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Conserved domains on  [gi|961989560|ref|XP_014825791|]
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PREDICTED: integrin beta-4 isoform X2 [Poecilia mexicana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 36-453 8.67e-151

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member smart00187:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 423  Bit Score: 472.58  E-value: 8.67e-151
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560     36 TCSDCLQAGVGCAYCSEEDF---GFPRCDLHEKILAHGCNVAYVIKATSKQTIERNEAIN---TNLQRSQVSPQEVRMTF 109
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFtsgGSARCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    110 LPGETRELDVNVFAPTKGPLDLYILMDFSNSMKDDLDNLKKMGNKLATVVQEISSDYTIGFGKFVDKVIEPQTDMRPDKL 189
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    190 KQPWPD----SDSPFSFKNVIPLIKDVNSFTAKLQKERISGNLDAPEGGFDAILQAAVC-KEIGWREGSTHLLVFSTESA 264
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCtEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    265 FHYEADGAnvLAGILPRNDEACHLDENGVYIQATKQDYPSIPTLVRVLGNHNIIPIFAVTNHSYMYYLKLKEYFPIAEIG 344
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    345 VLQEDSSNILEIMRDAFVSIQSKMSIRADNRPK----AFGAQFLDMSNKVVNYGAFNFKPGEIGKFKVKLTAqqmlgeqP 420
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEgvsvTYTSSCPGGVTGPGTRKCEGVKIGDTVSFEVTVTA-------T 391

                           410       420       430
                    ....*....|....*....|....*....|...
gi 961989560    421 VCkvDPGDKEGTIKVKPTTFDSAVNVKASILCE 453
Cdd:smart00187  392 KC--PPEDQEQSIRIRPVGFSETLEVEVTFLCD 422
fn3 pfam00041
Fibronectin type III domain;
1814-1899 1.01e-22

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 94.02  E-value: 1.01e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1814 SAPGPLVFTALSPDSLQLTWEKPRKPNGDILSYRVTCEQLHGGGDMRSFNVSGNnaETSLTVPNLTENVPYKFKVQAQTT 1893
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 961989560  1894 QGFGPE 1899
Cdd:pfam00041   79 GGEGPP 84
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 628-712 1.43e-18

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


:

Pssm-ID: 462325  Cd Length: 84  Bit Score: 81.94  E-value: 1.43e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   628 CEETRKCVQCKAWKTGEKKDE---AKCKDclvEVIMVDELKERGE-VLDSCRFVDEDnDCTYEYTVETSKdptNTKLLAE 703
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKncsRNCKF---EIILVEVLKEDEEpGAVLCSFKDED-DCWFTFTYYEDE---SGKYVVH 73


                   ....*....
gi 961989560   704 VLKKRDCPA 712
Cdd:pfam07965   74 VQKERECPP 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1234-1458 1.93e-17

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.52  E-value: 1.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1234 VSPRGTTPggrlLPPGNLKAKATGPRNIRLNWDPPPGNPV-GYKVKYWIYGDpEKDAKVLDVRTPQAELTNLLPFCDYET 1312
Cdd:COG3401   226 VTTPTTPP----SAPTGLTATADTPGSVTLSWDPVTESDAtGYRVYRSNSGD-GPFTKVATVTTTSYTDTGLTNGTTYYY 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1313 RVCAYNSMGD-GPDTNIVSCQTLEDAPGEPGRLAFNVISPTVTQLSWAEPaeTNGDITAYEViytpiddEMKPVGGAKKV 1391
Cdd:COG3401   301 RVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNV-------YRSTSGGGTYT 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961989560 1392 KI-DNPKKRMLLIENLQSAQTYQYKVRAQNSVGwgpfrdatinLASQPSRPMSIPIIPDVPIVDAEAG 1458
Cdd:COG3401   372 KIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAG----------NESAPSEEVSATTASAASGESLTAS 429
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1700-1790 9.78e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.46  E-value: 9.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1700 PDTPSRLVFSALGPTALKVSWQEP-HCEKDVLGYCVLYQLLNGGETKRLNVTNPAENSVVIHDLLPNHSYLFKVKAQSQE 1778
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|..
gi 961989560 1779 GWGPEREGVITI 1790
Cdd:cd00063    81 GESPPSESVTVT 92
Calx-beta super family cl02522
Calx-beta domain;
999-1093 4.20e-12

Calx-beta domain;


The actual alignment was detected with superfamily member pfam03160:

