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BRCA1 BRCA1 DNA repair associated [ Felis catus (domestic cat) ]

Gene ID: 101081937, updated on 17-Aug-2024

Summary

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Official Symbol
BRCA1
Official Full Name
BRCA1 DNA repair associated
Primary source
VGNC:VGNC:60165
See related
EnsemblRapid:ENSFCTG00005008200
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: E1
Exon count:
25
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) E1 NC_058381.1 (41522244..41581030, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) E1 NC_018736.3 (43501000..43560918, complement)

Chromosome E1 - NC_058381.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109494380 Neighboring gene Rho family GTPase 2 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene uncharacterized LOC123382036 Neighboring gene transmembrane protein 106A Neighboring gene coiled-coil domain containing 200

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Parallel adaptive radiations in two major clades of placental mammals. Madsen O, et al. Nature, 2001 Feb 1. PMID 11214318
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein
Names
breast cancer 1, early onset
breast cancer type 1 susceptibility protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058381.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    41522244..41581030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019817934.2 → XP_019673493.2  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1761 → 1858
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  2. XM_045044988.1 → XP_044900923.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1761 → 1858
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  3. XM_045044991.1 → XP_044900926.1  breast cancer type 1 susceptibility protein isoform X4

    UniProtKB/TrEMBL
    M3WIB0
    Related
    ENSFCTP00005014981.1, ENSFCTT00005022972.1
    Conserved Domains (4) summary
    TIGR00599
    Location:15 → 156
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1759 → 1856
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1651 → 1747
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  4. XM_045044990.1 → XP_044900925.1  breast cancer type 1 susceptibility protein isoform X3

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    TIGR00599
    Location:15 → 156
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1760 → 1857
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1652 → 1748
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  5. XM_045044993.1 → XP_044900928.1  breast cancer type 1 susceptibility protein isoform X6

    UniProtKB/TrEMBL
    A0A337S3M9
    Related
    ENSFCTP00005014958.1, ENSFCTT00005022939.1
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:653 → 750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:545 → 641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  6. XM_045044992.1 → XP_044900927.1  breast cancer type 1 susceptibility protein isoform X5

    UniProtKB/TrEMBL
    A0A337S3M9
    Related
    ENSFCTP00005015000.1, ENSFCTT00005023004.1
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:654 → 751
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:546 → 642
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  7. XM_045044989.1 → XP_044900924.1  breast cancer type 1 susceptibility protein isoform X2

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1760 → 1857
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1652 → 1748
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  8. XM_019817933.3 → XP_019673492.2  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    M3WIB0
    Related
    ENSFCTP00005014933.1, ENSFCTT00005022901.1
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1761 → 1858
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  9. XM_045044987.1 → XP_044900922.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    M3WIB0
    Conserved Domains (4) summary
    COG5432
    Location:15 → 122
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1761 → 1858
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
Nucleotide Protein
Heading Accession and Version

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