U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Rousettus aegyptiacus (Egyptian rousette) ]

    Gene ID: 107513958, updated on 30-Mar-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    PIK3CB
    Gene description
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
    Locus tag
    HJG63_015322
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rousettus aegyptiacus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea; Pteropodidae; Rousettinae; Rousettus
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PIK3CB in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    101 current mRouAeg1.p (GCF_014176215.1) Unplaced Scaffold NW_023416307.1 (125971380..126138460)
    100 previous assembly Raegyp2.0 (GCF_001466805.2) Unplaced Scaffold NW_015494534.1 (1349689..1517707, complement)

    NW_023416307.1Genomic Context describing neighboring genes Neighboring gene proline-rich protein 23A-like Neighboring gene translation initiation factor IF-2 Neighboring gene forkhead box L2 Neighboring gene riboflavin kinase-like Neighboring gene 5S ribosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene polypeptide N-acetylgalactosaminyltransferase 1-like Neighboring gene small nucleolar RNA SNORA15 Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene 5S ribosomal RNA Neighboring gene centrosomal protein 70

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Rousettus aegyptiacus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRouAeg1.p

    Genomic

    1. NW_023416307.1 Reference mRouAeg1.p

      Range
      125971380..126138460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016151202.2 → XP_016006688.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A0A7J8HUU2
      Conserved Domains (5) summary
      cd08693
      Location:318 → 495
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:35 → 112
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:174 → 282
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:526 → 734
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:738 → 1099
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

    2. XM_016151204.2 → XP_016006690.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

      UniProtKB/TrEMBL
      A0A7J8HUJ0
      Conserved Domains (5) summary
      cd08693
      Location:318 → 495
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:174 → 282
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:526 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:700 → 1061
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
      pfam02192
      Location:36 → 111
      PI3K_p85B; PI3-kinase family, p85-binding domain

    3. XM_016151203.2 → XP_016006689.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A0A7J8HUU2
      Conserved Domains (5) summary
      cd08693
      Location:318 → 495
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:35 → 112
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:174 → 282
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:526 → 734
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:738 → 1099
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.