Pssm-ID: 413355 [Multi-domain]  Cd Length: 91  Bit Score: 63.81  E-value: 4.20e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   999 SIFSFLQPKYTYSRKDGVAHIPISREIIEDGRT-QVTYTTQDLSAKNKKDYMSVQGDLSYAPGETEKIVPVRLLElsekD 1077
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTvVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 961989560  1078 GFLEdkPIKQFVMDLS 1093
Cdd:pfam03160   78 DVYE--GDENFFVLLS 91
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 997-1228 5.35e-09

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 61.35  E-value: 5.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   997 ATSIFsFLQPKYTYSRKDGVAHIPISREIIEDGRT-QVTYTTQDLSAKNKKDYMSVQGDLSYAPGETEKIVPVrllELSE 1075
Cdd:TIGR00845  399 VSKIF-FEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRI---GIID 474

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1076 KDGFLEDkpiKQFVMDLSNPRQGAKLGRYPR--------------TTVTIADTQEPSVMMFKKGNQNFSTLDQTYPIPVV 1141
Cdd:TIGR00845  475 DDIFEED---EHFYVRLSNLRVGSEDGILEAnhvsavaqlaspntATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVL 551

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1142 RSRNEDSPATVKWRTKKSQCF-------DLSGSLKFAPGETEKNIVIEPFPGSA--QPETFQLELYDP------------ 1200
Cdd:TIGR00845  552 RTSGARGTVIVPYRTVEGTARgggkdfeDTCGELEFENDETEKTIRVKIVDDEEyeKNDTFFIELGEPrwakrgikaall 631

                          250       260
                   ....*....|....*....|....*....
gi 961989560  1201 -STNAVVGERKNTVvnitEEPRSPEIAQM 1228
Cdd:TIGR00845  632 lNETITDDDQKLTS----KEEEERRIAEM 656
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 457-485 7.11e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


:

Pssm-ID: 465729  Cd Length: 29  Bit Score: 52.88  E-value: 7.11e-09
                           10        20
                   ....*....|....*....|....*....
gi 961989560   457 CEKTPTLKAKRCNGKGNLVCGKCLCDDGW 485
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 36-453 8.67e-151

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 472.58  E-value: 8.67e-151
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560     36 TCSDCLQAGVGCAYCSEEDF---GFPRCDLHEKILAHGCNVAYVIKATSKQTIERNEAIN---TNLQRSQVSPQEVRMTF 109
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFtsgGSARCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    110 LPGETRELDVNVFAPTKGPLDLYILMDFSNSMKDDLDNLKKMGNKLATVVQEISSDYTIGFGKFVDKVIEPQTDMRPDKL 189
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    190 KQPWPD----SDSPFSFKNVIPLIKDVNSFTAKLQKERISGNLDAPEGGFDAILQAAVC-KEIGWREGSTHLLVFSTESA 264
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCtEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    265 FHYEADGAnvLAGILPRNDEACHLDENGVYIQATKQDYPSIPTLVRVLGNHNIIPIFAVTNHSYMYYLKLKEYFPIAEIG 344
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    345 VLQEDSSNILEIMRDAFVSIQSKMSIRADNRPK----AFGAQFLDMSNKVVNYGAFNFKPGEIGKFKVKLTAqqmlgeqP 420
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEgvsvTYTSSCPGGVTGPGTRKCEGVKIGDTVSFEVTVTA-------T 391

                           410       420       430
                    ....*....|....*....|....*....|...
gi 961989560    421 VCkvDPGDKEGTIKVKPTTFDSAVNVKASILCE 453
Cdd:smart00187  392 KC--PPEDQEQSIRIRPVGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 124-368 1.15e-139

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 434.23  E-value: 1.15e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   124 PTKGPLDLYILMDFSNSMKDDLDNLKKMGNKLATVVQEISSDYTIGFGKFVDKVIEPQTDMRPDKLKQPWPDS----DSP 199
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   200 FSFKNVIPLIKDVNSFTAKLQKERISGNLDAPEGGFDAILQAAVCKE-IGWREGSTHLLVFSTESAFHYEADGAnvLAGI 278
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDqIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   279 LPRNDEACHLDENGVYIQATKQDYPSIPTLVRVLGNHNIIPIFAVTNHSYMYYLKLKEYFPIAEIGVLQEDSSNILEIMR 358
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 961989560   359 DAFVSIQSKM 368
Cdd:pfam00362  239 EAYEKIRSKV 248
fn3 pfam00041
Fibronectin type III domain;
1814-1899 1.01e-22

