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    BRCA1 BRCA1 DNA repair associated [ Bos taurus (domestic cattle) ]

    Gene ID: 353120, updated on 27-Dec-2024

    Summary

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    Official Symbol
    BRCA1provided by VGNC
    Official Full Name
    BRCA1 DNA repair associatedprovided by VGNC
    Primary source
    VGNC:VGNC:55781
    See related
    BGD:BT11167; Ensembl:ENSBTAG00000022520
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BRCA1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (43069050..43140040, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene transmembrane protein 106A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score. Yuan Z, et al. Mol Biol Rep, 2012 Jun. PMID 22327776
    2. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle. Yuan Z, et al. Gene, 2012 Aug 15. PMID 22583824
    3. Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States). Modugno F, et al. Cancer Causes Control, 2003 Jun. PMID 12946038
    4. Parallel adaptive radiations in two major clades of placental mammals. Madsen O, et al. Nature, 2001 Feb 1. PMID 11214318
    5. Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. Krum SA, et al. Oncogene, 2003 Sep 4. PMID 12955082

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.
      Title: Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.
    2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.
      Title: BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score.
    3. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.
      Title: Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity.
    4. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.
      Title: Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chordate embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in dosage compensation by inactivation of X chromosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BRCA1-A complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of BRCA1-BARD1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    breast cancer type 1 susceptibility protein homolog
    Names
    BRCA1 homologue
    RING-type E3 ubiquitin transferase BRCA1
    breast and ovarian cancer susceptibility 1
    breast cancer 1, early onset
    NP_848668.1
    XP_005220736.2
    XP_010814518.2
    XP_059733745.1
    XP_059733746.1
    XP_059733747.1
    XP_059733748.1
    XP_059733749.1
    XP_059733751.1
    XP_059733752.1
    XP_059733753.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178573.1 → NP_848668.1  breast cancer type 1 susceptibility protein homolog

      See identical proteins and their annotated locations for NP_848668.1

      Status: PROVISIONAL

      Source sequence(s)
      AY077732
      UniProtKB/Swiss-Prot
      Q864U1
      UniProtKB/TrEMBL
      A0A3Q1MFV5
      Related
      ENSBTAP00000011616.5, ENSBTAT00000011616.5
      Conserved Domains (4) summary
      smart00292
      Location:1752 → 1835
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:1643 → 1717
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00162
      Location:23 → 68
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12820
      Location:345 → 505
      BRCT_assoc; Serine-rich domain associated with BRCT

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      43069050..43140040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059877770.1 → XP_059733753.1  breast cancer type 1 susceptibility protein homolog isoform X10

      UniProtKB/TrEMBL
      Q864T9

    2. XM_059877764.1 → XP_059733747.1  breast cancer type 1 susceptibility protein homolog isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MFV5

    3. XM_059877769.1 → XP_059733752.1  breast cancer type 1 susceptibility protein homolog isoform X9

      UniProtKB/TrEMBL
      Q864T9

    4. XM_059877763.1 → XP_059733746.1  breast cancer type 1 susceptibility protein homolog isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MFV5, A0AAA9TSB1
      Related
      ENSBTAP00000101267.1, ENSBTAT00000110697.1

    5. XM_059877768.1 → XP_059733751.1  breast cancer type 1 susceptibility protein homolog isoform X8

      UniProtKB/TrEMBL
      Q864T9
      Related
      ENSBTAP00000089820.1, ENSBTAT00000094868.1

    6. XM_059877762.1 → XP_059733745.1  breast cancer type 1 susceptibility protein homolog isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MFV5, A0AAA9SKW6
      Related
      ENSBTAP00000087002.1, ENSBTAT00000129498.1

    7. XM_005220679.5 → XP_005220736.2  breast cancer type 1 susceptibility protein homolog isoform X7

      UniProtKB/TrEMBL
      Q864T9
      Related
      ENSBTAP00000071523.1, ENSBTAT00000071426.2
      Conserved Domains (3) summary
      smart00292
      Location:654 → 737
      BRCT; breast cancer carboxy-terminal domain
      pfam00533
      Location:545 → 618
      BRCT; BRCA1 C Terminus (BRCT) domain
      cd16498
      Location:18 → 65
      RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

    8. XM_010816216.4 → XP_010814518.2  breast cancer type 1 susceptibility protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MFV5
      Related
      ENSBTAP00000070037.1, ENSBTAT00000082527.2
      Conserved Domains (4) summary
      smart00292
      Location:1752 → 1835
      BRCT; breast cancer carboxy-terminal domain
      pfam00533
      Location:1643 → 1716
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12820
      Location:345 → 505
      BRCT_assoc; Serine-rich domain associated with BRCT
      cd16498
      Location:18 → 65
      RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

    9. XM_059877766.1 → XP_059733749.1  breast cancer type 1 susceptibility protein homolog isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MFG4
      Related
      ENSBTAP00000067686.2, ENSBTAT00000067174.2

    10. XM_059877765.1 → XP_059733748.1  breast cancer type 1 susceptibility protein homolog isoform X5

      UniProtKB/TrEMBL
      F1MYX8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q864U1.1 GenPept UniProtKB/Swiss-Prot:Q864U1

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