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Degenerative disease of the central nervous system

MedGen UID:
124363
•Concept ID:
C0270715
•
Disease or Syndrome
Synonym: Degenerative Diseases, Central Nervous System
SNOMED CT: Degenerative disease of the central nervous system (80690008)

Definition

A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDegenerative disease of the central nervous system

Professional guidelines

PubMed

Multiple sclerosis and pregnancy: Pathogenesis, influencing factors, and treatment options.
Wang Y, Wang J, Feng J
Autoimmun Rev 2023 Nov;22(11):103449. Epub 2023 Sep 21 doi: 10.1016/j.autrev.2023.103449. PMID: 37741528
Haematopoietic Stem Cell Transplantation for the Treatment of Multiple Sclerosis: Recent Advances.
Mariottini A, De Matteis E, Cencioni MT, Muraro PA
Curr Neurol Neurosci Rep 2023 Sep;23(9):507-520. Epub 2023 Aug 17 doi: 10.1007/s11910-023-01290-2. PMID: 37589918Free PMC Article
Current study on diagnosis and treatment of Alzheimer's disease by targeting amyloid b-protein.
Hua KY, Zhao WJ
Folia Neuropathol 2023;61(1):8-15. doi: 10.5114/fn.2022.119778. PMID: 37114956

Recent clinical studies

Etiology

Cognitive-motor dual-task training improves dynamic stability during straight and curved gait in patients with multiple sclerosis: a randomized controlled trial.
Tramontano M, Argento O, Orejel Bustos AS, DE Angelis S, Montemurro R, Bossa M, Belluscio V, Bergamini E, Vannozzi G, Nocentini U
Eur J Phys Rehabil Med 2024 Feb;60(1):27-36. Epub 2023 Nov 23 doi: 10.23736/S1973-9087.23.08156-X. PMID: 37997324Free PMC Article
Haematopoietic Stem Cell Transplantation for the Treatment of Multiple Sclerosis: Recent Advances.
Mariottini A, De Matteis E, Cencioni MT, Muraro PA
Curr Neurol Neurosci Rep 2023 Sep;23(9):507-520. Epub 2023 Aug 17 doi: 10.1007/s11910-023-01290-2. PMID: 37589918Free PMC Article
Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting.
Charabati M, Wheeler MA, Weiner HL, Quintana FJ
Cell 2023 Mar 30;186(7):1309-1327. doi: 10.1016/j.cell.2023.03.008. PMID: 37001498Free PMC Article
Correlation between head tremble and the severity of Parkinson's disease.
Yang J, Guo Q, Zou X, Wang M, Wen Y, Chen X, Weng X, Xu F
CNS Neurosci Ther 2022 Feb;28(2):218-225. Epub 2021 Nov 10 doi: 10.1111/cns.13753. PMID: 34758102Free PMC Article
Kuru; clinical, pathological and epidemiological study of an acute progressive degenerative disease of the central nervous system among natives of the Eastern Highlands of New Guinea.
GAJDUSEK DC, ZIGAS V
Am J Med 1959 Mar;26(3):442-69. doi: 10.1016/0002-9343(59)90251-7. PMID: 13626997

Diagnosis

Current study on diagnosis and treatment of Alzheimer's disease by targeting amyloid b-protein.
Hua KY, Zhao WJ
Folia Neuropathol 2023;61(1):8-15. doi: 10.5114/fn.2022.119778. PMID: 37114956
Correlation between head tremble and the severity of Parkinson's disease.
Yang J, Guo Q, Zou X, Wang M, Wen Y, Chen X, Weng X, Xu F
CNS Neurosci Ther 2022 Feb;28(2):218-225. Epub 2021 Nov 10 doi: 10.1111/cns.13753. PMID: 34758102Free PMC Article
The relationship between diabetes-related cognitive dysfunction and leukoaraiosis.
Yuan CL, Yi R, Dong Q, Yao LF, Liu B
Acta Neurol Belg 2021 Oct;121(5):1101-1110. Epub 2021 Apr 24 doi: 10.1007/s13760-021-01676-4. PMID: 33893981
Investigation of degenerative disease of the central nervous system.
Wilson J
Arch Dis Child 1972 Apr;47(252):163-70. doi: 10.1136/adc.47.252.163. PMID: 4554083Free PMC Article
Degenerative disease of the central nervous system.
Freeman JM, McKhann GM
Adv Pediatr 1969;16:121-75. PMID: 4242467

Therapy

Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease.
Peng Y, Chen Q, Xue YH, Jin H, Liu S, Du MQ, Yao SY
Am J Chin Med 2024;52(3):625-666. Epub 2024 Apr 24 doi: 10.1142/S0192415X24500277. PMID: 38654507
Cognitive-motor dual-task training improves dynamic stability during straight and curved gait in patients with multiple sclerosis: a randomized controlled trial.
Tramontano M, Argento O, Orejel Bustos AS, DE Angelis S, Montemurro R, Bossa M, Belluscio V, Bergamini E, Vannozzi G, Nocentini U
Eur J Phys Rehabil Med 2024 Feb;60(1):27-36. Epub 2023 Nov 23 doi: 10.23736/S1973-9087.23.08156-X. PMID: 37997324Free PMC Article
Haematopoietic Stem Cell Transplantation for the Treatment of Multiple Sclerosis: Recent Advances.
Mariottini A, De Matteis E, Cencioni MT, Muraro PA
Curr Neurol Neurosci Rep 2023 Sep;23(9):507-520. Epub 2023 Aug 17 doi: 10.1007/s11910-023-01290-2. PMID: 37589918Free PMC Article
Current study on diagnosis and treatment of Alzheimer's disease by targeting amyloid b-protein.
Hua KY, Zhao WJ
Folia Neuropathol 2023;61(1):8-15. doi: 10.5114/fn.2022.119778. PMID: 37114956
Research Progress of Targeting Neuro-Immune Inflammation in the Treatment of Alzheimer's Disease.
Chen H, Deng C, Meng Z, Meng S
Front Biosci (Landmark Ed) 2022 Nov 25;27(11):312. doi: 10.31083/j.fbl2711312. PMID: 36472107