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 94.02  E-value: 1.01e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1814 SAPGPLVFTALSPDSLQLTWEKPRKPNGDILSYRVTCEQLHGGGDMRSFNVSGNnaETSLTVPNLTENVPYKFKVQAQTT 1893
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 961989560  1894 QGFGPE 1899
Cdd:pfam00041   79 GGEGPP 84
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 628-712 1.43e-18

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 81.94  E-value: 1.43e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   628 CEETRKCVQCKAWKTGEKKDE---AKCKDclvEVIMVDELKERGE-VLDSCRFVDEDnDCTYEYTVETSKdptNTKLLAE 703
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKncsRNCKF---EIILVEVLKEDEEpGAVLCSFKDED-DCWFTFTYYEDE---SGKYVVH 73


                   ....*....
gi 961989560   704 VLKKRDCPA 712
Cdd:pfam07965   74 VQKERECPP 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1234-1458 1.93e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.52  E-value: 1.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1234 VSPRGTTPggrlLPPGNLKAKATGPRNIRLNWDPPPGNPV-GYKVKYWIYGDpEKDAKVLDVRTPQAELTNLLPFCDYET 1312
Cdd:COG3401   226 VTTPTTPP----SAPTGLTATADTPGSVTLSWDPVTESDAtGYRVYRSNSGD-GPFTKVATVTTTSYTDTGLTNGTTYYY 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1313 RVCAYNSMGD-GPDTNIVSCQTLEDAPGEPGRLAFNVISPTVTQLSWAEPaeTNGDITAYEViytpiddEMKPVGGAKKV 1391
Cdd:COG3401   301 RVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNV-------YRSTSGGGTYT 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961989560 1392 KI-DNPKKRMLLIENLQSAQTYQYKVRAQNSVGwgpfrdatinLASQPSRPMSIPIIPDVPIVDAEAG 1458
Cdd:COG3401   372 KIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAG----------NESAPSEEVSATTASAASGESLTAS 429
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1813-1898 2.69e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 78.69  E-value: 2.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1813 PSAPGPLVFTALSPDSLQLTWEKPRKPNGDILSYRVTCEQLhGGGDMRSFNVSGNNaETSLTVPNLTENVPYKFKVQAQT 1892
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREK-GSGDWKEVEVTPGS-ETSYTLTGLKPGTEYEFRVRAVN 78


                  ....*.
gi 961989560 1893 TQGFGP 1898
Cdd:cd00063    79 GGGESP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1700-1790 9.78e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.46  E-value: 9.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1700 PDTPSRLVFSALGPTALKVSWQEP-HCEKDVLGYCVLYQLLNGGETKRLNVTNPAENSVVIHDLLPNHSYLFKVKAQSQE 1778
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|..
gi 961989560 1779 GWGPEREGVITI 1790
Cdd:cd00063    81 GESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1813-1897 1.90e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 73.03  E-value: 1.90e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   1813 PSAPGPLVFTALSPDSLQLTWEKPRKPNGDilSYRVTCEQLHGGGDMRSFNVSGNNAETSLTVPNLTENVPYKFKVQAQT 1892
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 961989560   1893 TQGFG 1897
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1701-1783 1.46e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.52  E-value: 1.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1701 DTPSRLVFSALGPTALKVSWQEP-HCEKDVLGYCVLYQLLNGGE-TKRLNVTNPaENSVVIHDLLPNHSYLFKVKAQSQE 1778
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 961989560  1779 GWGPE 1783
Cdd:pfam00041   80 GEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1699-1923 2.37e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.51  E-value: 2.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1699 VPDTPSRLVFSALGPTALKVSWQePHCEKDVLGYCVLYQLLNGGETKRlnVTNPAENSVVIHDLLPNHSYLFKVKAQSQE 1778
Cdd:COG3401   232 PPSAPTGLTATADTPGSVTLSWD-PVTESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1779 GWGPEREGVITIESAVDPksplspmpgspftlstPSAPGPLVFTALSPDSLQLTWEKPrkPNGDILSYRVTceqlhgggd 1858
Cdd:COG3401   309 GNESAPSNVVSVTTDLTP----------------PAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY--------- 361

