SIFIERLSQFFKFKNLSEN 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1152 ASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQI-FIPMVNKVL-VRHRINHQRYDVLICRIVKgytladeeEDP 1229
Cdd:COG5032   799 ASRLLPPLMDNLSKSHELRCVSEDDVSALLIQLLTDRVIcFIPVINSSLgDSRRIFLSLLAQLLDDSLK--------EES 870
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1230 LIYQHRMLR-SGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQ 1308
Cdd:COG5032   871 LPYNLNVDRgTDLREFFQTVKSKAEVLSMLPFVQSILFEAWNRVDFLLKDFWQEELDNLLVALLKELPFMALRDCSILSD 950
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1309 AYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIA-EVTQTLL---NLAEFMEHSDKG-PLPLRDdngivlL 1383
Cdd:COG5032   951 LYFMLGRELWNSVSFECWLELMNSYKRLLIKSLKSKLHLPTIPiLILQMLLdskNLTEFTEHQLKNlPLPSLS------I 1024
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1384 GERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFgELEIQATWYEKLHEWEDALVAY 1463
Cdd:COG5032  1025 GFYESLCSFLAKLLHDEELYFFPLLFVSSLETLLSVNYHINQLDLRPNILKHFGSFV-RFQLKPHLVKYLQRWYEALNRY 1103
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1464 DKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDG 1543
Cdd:COG5032  1104 FELLSKGDRLFAISFTKLRNVDALGKLELYSSLAEIDMFLSLHRRRKLLETLVATAYEQVGEWYKAQQLYEVAQRKARSK 1183
                        1210      1220      1230      1240      1250
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767903554 1544 AFY--RAVLALHQDLFslaqQCIDK-----ARDLLDAELTAMA-GESYSRAY 1587
Cdd:COG5032  1184 EFPfsLQYLYWHINDI----DCADKlqsvlAELSLVTGISELLlEESWRRAL 1231
DUF3385 pfam11865
Domain of unknown function (DUF3385); This domain is functionally uncharacterized. This domain ...
854-1024 1.68e-75

Domain of unknown function (DUF3385); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 160 to 172 amino acids in length. This domain is found associated with pfam00454, pfam02260, pfam02985, pfam02259 and pfam08771.


Pssm-ID: 463377  Cd Length: 160  Bit Score: 247.51  E-value: 1.68e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554   854 VVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSlseskssqdsSDYSTSE 933
Cdd:pfam11865    1 VIDPYLDYPQLLGILLNILKTEQSQSIRRETIRVLGILGALDPYKHKENEGKSEDSDSEEQNA----------PSTDVSL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554   934 MLVNMGNLPlDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLF 1013
Cdd:pfam11865   71 LMVGMSPSN-EEYYPTVVINSLMRILRDPSLSSHHTAVVQAIMFIFKTLGLKCVPFLPQVIPALLSVIRTCPPSLREFYF 149
                          170
                   ....*....|.
gi 767903554  1014 QQLGMLVSFVK 1024
Cdd:pfam11865  150 QQLATLVSIVK 160
FAT pfam02259
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
1521-1589 5.00e-25

FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.


Pssm-ID: 396714 [Multi-domain]  Cd Length: 342  Bit Score: 108.21  E-value: 5.00e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767903554  1521 WGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGI 1589
Cdd:pfam02259    9 WRLGQWDLMREYLSLMKKDSPDKAFFEAILALHRNQFDEAERYIEKARQLLDTELSALSGESYNRAYPL 77
HEAT COG1413
HEAT repeat [General function prediction only];
610-718 3.24e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.61  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554  610 FLNSEHKEIRMEAARTCSRLLTPS-----IHLISGHAHVVSQTAVQVVADVLSK----LLVVGITDPDPDIRYCVLASLd 680
Cdd:COG1413    24 ALADEDPDVRAAAARALGRLGDPRavpalLEALKDPDPEVRAAAAEALGRIGDPeavpALIAALKDEDPEVRRAAAEAL- 102
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767903554  681 erfdAHLAQAENLQALFVALNDQVFEIRELAICTVGRL 718
Cdd:COG1413   103 ----GRLGDPAAVPALLEALKDPDWEVRRAAARALGRL 136
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
1383-1492 7.91e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 7.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903554 1383 LGERAAKCRAYAKAL-HYKELeFQKGPT-PAILESLISINNKLQQPEAAAGVLEYAMKHF-GELEIQ---ATWYEKLHEW 1456
Cdd:COG4783    10 LAQALLLAGDYDEAEaLLEKA-LELDPDnPEAFALLGEILLQLGDLDEAIVLLHEALELDpDEPEARlnlGLALLKAGDY 88
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767903554 1457 EDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQ 1492
Cdd:COG4783    89 DEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH