NCBI Conserved Domain Search

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

313-356

3.10e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 52.61 E-value: 3.10e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034629713 313 ADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLK 356
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-75

3.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 55.24 E-value: 3.43e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENI 75
Cdd:cd18236    53 MFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENC 127

BACK_KLHL36

cd18475

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...

70-172

4.30e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pssm-ID: 350550 Cd Length: 100 Bit Score: 54.08 E-value: 4.30e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQ-LPLEKVYSLLSSNRLEVSCETEVYEGAL--LYHYS 146
Cdd:cd18475     1 VSEENYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALqwLTQSP 80

                          90       100
                  ....*....|....*....|....*.
gi 1034629713 147 LEQVQADQislheppkLLETVRFPLM 172
Cdd:cd18475    81 ERENEAYQ--------VLSNIHFPLI 98

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

16-77

9.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 53.66 E-value: 9.33e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034629713  16 IHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILD 77
Cdd:cd18260    59 LNDISPLGLATVITYAYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

74-177

2.03e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 52.62 E-value: 2.03e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQAD 153
Cdd:cd18445     5 NCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRKE 84

                          90       100
                  ....*....|....*....|....
gi 1034629713 154 QIslhepPKLLETVRFPLMEAEVL 177
Cdd:cd18445    85 HL-----AELLEHVRLPLLSPEYL 103

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

70-171

2.46e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 51.98 E-value: 2.46e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-HYSLE 148
Cdd:cd18447     2 VDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWlKYDEP 81

                          90       100
                  ....*....|....*....|...
gi 1034629713 149 QVQadqislHEPPKLLETVRFPL 171
Cdd:cd18447    82 NRQ------PYMVDILAKVRFPL 98

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

73-173

3.32e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 51.70 E-value: 3.32e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  73 ENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQA 152
Cdd:cd18446     4 ENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERL 83

                          90       100
                  ....*....|....*....|.
gi 1034629713 153 DQIslhepPKLLETVRFPLME 173
Cdd:cd18446    84 PLL-----PRVLENVRLPLLD 99

Kelch

Kelch domain;

324-369

4.21e-08

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 49.48 E-value: 4.21e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1034629713  324 IYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEG 369
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

70-172

4.81e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 51.15 E-value: 4.81e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALlyhySLEQ 149
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVL----SWVK 76

                          90       100
                  ....*....|....*....|...
gi 1034629713 150 VQADQISLHePPKLLETVRFPLM 172
Cdd:cd18456    77 HDVDGRRQH-VPRLMKCVRLPLL 98

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

74-200

5.18e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 51.99 E-value: 5.18e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYhysleqVQAD 153
Cdd:cd18513     5 NCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISW------IKYD 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034629713 154 -QISLHEPPKLLETVRFPLMEAEVLQRLhdkLDPSPL-------RDTVASALMYH 200
Cdd:cd18513    79 kEARLEHMAKLMEHVRLPLLPRDYLVQT---VEEEALiknnntcKDFLIEAMKYH 130

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

71-210

8.81e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 51.24 E-value: 8.81e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  71 DEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYhysleqV 150
Cdd:cd18452     2 DPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNW------V 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034629713 151 QADQISLHEP-PKLLETVRFPLMEAEVLQrlhDKLDPSPL-------RDTVASALMYHrnesLQPSLQ 210
Cdd:cd18452    76 KHDKEEREDYlPELLQYVRLPLLSPRYIT---DVVDAEPLircslecRDLVDEAKKFH----LRPELR 136

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-74

9.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 50.99 E-value: 9.08e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 74
Cdd:cd18253    47 MFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-77

9.59e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 51.12 E-value: 9.59e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILD 77
Cdd:cd18261    57 MFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYLD 133

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

70-172

1.39e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 49.80 E-value: 1.39e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYhysleq 149
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRW------ 74

                          90       100
                  ....*....|....*....|....
gi 1034629713 150 VQAD-QISLHEPPKLLETVRFPLM 172
Cdd:cd18460    75 VKADpKHRQHFWPELLQHVRLPFV 98

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-68

1.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 50.07 E-value: 1.74e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMS 68
Cdd:cd18338    50 MFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLES 117

BACK_KLHL15

cd18454

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...

73-172

1.79e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.