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961989560 1859 mRSFNVSGN-------NAETSLTVPNLTENVPYKFKVQAQTTQGFGPEREGIITIESQDGGALSQYNSQSVT 1923
Cdd:COG3401   362 -RSTSGGGTytkiaetVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDA 432
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1247-1333 3.07e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1247 PPGNLKAKATGPRNIRLNWDPPP---GNPVGYKVKYWIYGDPE-KDAKVLDVRTPQAELTNLLPFCDYETRVCAYNSMGD 1322
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|.
gi 961989560 1323 GPDTNIVSCQT 1333
Cdd:cd00063    83 SPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1247-1324 1.85e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 1.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1247 PPGNLKAKATGPRNIRLNWDPPP---GNPVGYKVKYWIYGDPEKDAKVLDVRTP-QAELTNLLPFCDYETRVCAYNSMGD 1322
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ..
gi 961989560  1323 GP 1324
Cdd:pfam00041   82 GP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1247-1323 2.19e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.19e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   1247 PPGNLKAKATGPRNIRLNWDPPP-GNPVGYKVKYWIYGDPEKDAKV---LDVRTPQAELTNLLPFCDYETRVCAYNSMGD 1322
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 961989560   1323 G 1323
Cdd:smart00060   83 G 83
Calx-beta pfam03160
Calx-beta domain;
999-1093 4.20e-12

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 63.81  E-value: 4.20e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   999 SIFSFLQPKYTYSRKDGVAHIPISREIIEDGRT-QVTYTTQDLSAKNKKDYMSVQGDLSYAPGETEKIVPVRLLElsekD 1077
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTvVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 961989560  1078 GFLEdkPIKQFVMDLS 1093
Cdd:pfam03160   78 DVYE--GDENFFVLLS 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1700-1781 5.63e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.40  E-value: 5.63e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   1700 PDTPSRLVFSALGPTALKVSWQEP---HCEKDVLGYCVLYQLlNGGETKRLNVTnPAENSVVIHDLLPNHSYLFKVKAQS 1776
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPpddGITGYIVGYRVEYRE-EGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 961989560   1777 QEGWG 1781
Cdd:smart00060   79 GAGEG 83
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 998-1077 9.41e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 62.66  E-value: 9.41e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    998 TSIFSFLQPKYTYSRKDGVAHIPISREIIEDGRTQVTYTTQDLSAKNKKDYMSVQGDLSYAPGETEKIVPVRLL--ELSE 1075
Cdd:smart00237    1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIddDIYE 80


                    ..
gi 961989560   1076 KD 1077
Cdd:smart00237   81 KD 82
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 997-1228 5.35e-09

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 61.35  E-value: 5.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   997 ATSIFsFLQPKYTYSRKDGVAHIPISREIIEDGRT-QVTYTTQDLSAKNKKDYMSVQGDLSYAPGETEKIVPVrllELSE 1075
Cdd:TIGR00845  399 VSKIF-FEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRI---GIID 474

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1076 KDGFLEDkpiKQFVMDLSNPRQGAKLGRYPR--------------TTVTIADTQEPSVMMFKKGNQNFSTLDQTYPIPVV 1141
Cdd:TIGR00845  475 DDIFEED---EHFYVRLSNLRVGSEDGILEAnhvsavaqlaspntATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVL 551

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1142 RSRNEDSPATVKWRTKKSQCF-------DLSGSLKFAPGETEKNIVIEPFPGSA--QPETFQLELYDP------------ 1200
Cdd:TIGR00845  552 RTSGARGTVIVPYRTVEGTARgggkdfeDTCGELEFENDETEKTIRVKIVDDEEyeKNDTFFIELGEPrwakrgikaall 631

                          250       260
                   ....*....|....*....|....*....
gi 961989560  1201 -STNAVVGERKNTVvnitEEPRSPEIAQM 1228
Cdd:TIGR00845  632 lNETITDDDQKLTS----KEEEERRIAEM 656
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 457-485 7.11e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 52.88  E-value: 7.11e-09
                           10        20
                   ....*....|....*....|....*....
gi 961989560   457 CEKTPTLKAKRCNGKGNLVCGKCLCDDGW 485
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1748-1895 4.05e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 4.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1748 NVTNPAENSVVIHDLLPNHSYLFKVKAQSQEGWGPEREGVitieSAVDPKSPlspmpgspftlstPSAPGPLVFTALSPD 1827
Cdd:COG3401   185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV----SVTTPTTP-------------PSAPTGLTATADTPG 247

