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    nectin2.L nectin cell adhesion molecule 2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 447468, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nectin2.L
    Official Full Name
    nectin cell adhesion molecule 2 L homeolog
    Primary source
    Xenbase:XB-GENE-947435
    Locus tag
    XELAEV_18036021mg
    See related
    EnsemblRapid:ENSXLAG00005021769 AllianceGenome:Xenbase:XB-GENE-947435
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    ed4; prr; higr; hveb; hvec; ofc7; prr1; prr2; pvrr; cd111; cd112; pvrl1; pvrl2; pvrr1; pvrr2; sk-12; clped1; pvrl2.L; nectin-1; nectin-2
    Summary
    Predicted to be located in membrane. Is expressed in dermal system and ectoderm. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2). [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See nectin2.L in Genome Data Viewer
    Location:
    chromosome: 7L
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (114826968..114858438)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (104296840..104328403)

    Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene Cbl proto-oncogene C L homeolog Neighboring gene basal cell adhesion molecule (Lutheran blood group) L homeolog Neighboring gene translocase of outer mitochondrial membrane 40 homolog L homeolog Neighboring gene apolipoprotein E L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. Morita H, et al. Development, 2010 Apr. PMID 20332149, Free PMC Article
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC81721

    Gene Ontology Provided by Xenbase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nectin cell adhesion molecule 2 L homeolog
    Names
    nectin 2
    nectin-2alpha
    poliovirus receptor-related 1 (herpesvirus entry mediator C)
    poliovirus receptor-related 2 (herpesvirus entry mediator B) L homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001094175.1 → NP_001087644.1  nectin cell adhesion molecule 2 L homeolog precursor

      See identical proteins and their annotated locations for NP_001087644.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081035
      UniProtKB/TrEMBL
      A0A974CGT6, Q66J72
      Related
      ENSXLAP00005063944.1, ENSXLAT00005065458.1
      Conserved Domains (4) summary
      cd05718
      Location:32 → 122
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:125 → 217
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00410
      Location:24 → 121
      IG_like; Immunoglobulin like
      pfam13927
      Location:240 → 294
      Ig_3; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      114826968..114858438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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