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Eastern equine encephalitis

MedGen UID:
102258
Concept ID:
C0153065
Disease or Syndrome
Synonyms: Eastern Equine Encephalitides; Eastern Equine Encephalitis; Eastern Equine Encephalomyelitides; Eastern Equine Encephalomyelitis; Eastern Equine Encephalomyelitis Virus Infection; Encephalitides, Eastern Equine; Encephalitis, Eastern Equine; Encephalomyelitides, Eastern Equine; Encephalomyelitis, Eastern Equine; Equine Encephalitides, Eastern; Equine Encephalitis, Eastern; Equine Encephalomyelitides, Eastern; Equine Encephalomyelitis, Eastern
SNOMED CT: Eastern equine encephalitis virus neuroinvasive disease (417496004); Eastern equine encephalitis virus infection (416925005); EEE - Eastern equine encephalitis (417496004); Eastern equine encephalomyelitis (417496004); Neuroinvasive Eastern equine encephalitis virus infection (417496004); Neuroinvasive Eastern equine encephalitis virus disease (417496004); Encephalitis, Eastern equine (416925005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005736
Orphanet: ORPHA83594

Definition

An acute arboviral infection caused by an <i>alphavirus</i> of the <i>Togaviridae</i> family transmitted by an infected mosquito, that is characterized by the onset of flulike symptoms including fever, chills, weakness, headache, vomiting, abdominal pain with diarrhea, myalgia, leucocytosis, and hematuria, rapidly progressing to diffuse central nervous system (CNS) involvement with confusion, somnolence, or even coma. Seizures, which may progress to status epilepticus and neurologic sequelae, cranial nerve palsies, and photophobia may occur. EEE is associated with a high rate of morbidity and mortality. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEastern equine encephalitis

Professional guidelines

PubMed

Zubair AS, McAlpine LS, Gobeske KT
J Neurol Sci 2024 Feb 15;457:122886. Epub 2024 Jan 13 doi: 10.1016/j.jns.2024.122886. PMID: 38278094
Aksamit AJ Jr
Neurol Clin 2021 Feb;39(1):197-207. Epub 2020 Nov 7 doi: 10.1016/j.ncl.2020.09.011. PMID: 33223083

Recent clinical studies

Etiology

Carrera J-P, Araúz D, Rojas A, Cardozo F, Stittleburg V, Morales Claro I, Galue J, Lezcano-Coba C, Romero Rebello Moreira F, -Rivera LF, Chen-Germán M, Moreno B, Capitan-Barrios Z, López-Vergès S, Pascale JM, Sabino EC, Valderrama A, Hanley KA, Donnelly CA, Vasilakis N, Faria NR, Waggoner JJ
J Clin Microbiol 2023 Dec 19;61(12):e0015223. Epub 2023 Nov 20 doi: 10.1128/jcm.00152-23. PMID: 37982611Free PMC Article
Hill V, Koch RT, Bialosuknia SM, Ngo K, Zink SD, Koetzner CA, Maffei JG, Dupuis AP, Backenson PB, Oliver J, Bransfield AB, Misencik MJ, Petruff TA, Shepard JJ, Warren JL, Gill MS, Baele G, Vogels CBF, Gallagher G, Burns P, Hentoff A, Smole S, Brown C, Osborne M, Kramer LD, Armstrong PM, Ciota AT, Grubaugh ND
Curr Biol 2023 Jun 19;33(12):2515-2527.e6. Epub 2023 Jun 8 doi: 10.1016/j.cub.2023.05.047. PMID: 37295427Free PMC Article
Pierson BC, Cardile AP, Okwesili AC, Downs IL, Reisler RB, Boudreau EF, Kortepeter MG, Koca CD, Ranadive MV, Petitt PL, Kanesa-Thasan N, Rivard RG, Liggett DL, Haller JM, Norris SL, Purcell BK, Pittman PR, Saunders DL, Keshtkar Jahromi M
Vaccine 2021 May 12;39(20):2780-2790. Epub 2021 Apr 19 doi: 10.1016/j.vaccine.2021.03.030. PMID: 33888325
Mermel LA
JAMA Netw Open 2020 Jan 3;3(1):e1920261. doi: 10.1001/jamanetworkopen.2019.20261. PMID: 32003815Free PMC Article
Kilpatrick AM, Pape WJ
Am J Epidemiol 2013 Sep 1;178(5):829-35. Epub 2013 Jul 3 doi: 10.1093/aje/kwt046. PMID: 23825164Free PMC Article

