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RASA4B RAS p21 protein activator 4B [ Homo sapiens (human) ]

Gene ID: 100271927, updated on 4-Jan-2025

Summary

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Official Symbol
RASA4Bprovided by HGNC
Official Full Name
RAS p21 protein activator 4Bprovided by HGNC
Primary source
HGNC:HGNC:35202
See related
Ensembl:ENSG00000170667 AllianceGenome:HGNC:35202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in cellular response to calcium ion; intracellular signal transduction; and negative regulation of Ras protein signal transduction. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in endometrium (RPKM 22.0), brain (RPKM 17.5) and 24 other tissues See more
Orthologs
all
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Genomic context

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See RASA4B in Genome Data Viewer
Location:
7q22.1
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102479976..102517777, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103797581..103835325, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102120423..102158224, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467 Neighboring gene RNA polymerase II subunit J Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102131046-102131546 Neighboring gene uncharacterized LOC124901715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102151767-102152268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102152269-102152768 Neighboring gene Sharpr-MPRA regulatory region 3260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102156842-102157466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165421-102165922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165923-102166422 Neighboring gene POLR2J3-UPK3BL2 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102179485-102180312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102184221-102184721 Neighboring gene uroplakin 3B like 2 Neighboring gene speedy/RINGO cell cycle regulator family member E2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. Lockyer PJ, et al. Curr Biol, 2001 Jun 26. PMID 11448776
  2. The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA. Jaffray EG, et al. J Cell Biol, 2023 Apr 3. PMID 36880596, Free PMC Article
  3. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
  4. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
  5. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ50902

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein 4B
Names
putative Ras GTPase-activating protein 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277335.2 → NP_001264264.1  ras GTPase-activating protein 4B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093668
    Consensus CDS
    CCDS59506.1
    UniProtKB/TrEMBL
    F5GXT2, Q2NL74
    Related
    ENSP00000440982.1, ENST00000541662.5
    Conserved Domains (5) summary
    cd04025
    Location:134 → 257
    C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
    cd04054
    Location:6 → 126
    C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
    cd05395
    Location:265 → 550
    RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
    smart00323
    Location:244 → 605
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cl17171
    Location:542 → 635
    PH-like; Pleckstrin homology-like domain

  2. NM_001367767.2 → NP_001354696.1  ras GTPase-activating protein 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093668
    Consensus CDS
    CCDS94160.1
    UniProtKB/Swiss-Prot
    C9J798
    UniProtKB/TrEMBL
    Q2NL74
    Related
    ENSP00000417895.1, ENST00000465829.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    102479976..102517777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419681.1 → XP_047275637.1  ras GTPase-activating protein 4B isoform X1

    UniProtKB/TrEMBL
    B7Z405, B7Z9G3, F8W6L0
    Related
    ENSP00000303968.6, ENST00000306682.6

  2. XM_047419684.1 → XP_047275640.1  ras GTPase-activating protein 4B isoform X3

    UniProtKB/TrEMBL
    B7Z9G3

  3. XM_047419685.1 → XP_047275641.1  ras GTPase-activating protein 4B isoform X3

    UniProtKB/TrEMBL
    B7Z9G3

  4. XM_047419686.1 → XP_047275642.1  ras GTPase-activating protein 4B isoform X4

  5. XM_047419682.1 → XP_047275638.1  ras GTPase-activating protein 4B isoform X2

    UniProtKB/TrEMBL
    A0A9L9PXW0, Q2NL74
    Related
    ENSP00000516751.1, ENST00000707123.1

  6. XM_047419683.1 → XP_047275639.1  ras GTPase-activating protein 4B isoform X5

RNA

  1. XR_007059979.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    103797581..103835325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356945.1 → XP_054212920.1  ras GTPase-activating protein 4B isoform X1

    UniProtKB/TrEMBL
    B7Z405, B7Z9G3

  2. XM_054356947.1 → XP_054212922.1  ras GTPase-activating protein 4B isoform X3

    UniProtKB/TrEMBL
    B7Z9G3

  3. XM_054356948.1 → XP_054212923.1  ras GTPase-activating protein 4B isoform X3

    UniProtKB/TrEMBL
    B7Z9G3

  4. XM_054356950.1 → XP_054212925.1  ras GTPase-activating protein 4B isoform X4

  5. XM_054356944.1 → XP_054212919.1  ras GTPase-activating protein 4B isoform X6

    UniProtKB/TrEMBL
    Q2NL74

  6. XM_054356946.1 → XP_054212921.1  ras GTPase-activating protein 4B isoform X2

    UniProtKB/TrEMBL
    Q2NL74

  7. XM_054356949.1 → XP_054212924.1  ras GTPase-activating protein 4B isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C9J798.2 GenPept UniProtKB/Swiss-Prot:C9J798

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