Pssm-ID: 350529 Cd Length: 108 Bit Score: 49.51 E-value: 1.79e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  73 ENILDVYRLAELF--DLSRLTEQLDTYILKNFVAF-SRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEG--ALLYHYSL 147
Cdd:cd18454     4 DNCAEIMRLLDDFsvNIEGVREKLDSFLLENFVPLmSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAvqAWLRHDRR 83

                          90       100
                  ....*....|....*....|....*
gi 1034629713 148 EQVQADQIslheppklLETVRFPLM 172
Cdd:cd18454    84 RWRHTDTI--------IQNIRFCLM 100

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

74-172

1.81e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 49.20 E-value: 1.81e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-HYSLEQVQA 152
Cdd:cd18515     4 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWvNYDLKKRHC 83

                          90       100
                  ....*....|....*....|
gi 1034629713 153 dqislhEPPKLLETVRFPLM 172
Cdd:cd18515    84 ------YLSELLQTVRLALL 97

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-71

2.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 50.03 E-value: 2.52e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVD 71
Cdd:cd18246    68 MFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLD 138

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

16-64

5.34e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 48.63 E-value: 5.34e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034629713  16 IHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCD 64
Cdd:cd18293    60 LQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAARRLQISELESLCLE 108

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-66

5.63e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 48.10 E-value: 5.63e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034629713  14 VLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18245    58 IELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

74-144

6.52e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 47.00 E-value: 6.52e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGAL--LYH 144
Cdd:cd18463     6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMrwVYH 78

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-76

7.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 48.63 E-value: 7.30e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENIL 76
Cdd:cd18268    52 MFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCL 127

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-78

7.34e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 48.41 E-value: 7.34e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034629713  14 VLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDV 78
Cdd:cd18306    60 VKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

1-77

9.36e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 47.88 E-value: 9.36e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILD 77
Cdd:cd18263    42 MFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

7-68

1.02e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 47.61 E-value: 1.02e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034629713   7 KEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMS 68
Cdd:cd18231    50 KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELIDS 111

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

461-502

1.04e-06

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 45.68 E-value: 1.04e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034629713 461 GIAVLDNRIYVLGGRSHNRGSRTgyVHIYDVEKDCWEEGPQL 502
Cdd:pfam01344   6 GVVVVGGKIYVIGGFDGNQSLNS--VEVYDPETNTWSKLPSM 45

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-76

1.18e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 47.90 E-value: 1.18e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENIL 76
Cdd:cd18252    51 MFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126

Kelch

Kelch domain;

370-416

1.58e-06

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 44.86 E-value: 1.58e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034629713  370 KMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLN 416
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

71-143

1.59e-06

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 45.86 E-value: 1.59e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034629713  71 DEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY 143
Cdd:cd18508     1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAW 73

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-76

2.95e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 46.69 E-value: 2.95e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENIL 76
Cdd:cd18265    52 MFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127

PHA02713

hypothetical protein; Provisional

305-509

3.39e-06

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 50.01 E-value: 3.39e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713 305 IQSLQQEHADLSVCVVGRYIYAVAGRDYHN-DLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYL 383
Cdd:PHA02713  287 ISTIPNHIINYASAIVDNEIIIAGGYNFNNpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVE 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713 384 KETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSN-----------NDAGYRRDVH---QVACYSCTSGQWSS 449
Cdd:PHA02713  367 RTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTehidytsvhhmNSIDMEEDTHssnKVIRYDTVNNIWET 446

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713 450 VCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGL 509
Cdd:PHA02713  447 LPNFWTGTIRPGVVSHKDDIYVVCDIKDEKNVKTCIFRYNTNTYNGWELITTTESRLSAL 506

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-66

3.47e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 46.12 E-value: 3.47e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFI----YTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18305    43 MFSGSWKESKETVINLEIPDDNITVEALNVVfgslYRDEIEIKPSRVVSILAAATLLQLDGLIQQCSEVM 112

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-74

3.90e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 46.53 E-value: 3.90e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 74
Cdd:cd18270    55 MFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAEN 128

Kelch_3

pfam13415

Galactose oxidase, central domain;

368-412

4.08e-06

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 43.82 E-value: 4.08e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034629713 368 EGKMYIT--CGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMA 412
Cdd:pfam13415   1 GDKLYIFggLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

