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Childhood Rhabdomyosarcoma

MedGen UID:
113091
•Concept ID:
C0220611
•
Neoplastic Process
Synonym: Pediatric Rhabdomyosarcoma

Definition

An aggressive malignant mesenchymal neoplasm arising from skeletal muscle in children. Only a small percentage of tumors arise in the skeletal muscle of the extremities. The majority arise in other anatomic sites. [from NCI]

Professional guidelines

PubMed

Radiotherapy in the Management of Childhood Rhabdomyosarcoma.
Mandeville HC
Clin Oncol (R Coll Radiol) 2019 Jul;31(7):462-470. Epub 2019 Apr 13 doi: 10.1016/j.clon.2019.03.047. PMID: 30992168
Identifying barriers to treatment of childhood rhabdomyosarcoma in resource-limited settings: A literature review.
Papyan R, Tamamyan G, Danielyan S, Tananyan A, Muradyan A, Saab R
Pediatr Blood Cancer 2019 Jul;66(7):e27708. Epub 2019 Mar 25 doi: 10.1002/pbc.27708. PMID: 30907501
Progress and controversy in the treatment of childhood rhabdomyosarcoma.
Green DM, Jaffe N
Cancer Treat Rev 1978 Mar;5(1):7-27. doi: 10.1016/s0305-7372(78)80003-6. PMID: 352513

Recent clinical studies

Etiology

Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes.
Kebudi R, Dural O, Bay SB, Gorgun O, Onder S, Bilgic B, Yilmaz I, Iribas A, Arndt CA, Harris AK, Field A, Schultz KAP, Hill DA
J Pediatr Adolesc Gynecol 2021 Aug;34(4):449-453. Epub 2021 Jan 20 doi: 10.1016/j.jpag.2021.01.011. PMID: 33484847
Radiotherapy in the Management of Childhood Rhabdomyosarcoma.
Mandeville HC
Clin Oncol (R Coll Radiol) 2019 Jul;31(7):462-470. Epub 2019 Apr 13 doi: 10.1016/j.clon.2019.03.047. PMID: 30992168
Childhood rhabdomyosarcoma.
Rodeberg D, Paidas C
Semin Pediatr Surg 2006 Feb;15(1):57-62. doi: 10.1053/j.sempedsurg.2005.11.009. PMID: 16458847
Treatment for childhood rhabdomyosarcoma: the cost of cure.
Stevens MC
Lancet Oncol 2005 Feb;6(2):77-84. doi: 10.1016/S1470-2045(05)01733-X. PMID: 15683816
Prognosis in childhood rhabdomyosarcoma of the extremity.
Ghavimi F, Mandell LR, Heller G, Hajdu SI, Exelby P
Cancer 1989 Dec 1;64(11):2233-7. doi: 10.1002/1097-0142(19891201)64:11<2233::aid-cncr2820641108>3.0.co;2-6. PMID: 2804912

Diagnosis

Anaplasia in childhood rhabdomyosarcoma: An under reported entity.
Ahuja M, Tomar R, Thakur S, Mallya V, Mandal S, Khurana N, Sarin YK
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):864-868. doi: 10.4103/ijpm.ijpm_178_21. PMID: 36308195
Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes.
Kebudi R, Dural O, Bay SB, Gorgun O, Onder S, Bilgic B, Yilmaz I, Iribas A, Arndt CA, Harris AK, Field A, Schultz KAP, Hill DA
J Pediatr Adolesc Gynecol 2021 Aug;34(4):449-453. Epub 2021 Jan 20 doi: 10.1016/j.jpag.2021.01.011. PMID: 33484847
Childhood rhabdomyosarcoma.
Córdoba Rovira SM, Inarejos Clemente EJ
Radiologia 2016 Nov-Dec;58(6):481-490. Epub 2016 Nov 1 doi: 10.1016/j.rx.2016.09.003. PMID: 27810092
Imaging findings in noncraniofacial childhood rhabdomyosarcoma.
Van Rijn RR, Wilde JC, Bras J, Oldenburger F, McHugh KM, Merks JH
Pediatr Radiol 2008 Jun;38(6):617-34. Epub 2008 Mar 7 doi: 10.1007/s00247-008-0751-y. PMID: 18324394Free PMC Article
The role of radiology in childhood rhabdomyosarcoma.
McHugh K, Boothroyd AE
Clin Radiol 1999 Jan;54(1):2-10. doi: 10.1016/s0009-9260(99)91233-3. PMID: 9915504