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961989560 1828 SLQLTWEKPrkPNGDILSYRVtceqLHGGGDMRSFNVSGNNAETSLTVPNLTENVPYKFKVQAQTTQG 1895
Cdd:COG3401   248 SVTLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 36-453 8.67e-151

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 472.58  E-value: 8.67e-151
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560     36 TCSDCLQAGVGCAYCSEEDF---GFPRCDLHEKILAHGCNVAYVIKATSKQTIERNEAIN---TNLQRSQVSPQEVRMTF 109
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFtsgGSARCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    110 LPGETRELDVNVFAPTKGPLDLYILMDFSNSMKDDLDNLKKMGNKLATVVQEISSDYTIGFGKFVDKVIEPQTDMRPDKL 189
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    190 KQPWPD----SDSPFSFKNVIPLIKDVNSFTAKLQKERISGNLDAPEGGFDAILQAAVC-KEIGWREGSTHLLVFSTESA 264
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCtEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    265 FHYEADGAnvLAGILPRNDEACHLDENGVYIQATKQDYPSIPTLVRVLGNHNIIPIFAVTNHSYMYYLKLKEYFPIAEIG 344
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    345 VLQEDSSNILEIMRDAFVSIQSKMSIRADNRPK----AFGAQFLDMSNKVVNYGAFNFKPGEIGKFKVKLTAqqmlgeqP 420
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEgvsvTYTSSCPGGVTGPGTRKCEGVKIGDTVSFEVTVTA-------T 391

                           410       420       430
                    ....*....|....*....|....*....|...
gi 961989560    421 VCkvDPGDKEGTIKVKPTTFDSAVNVKASILCE 453
Cdd:smart00187  392 KC--PPEDQEQSIRIRPVGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 124-368 1.15e-139

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 434.23  E-value: 1.15e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   124 PTKGPLDLYILMDFSNSMKDDLDNLKKMGNKLATVVQEISSDYTIGFGKFVDKVIEPQTDMRPDKLKQPWPDS----DSP 199
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   200 FSFKNVIPLIKDVNSFTAKLQKERISGNLDAPEGGFDAILQAAVCKE-IGWREGSTHLLVFSTESAFHYEADGAnvLAGI 278
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDqIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   279 LPRNDEACHLDENGVYIQATKQDYPSIPTLVRVLGNHNIIPIFAVTNHSYMYYLKLKEYFPIAEIGVLQEDSSNILEIMR 358
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 961989560   359 DAFVSIQSKM 368
Cdd:pfam00362  239 EAYEKIRSKV 248
fn3 pfam00041
Fibronectin type III domain;
1814-1899 1.01e-22

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 94.02  E-value: 1.01e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1814 SAPGPLVFTALSPDSLQLTWEKPRKPNGDILSYRVTCEQLHGGGDMRSFNVSGNnaETSLTVPNLTENVPYKFKVQAQTT 1893
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 961989560  1894 QGFGPE 1899
Cdd:pfam00041   79 GGEGPP 84
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 628-712 1.43e-18

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 81.94  E-value: 1.43e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   628 CEETRKCVQCKAWKTGEKKDE---AKCKDclvEVIMVDELKERGE-VLDSCRFVDEDnDCTYEYTVETSKdptNTKLLAE 703
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKncsRNCKF---EIILVEVLKEDEEpGAVLCSFKDED-DCWFTFTYYEDE---SGKYVVH 73


                   ....*....
gi 961989560   704 VLKKRDCPA 712
Cdd:pfam07965   74 VQKERECPP 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1234-1458 1.93e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.52  E-value: 1.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1234 VSPRGTTPggrlLPPGNLKAKATGPRNIRLNWDPPPGNPV-GYKVKYWIYGDpEKDAKVLDVRTPQAELTNLLPFCDYET 1312
Cdd:COG3401   226 VTTPTTPP----SAPTGLTATADTPGSVTLSWDPVTESDAtGYRVYRSNSGD-GPFTKVATVTTTSYTDTGLTNGTTYYY 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1313 RVCAYNSMGD-GPDTNIVSCQTLEDAPGEPGRLAFNVISPTVTQLSWAEPaeTNGDITAYEViytpiddEMKPVGGAKKV 1391
Cdd:COG3401   301 RVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNV-------YRSTSGGGTYT 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961989560 1392 KI-DNPKKRMLLIENLQSAQTYQYKVRAQNSVGwgpfrdatinLASQPSRPMSIPIIPDVPIVDAEAG 1458
Cdd:COG3401   372 KIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAG----------NESAPSEEVSATTASAASGESLTAS 429
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1813-1898 2.69e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 78.69  E-value: 2.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1813 PSAPGPLVFTALSPDSLQLTWEKPRKPNGDILSYRVTCEQLhGGGDMRSFNVSGNNaETSLTVPNLTENVPYKFKVQAQT 1892
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREK-GSGDWKEVEVTPGS-ETSYTLTGLKPGTEYEFRVRAVN 78


