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BRCA1 BRCA1 DNA repair associated [ Pongo pygmaeus (Bornean orangutan) ]

Gene ID: 129017314, updated on 3-Dec-2024

Summary

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Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
Gene type
protein coding
RefSeq status
MODEL
Organism
Pongo pygmaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonPyg2-v2.0_pri (GCF_028885625.2) 19 NC_072392.2 (76139152..76234036, complement)
RS_2023_04 previous assembly NHGRI_mPonPyg2-v1.1-hic.freeze_pri (GCF_028885625.1) 17 NC_072390.1 (72502308..72597189, complement)

Chromosome 19 - NC_072392.2Genomic Context describing neighboring genes Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2 Neighboring gene next to BRCA1 gene 2 protein Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene collagen, type I, alpha 1a-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. Roncaglioni MC, et al. Haematologica, 1989 Mar-Apr. PMID 2501168
  2. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. Lou DI, et al. BMC Evol Biol, 2014 Jul 11. PMID 25011685, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein homolog
Names
Breast cancer type 1 susceptibility protein homolog
RING-type E3 ubiquitin transferase BRCA1
breast cancer type 1
breast cancer type 1 susceptibility protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028885625.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonPyg2-v2.0_pri Primary Assembly

Genomic

  1. NC_072392.2 Reference NHGRI_mPonPyg2-v2.0_pri Primary Assembly

    Range
    76139152..76234036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054457711.2 → XP_054313686.2  breast cancer type 1 susceptibility protein homolog isoform X5

    UniProtKB/TrEMBL
    A0A075VSA3

  2. XM_063656679.1 → XP_063512749.1  breast cancer type 1 susceptibility protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A075VSA3

  3. XM_054457710.2 → XP_054313685.2  breast cancer type 1 susceptibility protein homolog isoform X5

    UniProtKB/TrEMBL
    A0A075VSA3

  4. XM_063656683.1 → XP_063512753.1  breast cancer type 1 susceptibility protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A075VSA3

  5. XM_063656684.1 → XP_063512754.1  breast cancer type 1 susceptibility protein homolog isoform X2

    UniProtKB/TrEMBL
    A0A075VSA3

  6. XM_063656678.1 → XP_063512748.1  breast cancer type 1 susceptibility protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A075VSA3

  7. XM_063656702.1 → XP_063512772.1  breast cancer type 1 susceptibility protein homolog isoform X17

    UniProtKB/TrEMBL
    A0A075VSA3

  8. XM_063656690.1 → XP_063512760.1  breast cancer type 1 susceptibility protein homolog isoform X8

    UniProtKB/TrEMBL
    A0A075VSA3

  9. XM_054457705.2 → XP_054313680.2  breast cancer type 1 susceptibility protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A075VSA3

  10. XM_054457701.2 → XP_054313676.2  breast cancer type 1 susceptibility protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A075VSA3

  11. XM_063656698.1 → XP_063512768.1  breast cancer type 1 susceptibility protein homolog isoform X16

    UniProtKB/TrEMBL
    A0A075VSA3

  12. XM_063656685.1 → XP_063512755.1  breast cancer type 1 susceptibility protein homolog isoform X5

    UniProtKB/TrEMBL
    A0A075VSA3

  13. XM_063656697.1 → XP_063512767.1  breast cancer type 1 susceptibility protein homolog isoform X15

    UniProtKB/TrEMBL
    A0A075VSA3

  14. XM_054457707.2 → XP_054313682.2  breast cancer type 1 susceptibility protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A075VSA3

  15. XM_063656696.1 → XP_063512766.1  breast cancer type 1 susceptibility protein homolog isoform X14

    UniProtKB/TrEMBL
    A0A075VSA3

  16. XM_063656680.1 → XP_063512750.1  breast cancer type 1 susceptibility protein homolog isoform X2

    UniProtKB/TrEMBL
    A0A075VSA3

  17. XM_063656695.1 → XP_063512765.1  breast cancer type 1 susceptibility protein homolog isoform X13

    UniProtKB/TrEMBL
    A0A075VSA3

  18. XM_054457700.2 → XP_054313675.2  breast cancer type 1 susceptibility protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A075VSA3