Therapy

Update on childhood rhabdomyosarcoma.
McDowell HP
Arch Dis Child 2003 Apr;88(4):354-7. doi: 10.1136/adc.88.4.354. PMID: 12651771Free PMC Article
Childhood rhabdomyosarcoma xenografts: responses to DNA-interacting agents and agents used in current clinical therapy.
Houghton JA, Cook RL, Lutz PJ, Houghton PJ
Eur J Cancer Clin Oncol 1984 Jul;20(7):955-60. doi: 10.1016/0277-5379(84)90170-6. PMID: 6430707
Progress and controversy in the treatment of childhood rhabdomyosarcoma.
Green DM, Jaffe N
Cancer Treat Rev 1978 Mar;5(1):7-27. doi: 10.1016/s0305-7372(78)80003-6. PMID: 352513
Childhood rhabdomyosarcoma. Analysis of coordinated therapy and results.
Fernandez CH, Sutow WW, Merino OR, George SL
Am J Roentgenol Radium Ther Nucl Med 1975 Mar;123(3):588-97. doi: 10.2214/ajr.123.3.588. PMID: 804823
Coordinated treatment of childhood rhabdomyosarcoma with surgery, radiotherapy, and combination chemotherapy.
Pratt CB, Hustu HO, Fleming ID, Pinkel D
Cancer Res 1972 Mar;32(3):606-10. PMID: 4551437

Prognosis

Treatment for childhood rhabdomyosarcoma: the cost of cure.
Stevens MC
Lancet Oncol 2005 Feb;6(2):77-84. doi: 10.1016/S1470-2045(05)01733-X. PMID: 15683816
Update on childhood rhabdomyosarcoma.
McDowell HP
Arch Dis Child 2003 Apr;88(4):354-7. doi: 10.1136/adc.88.4.354. PMID: 12651771Free PMC Article
Prognosis in childhood rhabdomyosarcoma of the extremity.
Ghavimi F, Mandell LR, Heller G, Hajdu SI, Exelby P
Cancer 1989 Dec 1;64(11):2233-7. doi: 10.1002/1097-0142(19891201)64:11<2233::aid-cncr2820641108>3.0.co;2-6. PMID: 2804912
Progress and controversy in the treatment of childhood rhabdomyosarcoma.
Green DM, Jaffe N
Cancer Treat Rev 1978 Mar;5(1):7-27. doi: 10.1016/s0305-7372(78)80003-6. PMID: 352513
Prognosis in childhood rhabdomyosarcoma.
Sutow WW, Sullivan MP, Ried HL, Taylor HG, Griffith KM
Cancer 1970 Jun;25(6):1384-90. doi: 10.1002/1097-0142(197006)25:6<1384::aid-cncr2820250617>3.0.co;2-t. PMID: 5422913

Clinical prediction guides

Anaplasia in childhood rhabdomyosarcoma: An under reported entity.
Ahuja M, Tomar R, Thakur S, Mallya V, Mandal S, Khurana N, Sarin YK
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):864-868. doi: 10.4103/ijpm.ijpm_178_21. PMID: 36308195
The CYP2W1 enzyme: regulation, properties and activation of prodrugs.
Guo J, Johansson I, Mkrtchian S, Ingelman-Sundberg M
Drug Metab Rev 2016 Aug;48(3):369-78. Epub 2016 Jun 3 doi: 10.1080/03602532.2016.1188939. PMID: 27257736
Microsatellite instability in childhood rhabdomyosarcoma is locus specific and correlates with fractional allelic loss.
Visser M, Bras J, Sijmons C, Devilee P, Wijnaendts LC, van der Linden JC, Voûte PA, Baas F
Proc Natl Acad Sci U S A 1996 Aug 20;93(17):9172-6. doi: 10.1073/pnas.93.17.9172. PMID: 8799173Free PMC Article
Prognosis in childhood rhabdomyosarcoma of the extremity.
Ghavimi F, Mandell LR, Heller G, Hajdu SI, Exelby P
Cancer 1989 Dec 1;64(11):2233-7. doi: 10.1002/1097-0142(19891201)64:11<2233::aid-cncr2820641108>3.0.co;2-6. PMID: 2804912
Childhood rhabdomyosarcoma: experience of the Children's Solid Tumour Group.
Kingston JE, McElwain TJ, Malpas JS
Br J Cancer 1983 Aug;48(2):195-207. doi: 10.1038/bjc.1983.175. PMID: 6882660Free PMC Article

Recent systematic reviews

Identifying barriers to treatment of childhood rhabdomyosarcoma in resource-limited settings: A literature review.
Papyan R, Tamamyan G, Danielyan S, Tananyan A, Muradyan A, Saab R
Pediatr Blood Cancer 2019 Jul;66(7):e27708. Epub 2019 Mar 25 doi: 10.1002/pbc.27708. PMID: 30907501
An emerging evidence base for PET-CT in the management of childhood rhabdomyosarcoma: systematic review.
Norman G, Fayter D, Lewis-Light K, Chisholm J, McHugh K, Levine D, Jenney M, Mandeville H, Gatz S, Phillips B
BMJ Open 2015 Jan 8;5(1):e006030. doi: 10.1136/bmjopen-2014-006030. PMID: 25573522Free PMC Article

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