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BRCA1 BRCA1 DNA repair associated [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100580360, updated on 8-Mar-2024

Summary

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Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
See related
EnsemblRapid:ENSNLEG00000011944
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) Unplaced Scaffold NW_022095770.1 (121755..206152)
102 previous assembly Nleu_3.0 (GCF_000146795.2) Unplaced Scaffold NW_003501569.1 (1973911..2103417, complement)

NW_022095770.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115833608 Neighboring gene uncharacterized LOC115833609 Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. Roncaglioni MC, et al. Haematologica, 1989 Mar-Apr. PMID 2501168
  2. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. Lou DI, et al. BMC Evol Biol, 2014 Jul 11. PMID 25011685, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein
Names
breast cancer type 1 susceptibility protein homolog
NP_001295597.1
XP_030663935.1
XP_030663936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308668.1 → NP_001295597.1  breast cancer type 1 susceptibility protein

    See identical proteins and their annotated locations for NP_001295597.1

    Status: PROVISIONAL

    Source sequence(s)
    KM017627
    UniProtKB/TrEMBL
    A0A075VSA7, G1RN17
    Related
    ENSNLEP00000014631.2, ENSNLET00000015362.3
    Conserved Domains (4) summary
    smart00292
    Location:1758 → 1842
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1650 → 1724
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:345 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NW_022095770.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    121755..206152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030808075.1 → XP_030663935.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    G1RN17
    Related
    ENSNLEP00000042201.2, ENSNLET00000048887.2
    Conserved Domains (4) summary
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1757 → 1854
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1649 → 1745
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

  2. XM_030808076.1 → XP_030663936.1  breast cancer type 1 susceptibility protein isoform X2

    UniProtKB/TrEMBL
    G1RN17
    Conserved Domains (4) summary
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1757 → 1854
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1649 → 1745
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:344 → 506
    BRCT_assoc; Serine-rich domain associated with BRCT
Nucleotide Protein
Heading Accession and Version

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