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BRCA1 BRCA1 DNA repair associated [ Trachypithecus francoisi (Francois's langur) ]

Gene ID: 117066917, updated on 19-Mar-2024

Summary

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Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
See related
EnsemblRapid:ENSTFRG00000007567
Gene type
protein coding
RefSeq status
MODEL
Organism
Trachypithecus francoisi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Trachypithecus
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
24
Annotation release Status Assembly Chr Location
100 current Tfra_2.0 (GCF_009764315.1) Unplaced Scaffold NW_022681466.1 (17117637..17218644)

NW_022681466.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene coiled-coil domain containing 200 Neighboring gene transmembrane protein 106A Neighboring gene NBR1 autophagy cargo receptor Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_022681466 Unplaced Scaffold Reference Tfra_2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. Roncaglioni MC, et al. Haematologica, 1989 Mar-Apr. PMID 2501168
  2. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. Lou DI, et al. BMC Evol Biol, 2014 Jul 11. PMID 25011685, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Trachypithecus francoisi Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Tfra_2.0 Primary Assembly

Genomic

  1. NW_022681466.1 Reference Tfra_2.0 Primary Assembly

    Range
    17117637..17218644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033182854.1 → XP_033038745.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (5) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1653 → 1750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1545 → 1641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345 → 508
    BRCT_assoc; Serine-rich domain associated with BRCT

  2. XM_033182851.1 → XP_033038742.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (5) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1653 → 1750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1545 → 1641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345 → 508
    BRCT_assoc; Serine-rich domain associated with BRCT

  3. XM_033182859.1 → XP_033038750.1  breast cancer type 1 susceptibility protein isoform X5

    Conserved Domains (5) summary
    PRK08581
    Location:188 → 439
    PRK08581; amidase domain-containing protein
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:549 → 646
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:441 → 537
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  4. XM_033182858.1 → XP_033038749.1  breast cancer type 1 susceptibility protein isoform X4

    Conserved Domains (4) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:745 → 842
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:637 → 733
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  5. XM_033182860.1 → XP_033038751.1  breast cancer type 1 susceptibility protein isoform X6

    Conserved Domains (4) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:510 → 607
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:402 → 498
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  6. XM_033182855.1 → XP_033038746.1  breast cancer type 1 susceptibility protein isoform X2

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (4) summary
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1652 → 1749
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1544 → 1640
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:344 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

  7. XM_033182856.1 → XP_033038747.1  breast cancer type 1 susceptibility protein isoform X3

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (3) summary
    cd17721
    Location:1606 → 1703
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1498 → 1594
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:298 → 461
    BRCT_assoc; Serine-rich domain associated with BRCT

  8. XM_033182852.1 → XP_033038743.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A075VNR5
    Related
    ENSTFRP00000008916.1, ENSTFRT00000011144.1
    Conserved Domains (5) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1653 → 1750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1545 → 1641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345 → 508
    BRCT_assoc; Serine-rich domain associated with BRCT

  9. XM_033182853.1 → XP_033038744.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A075VNR5
    Conserved Domains (5) summary
    TIGR00599
    Location:22 → 151
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1653 → 1750
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1545 → 1641
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:345 → 508
    BRCT_assoc; Serine-rich domain associated with BRCT
Nucleotide Protein
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