1-63

4.69e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 45.69 E-value: 4.69e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSEL-ELSLSNVQETLVAACQLQIPEIIHFCC 63
Cdd:cd18300    38 MFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQApILEDGDCVGLIVLANRLCLPRLVALCE 101

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

71-143

4.91e-06

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 44.65 E-value: 4.91e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034629713  71 DEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY 143
Cdd:cd18503     2 DRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNW 74

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-66

5.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 45.70 E-value: 5.13e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18326    54 LFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

Kelch

Kelch domain;

468-514

5.50e-06

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 43.32 E-value: 5.50e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034629713  468 RIYVLGGrsHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVL 514
Cdd:smart00612   1 KIYVVGG--FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45

PLN02153

epithiospecifier protein

260-498

6.55e-06

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 48.44 E-value: 6.55e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713 260 PRMSNqGIAVLNNFVYLIGG--------DNNVQGFRAESRCWRYDPRHNRWFQIQSLqqehaDLSVCVVGRYIYAVAGRD 331
Cdd:PLN02153   22 PRCSH-GIAVVGDKLYSFGGelkpnehiDKDLYVFDFNTHTWSIAPANGDVPRISCL-----GVRMVAVGTKLYIFGGRD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713 332 YHNDLNAVERYDPATNSWAYVAPLKREvyahagatlegkmyitcgrrgedylkethcydpgsntwhtlaDGPVRRAWHGM 411
Cdd:PLN02153   96 EKREFSDFYSYDTVKNEWTFLTKLDEE------------------------------------------GGPEARTFHSM 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713 412 ATLLNKLYVIGGSNNDAGYR--RDVHQVACYSCTSGQWSSVcPLPAGH----GEPGIAVLDNRIYVLGG--RSHNRGSRT 483
Cdd:PLN02153  134 ASDENHVYVFGGVSKGGLMKtpERFRTIEAYNIADGKWVQL-PDPGENfekrGGAGFAVVQGKIWVVYGfaTSILPGGKS 212

                         250
                  ....*....|....*....
gi 1034629713 484 GY----VHIYDVEKDCWEE 498
Cdd:PLN02153  213 DYesnaVQFFDPASGKWTE 231

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

74-170

7.21e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 44.60 E-value: 7.21e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLyhYSLEQVQAD 153
Cdd:cd18448     6 NCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMK--WVKHDPQHR 83

                          90
                  ....*....|....*..
gi 1034629713 154 QISLhepPKLLETVRFP 170
Cdd:cd18448    84 KRHL---DDLLSQVRLP 97

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

8-78

9.85e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 45.22 E-value: 9.85e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034629713   8 EMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDV 78
Cdd:cd18341    63 EEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

73-169

1.30e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 44.10 E-value: 1.30e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  73 ENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYhysleqVQA 152
Cdd:cd18470     4 ENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKW------LDF 77

                          90
                  ....*....|....*..
gi 1034629713 153 DQISLHEPPKLLETVRF 169
Cdd:cd18470    78 DQKRVKYAADLLSNIRF 94

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-66

1.99e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 43.92 E-value: 1.99e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034629713   1 MFAGGLKEMEQEeVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18282    40 MFYGGLAENKNE-IEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQFL 104

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-76

2.09e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 44.44 E-value: 2.09e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENIL 76
Cdd:cd18259    61 MFTGDFVESISARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

1-62

2.28e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 43.10 E-value: 2.28e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFC 62
Cdd:cd18314    35 MLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLEKLC 96

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-76

3.16e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 43.67 E-value: 3.16e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENIL 76
Cdd:cd18271    53 MFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

5-66

3.74e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 43.28 E-value: 3.74e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034629713   5 GLKEMEQEEVLIHGV-SYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18329    54 NAKETGQPTVATFDVfSPDTFTIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

360-401

4.82e-05

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 40.67 E-value: 4.82e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034629713 360 YAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLAD 401
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44

Kelch

Kelch domain;

274-321

4.97e-05

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 40.62 E-value: 4.97e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034629713  274 VYLIGGDNNVQgfrAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVG 321
Cdd:smart00612   2 IYVVGGFDGGQ---RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

74-172

5.25e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 42.48 E-value: 5.25e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYhysleqVQAD 153
Cdd:cd18464     4 NCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGW------IRYD 77

