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Occult Breast Carcinoma

MedGen UID:
1612883
•Concept ID:
C4527188
•
Neoplastic Process

Definition

Breast carcinoma presenting with isolated axillary lymphadenopathy, without clinical or mammographic evidence of breast tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOccult Breast Carcinoma

Professional guidelines

PubMed

Optimal Surgical Management for Occult Breast Carcinoma: A Meta-analysis.
Macedo FI, Eid JJ, Flynn J, Jacobs MJ, Mittal VK
Ann Surg Oncol 2016 Jun;23(6):1838-44. Epub 2016 Feb 1 doi: 10.1245/s10434-016-5104-8. PMID: 26832884
Treatment outcomes of occult breast carcinoma and prognostic analyses.
Wang J, Zhang YF, Wang X, Wang J, Yang X, Gao YQ, Fang Y
Chin Med J (Engl) 2013 Aug;126(16):3026-9. PMID: 23981605
Clinical benefits of mastectomy on treatment of occult breast carcinoma presenting axillary metastases.
Wang X, Zhao Y, Cao X
Breast J 2010 Jan-Feb;16(1):32-7. doi: 10.1111/j.1524-4741.2009.00848.x. PMID: 20465598

Recent clinical studies

Etiology

Sentinel lymph node biopsy after nipple-sparing mastectomy in early postoperative period: Is it feasible?
Kara H, Arikan AE, Dülgeroğlu O, Uras C
Indian J Cancer 2023 Apr-Jun;60(2):237-241. doi: 10.4103/ijc.IJC_1175_20. PMID: 37530247
Occult disease in reduction mammoplasties and prophylactic mastectomies.
Nomikos A, Husain EA, Graham AD
Breast J 2020 Apr;26(4):691-696. Epub 2019 Aug 25 doi: 10.1111/tbj.13512. PMID: 31448509
Treatment outcomes of occult breast carcinoma and prognostic analyses.
Wang J, Zhang YF, Wang X, Wang J, Yang X, Gao YQ, Fang Y
Chin Med J (Engl) 2013 Aug;126(16):3026-9. PMID: 23981605
Immunohistochemically defined subtypes and outcome in occult breast carcinoma with axillary presentation.
Montagna E, Bagnardi V, Rotmensz N, Viale G, Cancello G, Mazza M, Cardillo A, Ghisini R, Galimberti V, Veronesi P, Monti S, Luini A, Raviele PR, Mastropasqua MG, Goldhirsch A, Colleoni M
Breast Cancer Res Treat 2011 Oct;129(3):867-75. Epub 2011 Aug 6 doi: 10.1007/s10549-011-1697-6. PMID: 21822638
Occult breast carcinoma in breast reduction specimens in European women.
Goyal A, Coulson SG, Wu JM, Suvarna SK, Reed MW, Caddy CM
Breast Cancer Res Treat 2011 Aug;128(3):749-53. Epub 2011 May 28 doi: 10.1007/s10549-011-1589-9. PMID: 21625930

Diagnosis

Paraneoplastic Cerebellar Syndrome Presented as Cerebellar Hypermetabolism in a Patient With Occult Breast Carcinoma.
Booij J, Adam JA, van Eerde MS, Bronner IM
Clin Nucl Med 2022 Feb 1;47(2):130-132. doi: 10.1097/RLU.0000000000004016. PMID: 35006107Free PMC Article
Occult Breast Carcinoma Is More Common in Women Undergoing Breast Reduction after Contralateral Cancer: A Systematic Review and Meta-Analysis.
Fitzpatrick SE, Lam TC
Plast Reconstr Surg 2020 Aug;146(2):117e-126e. doi: 10.1097/PRS.0000000000006965. PMID: 32740565
Treatment outcomes of occult breast carcinoma and prognostic analyses.
Wang J, Zhang YF, Wang X, Wang J, Yang X, Gao YQ, Fang Y
Chin Med J (Engl) 2013 Aug;126(16):3026-9. PMID: 23981605
Mucinous metastases from occult breast carcinoma.
Pauciulo A, Polito R, Masini V, Del Ciello A, Tartaglione T, Campioni P
Rays 2005 Jan-Mar;30(1):11-7. PMID: 16022115
Complementary diagnostic procedures in occult breast carcinoma.
Matallana RH
Wis Med J 1981 Mar;80(3):35-6. PMID: 7281710