Diagnosis

Morens DM, Folkers GK, Fauci AS
N Engl J Med 2019 Nov 21;381(21):1989-1992. doi: 10.1056/NEJMp1914328. PMID: 31747726
Yu YA, Bolton M
Clin Pediatr (Phila) 2019 Feb;58(2):245-246. Epub 2018 Oct 15 doi: 10.1177/0009922818806842. PMID: 30318912
Berlin D, Gilani AI, Grewal AK, Fowkes M
Pract Neurol 2017 Oct;17(5):387-391. Epub 2017 Jul 28 doi: 10.1136/practneurol-2017-001659. PMID: 28754695
Min Z, Gnann JW Jr
QJM 2014 May;107(5):397-8. Epub 2013 Aug 22 doi: 10.1093/qjmed/hct168. PMID: 23970186
Chiodini J
Nurs Stand 2008 May 7-13;22(35):50-7; quiz 58. doi: 10.7748/ns2008.05.22.35.50.c6536. PMID: 18524128

Therapy

Panny L, Akrhymuk I, Bracci N, Woodson C, Flor R, Elliott I, Zhou W, Narayanan A, Campbell C, Kehn-Hall K
Antiviral Res 2023 Apr;212:105560. Epub 2023 Feb 22 doi: 10.1016/j.antiviral.2023.105560. PMID: 36822370
Wilcox DR, Collens SI, Solomon IH, Mateen FJ, Mukerji SS
Neurol Neuroimmunol Neuroinflamm 2021 Jan;8(1) Epub 2020 Nov 10 doi: 10.1212/NXI.0000000000000917. PMID: 33172962Free PMC Article
Yu YA, Bolton M
Clin Pediatr (Phila) 2019 Feb;58(2):245-246. Epub 2018 Oct 15 doi: 10.1177/0009922818806842. PMID: 30318912
Shapiro R
J Pediatr Nurs 2012 Aug;27(4):346-9. Epub 2011 May 25 doi: 10.1016/j.pedn.2011.03.011. PMID: 22703681
Golomb MR, Durand ML, Schaefer PW, McDonald CT, Maia M, Schwamm LH
Neurology 2001 Feb 13;56(3):420-1. doi: 10.1212/wnl.56.3.420. PMID: 11171919

Prognosis

Quilliam DN, Gosciminski M, Bandy U
R I Med J (2013) 2020 Apr 1;103(3):68-70. PMID: 32236168
Baxter VK, Heise MT
Mamm Genome 2018 Aug;29(7-8):408-424. Epub 2018 Aug 27 doi: 10.1007/s00335-018-9776-1. PMID: 30151711Free PMC Article
Berlin D, Gilani AI, Grewal AK, Fowkes M
Pract Neurol 2017 Oct;17(5):387-391. Epub 2017 Jul 28 doi: 10.1136/practneurol-2017-001659. PMID: 28754695
Babi MA, Raleigh T, Shapiro RE, McSherry J, Applebee A
Neurology 2014 Oct 14;83(16):1483. doi: 10.1212/WNL.0000000000000876. PMID: 25313378
Kilpatrick AM, Pape WJ
Am J Epidemiol 2013 Sep 1;178(5):829-35. Epub 2013 Jul 3 doi: 10.1093/aje/kwt046. PMID: 23825164Free PMC Article

Clinical prediction guides

Hill V, Koch RT, Bialosuknia SM, Ngo K, Zink SD, Koetzner CA, Maffei JG, Dupuis AP, Backenson PB, Oliver J, Bransfield AB, Misencik MJ, Petruff TA, Shepard JJ, Warren JL, Gill MS, Baele G, Vogels CBF, Gallagher G, Burns P, Hentoff A, Smole S, Brown C, Osborne M, Kramer LD, Armstrong PM, Ciota AT, Grubaugh ND
Curr Biol 2023 Jun 19;33(12):2515-2527.e6. Epub 2023 Jun 8 doi: 10.1016/j.cub.2023.05.047. PMID: 37295427Free PMC Article
Ludwig A, Rousseu F, Kotchi SO, Allostry J, Fournier RA
BMC Public Health 2023 May 22;23(1):924. doi: 10.1186/s12889-023-15773-x. PMID: 37217931Free PMC Article
Cao X, Yang D, Parvathareddy J, Chu YK, Kim EJ, Fitz-Henley JN, Li X, Lukka PB, Parmar KR, Temrikar ZH, Dhole P, Adcock RS, Gabbard J, Bansal S, Lee J, Zalduondo L, Hayes E, Stabenow J, Meibohm B, Fitzpatrick EA, Bailey K, Campos RK, Julander JG, Rossi SL, Chung D, Jonsson CB, Golden JE
Sci Transl Med 2023 Apr 12;15(691):eabl9344. doi: 10.1126/scitranslmed.abl9344. PMID: 37043558Free PMC Article
Wilcox DR, Collens SI, Solomon IH, Mateen FJ, Mukerji SS
Neurol Neuroimmunol Neuroinflamm 2021 Jan;8(1) Epub 2020 Nov 10 doi: 10.1212/NXI.0000000000000917. PMID: 33172962Free PMC Article
Kilpatrick AM, Pape WJ
Am J Epidemiol 2013 Sep 1;178(5):829-35. Epub 2013 Jul 3 doi: 10.1093/aje/kwt046. PMID: 23825164Free PMC Article

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