GSM521162[Accession] - GEO DataSets

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Items: 3

Select item 2000208421.

Mutated KRAS induces overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas

(Submitter supplied) Mutations of the KRAS oncogene are predictive for resistance to treatment with antibodies against the epithelial growth factor receptor in patients with colorectal cancer. Overcoming this therapeutic dilemma could potentially be achieved by the introduction of drugs that inhibit signaling pathways that are activated by KRAS mutations. To comprehensively identify such signaling pathways we profiled pretreatment biopsies from 65 patients with locally advanced rectal cancer – 30 of which carried mutated KRAS - using global gene expression microarrays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
130 Samples

Download data: TXT

Series

Accession:: GSE20842

ID:: 200020842

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000041332.

Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)

(Submitter supplied) This multi-pack (4X44K) formatted microarray represents a compiled view of the human genome as it is understood today. The sequence information used to design this product was derived from a broad survey of well known sources such as RefSeq, Goldenpath, Ensembl, Unigene and others. The resulting view of the human genome covers 41K unique genes and transcripts which have been verified and optimized by alignment to the human genome assembly and by Agilent's Empirical Validation process. more...