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Adrenal Cortical Clear Cell Adenoma

MedGen UID:
137745
•Concept ID:
C0334334
•
Neoplastic Process
Synonyms: Adrenal Cortex Clear Cell Adenoma; Adrenal cortical adenoma - clear cell; Adrenal cortical adenoma, clear cell; Adrenal Gland Clear Cell Adenoma; Clear Cell Adrenal Cortex Adenoma; Clear Cell Adrenal Cortical Adenoma; Clear Cell Adrenocortical Adenoma
SNOMED CT: Adrenal cortical adenoma - clear cell (18977007); Adrenal cortical adenoma, clear cell (18977007)

Definition

An adenoma of the adrenal cortex composed of neoplastic clear cells containing intracytoplasmic lipid droplets. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenal Cortical Clear Cell Adenoma

Professional guidelines

PubMed

Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism.
Harashima S, Yamazaki Y, Motomura N, Ono Y, Omata K, Tezuka Y, Morimoto R, Nakamura Y, Satoh F, Suzuki H, Kwon GE, Choi MH, Sasano H
J Steroid Biochem Mol Biol 2022 Jul;221:106116. Epub 2022 May 6 doi: 10.1016/j.jsbmb.2022.106116. PMID: 35533918
Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼.
Gao X, Yamazaki Y, Tezuka Y, Pieroni J, Ishii K, Atsumi N, Ono Y, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H
J Steroid Biochem Mol Biol 2020 Nov;204:105764. Epub 2020 Sep 28 doi: 10.1016/j.jsbmb.2020.105764. PMID: 33002589
Differential diagnosis of renal tumors with clear cytoplasm: clinical relevance of renal tumor subclassification in the era of targeted therapies and personalized medicine.
Goyal R, Gersbach E, Yang XJ, Rohan SM
Arch Pathol Lab Med 2013 Apr;137(4):467-80. doi: 10.5858/arpa.2012-0085-RA. PMID: 23544936

Recent clinical studies

Etiology

Characteristics of benign adrenocortical adenomas with 18F-FDG PET accumulation.
Ishiwata K, Suzuki S, Igarashi K, Ruike Y, Naito K, Ishida A, Deguchi-Horiuchi H, Fujimoto M, Koide H, Imamura Y, Sakamoto S, Ichikawa T, Ikeda JI, Yokote K
Eur J Endocrinol 2021 Jun 5;185(1):155-165. doi: 10.1530/EJE-20-1459. PMID: 33960957
Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma.
De Sousa K, Boulkroun S, Baron S, Nanba K, Wack M, Rainey WE, Rocha A, Giscos-Douriez I, Meatchi T, Amar L, Travers S, Fernandes-Rosa FL, Zennaro MC
Hypertension 2020 Apr;75(4):1034-1044. Epub 2020 Mar 2 doi: 10.1161/HYPERTENSIONAHA.119.14177. PMID: 32114847Free PMC Article
The 10 Hounsfield units unenhanced computed tomography attenuation threshold does not apply to cortisol secreting adrenocortical adenomas.
Chambre C, McMurray E, Baudry C, Lataud M, Guignat L, Gaujoux S, Lahlou N, Guibourdenche J, Tissier F, Sibony M, Dousset B, Bertagna X, Bertherat J, Legmann P, Groussin L
Eur J Endocrinol 2015 Sep;173(3):325-32. doi: 10.1530/EJE-15-0036. PMID: 26243637
cAMP signaling in cortisol-producing adrenal adenoma.
Calebiro D, Di Dalmazi G, Bathon K, Ronchi CL, Beuschlein F
Eur J Endocrinol 2015 Oct;173(4):M99-106. Epub 2015 Jul 2 doi: 10.1530/EJE-15-0353. PMID: 26139209
Differentiation of primary and metastatic clear cell tumors in the liver by in situ hybridization for albumin messenger RNA.
Oliveira AM, Erickson LA, Burgart LJ, Lloyd RV
Am J Surg Pathol 2000 Feb;24(2):177-82. doi: 10.1097/00000478-200002000-00002. PMID: 10680884

Diagnosis

A Cyst-ematic Analysis of the Adrenal Gland: A Compilation of Primary Cystic Lesions From Our Institution and Review of the Literature.
Gubbiotti MA, LiVolsi V, Montone K, Baloch Z
Am J Clin Pathol 2022 Apr 1;157(4):531-539. doi: 10.1093/ajcp/aqab156. PMID: 34596217
Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma.
Ortiz-Rey JA, Fachal C, Juaneda-Magdalena L, Muñoz-Martín M, Repáraz-Andrade A, Teijeira S, Lamas-Barreiro JM, Almuster-Domínguez S, San Miguel-Fraile P, Gómez-de María C
Virchows Arch 2021 Jul;479(1):57-67. Epub 2021 Jan 14 doi: 10.1007/s00428-021-03018-4. PMID: 33447899
Non-mesenchymal Mimics of Sarcoma.
Doyle LA
Surg Pathol Clin 2015 Sep;8(3):493-513. doi: 10.1016/j.path.2015.05.010. PMID: 26297067
Myxoid adrenal cortical adenoma.
Honda K, Kashima K, Daa T, Gamachi A, Nakayama I, Yokoyama S
Pathol Int 2001 Nov;51(11):887-91. doi: 10.1046/j.1440-1827.2001.01287.x. PMID: 11844057
Von Hippel-Lindau syndrome with microscopic hemangioblastomas of the spinal nerve roots. Case report.
Ismail SM, Cole G
J Neurosurg 1984 Jun;60(6):1279-81. doi: 10.3171/jns.1984.60.6.1279. PMID: 6539366