                  ....*.
gi 961989560 1893 TQGFGP 1898
Cdd:cd00063    79 GGGESP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1700-1790 9.78e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.46  E-value: 9.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1700 PDTPSRLVFSALGPTALKVSWQEP-HCEKDVLGYCVLYQLLNGGETKRLNVTNPAENSVVIHDLLPNHSYLFKVKAQSQE 1778
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|..
gi 961989560 1779 GWGPEREGVITI 1790
Cdd:cd00063    81 GESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1813-1897 1.90e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 73.03  E-value: 1.90e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   1813 PSAPGPLVFTALSPDSLQLTWEKPRKPNGDilSYRVTCEQLHGGGDMRSFNVSGNNAETSLTVPNLTENVPYKFKVQAQT 1892
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 961989560   1893 TQGFG 1897
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1701-1783 1.46e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.52  E-value: 1.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1701 DTPSRLVFSALGPTALKVSWQEP-HCEKDVLGYCVLYQLLNGGE-TKRLNVTNPaENSVVIHDLLPNHSYLFKVKAQSQE 1778
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 961989560  1779 GWGPE 1783
Cdd:pfam00041   80 GEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1699-1923 2.37e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.51  E-value: 2.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1699 VPDTPSRLVFSALGPTALKVSWQePHCEKDVLGYCVLYQLLNGGETKRlnVTNPAENSVVIHDLLPNHSYLFKVKAQSQE 1778
Cdd:COG3401   232 PPSAPTGLTATADTPGSVTLSWD-PVTESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1779 GWGPEREGVITIESAVDPksplspmpgspftlstPSAPGPLVFTALSPDSLQLTWEKPrkPNGDILSYRVTceqlhgggd 1858
Cdd:COG3401   309 GNESAPSNVVSVTTDLTP----------------PAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY--------- 361

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961989560 1859 mRSFNVSGN-------NAETSLTVPNLTENVPYKFKVQAQTTQGFGPEREGIITIESQDGGALSQYNSQSVT 1923
Cdd:COG3401   362 -RSTSGGGTytkiaetVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDA 432
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1247-1333 3.07e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1247 PPGNLKAKATGPRNIRLNWDPPP---GNPVGYKVKYWIYGDPE-KDAKVLDVRTPQAELTNLLPFCDYETRVCAYNSMGD 1322
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|.
gi 961989560 1323 GPDTNIVSCQT 1333
Cdd:cd00063    83 SPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1338-1427 1.83e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 1.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1338 PGEPGRLAFNVISPTVTQLSWAEPAETNGDITAYEVIYTPIDDemkpvGGAKKVKIDNPKKRMLLIENLQSAQTYQYKVR 1417
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS-----GDWKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|
gi 961989560 1418 AQNSVGWGPF 1427
Cdd:cd00063    76 AVNGGGESPP 85
fn3 pfam00041
Fibronectin type III domain;
1247-1324 1.85e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 1.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1247 PPGNLKAKATGPRNIRLNWDPPP---GNPVGYKVKYWIYGDPEKDAKVLDVRTP-QAELTNLLPFCDYETRVCAYNSMGD 1322
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ..
gi 961989560  1323 GP 1324
Cdd:pfam00041   82 GP 83
fn3 pfam00041
Fibronectin type III domain;
1339-1427 1.45e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1339 GEPGRLAFNVISPTVTQLSWAEPAETNGDITAYEVIYTPIDDEmkpvGGAKKVKIDNPKKRMLLiENLQSAQTYQYKVRA 1418
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG----EPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 961989560  1419 QNSVGWGPF 1427
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1247-1323 2.19e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.19e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   1247 PPGNLKAKATGPRNIRLNWDPPP-GNPVGYKVKYWIYGDPEKDAKV---LDVRTPQAELTNLLPFCDYETRVCAYNSMGD 1322
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 961989560   1323 G 1323
Cdd:smart00060   83 G 83
Calx-beta pfam03160
Calx-beta domain;
999-1093 4.20e-12

