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Conserved domains on  [gi|1370483677|ref|XP_024309205|]
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germinal center-associated signaling and motility protein isoform X2 [Homo sapiens]

Protein Classification

HGAL domain-containing protein( domain architecture ID 11238830)

HGAL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HGAL pfam15666
Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between ...
 65-154 9.00e-53

Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas. HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration. It also modulates the RhoA signalling pathway.


:

Pssm-ID: 464789  Cd Length: 88  Bit Score: 163.01  E-value: 9.00e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370483677  65 ERMSSTPIQqDNVDQTYSEELCYTLINHRVLCTRPSGNSAEEYYENVPCKAERPRESLGGTETEYSLLHMPSTdPRHARS 144
Cdd:pfam15666   1 KGMSSAPIQ-DNADQSYSEELCYTLINHKVLGRRPSGNSAEEYYENISCKTERPRESLGGTETEYSLLRVPST-PRHPPS 78

                          90
                  ....*....|
gi 1370483677 145 PEDEYELLMP 154
Cdd:pfam15666  79 PEDEYELLMP 88
 
Name Accession Description Interval E-value
HGAL pfam15666
Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between ...
 65-154 9.00e-53

Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas. HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration. It also modulates the RhoA signalling pathway.


Pssm-ID: 464789  Cd Length: 88  Bit Score: 163.01  E-value: 9.00e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370483677  65 ERMSSTPIQqDNVDQTYSEELCYTLINHRVLCTRPSGNSAEEYYENVPCKAERPRESLGGTETEYSLLHMPSTdPRHARS 144
Cdd:pfam15666   1 KGMSSAPIQ-DNADQSYSEELCYTLINHKVLGRRPSGNSAEEYYENISCKTERPRESLGGTETEYSLLRVPST-PRHPPS 78

                          90
                  ....*....|
gi 1370483677 145 PEDEYELLMP 154
Cdd:pfam15666  79 PEDEYELLMP 88
 
Name Accession Description Interval E-value
HGAL pfam15666
Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between ...
 65-154 9.00e-53

Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas. HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration. It also modulates the RhoA signalling pathway.


Pssm-ID: 464789  Cd Length: 88  Bit Score: 163.01  E-value: 9.00e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370483677  65 ERMSSTPIQqDNVDQTYSEELCYTLINHRVLCTRPSGNSAEEYYENVPCKAERPRESLGGTETEYSLLHMPSTdPRHARS 144
Cdd:pfam15666   1 KGMSSAPIQ-DNADQSYSEELCYTLINHKVLGRRPSGNSAEEYYENISCKTERPRESLGGTETEYSLLRVPST-PRHPPS 78

                          90
                  ....*....|
gi 1370483677 145 PEDEYELLMP 154
Cdd:pfam15666  79 PEDEYELLMP 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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