Therapy

Occult Breast Carcinoma Is More Common in Women Undergoing Breast Reduction after Contralateral Cancer: A Systematic Review and Meta-Analysis.
Fitzpatrick SE, Lam TC
Plast Reconstr Surg 2020 Aug;146(2):117e-126e. doi: 10.1097/PRS.0000000000006965. PMID: 32740565
Clinical and pathological characteristics of occult breast cancer and review of the literature.
Altan E, Altundag K
J BUON 2011 Jul-Sep;16(3):434-6. PMID: 22006745
Immunohistochemically defined subtypes and outcome in occult breast carcinoma with axillary presentation.
Montagna E, Bagnardi V, Rotmensz N, Viale G, Cancello G, Mazza M, Cardillo A, Ghisini R, Galimberti V, Veronesi P, Monti S, Luini A, Raviele PR, Mastropasqua MG, Goldhirsch A, Colleoni M
Breast Cancer Res Treat 2011 Oct;129(3):867-75. Epub 2011 Aug 6 doi: 10.1007/s10549-011-1697-6. PMID: 21822638
Optimised nuclear medicine method for tumour marking and sentinel node detection in occult primary breast lesions.
De Cicco C, Trifirò G, Intra M, Marotta G, Ciprian A, Frasson A, Prisco G, Luini A, Viale G, Paganelli G
Eur J Nucl Med Mol Imaging 2004 Mar;31(3):349-54. Epub 2003 Nov 29 doi: 10.1007/s00259-003-1390-z. PMID: 14647985
Microangiopathic haemolysis associated with occult carcinoma.
Collins PW, Jones L, Pocock C, Newland AC
Clin Lab Haematol 1991;13(3):245-9. doi: 10.1111/j.1365-2257.1991.tb00279.x. PMID: 1794226

Prognosis

Occult Breast Carcinoma Is More Common in Women Undergoing Breast Reduction after Contralateral Cancer: A Systematic Review and Meta-Analysis.
Fitzpatrick SE, Lam TC
Plast Reconstr Surg 2020 Aug;146(2):117e-126e. doi: 10.1097/PRS.0000000000006965. PMID: 32740565
Optimal Surgical Management for Occult Breast Carcinoma: A Meta-analysis.
Macedo FI, Eid JJ, Flynn J, Jacobs MJ, Mittal VK
Ann Surg Oncol 2016 Jun;23(6):1838-44. Epub 2016 Feb 1 doi: 10.1245/s10434-016-5104-8. PMID: 26832884
Treatment outcomes of occult breast carcinoma and prognostic analyses.
Wang J, Zhang YF, Wang X, Wang J, Yang X, Gao YQ, Fang Y
Chin Med J (Engl) 2013 Aug;126(16):3026-9. PMID: 23981605
Clinical and pathological characteristics of occult breast cancer and review of the literature.
Altan E, Altundag K
J BUON 2011 Jul-Sep;16(3):434-6. PMID: 22006745
Prognosis of occult breast carcinoma presenting as isolated axillary nodal metastasis.
Varadarajan R, Edge SB, Yu J, Watroba N, Janarthanan BR
Oncology 2006;71(5-6):456-9. Epub 2007 Aug 9 doi: 10.1159/000107111. PMID: 17690561

Clinical prediction guides

Sentinel lymph node biopsy after nipple-sparing mastectomy in early postoperative period: Is it feasible?
Kara H, Arikan AE, Dülgeroğlu O, Uras C
Indian J Cancer 2023 Apr-Jun;60(2):237-241. doi: 10.4103/ijc.IJC_1175_20. PMID: 37530247
Optimal Surgical Management for Occult Breast Carcinoma: A Meta-analysis.
Macedo FI, Eid JJ, Flynn J, Jacobs MJ, Mittal VK
Ann Surg Oncol 2016 Jun;23(6):1838-44. Epub 2016 Feb 1 doi: 10.1245/s10434-016-5104-8. PMID: 26832884
Clinical and pathological characteristics of occult breast cancer and review of the literature.
Altan E, Altundag K
J BUON 2011 Jul-Sep;16(3):434-6. PMID: 22006745
Immunohistochemically defined subtypes and outcome in occult breast carcinoma with axillary presentation.
Montagna E, Bagnardi V, Rotmensz N, Viale G, Cancello G, Mazza M, Cardillo A, Ghisini R, Galimberti V, Veronesi P, Monti S, Luini A, Raviele PR, Mastropasqua MG, Goldhirsch A, Colleoni M
Breast Cancer Res Treat 2011 Oct;129(3):867-75. Epub 2011 Aug 6 doi: 10.1007/s10549-011-1697-6. PMID: 21822638
Occult breast carcinoma presenting with axillary lymph node metastases: follow-up of eleven patients.
Matsuoka K, Ohsumi S, Takashima S, Saeki T, Aogi K, Mandai K
Breast Cancer 2003;10(4):330-4. doi: 10.1007/BF02967653. PMID: 14634511

Recent systematic reviews

Occult Breast Carcinoma Is More Common in Women Undergoing Breast Reduction after Contralateral Cancer: A Systematic Review and Meta-Analysis.
Fitzpatrick SE, Lam TC
Plast Reconstr Surg 2020 Aug;146(2):117e-126e. doi: 10.1097/PRS.0000000000006965. PMID: 32740565

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