Therapy

The use of immunohistochemical expression of SF-1 and EMA in distinguishing adrenocortical tumors from renal neoplasms.
Enriquez ML, Lal P, Ziober A, Wang L, Tomaszewski JE, Bing Z
Appl Immunohistochem Mol Morphol 2012 Mar;20(2):141-5. doi: 10.1097/pai.0b013e31823605e7. PMID: 22553814
Bilateral aldosteronoma associated with secondary aldosteronism in a chronic hemodialysis subject.
Ikoma A, Saito T, Murata M, Toyoshima H, Nakamura Y, Kawakami M, Sasano H, Ishikawa SE
Intern Med 2010;49(11):1017-21. Epub 2010 Jun 1 doi: 10.2169/internalmedicine.49.2808. PMID: 20519819
Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions.
Mete O, Asa SL
Endocr Pathol 2009 Fall;20(3):182-5. doi: 10.1007/s12022-009-9082-2. PMID: 19462261
Leptin inhibits cortisol and corticosterone secretion in pathologic human adrenocortical cells.
Szücs N, Varga I, Jakab C, Patócs A, Gláz E, Tóth M, Kiss R, Rácz K
Pituitary 2001 Jan-Apr;4(1-2):71-7. doi: 10.1023/a:1012990928218. PMID: 11824511
Cushing's syndrome due to bilateral adrenocortical adenomas with different pathological features.
Tamura H, Sugihara H, Minami S, Emoto N, Shibasaki T, Shuto Y, Shimizu K, Gomi Y, Sasano H, Wakabayashi I
Intern Med 1997 Nov;36(11):804-9. doi: 10.2169/internalmedicine.36.804. PMID: 9392354

Prognosis

Application of TFE3 Immunophenotypic and TFE3 mRNA Expressions in Diagnosis and Prognostication of Adrenal Cortical Neoplasms and Distinction From Kidney Tumors.
Wang X, Ng CS, Yin W, Liang L
Appl Immunohistochem Mol Morphol 2023 Jan 1;31(1):9-16. Epub 2022 Nov 21 doi: 10.1097/PAI.0000000000001090. PMID: 36476598
Expression of Glutamine Metabolism-Related and Amino Acid Transporter Proteins in Adrenal Cortical Neoplasms and Pheochromocytomas.
Kim HM, Koo JS
Dis Markers 2021;2021:8850990. Epub 2021 Jan 5 doi: 10.1155/2021/8850990. PMID: 33505538Free PMC Article
Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma.
Ortiz-Rey JA, Fachal C, Juaneda-Magdalena L, Muñoz-Martín M, Repáraz-Andrade A, Teijeira S, Lamas-Barreiro JM, Almuster-Domínguez S, San Miguel-Fraile P, Gómez-de María C
Virchows Arch 2021 Jul;479(1):57-67. Epub 2021 Jan 14 doi: 10.1007/s00428-021-03018-4. PMID: 33447899
Gene expression profiling in adrenocortical neoplasia.
Assie G, Giordano TJ, Bertherat J
Mol Cell Endocrinol 2012 Mar 31;351(1):111-7. Epub 2011 Oct 25 doi: 10.1016/j.mce.2011.09.044. PMID: 22056416
Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors.
Weiss LM
Am J Surg Pathol 1984 Mar;8(3):163-9. doi: 10.1097/00000478-198403000-00001. PMID: 6703192

Clinical prediction guides

Expression of Glutamine Metabolism-Related and Amino Acid Transporter Proteins in Adrenal Cortical Neoplasms and Pheochromocytomas.
Kim HM, Koo JS
Dis Markers 2021;2021:8850990. Epub 2021 Jan 5 doi: 10.1155/2021/8850990. PMID: 33505538Free PMC Article
Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma.
Ortiz-Rey JA, Fachal C, Juaneda-Magdalena L, Muñoz-Martín M, Repáraz-Andrade A, Teijeira S, Lamas-Barreiro JM, Almuster-Domínguez S, San Miguel-Fraile P, Gómez-de María C
Virchows Arch 2021 Jul;479(1):57-67. Epub 2021 Jan 14 doi: 10.1007/s00428-021-03018-4. PMID: 33447899
Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma.
De Sousa K, Boulkroun S, Baron S, Nanba K, Wack M, Rainey WE, Rocha A, Giscos-Douriez I, Meatchi T, Amar L, Travers S, Fernandes-Rosa FL, Zennaro MC
Hypertension 2020 Apr;75(4):1034-1044. Epub 2020 Mar 2 doi: 10.1161/HYPERTENSIONAHA.119.14177. PMID: 32114847Free PMC Article
Adrenal cortical adenoma: the fourth component of the Carney triad and an association with subclinical Cushing syndrome.
Carney JA, Stratakis CA, Young WF Jr
Am J Surg Pathol 2013 Aug;37(8):1140-9. doi: 10.1097/PAS.0b013e318285f6a2. PMID: 23681078Free PMC Article
Adrenal hyperplasia and tumours in mice in connection with aberrant pituitary-gonadal function.
Bernichtein S, Peltoketo H, Huhtaniemi I
Mol Cell Endocrinol 2009 Mar 5;300(1-2):164-8. Epub 2008 Oct 19 doi: 10.1016/j.mce.2008.10.005. PMID: 19007852

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