  19. XM_054457708.2 → XP_054313683.2  breast cancer type 1 susceptibility protein homolog isoform X6

    UniProtKB/TrEMBL
    A0A075VSA3

  20. XM_063656693.1 → XP_063512763.1  breast cancer type 1 susceptibility protein homolog isoform X11

    UniProtKB/TrEMBL
    A0A075VSA3

  21. XM_063656687.1 → XP_063512757.1  breast cancer type 1 susceptibility protein homolog isoform X7

    UniProtKB/TrEMBL
    A0A075VSA3

  22. XM_063656686.1 → XP_063512756.1  breast cancer type 1 susceptibility protein homolog isoform X5

    UniProtKB/TrEMBL
    A0A075VSA3

  23. XM_063656682.1 → XP_063512752.1  breast cancer type 1 susceptibility protein homolog isoform X4

    UniProtKB/TrEMBL
    A0A075VSA3

  24. XM_063656691.1 → XP_063512761.1  breast cancer type 1 susceptibility protein homolog isoform X9

    UniProtKB/TrEMBL
    A0A075VSA3

  25. XM_063656692.1 → XP_063512762.1  breast cancer type 1 susceptibility protein homolog isoform X10

    UniProtKB/TrEMBL
    A0A075VSA3

  26. XM_063656681.1 → XP_063512751.1  breast cancer type 1 susceptibility protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A075VSA3

  27. XM_054457703.2 → XP_054313678.2  breast cancer type 1 susceptibility protein homolog isoform X2

    UniProtKB/TrEMBL
    A0A075VSA3

  28. XM_063656688.1 → XP_063512758.1  breast cancer type 1 susceptibility protein homolog isoform X8

    UniProtKB/TrEMBL
    A0A075VSA3

  29. XM_063656689.1 → XP_063512759.1  breast cancer type 1 susceptibility protein homolog isoform X8

    UniProtKB/TrEMBL
    A0A075VSA3

  30. XM_054457737.2 → XP_054313712.2  breast cancer type 1 susceptibility protein homolog isoform X23

  31. XM_054457735.2 → XP_054313710.2  breast cancer type 1 susceptibility protein homolog isoform X22

  32. XM_054457697.2 → XP_054313672.2  breast cancer type 1 susceptibility protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A075VSA3

  33. XM_054457733.2 → XP_054313708.2  breast cancer type 1 susceptibility protein homolog isoform X21

  34. XM_063656705.1 → XP_063512775.1  breast cancer type 1 susceptibility protein homolog isoform X25

  35. XM_054457729.2 → XP_054313704.2  breast cancer type 1 susceptibility protein homolog isoform X20

  36. XM_063656703.1 → XP_063512773.1  breast cancer type 1 susceptibility protein homolog isoform X24

  37. XM_054457727.2 → XP_054313702.2  breast cancer type 1 susceptibility protein homolog isoform X19

  38. XM_063656704.1 → XP_063512774.1  breast cancer type 1 susceptibility protein homolog isoform X24

  39. XM_063656694.1 → XP_063512764.1  breast cancer type 1 susceptibility protein homolog isoform X12

    UniProtKB/TrEMBL
    A0A075VSA3

  40. XM_063656700.1 → XP_063512770.1  breast cancer type 1 susceptibility protein homolog isoform X18

    UniProtKB/TrEMBL
    A0A075VSA3

  41. XM_063656699.1 → XP_063512769.1  breast cancer type 1 susceptibility protein homolog isoform X17

    UniProtKB/TrEMBL
    A0A075VSA3

RNA

  1. XR_010124717.1 RNA Sequence

  2. XR_010124718.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6J6J0.1 GenPept UniProtKB/Swiss-Prot:Q6J6J0

Gene LinkOut

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