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 63.81  E-value: 4.20e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   999 SIFSFLQPKYTYSRKDGVAHIPISREIIEDGRT-QVTYTTQDLSAKNKKDYMSVQGDLSYAPGETEKIVPVRLLElsekD 1077
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTvVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 961989560  1078 GFLEdkPIKQFVMDLS 1093
Cdd:pfam03160   78 DVYE--GDENFFVLLS 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1700-1781 5.63e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.40  E-value: 5.63e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   1700 PDTPSRLVFSALGPTALKVSWQEP---HCEKDVLGYCVLYQLlNGGETKRLNVTnPAENSVVIHDLLPNHSYLFKVKAQS 1776
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPpddGITGYIVGYRVEYRE-EGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 961989560   1777 QEGWG 1781
Cdd:smart00060   79 GAGEG 83
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 998-1077 9.41e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 62.66  E-value: 9.41e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560    998 TSIFSFLQPKYTYSRKDGVAHIPISREIIEDGRTQVTYTTQDLSAKNKKDYMSVQGDLSYAPGETEKIVPVRLL--ELSE 1075
Cdd:smart00237    1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIddDIYE 80


                    ..
gi 961989560   1076 KD 1077
Cdd:smart00237   81 KD 82
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 27-72 4.41e-11

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 59.49  E-value: 4.41e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 961989560    27 NSClEARSGTCSDCLQAGVGCAYCSEEDFG--FPRCDLHEKILAHGCN 72
Cdd:pfam17205    1 NRC-TSASTSCEECIQSGPDCAWCTDENFTsgSPRCDTRENLLARGCS 47
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1209-1423 9.86e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.48  E-value: 9.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1209 RKNTVVNITEEPRSPEIAQMQSKGYVSPRGTTPGGRLLPPGNLKAKATGPRNIRLNWDPPPGNPVGYKVKywiyGDPEKD 1288
Cdd:COG3401   108 NTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSAT----AAVATT 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1289 AKVLDVRTPQAELTNLLPFCDYETRVCAYNSMGDGPDTNIVSCQTLEDAPGEPGRLAFNVISPTVTQLSWAEPaeTNGDI 1368
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPV--TESDA 261

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 961989560 1369 TAYEvIY--TPIDDEMKPVGGAKKVK-IDNpkkrmllieNLQSAQTYQYKVRAQNSVG 1423
Cdd:COG3401   262 TGYR-VYrsNSGDGPFTKVATVTTTSyTDT---------GLTNGTTYYYRVTAVDAAG 309
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1338-1425 5.33e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 5.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   1338 PGEPGRLAFNVISPTVTQLSWAEPAETNGD--ITAYEVIYTPIDDEMKPVggakkvkIDNPKKRMLLIENLQSAQTYQYK 1415
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEV-------NVTPSSTSYTLTGLKPGTEYEFR 73

                            90
                    ....*....|
gi 961989560   1416 VRAQNSVGWG 1425
Cdd:smart00060   74 VRAVNGAGEG 83
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 997-1228 5.35e-09

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 61.35  E-value: 5.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560   997 ATSIFsFLQPKYTYSRKDGVAHIPISREIIEDGRT-QVTYTTQDLSAKNKKDYMSVQGDLSYAPGETEKIVPVrllELSE 1075
Cdd:TIGR00845  399 VSKIF-FEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRI---GIID 474

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1076 KDGFLEDkpiKQFVMDLSNPRQGAKLGRYPR--------------TTVTIADTQEPSVMMFKKGNQNFSTLDQTYPIPVV 1141
Cdd:TIGR00845  475 DDIFEED---EHFYVRLSNLRVGSEDGILEAnhvsavaqlaspntATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVL 551

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560  1142 RSRNEDSPATVKWRTKKSQCF-------DLSGSLKFAPGETEKNIVIEPFPGSA--QPETFQLELYDP------------ 1200
Cdd:TIGR00845  552 RTSGARGTVIVPYRTVEGTARgggkdfeDTCGELEFENDETEKTIRVKIVDDEEyeKNDTFFIELGEPrwakrgikaall 631

                          250       260
                   ....*....|....*....|....*....
gi 961989560  1201 -STNAVVGERKNTVvnitEEPRSPEIAQM 1228
Cdd:TIGR00845  632 lNETITDDDQKLTS----KEEEERRIAEM 656
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 457-485 7.11e-09