                          90       100
                  ....*....|....*....|
gi 1034629713 154 QISLHEP-PKLLETVRFPLM 172
Cdd:cd18464    78 LPRRHEVlPELLRSVRLALL 97

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

462-502

6.26e-05

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 40.40 E-value: 6.26e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034629713 462 IAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQL 502
Cdd:pfam07646   7 SSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWTEVPRL 47

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

74-172

7.52e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 42.05 E-value: 7.52e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYhysleqVQAD 153
Cdd:cd18516     5 NCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKW------VGKD 78

                          90       100
                  ....*....|....*....|
gi 1034629713 154 QIS-LHEPPKLLETVRFPLM 172
Cdd:cd18516    79 QEErTKALPVLLESIRFRLM 98

Kelch_6

Kelch motif;

312-356

8.52e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 40.40 E-value: 8.52e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034629713 312 HADLSVCVVGRYIYAVAGR-DYHNDLNAVERYDPATNSWAYVAPLK 356
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLP 47

Kelch

Kelch domain;

417-467

8.62e-05

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 40.23 E-value: 8.62e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034629713  417 KLYVIGGSNNdagyRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDN 467
Cdd:smart00612   1 KIYVVGGFDG----GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-66

8.97e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 42.16 E-value: 8.97e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1034629713  19 VSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18198    72 VSPEALTALLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

16-66

9.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 42.18 E-value: 9.41e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034629713  16 IHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18328    69 IDFVTPEALSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-66

1.08e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 41.80 E-value: 1.08e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034629713  26 QILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18233    71 QILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

19-62

1.13e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 41.43 E-value: 1.13e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034629713  19 VSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFC 62
Cdd:cd18299    55 ITPEAFRRVLEFLYTGVLDENEDDLKELKDAAELLELFDLVMMC 98

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

70-170

1.30e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 41.00 E-value: 1.30e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEgALLYHYSLEQ 149
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYE-SIIHWFEHEQ 79

                          90       100
                  ....*....|....*....|.
gi 1034629713 150 vqaDQISLHEPPKLLETVRFP 170
Cdd:cd18483    80 ---SKREMHLPEIFAKCIRMP 97

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

74-177

1.49e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 41.16 E-value: 1.49e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-HYSLEQVQA 152
Cdd:cd18444     6 NCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWvKHDLPERKK 85

                          90       100
                  ....*....|....*....|....*
gi 1034629713 153 DQislhepPKLLETVRFPLMEAEVL 177
Cdd:cd18444    86 HL------AKLLALIRLPLLTPQFL 104

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

405-454

1.71e-04

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 39.13 E-value: 1.71e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034629713 405 RRAWHGMATLLNKLYVIGGSNNDagyrRDVHQVACYSCTSGQWSSVCPLP 454
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN----QSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-66

1.72e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 41.25 E-value: 1.72e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1034629713  19 VSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18199    66 FSSDAFSIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

9-65

2.20e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 41.07 E-value: 2.20e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034629713   9 MEQEEVLIHGVSYNA-MCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDF 65
Cdd:cd18206    53 VDQKDVVHLDISNAAgLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

261-309

2.28e-04

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 38.75 E-value: 2.28e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034629713 261 RMSNQGIAVLNNFVYLIGGDNNVQGFraeSRCWRYDPRHNRWFQIQSLQ 309
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSL---NSVEVYDPETNTWSKLPSMP 46

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-97

2.67e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 40.68 E-value: 2.67e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLsnvqetlvaacqlqipeiihfccdflmswVDEENILDVYR 80
Cdd:cd18287    51 LLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTLTD-----------------------------LKEDVLLDVLG 101

                          90
                  ....*....|....*..
gi 1034629713  81 LAELFDLSRLTEQLDTY 97
Cdd:cd18287   102 LAHQYGFEELEAAISDY 118

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

71-177

2.84e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 40.47 E-value: 2.84e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  71 DEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQV 150
Cdd:cd18468     1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|....*..
gi 1034629713 151 QADQIslhepPKLLETVRFPLMEAEVL 177
Cdd:cd18468    81 RKQHI-----AELLAVVRLPFIHPSYL 102

BACK_ABTB1_BPOZ

cd18497

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...

