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    LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough [ Homo sapiens (human) ]

    Gene ID: 133039973, updated on 3-Dec-2024

    Summary

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    Gene symbol
    LYPLA1-TCEA1
    Gene description
    LYPLA1-TCEA1 readthrough
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring LYPLA1 (acyl-protein thioesterase 1) and TCEA1 (transcription elongation factor A protein 1) genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. [provided by RefSeq, Nov 2023]
    Orthologs
    all
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    Genomic context

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    See LYPLA1-TCEA1 in Genome Data Viewer
    Location:
    8q11.23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (53966556..54101947, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (54343951..54479027, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54879116..55014507, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 20 Neighboring gene RPS27A pseudogene 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27366 Neighboring gene RNA, U6 small nuclear 1331, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:54856969-54858168 Neighboring gene ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) pseudogene Neighboring gene transcription elongation factor A1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19197 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54934747-54935540 Neighboring gene Uncharacterized LOC133039971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54935541-54936332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54942814-54943544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54943545-54944276 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:54958280-54958473 Neighboring gene lysophospholipase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:54997169-54998116 Neighboring gene CRIPTO pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19199 Neighboring gene MPRA-validated peak7022 silencer Neighboring gene RNA, U6atac small nuclear 32, pseudogene Neighboring gene mitochondrial ribosomal protein L15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    LYPLA1-TCEA1 readthrough

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425839.1 → NP_001412768.1  LYPLA1-TCEA1 readthrough isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC100821

    2. NM_001425840.1 → NP_001412769.1  LYPLA1-TCEA1 readthrough isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC100821

    3. NM_001425841.1 → NP_001412770.1  LYPLA1-TCEA1 readthrough isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC100821
      UniProtKB/TrEMBL
      B7Z4W0

    4. NM_001425842.1 → NP_001412771.1  LYPLA1-TCEA1 readthrough isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC100821
      UniProtKB/TrEMBL
      B7Z4W0

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      53966556..54101947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      54343951..54479027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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