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BRCA1 BRCA1 DNA repair associated [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 712634, updated on 17-Aug-2024

Summary

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Official Symbol
BRCA1provided by VGNC
Official Full Name
BRCA1 DNA repair associatedprovided by VGNC
Primary source
VGNC:VGNC:99124
See related
Ensembl:ENSMMUG00000001329
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
23
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (54186473..54273232, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (48915562..49005800, complement)

Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene uncharacterized LOC106994055 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene uncharacterized LOC106994056

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition. Pavlicek A, et al. Hum Mol Genet, 2004 Nov 15. PMID 15385441
  2. Evolutionary sequence comparisons using high-density oligonucleotide arrays. Hacia JG, et al. Nat Genet, 1998 Feb. PMID 9462745
  3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein homolog
Names
RING-type E3 ubiquitin transferase BRCA1
breast cancer 1, early onset
NP_001108421.1
XP_014975230.1
XP_014975231.1
XP_014975232.1
XP_014975233.1
XP_014975234.1
XP_028691465.1
XP_028691466.1
XP_028691467.1
XP_028691468.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114949.1 → NP_001108421.1  breast cancer type 1 susceptibility protein homolog

    See identical proteins and their annotated locations for NP_001108421.1

    Status: PROVISIONAL

    Source sequence(s)
    AY589041
    UniProtKB/Swiss-Prot
    O46487, Q28525, Q6J6I9
    UniProtKB/TrEMBL
    H9ZCR7
    Related
    ENSMMUP00000034386.2, ENSMMUT00000041358.3
    Conserved Domains (4) summary
    smart00292
    Location:1758 → 1842
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1650 → 1724
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:344 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041769.1 Reference Mmul_10 Primary Assembly

    Range
    54186473..54273232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015119747.2 → XP_014975233.1  breast cancer type 1 susceptibility protein homolog isoform X3

    UniProtKB/TrEMBL
    H9ZCR7
    Conserved Domains (4) summary
    smart00292
    Location:1757 → 1841
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1649 → 1723
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:343 → 506
    BRCT_assoc; Serine-rich domain associated with BRCT

  2. XM_015119746.2 → XP_014975232.1  breast cancer type 1 susceptibility protein homolog isoform X2

    UniProtKB/TrEMBL
    H9ZCR7
    Conserved Domains (4) summary
    smart00292
    Location:1757 → 1841
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1649 → 1723
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:344 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

  3. XM_015119745.2 → XP_014975231.1  breast cancer type 1 susceptibility protein homolog isoform X1

    UniProtKB/TrEMBL
    F7BG30, H9ZCR7
    Related
    ENSMMUP00000001777.3, ENSMMUT00000001882.4
    Conserved Domains (4) summary
    smart00292
    Location:1758 → 1842
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1650 → 1724
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:344 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

  4. XM_015119748.2 → XP_014975234.1  breast cancer type 1 susceptibility protein homolog isoform X4

    UniProtKB/TrEMBL
    F7BFJ5
    Related
    ENSMMUP00000001780.4, ENSMMUT00000001885.4
    Conserved Domains (4) summary
    smart00292
    Location:1732 → 1816
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1624 → 1698
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12820
    Location:318 → 481
    BRCT_assoc; Serine-rich domain associated with BRCT
    cl17238
    Location:24 → 46
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  5. XM_015119744.2 → XP_014975230.1  breast cancer type 1 susceptibility protein homolog isoform X1

    UniProtKB/TrEMBL
    F7BG30, H9ZCR7
    Conserved Domains (4) summary
    smart00292
    Location:1758 → 1842
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1650 → 1724
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:344 → 507
    BRCT_assoc; Serine-rich domain associated with BRCT

  6. XM_028835632.1 → XP_028691465.1  breast cancer type 1 susceptibility protein homolog isoform X5

    UniProtKB/TrEMBL
    F6PQP0
    Related
    ENSMMUP00000034384.3, ENSMMUT00000041356.3
    Conserved Domains (4) summary
    TIGR00599
    Location:22 → 137
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:667 → 764
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:559 → 655
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  7. XM_028835633.1 → XP_028691466.1  breast cancer type 1 susceptibility protein homolog isoform X6

    UniProtKB/TrEMBL
    F7BG22
    Related
    ENSMMUP00000001778.3, ENSMMUT00000001883.4
    Conserved Domains (4) summary
    TIGR00599
    Location:22 → 137
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:616 → 713
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:508 → 604
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  8. XM_028835634.1 → XP_028691467.1  breast cancer type 1 susceptibility protein homolog isoform X7

    UniProtKB/TrEMBL
    H9F3L4
    Conserved Domains (2) summary
    cd17721
    Location:469 → 566
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:361 → 457
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  9. XM_028835635.1 → XP_028691468.1  breast cancer type 1 susceptibility protein homolog isoform X7

    UniProtKB/TrEMBL
    H9F3L4
    Conserved Domains (2) summary
    cd17721
    Location:469 → 566
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:361 → 457
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6J6I9.1 GenPept UniProtKB/Swiss-Prot:Q6J6I9

Gene LinkOut

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