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Phyllodes tumor

MedGen UID:: 1209
•Concept ID:: C0010701
•: Neoplastic Process

Synonyms:	Cystosarcoma Phyllodes; Cystosarcoma Phylloides; Phyllodes Tumor; Phyllodes Tumors; Tumor, Phyllodes; Tumors, Phyllodes

Monarch Initiative:	MONDO:0005078

Definition

A benign, borderline, or malignant fibroepithelial neoplasm arising from the breast and rarely the prostate gland. It may recur following resection. The recurrence rates are higher for borderline and malignant phyllodes tumors. In borderline and malignant phyllodes tumors metastases to distant anatomic sites can occur. The incidence of metastases is higher in malignant phyllodes tumors. [from NCI]

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPhyllodes tumor

Follow this link to review classifications for Phyllodes tumor in Orphanet.

Professional guidelines

PubMed

Breast Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.

Gradishar WJ, Moran MS, Abraham J, Abramson V, Aft R, Agnese D, Allison KH, Anderson B, Bailey J, Burstein HJ, Chen N, Chew H, Dang C, Elias AD, Giordano SH, Goetz MP, Jankowitz RC, Javid SH, Krishnamurthy J, Leitch AM, Lyons J, McCloskey S, McShane M, Mortimer J, Patel SA, Rosenberger LH, Rugo HS, Santa-Maria C, Schneider BP, Smith ML, Soliman H, Stringer-Reasor EM, Telli ML, Wei M, Wisinski KB, Yeung KT, Young JS, Schonfeld R, Kumar R
J Natl Compr Canc Netw 2024 Jul;22(5):331-357. doi: 10.6004/jnccn.2024.0035. PMID: 39019058

Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.

Gradishar WJ, Moran MS, Abraham J, Aft R, Agnese D, Allison KH, Anderson B, Burstein HJ, Chew H, Dang C, Elias AD, Giordano SH, Goetz MP, Goldstein LJ, Hurvitz SA, Isakoff SJ, Jankowitz RC, Javid SH, Krishnamurthy J, Leitch M, Lyons J, Mortimer J, Patel SA, Pierce LJ, Rosenberger LH, Rugo HS, Sitapati A, Smith KL, Smith ML, Soliman H, Stringer-Reasor EM, Telli ML, Ward JH, Wisinski KB, Young JS, Burns J, Kumar R
J Natl Compr Canc Netw 2022 Jun;20(6):691-722. doi: 10.6004/jnccn.2022.0030. PMID: 35714673

Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.

Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

See all (38)

Recent clinical studies

Etiology

Phyllodes Tumors of the Breast: Canadian National Consensus Document Using Modified Delphi Methodology.

Bogach J, Sriskandarajah A, Wright FC, Look Hong N; Canadian Phyllodes Tumor Consensus Panel
Ann Surg Oncol 2023 Oct;30(11):6386-6397. Epub 2023 Aug 9 doi: 10.1245/s10434-023-13912-7. PMID: 37556009

Management of phyllodes tumor: A systematic review and meta-analysis of real-world evidence.

Yu CY, Huang TW, Tam KW
Int J Surg 2022 Nov;107:106969. Epub 2022 Oct 31 doi: 10.1016/j.ijsu.2022.106969. PMID: 36328344

Malignant phyllodes tumor of the breast: a systematic review.

Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723 Free PMC Article

A Diagnostic Approach to Fibroepithelial Breast Lesions.

Tan BY, Tan PH
Surg Pathol Clin 2018 Mar;11(1):17-42. Epub 2017 Dec 1 doi: 10.1016/j.path.2017.09.003. PMID: 29413655

Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.

Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

See all (628)

Diagnosis

Phyllodes Tumors of the Breast: Canadian National Consensus Document Using Modified Delphi Methodology.

Bogach J, Sriskandarajah A, Wright FC, Look Hong N; Canadian Phyllodes Tumor Consensus Panel
Ann Surg Oncol 2023 Oct;30(11):6386-6397. Epub 2023 Aug 9 doi: 10.1245/s10434-023-13912-7. PMID: 37556009

Malignant phyllodes tumor of the breast: a systematic review.

Snapshot quiz.

Br J Surg 2020 May;107(6):733. doi: 10.1002/bjs.11606. PMID: 32339274

Update on the diagnosis and management of malignant phyllodes tumors of the breast.

Strode M, Khoury T, Mangieri C, Takabe K
Breast 2017 Jun;33:91-96. Epub 2017 Mar 19 doi: 10.1016/j.breast.2017.03.001. PMID: 28327352

Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.

Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

See all (980)

Therapy

Management of Stromal Lesions.

Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922

Malignant phyllodes tumors of the breast: A comprehensive literature review.

Papas Y, Asmar AE, Ghandour F, Hajj I
Breast J 2020 Feb;26(2):240-244. Epub 2019 Sep 3 doi: 10.1111/tbj.13523. PMID: 31478587

Ductal carcinoma in-situ arising within benign phyllodes tumours.

Lui SA, Oh HB, Wang S, Chan CW
Ann R Coll Surg Engl 2018 Apr;100(4):e97-e102. Epub 2018 Feb 27 doi: 10.1308/rcsann.2018.0024. PMID: 29484937 Free PMC Article

Sarcomas of the Breast with a Spotlight on Angiosarcoma and Cystosarcoma Phyllodes.

Thornton K
Surg Oncol Clin N Am 2016 Oct;25(4):713-20. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.004. PMID: 27591494

Benign breast disease.

Hamed H, Fentiman IS
Int J Clin Pract 2001 Sep;55(7):461-4. PMID: 11594256

See all (118)

Prognosis

Management of phyllodes tumor: A systematic review and meta-analysis of real-world evidence.

Yu CY, Huang TW, Tam KW
Int J Surg 2022 Nov;107:106969. Epub 2022 Oct 31 doi: 10.1016/j.ijsu.2022.106969. PMID: 36328344

Preoperative radiological and histological features predict phyllodes tumor grade.

Yan Z, Gudi M, Saffari SE, Abdrashid F, Lim SH, Teo SY, Leong MY, Lee YS, Lau L, Win T, Tan PH
Breast J 2020 Oct;26(10):2122-2124. Epub 2020 Oct 16 doi: 10.1111/tbj.13983. PMID: 33064334

Phyllodes tumour of the breast and margins: How much is enough.

Ogunbiyi S, Perry A, Jakate K, Simpson J, George R
Can J Surg 2019 Feb 1;62(1):E19-E21. doi: 10.1503/cjs.005718. PMID: 30694037 Free PMC Article

Breast sarcoma.

Moore MP, Kinne DW
Surg Clin North Am 1996 Apr;76(2):383-92. doi: 10.1016/s0039-6109(05)70445-x. PMID: 8610270

Cystosarcoma phyllodes.

Deodhar SD, Joshi S, Khubchandani S
J Postgrad Med 1989 Apr;35(2):98-103. PMID: 2559981

See all (610)

Clinical prediction guides

CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway.

Chen J, Xu Q, Liu D, Li X, Guo M, Chen X, Liao J, Lei R, Li W, Huang H, Saw PE, Song E, Yan X, Nie Y
Cancer Commun (Lond) 2023 Nov;43(11):1244-1266. Epub 2023 Oct 19 doi: 10.1002/cac2.12495. PMID: 37856423 Free PMC Article

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).

Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436 Free PMC Article

Preoperative radiological and histological features predict phyllodes tumor grade.

Yan Z, Gudi M, Saffari SE, Abdrashid F, Lim SH, Teo SY, Leong MY, Lee YS, Lau L, Win T, Tan PH
Breast J 2020 Oct;26(10):2122-2124. Epub 2020 Oct 16 doi: 10.1111/tbj.13983. PMID: 33064334

Spindle Cell Lesions of the Breast on Fine-Needle Aspiration Biopsy: A Miscellany of Masses.

Michelow P, Field AS
Acta Cytol 2019;63(4):328-339. Epub 2019 May 22 doi: 10.1159/000500703. PMID: 31117069

Phyllodes tumours of the breast: a consensus review.

Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026 Free PMC Article

See all (416)

Recent systematic reviews

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.

Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540

Management of phyllodes tumor: A systematic review and meta-analysis of real-world evidence.

Yu CY, Huang TW, Tam KW
Int J Surg 2022 Nov;107:106969. Epub 2022 Oct 31 doi: 10.1016/j.ijsu.2022.106969. PMID: 36328344

Malignant phyllodes tumor of the breast: a systematic review.

Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review.

Alipour S, Eskandari A, Johar FM, Furuya S
Arch Iran Med 2020 Jul 1;23(7):488-497. doi: 10.34172/aim.2020.46. PMID: 32657600

Surgical margins for borderline and malignant phyllodes tumours.

Thind A, Patel B, Thind K, Isherwood J, Phillips B, Dhaliwal K, Remoundos DD
Ann R Coll Surg Engl 2020 Mar;102(3):165-173. Epub 2020 Jan 10 doi: 10.1308/rcsann.2019.0140. PMID: 31918563 Free PMC Article

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Phyllodes tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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