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Childhood Acute Monoblastic Leukemia

MedGen UID:
124640
•Concept ID:
C0279645
•
Neoplastic Process
Synonyms: Childhood Acute M5a Leukemia; Childhood Acute Monoblastic Leukemia without Differentiation; M5a Childhood Acute Monoblastic Leukemia without Differentiation; M5a Pediatric Acute Monoblastic Leukemia without Differentiation; Pediatric Acute M5a Leukemia; Pediatric Acute Monoblastic Leukemia without Differentiation

Definition

An acute monoblastic leukemia occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Monoblastic Leukemia

Professional guidelines

PubMed

Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia.
Loh ML
Br J Haematol 2011 Mar;152(6):677-87. doi: 10.1111/j.1365-2141.2010.08525.x. PMID: 21623760
Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic leukemia.
Loh ML
Hematology Am Soc Hematol Educ Program 2010;2010:357-62. doi: 10.1182/asheducation-2010.1.357. PMID: 21239819
Advances in the management of childhood leukemia.
Bowman WP
Tex Med 1985 Mar;81(3):39-44. PMID: 3885465

Recent clinical studies

Etiology

Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10(9)/L.
Zhang A, Liu L, Zong S, Chang L, Chen X, Yang W, Guo Y, Zhang L, Zou Y, Chen Y, Zhang Y, Ruan M, Zhu X
Int J Hematol 2023 Dec;118(6):737-744. Epub 2023 Sep 21 doi: 10.1007/s12185-023-03665-0. PMID: 37733171
Novel therapies for children with acute myeloid leukaemia.
Moore AS, Kearns PR, Knapper S, Pearson AD, Zwaan CM
Leukemia 2013 Jul;27(7):1451-60. Epub 2013 Apr 8 doi: 10.1038/leu.2013.106. PMID: 23563239
Chromosome studies on acute nonlymphocytic leukaemia in children.
Slater RM, Behrendt H, De Waal FC
Pediatr Res 1983 May;17(5):398-405. doi: 10.1203/00006450-198305000-00016. PMID: 6574421
The classification of acute leukaemia in childhood.
Bird AR, Karabus CD, Pearl R, Hartley P
S Afr Med J 1981 Nov 14;60(20):769-73. PMID: 6171040
Acute nonlymphoblastic leukemia in childhood.
Morse H, Hays T, Peakman D, Rose B, Robinson A
Cancer 1979 Jul;44(1):164-70. doi: 10.1002/1097-0142(197907)44:1<164::aid-cncr2820440128>3.0.co;2-9. PMID: 287549

Diagnosis

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S
Blood Adv 2024 Jan 9;8(1):112-129. doi: 10.1182/bloodadvances.2022008899. PMID: 37729615Free PMC Article
Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10(9)/L.
Zhang A, Liu L, Zong S, Chang L, Chen X, Yang W, Guo Y, Zhang L, Zou Y, Chen Y, Zhang Y, Ruan M, Zhu X
Int J Hematol 2023 Dec;118(6):737-744. Epub 2023 Sep 21 doi: 10.1007/s12185-023-03665-0. PMID: 37733171
Chromosome studies on acute nonlymphocytic leukaemia in children.
Slater RM, Behrendt H, De Waal FC
Pediatr Res 1983 May;17(5):398-405. doi: 10.1203/00006450-198305000-00016. PMID: 6574421
Acute nonlymphoblastic leukemia in childhood.
Morse H, Hays T, Peakman D, Rose B, Robinson A
Cancer 1979 Jul;44(1):164-70. doi: 10.1002/1097-0142(197907)44:1<164::aid-cncr2820440128>3.0.co;2-9. PMID: 287549
Acute childhood leukemia: epidemiologic study by cell type of 1,263 cases at the Children's Cancer Research Foundation in Boston, 1947-65.
Fraumeni JF Jr, Manning MD, Mitus WJ
J Natl Cancer Inst 1971 Mar;46(3):461-70. PMID: 4251157