70-130

2.89e-04

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

Pssm-ID: 350572 Cd Length: 72 Bit Score: 39.46 E-value: 2.89e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLlsSNRLEV 130
Cdd:cd18497     1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASV--KNRQET 59

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

1-50

2.90e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 39.57 E-value: 2.90e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAA 50
Cdd:cd01165    27 LFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

14-74

2.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 41.18 E-value: 2.94e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034629713  14 VLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 74
Cdd:cd18243    67 LVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127

Kelch_6

Kelch motif;

260-309

3.18e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 38.47 E-value: 3.18e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034629713 260 PRMSNQgIAVLNNFVYLIGGdnNVQGFRAESRCWRYDPRHNRWFQIQSLQ 309
Cdd:pfam13964   1 PRTFHS-VVSVGGYIYVFGG--YTNASPALNKLEVYNPLTKSWEELPPLP 47

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-74

3.83e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 40.33 E-value: 3.83e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYT---SELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 74
Cdd:cd18297    41 MLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTggvESLDVAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

1-39

3.91e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 40.32 E-value: 3.91e-04

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELS 39
Cdd:cd18286    46 MLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLP 84

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

6-71

4.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 40.43 E-value: 4.04e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034629713   6 LKEMEQEEVLIHG--VSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVD 71
Cdd:cd18230    54 VQKTSDQATVTHLdiVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALD 121

Kelch_6

Kelch motif;

462-504

4.15e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 38.47 E-value: 4.15e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034629713 462 IAVLDNRIYVLGGRShNRGSRTGYVHIYDVEKDCWEEGPQLDN 504
Cdd:pfam13964   7 VVSVGGYIYVFGGYT-NASPALNKLEVYNPLTKSWEELPPLPT 48

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

74-172

5.44e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 39.37 E-value: 5.44e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYhysleqVQAD 153
Cdd:cd18517     5 NCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKW------VRTD 78

                          90       100
                  ....*....|....*....|...
gi 1034629713 154 Q----ISLHEppkLLETVRFPLM 172
Cdd:cd18517    79 KenrvKSLGE---IFDCIRFRLM 98

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

74-172

5.67e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 39.50 E-value: 5.67e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAF--SRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGAL--LYHYSLEQ 149
Cdd:cd18471     5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELlkSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVrwLEHNCRYQ 84

                          90       100
                  ....*....|....*....|...
gi 1034629713 150 VQADqislheppkLLETVRFPLM 172
Cdd:cd18471    85 YMDE---------LLQYVRFGLM 98

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

74-172

5.76e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 39.44 E-value: 5.76e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  74 NILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEgaLLYHYSLEQVQAD 153
Cdd:cd18477     5 NCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFE--AVMKWVREAKENR 82

                          90
                  ....*....|....*....
gi 1034629713 154 QISLhepPKLLETVRFPLM 172
Cdd:cd18477    83 QKAL---PTVFESIRFRLL 98

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-65

6.63e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 39.36 E-value: 6.63e-04

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034629713  27 ILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDF 65
Cdd:cd18232    69 LLDFFYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

70-141

8.88e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 38.26 E-value: 8.88e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGAL 141
Cdd:cd18474     1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAAL 72

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-66

9.54e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 39.44 E-value: 9.54e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1034629713  19 VSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18327    79 VGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

70-143

1.29e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 37.69 E-value: 1.29e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY 143
Cdd:cd18480     1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRW 74

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-62

1.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 38.75 E-value: 1.49e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034629713  19 VSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFC 62
Cdd:cd18330    66 VTSEAFSIILDFLYSGKLDLCSENVIEVMSAASYLQMTDVVNFC 109

PHA02713

hypothetical protein; Provisional

258-384

1.61e-03

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 41.15 E-value: 1.61e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713 258 LAPRMSNQ---GIAVLNNFVYLIGGDNnvqGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHN 334
Cdd:PHA02713  335 LPPMIKNRcrfSLAVIDDTIYAIGGQN---GTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHI 411

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034629713 335 DL------------------NAVERYDPATNSWA-----YVAPLKREVYAHagatlEGKMYITCGRRGEDYLK 384
Cdd:PHA02713  412 DYtsvhhmnsidmeedthssNKVIRYDTVNNIWEtlpnfWTGTIRPGVVSH-----KDDIYVVCDIKDEKNVK 479

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

70-148

1.72e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 38.11 E-value: 1.72e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-HYSLE 148
Cdd:cd18479     1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWlEYNTE 80

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

1-52

1.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 38.23 E-value: 1.82e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQ 52
Cdd:cd18352    42 MFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQ 93

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-66

1.95e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 38.04 E-value: 1.95e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034629713   1 MFAGGLKEMEQEeVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18349    41 MFYGDLAEVKSE-IHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACVNFL 105

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

6-55

2.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 37.14 E-value: 2.18e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034629713   6 LKEMEQEE---VLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQI 55
Cdd:cd18315    31 LKETPPDEhpvIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAELLQI 83

mutarot_permut

TIGR03548

cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...