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 52.88  E-value: 7.11e-09
                           10        20
                   ....*....|....*....|....*....
gi 961989560   457 CEKTPTLKAKRCNGKGNLVCGKCLCDDGW 485
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1238-1498 8.28e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.79  E-value: 8.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1238 GTTPGGRLLPPGNLKAKATGPRNIRLNWDPPPGNPV-GYKVKYWIYGDPEKDAKVLDVRTPQAELTNLLPFCDYETRVCA 1316
Cdd:COG3401   320 VTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADVtGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1317 YNSMGD-GPDTNIVSCQTLEDAPGE-PGRLAFNVISPTVTQLSWAEPAETNGDITAYEVIYTPIDDEMKPVGGAKKVKID 1394
Cdd:COG3401   400 VDAAGNeSAPSEEVSATTASAASGEsLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1395 NPkkrmllienLQSAQTYQYKVRAQNSVGWGPFRDATINLASQPSRPMSIPIIPDVPIVDAEAGDEYDSYlmYSNDVLKS 1474
Cdd:COG3401   480 TT---------TDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGA--STGDVLIT 548

                         250       260
                  ....*....|....*....|....
gi 961989560 1475 PTSSKTPSVSGDGWQHIKLVGSNL 1498
Cdd:COG3401   549 DLVSLTTSASSSVSGAGLGSGNLY 572
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1748-1895 4.05e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 4.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1748 NVTNPAENSVVIHDLLPNHSYLFKVKAQSQEGWGPEREGVitieSAVDPKSPlspmpgspftlstPSAPGPLVFTALSPD 1827
Cdd:COG3401   185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV----SVTTPTTP-------------PSAPTGLTATADTPG 247

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961989560 1828 SLQLTWEKPrkPNGDILSYRVtceqLHGGGDMRSFNVSGNNAETSLTVPNLTENVPYKFKVQAQTTQG 1895
Cdd:COG3401   248 SVTLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1696-1941 2.69e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1696 SPGVPDTPSRLVFSALGPTALKVSWQEPHcEKDVLGYCVLYQLLNGGETKRLNVTnPAENSVVIHDLLPNHSYLFKVKAQ 1775
Cdd:COG3401   323 DLTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRSTSGGGTYTKIAET-VTTTSYTDTGLTPGTTYYYKVTAV 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1776 SQEGWGPEREGVITIESAVDPKSPlSPMPGSPFTLSTPSAPGPLVFTALSPDSLQLTWEKP------RKPNGDILSYRVT 1849
Cdd:COG3401   401 DAAGNESAPSEEVSATTASAASGE-SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADggdtgnAVPFTTTSSTVTA 479

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1850 CEQLHGGGDMRSFNVSGNNAETSLTVPNlTENVPYKFKVQAQTTQGFGPEREGIITIESQDGGALSQYNSQSVTRREVFQ 1929
Cdd:COG3401   480 TTTDTTTANLSVTTGSLVGGSGASSVTN-SVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558

                         250
                  ....*....|..
gi 961989560 1930 MSPEMTTRTNVS 1941
Cdd:COG3401   559 SSVSGAGLGSGN 570
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1261-1423 1.53e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 46.86  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1261 IRLNWDPPPGNpVGYKVKY------WIYgdpekdakVLDVRTPQAELTNLLPfCDYETRVCAYNSMGD-GPDTNIVSCQT 1333
Cdd:COG4733   554 LTVSWDAPAGA-VAYEVEWrrddgnWVS--------VPRTSGTSFEVPGIYA-GDYEVRVRAINALGVsSAWAASSETTV 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961989560 1334 --LEDAPGEPGRLAFnVISPTVTQLSWAEPAETngDITAYEVIYTPIDDEmkpvGGAKKVKIDNPKKRMLLIeNLQSAQT 1411
Cdd:COG4733   624 tgKTAPPPAPTGLTA-TGGLGGITLSWSFPVDA--DTLRTEIRYSTTGDW----ASATVAQALYPGNTYTLA-GLKAGQT 695

                         170
                  ....*....|..
gi 961989560 1412 YQYKVRAQNSVG 1423
Cdd:COG4733   696 YYYRARAVDRSG 707
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 468-490 3.46e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.56  E-value: 3.46e-03
                           10        20
                   ....*....|....*....|....*
gi 961989560   468 CNGKG--NLVCGKCLCDDGWAGAFC 490
Cdd:pfam07974    2 CSGRGtcVNQCGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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