Prognosis

Multiple sclerosis and pregnancy: Pathogenesis, influencing factors, and treatment options.
Wang Y, Wang J, Feng J
Autoimmun Rev 2023 Nov;22(11):103449. Epub 2023 Sep 21 doi: 10.1016/j.autrev.2023.103449. PMID: 37741528
Haematopoietic Stem Cell Transplantation for the Treatment of Multiple Sclerosis: Recent Advances.
Mariottini A, De Matteis E, Cencioni MT, Muraro PA
Curr Neurol Neurosci Rep 2023 Sep;23(9):507-520. Epub 2023 Aug 17 doi: 10.1007/s11910-023-01290-2. PMID: 37589918Free PMC Article
Current study on diagnosis and treatment of Alzheimer's disease by targeting amyloid b-protein.
Hua KY, Zhao WJ
Folia Neuropathol 2023;61(1):8-15. doi: 10.5114/fn.2022.119778. PMID: 37114956
The relationship between diabetes-related cognitive dysfunction and leukoaraiosis.
Yuan CL, Yi R, Dong Q, Yao LF, Liu B
Acta Neurol Belg 2021 Oct;121(5):1101-1110. Epub 2021 Apr 24 doi: 10.1007/s13760-021-01676-4. PMID: 33893981
Interactions between platelets and leukocytes in pathogenesis of multiple sclerosis.
Dziedzic A, Bijak M
Adv Clin Exp Med 2019 Feb;28(2):277-285. doi: 10.17219/acem/83588. PMID: 30411550

Clinical prediction guides

Cognitive-motor dual-task training improves dynamic stability during straight and curved gait in patients with multiple sclerosis: a randomized controlled trial.
Tramontano M, Argento O, Orejel Bustos AS, DE Angelis S, Montemurro R, Bossa M, Belluscio V, Bergamini E, Vannozzi G, Nocentini U
Eur J Phys Rehabil Med 2024 Feb;60(1):27-36. Epub 2023 Nov 23 doi: 10.23736/S1973-9087.23.08156-X. PMID: 37997324Free PMC Article
Reexamining the Causes and Effects of Cholesterol Deposition in the Brains of Patients with Alzheimer's Disease.
Hu ZL, Yuan YQ, Tong Z, Liao MQ, Yuan SL, Jian Y, Yang JL, Liu WF
Mol Neurobiol 2023 Dec;60(12):6852-6868. Epub 2023 Jul 28 doi: 10.1007/s12035-023-03529-y. PMID: 37507575
The Role of BDNF in Multiple Sclerosis Neuroinflammation.
Nociti V, Romozzi M
Int J Mol Sci 2023 May 8;24(9) doi: 10.3390/ijms24098447. PMID: 37176155Free PMC Article
The relationship between diabetes-related cognitive dysfunction and leukoaraiosis.
Yuan CL, Yi R, Dong Q, Yao LF, Liu B
Acta Neurol Belg 2021 Oct;121(5):1101-1110. Epub 2021 Apr 24 doi: 10.1007/s13760-021-01676-4. PMID: 33893981
Quantifying multiple sclerosis pathology in post mortem spinal cord using MRI.
Schmierer K, McDowell A, Petrova N, Carassiti D, Thomas DL, Miquel ME
Neuroimage 2018 Nov 15;182:251-258. Epub 2018 Jan 31 doi: 10.1016/j.neuroimage.2018.01.052. PMID: 29373838

Recent systematic reviews

Psychometric properties of patient-reported outcome measures, measuring fatigue in patients with multiple sclerosis, a systematic review.
Ruzzi MAJ, Coll MB, Mata MJD, Tello MCR, García IC
Mult Scler Relat Disord 2024 Dec;92:106169. Epub 2024 Nov 14 doi: 10.1016/j.msard.2024.106169. PMID: 39579647
The association between brain volume loss and disability in multiple sclerosis: A systematic review.
Matthews PM, Gupta D, Mittal D, Bai W, Scalfari A, Pollock KG, Sharma V, Hill N
Mult Scler Relat Disord 2023 Jun;74:104714. Epub 2023 Apr 9 doi: 10.1016/j.msard.2023.104714. PMID: 37068369
Clinical efficacy and safety of compound Congrong Yizhi Capsules on Alzheimer's disease in mainland China: A systematic review with trial sequential analysis and GRADE assessment.
Wang Y, Wang N, Xu Z, Liu S, Liang X, Zhang Y, Jin X
J Ethnopharmacol 2023 Jun 12;309:116208. Epub 2023 Jan 31 doi: 10.1016/j.jep.2023.116208. PMID: 36731808
A Systematic Review of Tissue and Single Cell Transcriptome/Proteome Studies of the Brain in Multiple Sclerosis.
Elkjaer ML, Röttger R, Baumbach J, Illes Z
Front Immunol 2022;13:761225. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.761225. PMID: 35309325Free PMC Article
A Systematic Review of Discrete-Choice Experiments and Conjoint Analysis Studies in People with Multiple Sclerosis.
Webb EJD, Meads D, Eskyte I, King N, Dracup N, Chataway J, Ford HL, Marti J, Pavitt SH, Schmierer K, Manzano A
Patient 2018 Aug;11(4):391-402. doi: 10.1007/s40271-017-0296-y. PMID: 29313265

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