363-474

2.18e-03

Pssm-ID: 274642 [Multi-domain] Cd Length: 331 Bit Score: 40.55 E-value: 2.18e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713 363 AGATLEGKMYITCGRRGEDYLKETHCYDPGSNT--WHTLADGPVR-RAWHGMATLLNKLYVIGG--SNNDAGYRRDVHqv 437
Cdd:TIGR03548 119 SATYKDGKIYVGGGNANGKPSNKFYCLDLSNDTsgWEELPEFPGEaRVQPVCQALHGKLYVFGGfqLGGDAIIYTDGY-- 196

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034629713 438 aCYSCTSGQWSSVCPLPAGHGEP-------GIAVLDNRIYVLGG 474
Cdd:TIGR03548 197 -AYSPKTNTWQTVADPVLSDGEPitllggnSVKLGDSLMLVIGG 239

BTB_POZ_BTBD3

cd18348

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-74

2.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349657 [Multi-domain] Cd Length: 131 Bit Score: 38.46 E-value: 2.32e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034629713   1 MFAGGLKEmEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 74
Cdd:cd18348    54 MFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKN 126

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

70-172

2.35e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 37.62 E-value: 2.35e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  70 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYegallyhYSLEQ 149
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVF-------YALES 73

                          90       100
                  ....*....|....*....|....*...
gi 1034629713 150 -----VQADQISLhepPKLLETVRFPLM 172
Cdd:cd18467    74 wikydVQERQKYL---AQLLHCVRLPLL 98

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-74

2.36e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 38.19 E-value: 2.36e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034629713   1 MFAGGLKEMEQEeVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 74
Cdd:cd18281    55 MFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

Kelch_3

pfam13415

Galactose oxidase, central domain;

466-502

2.64e-03

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 36.11 E-value: 2.64e-03

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1034629713 466 DNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQL 502
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDL 37

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

73-141

2.94e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 36.82 E-value: 2.94e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713  73 ENILDVYRLAELFDLSRLTEQLDTYILKNFVAF-SRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGAL 141
Cdd:cd18450     4 ENCIGIRKFARYYFCPELERKAYRYILRNFEEVaKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIV 73

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

71-141

3.24e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 36.89 E-value: 3.24e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034629713  71 DEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGAL 141
Cdd:cd18458     3 DPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVI 73

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-66

4.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 38.05 E-value: 4.12e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQ-ILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 66
Cdd:cd18267    69 MFSGGLKESQDSEVNFHDSIHPEVLElLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFL 135

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

73-151

4.17e-03

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 36.83 E-value: 4.17e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034629713  73 ENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRlevscETEVYEGALLYHYSLEQVQ 151
Cdd:cd18502     4 ENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQ-----ELESINERKLCQLVLEWVQ 77

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

73-138

4.37e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 36.91 E-value: 4.37e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034629713  73 ENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYE 138
Cdd:cd18455     3 ENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFE 68

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

1-78

5.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 37.57 E-value: 5.18e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034629713   1 MFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDV 78
Cdd:cd18272    61 MFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138

PHA02790

Kelch-like protein; Provisional

393-522

6.06e-03

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 39.26 E-value: 6.06e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034629713 393 SNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHqvacyscTSGQWSSVCPLPAGHGEPGIAVLDNRIYVL 472
Cdd:PHA02790  296 SNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPTSVERWFH-------GDAAWVNMPSLLKPRCNPAVASINNVIYVI 368

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034629713 473 GGRSHNrGSRTGYVHiydVEKDCWEEGPQldNSISGLAACVLTLPRSLLL 522
Cdd:PHA02790  369 GGHSET-DTTTEYLL---PNHDQWQFGPS--TYYPHYKSCALVFGRRLFL 412

Kelch_6