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Acquired factor V deficiency

MedGen UID:
1380582
•Concept ID:
C4329256
•
Disease or Syndrome
Synonyms: Acquired Factor V Deficiency; acquired factor V deficiency
 
Monarch Initiative: MONDO:0035737
Orphanet: ORPHA599490

Definition

An acquired coagulation disorder characterized by the partial or complete absence of factor V activity in the blood. [from NCI]

Professional guidelines

PubMed

Factor V Deficiency in Korean Patients: Clinical and Laboratory Features, Treatment, and Outcome.
Park YH, Lim JH, Yi HG, Lee MH, Kim CS
J Korean Med Sci 2016 Feb;31(2):208-13. Epub 2016 Jan 25 doi: 10.3346/jkms.2016.31.2.208. PMID: 26839474Free PMC Article

Recent clinical studies

Etiology

A Review of Coagulation Abnormalities of Autoimmune Acquired Factor V Deficiency with a Focus on Japan.
Ichinose A, Osaki T, Souri M
Semin Thromb Hemost 2022 Mar;48(2):206-218. Epub 2021 Dec 23 doi: 10.1055/s-0041-1740149. PMID: 34942668
A case of mitral valve repair complicated by acquired factor V deficiency.
Nakashima K, Hari Y, Takagi H, Okazaki T, Kitamura T, Miyaji K
Gen Thorac Cardiovasc Surg 2021 May;69(5):874-876. Epub 2021 Mar 20 doi: 10.1007/s11748-020-01567-0. PMID: 33743135
Acquired Factor V Deficiency Associated with CFPM Administration.
Yamanishi M, Nishimi Y, Usui M, Miki K, Imashuku S
Clin Lab 2019 Oct 1;65(10) doi: 10.7754/Clin.Lab.2019.190240. PMID: 31625361
Acquired factor V inhibitor in a patient receiving venous-venous extracorporeal membrane oxygenation for Legionella pneumonia.
Leung AK, Ng GW, Sin KC, Au SY, Lai KY, Lee KL, Law KI
Hong Kong Med J 2015 Apr;21(2):175-8. doi: 10.12809/hkmj134141. PMID: 25904567
Acquired factor V deficiency associated with exposure to bovine thrombin in a burn patient.
Foster KN, Kim H, Potter K, Matthews MR, Pressman M, Caruso DM
J Burn Care Res 2010 Mar-Apr;31(2):353-60. doi: 10.1097/BCR.0b013e3181d0f5b4. PMID: 20182366

Diagnosis

Acquired Factor V Deficiency: A New Cause of Bleeding in Patients with Chronic Myeloid Leukemia and Extreme Leukocytosis.
To AQ, Ciurea SO, Kongtim P
Acta Haematol 2023;146(6):546-549. Epub 2022 May 2 doi: 10.1159/000524630. PMID: 35500558
Acquired Factor V Deficiency Associated with CFPM Administration.
Yamanishi M, Nishimi Y, Usui M, Miki K, Imashuku S
Clin Lab 2019 Oct 1;65(10) doi: 10.7754/Clin.Lab.2019.190240. PMID: 31625361
Challenges in management of unusual acquired factor V deficiency: A case report.
Takemoto K, Hamada O, Kitamura K, Fujiwara N, Miyakawa Y
Medicine (Baltimore) 2019 Apr;98(17):e15259. doi: 10.1097/MD.0000000000015259. PMID: 31027075Free PMC Article
Acquired factor V inhibitor in a patient receiving venous-venous extracorporeal membrane oxygenation for Legionella pneumonia.
Leung AK, Ng GW, Sin KC, Au SY, Lai KY, Lee KL, Law KI
Hong Kong Med J 2015 Apr;21(2):175-8. doi: 10.12809/hkmj134141. PMID: 25904567
Inherited and acquired factor V deficiency.
Lippi G, Favaloro EJ, Montagnana M, Manzato F, Guidi GC, Franchini M
Blood Coagul Fibrinolysis 2011 Apr;22(3):160-6. doi: 10.1097/MBC.0b013e3283424883. PMID: 21245750

Therapy

A case of mitral valve repair complicated by acquired factor V deficiency.
Nakashima K, Hari Y, Takagi H, Okazaki T, Kitamura T, Miyaji K
Gen Thorac Cardiovasc Surg 2021 May;69(5):874-876. Epub 2021 Mar 20 doi: 10.1007/s11748-020-01567-0. PMID: 33743135
Plasma Exchange as an Initial Treatment for Severe Bleeding Induced by Acquired Factor V Deficiency: A Case Report and Mini Literature Review.
Yanagiya R, Kanouchi K, Toubai T, Yamada A, Aizawa K, Shiono Y, Ito S, Ishizawa K
Acta Haematol 2021;144(1):82-87. Epub 2020 Aug 12 doi: 10.1159/000505770. PMID: 32784304
Acquired Factor V Deficiency Associated with CFPM Administration.
Yamanishi M, Nishimi Y, Usui M, Miki K, Imashuku S
Clin Lab 2019 Oct 1;65(10) doi: 10.7754/Clin.Lab.2019.190240. PMID: 31625361
Challenges in management of unusual acquired factor V deficiency: A case report.
Takemoto K, Hamada O, Kitamura K, Fujiwara N, Miyakawa Y
Medicine (Baltimore) 2019 Apr;98(17):e15259. doi: 10.1097/MD.0000000000015259. PMID: 31027075Free PMC Article
Acquired factor V inhibitor in a patient receiving venous-venous extracorporeal membrane oxygenation for Legionella pneumonia.
Leung AK, Ng GW, Sin KC, Au SY, Lai KY, Lee KL, Law KI
Hong Kong Med J 2015 Apr;21(2):175-8. doi: 10.12809/hkmj134141. PMID: 25904567

Prognosis

A Review of Coagulation Abnormalities of Autoimmune Acquired Factor V Deficiency with a Focus on Japan.
Ichinose A, Osaki T, Souri M
Semin Thromb Hemost 2022 Mar;48(2):206-218. Epub 2021 Dec 23 doi: 10.1055/s-0041-1740149. PMID: 34942668
Acquired Factor V Deficiency Associated with CFPM Administration.
Yamanishi M, Nishimi Y, Usui M, Miki K, Imashuku S
Clin Lab 2019 Oct 1;65(10) doi: 10.7754/Clin.Lab.2019.190240. PMID: 31625361
Acquired factor V inhibitor in a patient receiving venous-venous extracorporeal membrane oxygenation for Legionella pneumonia.
Leung AK, Ng GW, Sin KC, Au SY, Lai KY, Lee KL, Law KI
Hong Kong Med J 2015 Apr;21(2):175-8. doi: 10.12809/hkmj134141. PMID: 25904567
T-cell prolymphocytic leukemia with autoimmune manifestations in Nijmegen breakage syndrome.
Michallet AS, Lesca G, Radford-Weiss I, Delarue R, Varet B, Buzyn A
Ann Hematol 2003 Aug;82(8):515-517. Epub 2003 Jul 3 doi: 10.1007/s00277-003-0697-y. PMID: 12845481
Life-threatening bleeding and acquired factor V deficiency associated with primary systemic amyloidosis.
Emori Y, Sakugawa M, Niiya K, Kiguchi T, Kojima K, Takenaka K, Shinagawa K, Ishimaru F, Ikeda K, Tanimoto M, Yamasaki R, Ohara N, Harada M
Blood Coagul Fibrinolysis 2002 Sep;13(6):555-9. doi: 10.1097/00001721-200209000-00011. PMID: 12192308

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