Therapy

Advances in the management of childhood leukemia.
Bowman WP
Tex Med 1985 Mar;81(3):39-44. PMID: 3885465
Vincristine, prednisone, and daunomycin in acute leukemia of childhood.
Vietti TJ, Starling K, Wilbur JR, Lonsdale D, Lane DM
Cancer 1971 Mar;27(3):602-7. doi: 10.1002/1097-0142(197103)27:3<602::aid-cncr2820270314>3.0.co;2-5. PMID: 5279331
Cyclic chemotherapy in childhood acute leukaemia.
Willoughby ML, Laurie HC
Arch Dis Child 1968 Apr;43(228):187-94. doi: 10.1136/adc.43.228.187. PMID: 5239002Free PMC Article
Prednisone therapy of acute childhood leukemia: prognosis and duration of response in 330 treated patients.
Wolff JA, Brubaker CA, Murphy ML, Pierce MI, Severo N
J Pediatr 1967 Apr;70(4):626-31. doi: 10.1016/s0022-3476(67)80052-0. PMID: 5227061
IMPLICATIONS OF LONG-TERM SURVIVAL IN ACUTE STEM CELL LEUKEMIA OF CHILDHOOD TREATED WITH COMPOSITE CYCLIC THERAPY.
ZUELZER WW
Blood 1964 Nov;24:477-94. PMID: 14236724

Prognosis

Pediatric acute myeloid leukemia and hyperleukocytosis with WBC count greater than 50 × 10(9)/L.
Zhang A, Liu L, Zong S, Chang L, Chen X, Yang W, Guo Y, Zhang L, Zou Y, Chen Y, Zhang Y, Ruan M, Zhu X
Int J Hematol 2023 Dec;118(6):737-744. Epub 2023 Sep 21 doi: 10.1007/s12185-023-03665-0. PMID: 37733171
Duchenne muscular dystrophy-rhabdomyosarcoma, ichthyosis vulgaris/acute monoblastic leukemia: association of rare genetic disorders and childhood malignant diseases.
Jakab Z, Szegedi I, Balogh E, Kiss C, Oláh E
Med Pediatr Oncol 2002 Jul;39(1):66-8. doi: 10.1002/mpo.10043. PMID: 12116087
Advances in the management of childhood leukemia.
Bowman WP
Tex Med 1985 Mar;81(3):39-44. PMID: 3885465
Prednisone therapy of acute childhood leukemia: prognosis and duration of response in 330 treated patients.
Wolff JA, Brubaker CA, Murphy ML, Pierce MI, Severo N
J Pediatr 1967 Apr;70(4):626-31. doi: 10.1016/s0022-3476(67)80052-0. PMID: 5227061
IMPLICATIONS OF LONG-TERM SURVIVAL IN ACUTE STEM CELL LEUKEMIA OF CHILDHOOD TREATED WITH COMPOSITE CYCLIC THERAPY.
ZUELZER WW
Blood 1964 Nov;24:477-94. PMID: 14236724

Clinical prediction guides

Leukemia Types and Subtypes Analysis: Epidemiological Age-Standardized Exploration in the Mexican Bajio Region.
Romero-Morelos P, González-Yebra AL, Bueno-Rosario LJ, González-Yebra B
Medicina (Kaunas) 2024 Apr 28;60(5) doi: 10.3390/medicina60050731. PMID: 38792914Free PMC Article
IL-1 signaling pathway molecules as key markers in childhood asthma.
Wei W, Huang J, Ma Y, Ma X, Fang L, Fang W, Hao C
Pediatr Allergy Immunol 2021 Feb;32(2):305-313. Epub 2020 Nov 4 doi: 10.1111/pai.13388. PMID: 33025692
Prognostic factors in childhood acute myelogenous leukemia.
Grier HE, Gelber RD, Camitta BM, Delorey MJ, Link MP, Price KN, Leavitt PR, Weinstein HJ
J Clin Oncol 1987 Jul;5(7):1026-32. doi: 10.1200/JCO.1987.5.7.1026. PMID: 3474356
Acute myeloid leukaemia in childhood: clinical features and prognosis.
Chessells JM, O'Callaghan U, Hardisty RM
Br J Haematol 1986 Jul;63(3):555-64. doi: 10.1111/j.1365-2141.1986.tb07533.x. PMID: 3460625
In vitro characteristics of childhood leukemic monoblasts.
Weetman RM, Chilcote RR, Rierden WJ, Baehner RL
Exp Hematol 1978 Jan;6(1):9-17. PMID: 304810

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